Can a modified vitamin a pill save sight in dry AMD?

NCT ID NCT03845582

Completed Disease control Sponsor: Alkeus Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a daily pill called ALK-001, a modified form of vitamin A, to see if it can slow the growth of geographic atrophy—an advanced form of dry age-related macular degeneration that causes blind spots. About 300 people with the condition took either the drug or a placebo for 24 months. Researchers measured changes in the size of the atrophy and checked for side effects and vision changes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ALK-001 (a modified form of vitamin A)
What this could lead to: If successful, this could slow the progression of geographic atrophy, helping preserve vision in people with dry age-related macular degeneration.
What could go wrong: This is a mid-stage trial with only 200 participants, so results may not apply to everyone. The treatment may not slow vision loss or could cause side effects.

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Conditions

The condition(s) this trial relates to.

age-related macular degeneration dry age related macular degeneration Geographic Atrophy macular degeneration serpiginous choroiditis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

Alkeus Site

Phoenix, Arizona, 85053, United States
Alkeus Site

Beverly Hills, California, 90211, United States
Alkeus Site

Lakewood, Colorado, 80228, United States
Alkeus Site

Clearwater, Florida, 33761, United States
Alkeus Site

Fort Myers, Florida, 33912, United States
Alkeus Site

Gainesville, Florida, 32601, United States
Alkeus Site

Tampa, Florida, 33609, United States
Alkeus Site

Winter Haven, Florida, 33880, United States
Alkeus Site

Bloomington, Illinois, 61704, United States
Alkeus Site

Lexington, Kentucky, 40509, United States
Alkeus Site

Chevy Chase, Maryland, 20815, United States
Alkeus Site

Worcester, Massachusetts, 01605, United States
Alkeus Site

Grand Rapids, Michigan, 49546, United States
Alkeus Site

Edina, Minnesota, 55435, United States
Alkeus Site

Northfield, New Jersey, 08225, United States
Alkeus Site

Great Neck, New York, 11021, United States
Alkeus Site

Hauppauge, New York, 11788, United States
Alkeus Site

Cleveland, Ohio, 44122, United States
Alkeus Site

Ashland, Oregon, 97520, United States
Alkeus Site

Houston, Texas, 77025, United States
Alkeus Site

Fairfax, Virginia, 22031, United States
Alkeus Site

Silverdale, Washington, 98383, United States
Alkeus Site-1

San Antonio, Texas, 78240, United States
Alkeus Site-2

San Antonio, Texas, 78240, United States

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