New eye injection could mean fewer doctor visits for wet AMD patients

NCT ID NCT05381948

Completed Disease control Sponsor: EyePoint Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tested a new drug called EYP-1901, given as an eye injection, for people with wet age-related macular degeneration (AMD). The goal was to see if it works as well as the standard treatment, aflibercept (Eylea), but with fewer injections. 161 participants received either EYP-1901 or aflibercept, and researchers measured changes in vision over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

EYP-1901 (a tyrosine kinase inhibitor given as an eye injection)

What this could lead to

If successful, EYP-1901 could offer a longer-lasting treatment for wet AMD, potentially reducing the number of eye injections needed.

What could go wrong

This is a Phase 2 trial with only 161 people, so results are preliminary. It may not prove better than the current standard treatment, and there are risks from the injection itself, such as infection or inflammation.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

WET AGE RELATED MACULAR DEGENERATION

Contacts and locations

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Locations

EyePoint Investigative Site

Phoenix, Arizona, 85053, United States
EyePoint Investigative Site

Springdale, Arkansas, 72762, United States
EyePoint Investigative Site

Beverly Hills, California, 90211, United States
EyePoint Investigative Site

Campbell, California, 95008, United States
EyePoint Investigative Site

Encino, California, 91436, United States
EyePoint Investigative Site

Fullerton, California, 92835, United States
EyePoint Investigative Site

Glendale, California, 91203, United States
EyePoint Investigative Site

Huntington Beach, California, 92647, United States
EyePoint Investigative Site

Irvine, California, 92697, United States
EyePoint Investigative Site

Pasadena, California, 91107, United States
EyePoint Investigative Site

Poway, California, 92064, United States
EyePoint Investigative Site

Redlands, California, 92373, United States
EyePoint Investigative Site

Sacramento, California, 95825, United States
EyePoint Investigative Site

Walnut Creek, California, 94598, United States
EyePoint Investigative Site

Lakewood, Colorado, 80228, United States
EyePoint Investigative Site

Clearwater, Florida, 33761, United States
EyePoint Investigative Site

Coral Springs, Florida, 33067, United States
EyePoint Investigative Site

Lakeland, Florida, 33805, United States
EyePoint Investigative Site

Melbourne, Florida, 32901, United States
EyePoint Investigative Site

Miami, Florida, 33143, United States
EyePoint Investigative Site

Pensacola, Florida, 32503, United States
EyePoint Investigative Site

Sarasota, Florida, 34239, United States
EyePoint Investigative Site

St. Petersburg, Florida, 33711, United States
EyePoint Investigative Site

Tampa, Florida, 33609, United States
EyePoint Investigative Site

Winter Haven, Florida, 33880, United States
EyePoint Investigative Site

Marietta, Georgia, 30060, United States
EyePoint Investigative Site

‘Aiea, Hawaii, 96701, United States
EyePoint Investigative Site

Chicago, Illinois, 60616, United States
EyePoint Investigative Site

Lemont, Illinois, 60439, United States
EyePoint Investigative Site

Carmel, Indiana, 46290, United States
EyePoint Investigative Site

West Des Moines, Iowa, 50266, United States
EyePoint Investigative Site

Baltimore, Maryland, 21209, United States
EyePoint Investigative Site

Hagerstown, Maryland, 21740, United States
EyePoint Investigative Site

Owings Mills, Maryland, 21117, United States
EyePoint Investigative Site

Boston, Massachusetts, 02114, United States
EyePoint Investigative Site

Springfield, Massachusetts, 01107, United States
EyePoint Investigative Site

Grand Rapids, Michigan, 49446, United States
EyePoint Investigative Site

Saint Louis, Michigan, 55416, United States
EyePoint Investigative Site

St Louis, Missouri, 63128, United States
EyePoint Investigative Site

Reno, Nevada, 89502, United States
EyePoint Investigative Site

Teaneck, New Jersey, 07666, United States
EyePoint Investigative Site

Great Neck, New York, 11021, United States
EyePoint Investigative Site

Hauppauge, New York, 11788, United States
EyePoint Investigative Site

Liverpool, New York, 13088, United States
EyePoint Investigative Site

Shirley, New York, 11967, United States
EyePoint Investigative Site

Asheville, North Carolina, 28803, United States
EyePoint Investigative Site

Wake Forest, North Carolina, 27587, United States
EyePoint Investigative Site

Eugene, Oregon, 97401, United States
EyePoint Investigative Site

Portland, Oregon, 97239, United States
EyePoint Investigative Site

Springfield, Oregon, 97488, United States
EyePoint Investigative Site

Charleston, South Carolina, 29414, United States
EyePoint Investigative Site

West Columbia, South Carolina, 29169, United States
EyePoint Investigative Site

Germantown, Tennessee, 38138, United States
EyePoint Investigative Site

Nashville, Tennessee, 37203, United States
EyePoint Investigative Site

Abilene, Texas, 79606, United States
EyePoint Investigative Site

Dallas, Texas, 75231, United States
EyePoint Investigative Site

McAllen, Texas, 78503, United States
EyePoint Investigative Site

Plano, Texas, 75075, United States
EyePoint Investigative Site

San Antonio, Texas, 78240, United States
EyePoint Investigative Site

The Woodlands, Texas, 77384, United States
EyePoint Investigative Site

Salt Lake City, Utah, 84107, United States
EyePoint Investigative Site

Fairfax, Virginia, 22031, United States
EyePoint Investigative Site

Lynchburg, Virginia, 24502, United States
EyePoint Investigative Site

Warrenton, Virginia, 20186, United States
EyePoint Investigative Site

Silverdale, Washington, 98383, United States
EyePoint Investigative Sites

Austin, Texas, 78750, United States
EyePoint Investigative Sites

Houston, Texas, 77025, United States