Fewer eye injections possible? new study tests Higher-Dose aflibercept for DME

NCT ID NCT06422507

Completed Disease control Sponsor: Bayer Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a higher dose (8 mg) of the drug aflibercept, given every 16 weeks, works as well as the standard dose (2 mg) given every 8 weeks for Chinese people with diabetic macular edema (DME), a diabetes-related eye condition that causes vision problems. 333 participants received either the high-dose or standard-dose injections into the eye. The main goal was to compare changes in vision after 48 weeks. If the higher dose works, it could mean fewer injections and less frequent doctor visits.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: aflibercept (8 mg and 2 mg doses)
What this could lead to: If successful, this could mean fewer eye injections for people with diabetic macular edema, making treatment easier and less burdensome.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. The higher dose may not be as effective or safe as the lower dose, and findings in Chinese participants may not apply to other populations.

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Conditions

The condition(s) this trial relates to.

diabetic macular edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC MACULAR EDEMA

Contacts and locations

Locations

Affiliated hospital of Nantong university

Nantong, Jiangsu, 226006, China
Aier Eye Hospital (LIAONING)

Shenyang, Liaoning, China
Beijing Aier Intech Eye Hospital

Beijing, 100000, China
Beijing Friendship Hospital, Capital Medical University

Beijing, 100050, China
Beijing Hospital

Beijing, Beijing Municipality, 100730, China
Capital Medical University (CMU) - Beijing Tongren Hospital

Beijing, 100062, China
Central South University - The Second Xiangya Hospital

Changsha, 410007, China
Chengdu Aier Ophthalmology Hospital

Chengdu, 610041, China
Chengdu University of Traditional Chinese Medicine - Teaching Hospital (Sichuan Province Traditional Chinese Medicine Hospital)

Chengdu, 610072, China
Eye & Ent Hospital of Fudan University

Shanghai, 200126, China
Eye Hospital of Wenzhou Medical University

Wenzhou, 325027, China
Eye hospital of Shandong First Medical University

Jinan, 250299, China
Grantham Hospital

Hong Kong, Hong Kong SAR, 00000, Hong Kong
Guangdong Provincial Hospital of TCM

Guangzhou, Guangdong, 510120, China
Guangzhou Aier Ophthalmology Hospital

Guangzhou, 510288, China
Guangzhou First People Hospital

Guangzhou, Guangdong, 510180, China
Hebei eye hospital

Hebei, 050010, China
Henan Provincial Eye Hospital

Henan, 450008, China
Jinan Second People's Hospital

Jinan, 250021, China
Joint Shantou International Eye Center (JSIEC)Shantou University & the Chinese University of Hong Kong

Shantou, 515041, China
Lanzhou University Second Hospital

Lanzhou, Gansu, 730030, China
Luoyang Third People's Hospital

Luoyang, Henan, 471002, China
Nanjing First Hospital

Nanjing, Jiangsu, 210006, China
People's Hospital of Ningxia Hui Autonomous Region - Opthalmology

Ningxia, 750002, China
Renmin Hosp., Wuhan Univ.

Wuhan, Hubei, 430040, China
Shandong University of Traditional Chinese Medicine Affiliated Ophthalmology Hospital

Shandong, 250299, China
Shanghai General Hospital

Shanghai, 200080, China
Shanghai Jiao Tong University School of Medicine (SJTUSM) - XinHua Hospital

Shanghai, 200092, China
Shanghai eye disease prevention and control center

Shanghai, 200041, China
Shanxi Bethune Hospital

Taiyuan, Shanxi, 030032, China
Shanxi Eye Hospital

Shanxi, 030002, China
Shenyang He Eye Specialist Hospital

Shenyang, 110034, China
Shijiazhuang People's Hospital

Shijiazhuang, 050011, China
Sichuan University West China Hospital

Chengdu, Sichuan, MISSING, China
Taizhou Hospital of Zhejiang Province

Taizhou, Zhejiang, 317099, China
The First Affiliated Hospital of Chongqing Medical Universit

Chongqing, 400042, China
The First Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, 150001, China
The First Affiliated Hospital of NanChang University

Nanchang, Jiangxi, 330006, China
The First Hospital of Jilin University

Changchun, Jilin, 130061, China
The Fourth People's Hospital of Shenyang

Shenyang, 110082, China
The People's Hospital of Guangxi Zhuang Autonomous Region

Nanning, Guangxi, 530021, China
The Second Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, 330200, China
The Second Hospital of Anhui medical university

Hefei, Anhui, 230601, China
The Second Hospital of Jilin University

Changchun, Jilin, 130000, China
Tianjin Medical University Eye Hospital

Tianjin, 300384, China
Tseung Kwan O Hospital

Tseung Kwan O, New Territories, 00000, Hong Kong
Weifang Ophthalmology Hospital

Shandong, 261041, China
Xi'an People's Hospital (Xi'an Fourth Hospital)

Xi'an, 710005, China
Xianyang First People's Hospital

Xianyang, 712099, China
Zhejiang University School of Medicine - The Second Affiliated Hospital

Hangzhou, 310003, China
Zhengzhou Second People's Hospital

Erqi, Zhengzhou, 450015, China
Zhujiang Hospital of Southern Medical University

Guangzhou, Guangdong, 510280, China

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