Diabetes mellitus

This phase 1 trial tests whether injecting RGB-5088 islet cells under the abdominal muscle can safely help people with type 2 diabetes. The study enrolls 10 adults aged 18 to 65 who have had diabetes for at least 5 years and currently use insulin. Researchers will monitor safety …

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This study tests a combination of four drugs (epalrestat, HAIC, donafenib, and tislelizumab) as a first treatment for people with advanced liver cancer that cannot be removed by surgery and who also have diabetes. The goal is to see if this approach can control the cancer for at …

Researchers test whether coconut oil pulling or a moringa mouthwash can reduce gingivitis in children with diabetes, compared with chlorhexidine. Thirty children aged 6 to 12 with mild to moderate gingivitis use one of the three rinses. The team measures gum inflammation and leve…

This study will enroll 20 severely obese adults scheduled for metabolic surgery. Half will use a continuous glucose monitor (CGM) and half will use standard finger-stick testing to track blood sugar. Researchers want to see if the CGM leads to steadier blood sugar levels and fewe…

Many people live with heart disease, kidney disease, and type 2 diabetes at the same time, but care often focuses on each condition separately. This trial tests a primary care model that brings these conditions together under one coordinated plan. Primary care centers receive tra…

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This trial tests whether the GX-01S continuous glucose monitoring system helps adults with type 1 or type 2 diabetes improve their blood sugar control. Participants wear the sensor for about 4.5 months, with the first 15 days blinded to establish a baseline, then full access to r…

This trial tests whether individualized nursing care can help adults with diabetes feel more confident and capable in managing their condition. Participants receive structured, personalized sessions that include education, goal-setting, and self-monitoring guidance. The study mea…

This trial tests whether two moderate low-carbohydrate diets, one higher in protein and one higher in fat, improve blood sugar, blood fats, and weight more than a standard diet. Adults with type 2 diabetes, high triglycerides, and overweight or obesity will follow one of the thre…

This trial tests whether continuous glucose monitoring (CGM) can improve blood sugar control and reduce complications in hospitalized adults with type 2 diabetes, compared to standard finger-prick testing. Participants are randomly assigned to either CGM with a sensor-guided insu…

This trial tests whether adding a second procedure to a standard weight-loss operation leads to greater weight loss and better metabolic health in adults with obesity. The standard procedure, endoscopic sleeve gastroplasty (ESG), uses stitches to make the stomach smaller. The add…

This study will give 100 adults with prediabetes a continuous glucose monitor (CGM) called Stelo, which tracks blood sugar every few minutes. The goal is to see if seeing real-time sugar levels helps people make better food and activity choices, lowering their A1c and improving h…

This trial tests whether combining nurse-delivered care with text message check-ins and support can help adults with uncontrolled high blood pressure lower their blood pressure and improve diabetes management. Participants receive either usual care or the enhanced support, which …

This study tests two drugs, finerenone and empagliflozin, in 30 African American veterans with diabetic kidney disease. The goal is to see if these drugs reduce kidney cell damage by measuring specific proteins in urine. Participants will take one or both drugs for 4 months to ch…

This trial aims to find out whether a standard exercise program (Otago) or a specialized balance training that engages multiple senses (multisensory integration) is more effective at improving balance and walking in older adults with type 2 diabetes. Participants, aged 65 to 75, …

This early-stage trial tests a small, soft implant that holds donor insulin-making cells (islets) and protects them from the immune system. The goal is to see if the device is safe and keeps the cells alive and working in adults with type 1 diabetes. Some participants are also on…

This trial compares three different negative-pressure wound dressings (NPseal, PICO, and Prevena) applied after total knee replacement surgery. The study enrolls adults at higher risk for wound problems, such as those with diabetes, obesity, or chronic kidney disease. Participant…

This trial tests whether different combinations of rowing and cycling exercise can reduce inflammation and improve blood sugar control in people newly diagnosed with type 2 diabetes. Participants, aged 18-60 and not yet on medication, will be assigned to one of five exercise prog…

This trial is testing an experimental procedure called pulsENDO therapy for adults with type 2 diabetes whose blood sugar is not well controlled with current medications. The procedure uses a thin tube to deliver gentle electric pulses to the lining of the small intestine, aiming…

This pilot trial tests whether a 4-week group education program that blends Chinese medicine concepts—like body constitution, dietary therapy, and acupressure—with standard diabetes self-management training is feasible and acceptable for adults with type 2 diabetes in Hong Kong. …

This study tests NeoMayor, a smartphone app that gives personalized advice on exercise, diet, sleep, and mood to improve heart health. Researchers will enroll 240 adults aged 55 to 75 in Chile who are at risk for heart problems. Participants use the app for 4 months, and some als…

This trial investigates whether adding a PCSK9 inhibitor to a high-intensity statin can reduce liver fat—measured by a non-invasive FibroScan—in diabetic patients who have recently had a heart attack or unstable angina. Half the participants will receive the combination therapy, …

This pilot study tests whether a voice-activated smart speaker can help adults aged 50 and older with poorly controlled type 2 diabetes improve their blood sugar levels. Participants receive weekly diabetes education and skills training calls through the smart speaker for 12 week…

This study tests whether using a real-time continuous glucose monitor (CGM) can improve blood sugar control and reduce hospital readmissions in people with type 2 diabetes and acute heart failure. Researchers will follow 140 adults during their hospital stay and for three months …

This study looks at whether eating a daily serving of peanut butter at breakfast can improve blood sugar control, thinking skills, and heart health in middle-aged adults with prediabetes. Participants will either add peanut butter to their first meal or stick with their usual die…

This pilot study tests whether a family-based, culturally tailored diabetes management program can help Native Hawaiian and Pacific Islander adults with type 2 diabetes. Participants attend group education sessions with a family member and receive help connecting to social servic…

This trial investigates whether tirzepatide, a medication already used for diabetes and weight loss, can help repair nerve damage in people with diabetic peripheral neuropathy. The study includes 40 adults with diabetes and nerve pain or numbness. Researchers will measure nerve h…

This study tests whether a home-based balance and strength program called Otago exercises can improve mobility, balance, and quality of life in adults with type 2 diabetes. Participants do the exercises 5 days a week for 4 weeks, plus walking. The trial measures how quickly they …

This study tests whether an AI-powered intensive lifestyle program can help people with obesity and newly diagnosed type 2 diabetes lose weight and control blood sugar as well as the drug tirzepatide. Adults aged 18 to 65 with a BMI of 28 to 40 and recent diabetes diagnosis are r…

This study tests whether a 10-week digital mindfulness program, combined with dietary advice, can help people with type 2 diabetes and obesity lose weight and improve blood sugar control. Participants learn mindful eating techniques through videos and home exercises. The trial me…

This study tests a new combination drug called TriGlytza-01 in overweight adults with type 2 diabetes whose blood sugar is not well controlled by metformin alone. The trial compares TriGlytza-01 to standard metformin over 16 weeks, measuring safety, blood sugar levels, and body w…

This study tests whether an integrated digital health platform—combining a continuous glucose monitor, activity and sleep tracker, and food log—can improve blood sugar control in adults with type 2 diabetes. Some participants also receive weekly feedback from a healthcare provide…

This study tests whether montelukast, a common allergy medication, can reduce damage to the kidneys, eyes, and blood vessels in adults with type 2 diabetes and early kidney disease. The drug works by blocking inflammatory chemicals called leukotrienes, which are linked to diabete…

This study tests whether replacing missing back teeth with dental implants can help people with uncontrolled type 2 diabetes improve their blood sugar levels. The idea is that better chewing leads to healthier eating, which may lower HbA1c. 140 adults will either get implants plu…

This pilot study tests whether the drug infliximab can safely reverse insulin dependence in people who developed diabetes after taking checkpoint inhibitor cancer therapy. About 14 participants will receive the drug and be monitored for side effects and changes in their need for …

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This study tests whether adding hyaluronic acid gel to standard deep cleaning (scaling and root planing) improves gum healing in people with both diabetes and advanced gum disease. Twenty-three participants will receive the standard cleaning on all teeth, and then two gum pockets…

This study tests whether a combination of three diabetes drugs (tirzepatide, empagliflozin, and pioglitazone) can help people newly diagnosed with type 2 diabetes achieve remission—meaning their blood sugar stays normal even after stopping medication. About 296 adults will take e…

This study gives 400 adults with diabetes or high blood pressure free home-delivered produce boxes and vouchers for 6 months, plus nutrition education and self-management classes. The goal is to see if this helps them eat more fruits and vegetables, feel less food insecure, and i…

This study tests a modified oral rehydration salts (ORS) drink designed for diabetic pilgrims at risk of heat stress and dehydration during the Hajj. The modified ORS has adjusted electrolytes and carbohydrates to avoid raising blood sugar. Researchers will compare it to standard…

This study tests whether a daily prebiotic drink (containing inulin) can improve blood sugar control in 30 postmenopausal women with prediabetes. Participants will consume the drink or a placebo for 4 weeks. The goal is to see if this simple dietary supplement can help reduce the…

This study tests whether a device that emits light (biophoton therapy) can help control type 2 diabetes. About 46 adults with diabetes will either receive the real device or a placebo for 4 weeks, then everyone gets the real device for 8 more weeks. Researchers will measure blood…

This study will test whether a continuous glucose monitor (CGM) can safely guide insulin therapy in cancer and transplant patients who are not in the ICU but need IV insulin due to steroids and nutrition. About 80 participants will be randomly assigned to CGM-guided care or stand…

This study tests if special reflective roof coatings can lower indoor temperatures and improve health in Fiji. About 800 households will receive either a cool roof or usual care. Researchers will measure heart rate, blood sugar, depression, and other heat-related symptoms to see …

This study will test a program based on WHO guidelines to improve diabetes screening and care in 10 primary health centers in Nigeria. About 2,800 adults with or at risk for diabetes will take part. The goal is to see if the program helps more people get diagnosed and treated.

This early-stage study tests a new treatment called SR-02 for adults with type 1 diabetes who experience dangerously low blood sugar. The treatment involves implanting insulin-producing cells into the belly lining. Nine participants will receive the implant and must take lifelong…

This study tests a program called Moxie that sends weekly mail and a mobile app to help people with chronic heart, kidney, or diabetes conditions manage their health after a hospital stay. The goal is to see if it reduces the chance of going back to the hospital. About 9000 adult…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study tests a new automated insulin delivery system (NMX8) in 230 adults with type 1 diabetes who are not meeting their blood sugar goals. Participants will use either the NMX8 system or another approved system to see which helps keep blood sugar in the target range more oft…

This study tests whether giving people with diabetes a continuous glucose monitor (CGM) when they leave the hospital helps them control their blood sugar better than traditional finger-stick testing. 120 participants will be randomly assigned to use either a CGM or finger sticks …

This study tests whether a 3-month video-based lifestyle program works better when delivered by a patient's own primary care doctor versus an unfamiliar doctor. The program covers healthy eating, physical activity, and behavior change. Researchers will measure blood sugar control…

This study will test whether a low-calorie diet rich in medium-chain triglycerides (MCTs) from traditional Minangkabau foods can improve metabolic health in 40 obese adults. Participants will follow a diet based on coconut milk dishes for a period, and researchers will measure ch…

This study tests a 12-week home exercise program combining aerobic and resistance training for older adults (60+) with type 2 diabetes and early muscle weakness. The goal is to see if short, regular workouts can improve physical activity levels and muscle strength. About 73 parti…

This study tests whether a mobile app can help people with diabetes better manage their condition after leaving the hospital. The app provides education, reminders, and monitoring tools for 90 days. Researchers will compare self-care behaviors, blood sugar control, and hospital r…

This study looks at whether using a continuous glucose monitor (CGM) can help manage high blood sugar better than standard finger-prick tests in people with type 2 diabetes who have had a stroke. High blood sugar after a stroke can lead to worse outcomes. The study will involve 8…

This study tests whether tributyrin, a dietary supplement that turns into butyrate in the body, can improve blood sugar control, reduce inflammation, and lower heart disease risk in people with type 2 diabetes. Sixty participants at high risk for heart problems will receive eithe…

This study tests whether a supplement called HMB, combined with exercise, can improve muscle mass, strength, and insulin resistance in older adults (ages 60-80) with type 2 diabetes and low muscle mass. Participants will be randomly assigned to receive HMB, exercise, both, or pla…

This study tests a new drug called IMC-S118AI in people with type 1 diabetes who have a specific genetic marker (HLA-A*02:01). The main goal is to check if the drug is safe and how it works in the body. Researchers will also look at whether it can help preserve the cells that mak…

This study tests a new treatment for diabetes using lab-grown cells that produce insulin. About 30 adults with diabetes who have used insulin for over 5 years will receive an infusion of these cells. The goal is to see if the cells are safe and can improve blood sugar control, po…

This study will test whether applying a special heat-reflecting coating to roofs can improve the health and well-being of 800 households in Colima, Mexico. The coating is designed to keep homes cooler indoors, which may help lower heart rate, improve blood sugar control, reduce d…

This study tests whether adding FoundationDRS Solo to usual wound care helps heal chronic foot ulcers in people with diabetes. About 124 adults with a nonhealing ulcer will get either the new treatment plus standard care or standard care alone for 12 weeks. The main goal is to se…

This study tests a procedure that uses radiofrequency energy to disable certain nerves near the kidneys and abdomen. The goal is to see if this can safely lower blood pressure and improve blood sugar control in 20 adults with resistant hypertension and type 2 diabetes who have no…

This study tests whether a 9-month lifestyle coaching program (individual and group sessions with a dietician) helps obese male firefighters lose weight and improve metabolic health. Fifty participants will be randomly assigned to coaching or usual care. The main outcomes are cha…

This study looks at how well a new type of dental filling (bioactive restorative system) works in people with controlled diabetes compared to those without diabetes. Fifty adults needing a filling in a back tooth will be followed for 18 months. Researchers will check for discolor…

This study tests whether regular phone calls from a nurse can help adults with diabetes in Ethiopia improve their blood sugar control, take medications correctly, and learn more about their condition. About 320 participants will either receive usual care or get structured phone c…

This study tests whether a special vacuum dressing (negative pressure wound therapy) placed on the closed surgical wound can prevent infections in diabetic patients who have emergency abdominal surgery. About 110 high-risk adults with diabetes will be randomly assigned to get eit…

This study will enroll 120 children and teens with type 1 diabetes who use automated insulin pumps. Participants will be randomly assigned to follow either the standard blood sugar target (70-180 mg/dL) or a tighter target (70-140 mg/dL) for 12 months. Researchers want to see if …

This study tests an experimental injection called IN-B00009 in adults with type 2 diabetes whose blood sugar is not well controlled by diet and exercise alone. About 110 participants will receive either the drug or a placebo to see if it safely lowers HbA1c levels over 24 weeks. …

This study tests a program that combines online diabetes education videos with help connecting to social services for low-income Chinese and Latino/a immigrants with type 2 diabetes. The goal is to improve blood sugar control and see if people find the program useful and easy to …

This study tests whether an AI-powered app called 'Smart family doctor' can help people who have had heart surgery (bypass or stent) better control their blood pressure, blood sugar, and cholesterol. About 951 participants from 10-20 hospitals will use the app for personalized he…

This early-phase study tests whether a low dose of oral amlodipine can prevent kidney damage caused by contrast dye in diabetic patients in the intensive care unit. The trial will enroll 40 adults with diabetes and normal kidney function who are stable enough for the procedure. R…

This study tests an experimental drug, DA-2811, in 288 adults with type 2 diabetes whose blood sugar is not well controlled despite taking two other diabetes medications. Participants will receive either DA-2811 or a placebo added to their current treatment. The main goal is to s…

This study tests whether a diabetes drug called sentagliptin (a DPP4 inhibitor) can improve thinking and memory in people who have had a mild stroke and also have type 2 diabetes. About 312 participants will receive either the drug or a placebo daily for 180 days. Researchers wil…

This study tests a 12-week program that uses WhatsApp to teach people with type 2 diabetes and their family members how to manage the disease better. Participants get videos, quizzes, and weekly phone calls to improve self-care and blood sugar levels. The goal is to see if this a…

This study tests whether a ginkgo biloba extract (EGb761) can slow or prevent diabetic retinopathy, an eye disease caused by diabetes. About 200 adults with long-standing diabetes will take either ginkgo or standard treatment for 2 years. Researchers will measure changes in eye b…

This study tests an experimental drug called DA-5218 in 238 adults with type 2 diabetes whose blood sugar is not well controlled by metformin alone. Participants will receive either DA-5218 or an active comparator, and researchers will measure changes in HbA1c over time. The tria…

This study compares two types of foot pads—siliconepads and felted foam—to see which one better reduces pressure under the ball of the foot in people with diabetes who are at high risk for foot ulcers. Researchers will measure pressure relief and ask participants about comfort an…

This study tests Mobili®, a portable digital dispenser that automatically gives the right pills at the right time. Researchers will enroll 96 adults with diabetes or heart disease who take at least two daily medications. Participants use the device for a period, and the study mea…

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized lifestyle advice, and long-term support. Researchers will …

This study tests an ointment called GM-XANTHO for treating stage II or III pressure ulcers (bedsores) in people with diabetes. About 58 participants will receive either a low or high dose of the ointment or a placebo, along with standard care. The goal is to see if the ointment h…

Many people with diabetes skip regular eye exams, even though early treatment can prevent vision loss. This pilot study tests whether offering retinal photography during routine occupational health visits makes screening easier to access. Workers with diabetes attend one visit wh…

Researchers at Assiut University are studying whether two types of routine blood measurements can help predict how quickly kidney disease worsens in people with diabetes. The first is the Triglyceride-Glucose index, a calculation from standard cholesterol and blood sugar tests. T…

This study tests whether using an AI program to screen for diabetic eye disease during regular primary care visits can get more people to follow up with an eye specialist. It will include 4,000 adults with diabetes who have Medicaid and haven't had an eye exam in the past year. T…

This study is testing a new device called PropArm-PosiMoF (PropArm) that aims to measure proprioception—your sense of where your arm is and how much force it uses—in the upper limbs. Researchers will first check how reliable and accurate the device is in healthy young adults, the…

This study checks if a cheap thermal camera (about 200 euros) works as well as a professional one for spotting early signs of foot problems in people with diabetes. 130 adults with diabetes will have both cameras take pictures of the bottom of their feet. The goal is to see if th…

This trial is testing a new implantable sensor called the HALO System in people with type 1 or type 2 diabetes. The sensor is designed to continuously measure glucose, ketones, and lactate in the fluid just beneath the skin, which could give a more complete picture of metabolic h…

This study tests a new, contactless camera technology that measures heart rate, blood pressure, and heart disease risk from a short video of your face. Researchers will compare these readings to standard medical tests in 300 adults aged 30 and older in Jakarta. If accurate, this …

This observational study in Jakarta will test whether a smartphone facial scan can accurately estimate blood sugar and HbA1c levels without needles. Researchers will compare the scan results with standard lab blood tests in 300 adults, with or without diabetes. If accurate, this …

This study will enroll 5000 adults to see if a one-minute, single-lead ECG, analyzed by machine learning, can detect heart conditions like high blood pressure, heart failure, and diabetes. Participants will have their ECG recorded twice and compared with full medical exams. The g…

This study tests a new way to detect early damage in the feet of people with diabetes by measuring how the skin responds to pressure. Researchers will compare 200 people with and without diabetes to see if skin stiffness and stretchiness can predict ulcer risk. The goal is to pre…

This study compares several non-invasive methods to measure foot calluses (plantar hyperkeratosis) in 50 people, half with diabetes and half without. The goal is to find the most reliable technique for assessing callus hardness and stiffness, which could help prevent foot ulcers …

This study will test a new intelligent diagnostic system for orthostatic hypotension (a sudden drop in blood pressure when standing up). The system continuously monitors blood pressure, brain blood flow, and heart signals to classify the condition more precisely. Researchers plan…

This study looks at how well nerve tests and ultrasound can detect diabetic peripheral neuropathy, a common complication of diabetes that causes pain and numbness in the feet. Researchers will compare results from 75 adults with diabetes and healthy volunteers to see which tests …

This study tests whether an enhanced version of the Intensive Diabetes Prevention Program (IDPP) works better than the standard program at recruiting and keeping participants in district health centres. Researchers will compare the two approaches in 170 adults with prediabetes, l…

Researchers are testing whether adding family health history and family participation to the standard Diabetes Prevention Program helps adults with prediabetes. The trial enrolls 400 adults with prediabetes and a family member who joins them. Participants are assigned to either t…

This study tests whether delivering prepared meals or boxes of unprepared food to pregnant people at risk of gestational diabetes is practical and acceptable. Researchers will give participants either ready-to-heat meals from a diabetes-friendly menu or boxes with fresh produce a…

This trial tests a family-focused program for women diagnosed with gestational diabetes in northern Vietnam. The program includes nutrition advice, physical activity guidance, breastfeeding support, and digital tools, delivered from pregnancy through two years after birth. The go…

This study investigates whether drinking kefir, a fermented dairy drink rich in live bacteria and yeasts, from around 14 weeks of pregnancy until routine diabetes screening can improve blood sugar control and reduce the risk of gestational diabetes. Pregnant individuals are rando…

This study tests a virtual platform called LEARN 2 that provides tailored education to help men living with HIV prevent related health problems like heart disease and metabolic issues. Participants will use the platform weekly, attend live health educator sessions, and track thei…

This study tests whether an enhanced diabetes prevention program that provides healthy food deliveries, exercise classes, and community resources helps African American adults with prediabetes lose more weight than a standard program. About 408 participants from low-income commun…

This study tests a mobile health app designed to help young adults (ages 20-35) reduce their risk of type 2 diabetes. The app provides guidance on nutrition, physical activity, sleep, and stress management. Researchers will compare changes in quality of life and blood sugar level…

This early-phase trial will test whether giving a salbutamol inhaler during surgery can prevent atelectasis (partial lung collapse) in diabetic patients. Atelectasis is a common complication after chest, belly, or spine surgery. The study plans to enroll 80 adults aged 18-70 who …

This study tests whether two types of fish oil, EPA and DHA, can improve metabolic health in people at high risk for type 2 diabetes. Over 12 weeks, 84 participants will take daily capsules of EPA, DHA, or a placebo (corn oil) and undergo specialized tests to measure insulin func…

This study tests a 12-session virtual program to help adults with prediabetes in the UAE prevent type 2 diabetes. The program covers diet, physical activity, sleep, and stress management, and is led by a health coach from the same cultural background. Thirty participants will att…

This study tests whether digital tools, including AI image analysis, can help prevent foot ulcers in people with diabetes at high risk. Over 1,500 participants will be assigned to standard care or one of two digital care programs with different levels of support. The goal is to s…

Researchers are testing a diabetes education program that combines standard self-management lessons with hands-on activities involving miniature horses. Children and teens ages 8 to 20 with type 1 or type 2 diabetes, along with their caregivers, attend four sessions led by a diab…

Diabetic foot ulcers heal in only about half of patients, even with standard care. Researchers are testing a turmeric-derived nanoparticle hydrogel applied to the wound alongside usual treatment, such as medication, insulin, or surgery. The trial enrolls adults with type 1 or typ…

Researchers at Mayo Clinic are running a pilot study to see whether clearing a blocked pancreatic duct improves how the pancreas makes insulin in people with chronic pancreatitis. Participants are adults with minimally symptomatic chronic pancreatitis and a duct blockage. The stu…

Researchers are testing DiaFootCare, a mobile app that teaches foot self-care, sends medication and care reminders, guides users through taking wound photos, and shares information with pharmacists. The trial enrolls 139 adults aged 40 to 60 with diabetes and an active foot ulcer…

This trial tests whether a virtual reality version of Mindfulness-Based Stress Reduction (MBSR-VR) can be delivered to young adults aged 16 to 20 with type 1 diabetes who report high stress. Participants will attend group sessions that teach meditation, body awareness, and mindfu…

This study tests whether a structured cognitive training program can improve memory, attention, and other thinking skills in older adults who have type 2 diabetes and mild cognitive impairment. Participants will be randomly assigned to either the cognitive intervention or a contr…

This early-stage study tests whether the drug sodium phenylbutyrate (NaPB) can improve blood pressure and blood vessel function. It will include 30 healthy volunteers and people with diabetes. The goal is to see if NaPB might help ease vascular problems linked to diabetes.

This study investigates whether the 4-7-8 breathing technique can help reduce pain and anxiety in people with type 2 diabetes and diabetic neuropathy during an electromyography (EMG) procedure. EMG can be uncomfortable and stressful, and this trial compares the breathing techniqu…

This study looks at whether morning or evening exercise is better for controlling blood sugar in men with type 2 diabetes. Sixty men aged 40-60 will do high-intensity interval and resistance training for 12 weeks, either in the morning or evening. Researchers will measure changes…

This study tests if a gentle electrical stimulation on the outer ear can activate the vagus nerve and reduce nausea, vomiting, and stomach discomfort in people with diabetes and gastroparesis. Sixty adults with both conditions will receive the treatment and report symptom changes…

This study aims to find a better colonoscopy preparation method for people with diabetes. Current prep methods can cause low blood sugar and poor bowel cleaning. The new approach uses a low-fiber diet the day before and same-day preparation to reduce risks. About 40 adults with d…

This study tests if laser acupuncture can improve arterial stiffness in people with cardiorenal metabolic syndrome (CRMS), a condition linking heart, kidney, and metabolic diseases. 35 adults with at least two of these conditions will receive laser acupuncture on their legs for 1…

This study tests whether a color-coded rotation training program helps people with diabetes improve their insulin self-management skills. Researchers will teach 112 participants how to rotate injection sites and change needles using a colorful chart and a mannequin. The goal is t…

This study compares pain after root canal therapy done in one visit versus two visits for people with diabetes. 200 patients aged 12-60 with a single-rooted tooth needing root canal will be randomly assigned to either a single session or two sessions. The main goal is to see whic…

This study tests whether an oral supplement called DLBS1033 (made from earthworm proteins) can reduce nerve damage symptoms in adults with diabetic polyneuropathy. Thirty-four people with type 2 diabetes will receive either the supplement or a placebo for 28 days, alongside stand…

This study will test a virtual reality program called 'Health for My Feet' for people with type 2 diabetes. The program aims to teach foot care through VR goggles and includes weekly reminder messages. Researchers will compare foot care knowledge, self-care habits, and foot healt…

This study tests a single injection of CIL001 (Paliroden) into the ear to repair nerve damage that causes hearing problems in people with type 2 diabetes. The trial includes 135 adults aged 45-75 with diabetes for at least 5 years. Researchers will check safety and whether the in…

This pilot study looks at whether it is safe and practical for pregnant women with type 1 or type 2 diabetes to continue using their insulin pump during labor, instead of switching to IV insulin. About 30 women who already use an insulin pump will be allowed to keep using it whil…

This study tests whether acupressure, a technique that applies gentle pressure to specific points on the body, can lower blood sugar and reduce anxiety in people aged 65 and older with diabetes. Forty-eight participants will receive either real acupressure or a sham version for 6…

This study looks at whether doing foot and ankle exercises at home can help people with diabetic nerve pain feel better. The exercises are done twice a day, three days a week, for eight weeks. Researchers will measure pain, sleep quality, and depression in 70 adults with diabetic…

This study will test whether a 4-week laughter yoga program can improve self-management and comfort in 80 adults with type 2 diabetes. Participants will attend twice-weekly 40-minute sessions led by a certified facilitator. The goal is to see if this fun, low-cost activity can bo…

This study tests whether low-level laser therapy or muscle energy techniques work better for reducing pain and improving shoulder movement in people with type 2 diabetes who have frozen shoulder. Thirty-six adults aged 18 to 65 will receive one of the two treatments plus standard…

This study will follow 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or have metabolic issues. Researchers will collect blood, saliva, urine, and stool samples during routine clinic visits, along with questionnaires about diet, sleep, and mood. The goal is …

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

Researchers at Assiut University Hospitals are studying whether a simple calculation from two routine blood tests, the leukocyte glucose index, relates to how severe diabetic ketoacidosis becomes in adults with diabetes. The index multiplies white blood cell count by blood sugar …

Researchers at Al-Azhar University are studying whether type 2 diabetes is linked to changes in women's hair and scalp. The study compares 130 women aged 20 to 60, half with diabetes for at least a year and half healthy controls matched by age. Participants undergo clinical hair …

This study will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brains of 100 people who had a stroke and underwent endovascular therapy (clot removal). The goal is to see if TCD readings can predict complications like bleeding or brain swelling in the days…

Researchers at Mass General Brigham are testing whether genetic information can help identify people who might benefit from early screening for type 1 diabetes, even before they feel sick. The study involves 150 adults from the MGB Biobank who agreed to be recontacted. Participan…

Doctors in the ICU often check blood gases through an arterial line, but that carries risks like clots and infection. This study asks whether blood drawn from a central venous line, which is already in place for other care, gives equally useful information. Researchers will compa…

This study follows 100 adults with diabetes who are on peritoneal dialysis or about to start it. Researchers use a continuous glucose monitor to track blood sugar levels over time. They will look for links between glucose patterns and health events like hospitalizations, heart pr…

This study is investigating how GLP-1 receptor agonist drugs, commonly used for type 2 diabetes, affect the movement of the entire digestive tract. Researchers will use a special swallowed capsule to measure gut motility in 20 adults before they start the medication and again aft…

This study will test how well the Dexcom G7 continuous glucose monitor works in 100 adults undergoing heart surgery with cardiopulmonary bypass. The device's readings will be compared to standard blood glucose checks during and after surgery. The goal is to see if the monitor sta…

This study looks at how the mouth heals after gum surgery in people with and without diabetes. Researchers will measure wound size and track healing over 12 weeks. They will also check bacteria and inflammation levels to see what affects recovery. The goal is to learn why healing…

This study looks at how well the mouth heals after gum surgery in people with diabetes compared to those without. Researchers will track healing, measure gum recession, and check factors like bacteria and inflammation. The goal is to understand what affects recovery in diabetic p…

This study investigates whether targeted electrical stimulation of peripheral nerves can improve blood flow and blood vessel function in the lower limbs of veterans with diabetic peripheral neuropathy. Researchers will measure skin blood flow, vessel density, and oxygen levels us…

This study tests whether continuous glucose monitors (CGMs) like the Dexcom G7 can be safely and effectively used in intensive care units. The monitors provide real-time blood sugar readings and alarms for dangerously high or low levels, potentially reducing the need for frequent…

This study looks at how anticipated stigma and illness identity affect quality of life in men with hypogonadism (low testosterone). It compares these men to those with other chronic endocrine conditions like diabetes, hypothyroidism, or hypertension. The goal is to see if these p…

This study looks at how the hormone glucagon works with insulin in the liver to manage blood sugar. Researchers want to understand glucagon's multiple, sometimes opposite, roles to create better diabetes medicines. Forty healthy adults aged 18-45 will have two 5-hour sessions whe…

This observational study looks at whether the total antioxidant capacity of a person's diet is linked to levels of inflammation and nutritional health in adults with type 2 diabetes. Researchers will compare people with well-controlled blood sugar to those with poorly controlled …

This observational study investigates whether cardiac autonomic neuropathy (nerve damage affecting the heart) changes the risk of death and cardiovascular events in people who have diabetes, coronary heart disease, and sleep apnea. Researchers will follow 326 participants, dividi…

This study tests whether showing patients with diabetes short animated videos (in English or Spanish) about diabetic eye disease can improve their understanding and increase how often they return for follow-up eye exams. About 150 patients at Zuckerberg San Francisco General Hosp…

This study investigates whether insulin resistance, measured by the TyG index, is linked to the no-reflow phenomenon—where blood flow fails to restore properly—after primary PCI (stenting) for heart attacks in people with type 2 diabetes. Researchers will also examine how insulin…

This study uses a hidden continuous glucose monitor (CGM) to track blood sugar levels in people with diabetes during vitrectomy eye surgery. The monitor records glucose every 15 minutes but does not show readings to doctors or patients, so it does not affect care. The goal is to …

This global registry study follows 5,000 people with diabetes who use a Dexcom continuous glucose monitor (CGM). Researchers will track changes in HbA1c, a key measure of blood sugar control, over time. The goal is to understand how CGM use affects diabetes management in real-wor…

This study screens adults aged 18 and older in suburban and peri-urban areas of Faisalabad, Pakistan, for four major noncommunicable diseases: diabetes, hypertension, obesity, and high cholesterol. Participants who are found to have these conditions are referred to doctors for st…

This study follows 3,000 adults in Qatar—both citizens and long-term residents—to track how cardiometabolic conditions like diabetes and heart disease develop over time. Participants are grouped by blood sugar status (normal, pre-diabetes, or diabetes) and monitored for major car…

This study will follow 5,500 first-time pregnant women to see if blood tests and eye scans can predict complications like preeclampsia, fetal growth restriction, and gestational diabetes. Researchers will collect samples and images at different points during pregnancy and compare…

This study will track 750 adults with prediabetes who are scheduled for non-cardiac surgery. Researchers will measure their blood sugar levels before, during, and after surgery to see how often high blood sugar occurs. They will also check if high blood sugar is linked to more co…

This pilot study will test how easy it is for 20 adults with diabetes to set up and use the Feetsee foot monitoring device at home over 8 weeks. Participants will use the device and app on their own, following the instructions provided. The goal is to see if people can use it cor…

This study looks at whether a hospital rehab and prosthetic training program helps people who lost a leg due to diabetes or blood vessel disease use their artificial limb regularly. Researchers will review past patient records and follow new patients for up to 6 months after they…

This study will send different types of WhatsApp messages to 235,000 people in Chile who are due for cancer or chronic disease screenings. Researchers want to see if the way a message is worded (basic, risk-focused, or peace-of-mind) and whether it mentions one test or both tests…

This study will follow 200 people with colorectal cancer and healthy controls to explore how genes, blood sugar, and immune responses are connected. Researchers will analyze blood and tissue samples to find shared genetic factors that may influence both cancer and diabetes. The g…

This study will test how accurate and safe two continuous glucose monitoring (CGM) systems, the Anytime 5Pro and Anytime 4Pro, are in adults with type 1 or type 2 diabetes. About 70 participants will wear both devices at the same time and have their blood sugar measured during cl…

This study follows 500 people with a type of heart failure called HFpEF, where the heart pumps normally but doesn't fill properly. Researchers will use heart ultrasounds, blood tests, and medical history to group patients into different subtypes. The goal is to better understand …

This study tests whether adding health messages to lab reports can reduce serious heart and kidney problems in people with both diabetes and chronic kidney disease. Over 125,000 participants will be randomly assigned to receive either routine care or extra health messages in thei…

This study looks at 199 children with type 1 diabetes who have been using insulin for at least 6 months. Researchers will check for skin problems like lumps under the skin (lipohypertrophy) caused by injections. They will also measure fat thickness with ultrasound and ask caregiv…

This study looks at how removing part or all of the pancreas changes blood sugar control in adults who already have diabetes and need pancreatic surgery. Researchers will track 408 patients over time to see if diabetes gets worse depending on how much pancreas is removed. The goa…

This study will ask 75 people with diabetes and their healthcare providers about their experience using the Instara-1 continuous glucose monitor. Participants will wear the device and answer questionnaires about comfort, ease of use, and how it helps manage their diabetes. The go…

This study looks at whether a new province-wide electronic health record system (called Connect Care) improves outcomes for adults with chronic diseases like diabetes, heart failure, or kidney disease. Researchers will compare hospital readmission and death rates before and after…

This study tracks physical activity in 175 pregnant women with type 1 or type 2 diabetes to see how it relates to blood sugar control and mental health. Participants wear an activity monitor for a week each trimester and complete questionnaires. The goal is to understand current …

This study looks at whether the way health information is presented can help people with diabetes better understand their risk of developing foot ulcers. Researchers will compare two types of messages—one focusing on the benefits of good foot care, the other on the risks of negle…

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study looks at whether using a stomach ultrasound before sedation can help anesthesiologists make safer decisions for chronic pain patients. These patients often take opioids or have other conditions that slow stomach emptying, raising the risk of food or liquid entering the…

This study is testing a new AI-powered tool called AIManage that helps doctors and patients manage medications for diabetes and obesity. The tool provides personalized advice on side effects and dose adjustments. The study is in its early stages, with only 16 participants, and is…

This study tests whether giving primary care doctors detailed feedback on how well they follow treatment guidelines can improve care for patients with high blood pressure and type 2 diabetes. Researchers will enroll 324 healthcare providers in Nepal, Mozambique, Tanzania, and Chi…

This early-stage trial will test a new tablet called AD-123 in 50 healthy adults. Researchers want to see if taking one AD-123 pill works similarly to taking two separate pills (AD-1231 and AD-1232) together. The study focuses on safety and how the drug moves through the body, no…

This observational study will test whether a 1-3 minute AI-powered facial scan can accurately measure vital signs like heart rate and blood pressure, as well as estimate blood sugar, cholesterol, and mental health status. Researchers will compare the scan results with standard me…

This study follows 450 adults with diabetes who were part of an earlier study. Researchers want to see if levels of a nutrient called glutamine in the blood are linked to future heart problems. No new treatments are given—just observation and data collection over time.

This study looks at how ups and downs in blood sugar affect diabetic patients admitted to the coronary care unit. Researchers will track 120 adults with diabetes and heart disease to see if glucose variability increases the risk of death or major heart problems like heart attack …

This study tests a companion mobile app that wirelessly collects real-time glucose readings from Dexcom G7 continuous glucose monitors (CGMs) used by children with diabetes in the hospital. The app sends the data to a central hospital database, making it accessible to care teams …

This study works with 35 primary care clinics to help them screen patients for physical inactivity and refer them to community-based exercise programs. The goal is to see if this approach can be smoothly integrated into routine care and whether it leads to better health outcomes …

This observational study will follow 100,000 elderly Chinese adults (age 65+) to see how metabolic conditions like diabetes, high blood pressure, and high cholesterol impact the development and progression of chronic kidney disease (CKD). Participants will provide blood and urine…

This study will use ultrasound to measure stomach volume after standard fasting in 220 diabetic and non-diabetic patients scheduled for surgery. The goal is to see if current fasting guidelines are safe for people with diabetes, who may have slower stomach emptying. Results could…

This study will check if a specific cholesterol ratio (non-HDL to HDL) is linked to kidney disease in people with diabetes. Researchers will measure this ratio and kidney function in 84 adults. The goal is to better understand risk factors, not to test a new treatment.

This study aims to create an AI-based warning system that helps people with diabetes detect early signs of foot ulcers returning. Researchers will follow 200 adults with healed diabetic foot ulcers, using a home monitoring tool and personalized follow-up plans. The goal is to cat…

This study looks at whether a moldable silicone toe divider (Otoform) can help people with diabetes who have had a lesser toe amputated. Researchers want to see if it is possible to run a larger trial by testing how well patients accept the device and how it affects walking and f…

This study tests a wrist-worn device that uses light sensors and AI to estimate blood sugar without piercing the skin. Up to 100 adults with type 1 diabetes, type 2 diabetes, or prediabetes will wear the device for 15 days while researchers collect data to improve its accuracy. P…

This study will analyze medical records of 400 adults with type 2 diabetes or obesity to see how semaglutide affects blood sugar, heart, and kidney health over three years. Researchers will compare those taking semaglutide to those on other diabetes medications. The goal is to un…

This study looks at how healthy people without diabetes respond to sitagliptin, an FDA-approved diabetes medication. Researchers want to understand why some people's bodies process sugar differently after taking the drug. About 400 healthy Amish adults will take part in two clini…

This study looks at how well ankle numbing (ankle block) works in people with and without diabetes during foot or ankle surgery. Researchers will measure how fast the numbing starts, how much pain medicine is needed afterward, and if blood sugar control plays a role. The goal is …

This study looks at how well a special type of dental filling called Giomer works in people with and without diabetes. Researchers will place fillings in cavities on the tooth neck and check them over 18 months to see if they stay in place and prevent new decay. The goal is to un…

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study looks at how lowering insulin levels changes the way the liver makes sugar and fat. Researchers will give 36 overweight or obese adults with insulin resistance and fatty liver disease two different insulin infusions—one that keeps insulin high and one that lowers it by…

This study aims to understand how dry eye disease and diabetic macular edema (a swelling in the back of the eye) are related in people with diabetes. About 50 adults with diabetes for over 8 years will have their eyes tested using questionnaires, tear measurements, and imaging. T…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This early-stage study looks at how three popular statins (atorvastatin, rosuvastatin, simvastatin) affect blood sugar levels in 100 healthy volunteers. Participants will take the medicine for two days, and researchers will measure changes in blood glucose, insulin, and C-peptide…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study looks at ways to help VA medical centers put proven health programs into practice for women Veterans in midlife. The programs focus on heart health, weight management, diabetes, mental health, and menopause care. Researchers will test two support strategies at 18 VA si…

This study will measure levels of a thyroid antibody called anti-thyroglobulin in 112 adults with diabetes. The goal is to see how common these antibodies are in diabetic patients, since diabetes and autoimmune thyroid disease often occur together. Participants will provide a blo…

This study compares two ways of making treatment decisions for people with diabetes and severe blockages in all three main heart arteries. One group gets a real-time online discussion among heart specialists during an angiogram, while the other gets usual care. The goal is to see…

This study looks at why some people with type 2 diabetes develop painful nerve damage while others do not. Researchers will measure how the central nervous system processes pain in 128 adults aged 18-80 who have had diabetes for at least one year. The goal is to better understand…

This study looks at whether training general practitioners to better monitor and manage kidney health can slow the loss of kidney function in people with type 2 diabetes. About 360 patients aged 50 and older with early kidney problems will take part. Doctors in the intervention g…

This study will see if community health workers (CHWs) can help people with two or more chronic conditions like diabetes, high blood pressure, or heart disease better manage their health. About 300 adults who are medically underserved will work with a CHW to create a personal hea…

This study investigates how two molecules—glycerol from fat and lactate from the blood—are converted into glucose by the liver, especially in people with type 2 diabetes. Researchers will compare these processes in 48 adults with and without diabetes or obesity. Participants rece…

This study will use a special eye scan called OCT to look for early signs of retinal damage in people with diabetes who have no vision problems. Researchers want to see if these scans can detect changes before symptoms appear. About 112 participants will get a detailed eye exam, …

This study tests a computer tool that helps doctors and cancer survivors decide together on the best heart-protective medications and tests. Researchers will enroll 60 cancer survivors at risk for heart problems. The goal is to see if the tool is easy to use and helps people foll…

This pilot study tests a program that provides education, motivation, and social support to adults with diabetes and early-stage chronic kidney disease (CKD). The goal is to see if the program is practical and helps patients stay motivated, learn about kidney disease, and use sup…

This 10-year observational study will follow 10,000 adults with diabetes, metabolic disorders, and related conditions like high blood pressure and fatty liver disease. Researchers will collect routine medical data to identify markers of disease severity and activity. The goal is …

This study will check heart disease risk scores in 238 adults with type 2 diabetes who are 40 or older. Researchers want to see if simple, non-invasive measures of belly fat (called LAP and VAI) are linked to higher cardiovascular risk. The goal is to find easier ways to identify…

This study looks at how diabetes affects small blood vessels and nerves in the eyes and brain. Researchers will use advanced imaging to detect damage and test a traditional Chinese herbal medicine called Tangshen'an Granules to see if it can help. 160 adults with diabetes will ta…

This study will follow 100 adults with diabetes and foot ulcers to see how non-vascular factors like nerve damage, infection, and poor blood sugar control affect ulcer severity and healing. Researchers hope to find which risk factors can be changed to prevent ulcers from coming b…

This study looks at menstrual cycle changes in adolescent girls with diabetes compared to those without. Researchers will track cycle length, frequency, and regularity, and check links to blood sugar control and body weight. The goal is to identify risk factors and improve care f…

This pilot study will test whether a weekly injection of a GLP-1 receptor agonist (a type 2 diabetes drug) can improve gum health in 30 adults who have both periodontitis and diabetes. Researchers will measure changes in gum pocket depth, bleeding, and tooth mobility. The goal is…

This study will enroll 1,000 people with diabetes who are having an emergency procedure to open a blocked artery after a severe heart attack (STEMI). Researchers want to see if certain blood markers of inflammation and clotting can predict complications like heart failure, abnorm…