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Could a gentler blood test spot tissue trouble in diabetic ICU patients?

NCT ID NCT07799727

Knowledge-focused Sponsor: Assiut University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

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This trial is taking on new participants right now.
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Registered, but not yet taking participants.
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The trial has finished. Results may not be published yet.
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Stopped early, before it reached the end. That can be for many reasons, including safety.
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Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

Doctors in the ICU often check blood gases through an arterial line, but that carries risks like clots and infection. This study asks whether blood drawn from a central venous line, which is already in place for other care, gives equally useful information. Researchers will compare paired samples from 100 critically ill adults, half with diabetes and half without, to see if diabetes changes the relationship between venous and arterial readings. They will also test whether the CO2 gap, a marker of blood flow to tissues, works as well in diabetic patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If central venous blood gas proves reliable, ICU teams could reduce the need for arterial catheters, lowering risks like infection and bleeding. The study may also clarify how diabetes alters tissue perfusion and gas exchange in critical illness.
What could go wrong
This is an observational study with 100 patients, so results may not apply to all ICU settings. Diabetes-related changes in blood vessels could make venous and arterial readings differ more than expected, limiting the usefulness of the approach.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult critically ill patients (both diabetic and non-diabetic) admitted to the Critical Care Unit of the Internal Medicine Department at Assiut University Hospital who have standard clinical indications for indwelling central venous catheters and arterial lines.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients aged 18 years and older * Critically ill patients admitted to the intensive care unit (ICU) * Patients with indwelling central venous catheter and arterial line placed for routine clinical management * Written informed consent obtained from the patient or legal next of kin Exclusion Criteria: * Known severe peripheral vascular occlusive disease affecting line placement * Use of a pulmonary artery catheter (mixed venous blood line) instead of a standard central venous catheter positioned at the superior/inferior vena cava junction * Refusal of the patient or legal representative to participate in the study * Patients younger than 18 years of age

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Conditions

The condition(s) this trial relates to.

Acid-Base Imbalance Critical Illness diabetes mellitus disorder of acid-base balance ischemic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acid-base imbalance Critical illness Diabetes mellitus Tissue hypoperfusion

How to take part

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  1. The official record

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