DEPRESSION

This study tested two types of short digital messages to see if they could encourage COVID-19 vaccination in adults with anxiety or depression. Over 1,400 undervaccinated participants received either standard public health messages, messages designed to build resistance to misinf…

This pilot study tested whether a problem-solving program delivered by video call or text message could help young adults (ages 18-29) living with HIV stay engaged in care, improve mental health, and reduce substance use. Fifty participants from the East Bay area of San Francisco…

This study tested a smartphone app called iGAME that uses game-like features to encourage people with low back pain, breast cancer, or depression to be more active and sit less. 48 adults who were sedentary joined the trial. The goal was to see if the app could help them change t…

This study tested a new way to help people with two or more long-term health problems like HIV, high blood pressure, diabetes, asthma, or depression. Over 1,800 adults aged 40 and older in South Africa took part. Some clinics used a special decision-support tool and home visits f…

This study tested a 12-month program where nurses provided phone-based support to 805 adults with depression and possible opioid use disorder. Participants were randomly assigned to receive the nurse care program or usual care. The goal was to see if nurse support could improve t…

This study tested a program called Positive Minds-Strong Bodies Enhanced for older adults from minority groups who have depression, anxiety, or physical limitations. The program combines mental health support with physical exercises to help prevent disability. Over 400 participan…

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes who also have depression. 120 teens aged 12-17 took part. The goal was to see if the program was practical and well-received, and if it could lower depression and insulin resistanc…

This study looked at whether adding mental health services and a clinical pharmacist to primary care could help people with chronic pain, anxiety, or depression use opioids more safely. About 490 adults who were already taking opioids for long-term pain took part. The program aim…

This study tested a new program called THRIVE for people with HIV who are not regularly seeing a doctor. The program helps them stay in HIV care after leaving the hospital. 75 adults took part, and the study looked at whether the program was acceptable and if it improved viral lo…

This study looked at whether a structured physical activity program, along with health education materials, could help prevent colon cancer from returning in people who had surgery and chemotherapy for high-risk stage II or stage III colon cancer. A total of 889 patients took par…

This study tested whether painting metal roofs with a special reflective coating (cool roofs) can lower indoor temperatures and improve health in Niue. 288 adults living in single-story homes with metal roofs took part. Researchers measured heart rate, blood sugar, depression, an…

This study tested whether a French translation of the HSCL25 questionnaire can help general practitioners accurately diagnose depression. Over 1,100 adults visiting their primary care doctor took part. The goal was to give doctors a simple, reliable tool to identify depression wh…

This study tested an online parenting program called Family Check-Up Online for rural families where a parent may misuse opioids or other substances. About 356 parents of young children (18 months to 5 years) took part. The program aimed to improve parenting skills, reduce stress…

This study tested a positive emotion-focused program in 73 children (ages 8-12) whose mothers had depression and anhedonia. The goal was to see if the program could improve how their brains respond to rewards, measured by EEG. This early-stage research aims to prevent anhedonia, …

This study tested whether a 12-week healthy lifestyle program could prevent major depression in older adults who recently lost a spouse. 151 participants aged 60+ at risk for depression were randomly assigned to either the program (self-monitoring sleep, meals, and activity with …

This study tested a 10-week program called Protecting Families for depressed parents and their pre-teen children. The goal was to see if the program could prevent depression in the children. 42 families took part, and researchers compared the program to parent training alone, loo…

This study tested two online education programs to see if they could prevent stress-related conditions like PTSD, depression, and burnout in paramedics working during the COVID-19 pandemic in Singapore. 63 paramedics took part, completing 6 weekly online modules. The goal was to …

This study looked at whether taking daily vitamin D or fish oil supplements could help prevent depression in over 18,000 healthy adults. Participants took either supplements or a placebo for about five years. The results showed that neither vitamin D nor fish oil reduced the risk…

This study tested a program called SSAGE designed to prevent mental health problems like anxiety and depression in teenage girls who were forced to leave Venezuela and move to Colombia. The program involved the whole family, including brothers, and aimed to create more equal and …

This study tested a painless brain stimulation treatment called tDCS in 38 veterans with chronic pain, PTSD, and depression. The treatment uses low-level electrical currents to calm overactive pain and stress circuits in the brain. Researchers wanted to see if adding tDCS to stan…

This study tested a new, non-invasive treatment for people with depression, anxiety, bipolar disorder, or PTSD. Researchers used low-intensity focused ultrasound to gently stimulate a brain region called the amygdala over 15 sessions. The goal was to see if this approach is safe …

This study tested a workshop called STEP-Home for 221 post-9/11 Veterans who had trouble readjusting to civilian life. The workshop taught practical skills like managing emotions, solving problems, and focusing attention. The goal was to help Veterans feel more connected to their…

This study tested if a 12-week home-based walking program could help people with heart failure feel less depressed, less frail, and have a better quality of life. 68 adults hospitalized for heart failure were split into two groups: one got standard health education, and the other…

This study looked at whether a version of cognitive behavioural therapy (CBT) adapted for South Asian culture could help reduce depression and anxiety. Researchers worked with 146 Canadian adults of South Asian origin who had mild to severe symptoms. The therapy was taught to the…

This study tested whether a program called PRISM (Promoting Resilience in Stress Management) is practical and helpful for young adults aged 18-39 who have been diagnosed with cancer or desmoid tumors. The program aims to reduce symptoms of depression and anxiety. Researchers enro…

This study tested a mobile app designed to help people with glaucoma manage feelings of distress, anxiety, and depression. Researchers worked with 28 patients and health experts to refine the app, then checked if it was practical and well-liked. The goal was to see if this approa…

This study looked at whether bright light therapy helps depression just as much in spring and summer as it does in fall and winter. 212 adults with depression received daily light sessions for at least one week. Researchers measured mood changes to see if the season affects how w…

This study tested a program called MOSAIC Plus for pregnant women and mothers of young children who have experienced intimate partner violence (IPV) and have symptoms of depression or PTSD. The program combines support from community advocates with therapy techniques to reduce th…

This study looked at whether a mindfulness program could improve mental health for Generation Z nursing students during their hospital internships. 39 students were split into two groups: one did mindfulness exercises, the other got usual check-in messages. Researchers measured a…

This study looked at whether two types of talk therapy—cognitive behavioral therapy (CBT) and relaxation training—could help people with relapsing-remitting multiple sclerosis (MS) who also have anxiety, depression, or trouble thinking. 140 people took part, attending weekly grou…

This study tested whether the JoyPop app can help post-secondary students (ages 18-25) better manage their emotions and reduce stress, anxiety, and depression. 160 students were randomly assigned to use the app or receive no intervention. The goal was to see if the app improves e…

This study tested a 16-session online therapy program for transgender and gender-diverse people in Romania who have depression or anxiety. The therapy was designed to help with LGBTQ-related stress and improve mental health. 25 people took part, and researchers measured changes i…

This study tested whether repeated doses of ketamine, given through an IV, can safely reduce depression in people with Parkinson's disease. 51 adults aged 40-80 with both conditions took part. Researchers compared ketamine to a placebo and used brain scans to see how it might wor…

This study tested a 45-minute chat with an AI bot that teaches a 'growth mindset'—the idea that you can get better at things with effort. About 383 students in grades 6-8 in India took part. The goal was to see if this simple talk could lower symptoms of anxiety and depression.

This study looked at ways to help people with long-term back or neck pain who also feel anxious or depressed. Researchers tested a smartphone app (Wysa) and a printed guide to see if they were helpful and easy to use. Thirty patients gave feedback through interviews and surveys o…

This study tested whether a mobile app-based education program could improve depression, social adaptation, and recovery quality in 45 adults with a tracheostomy. Participants used the app to learn about their condition and care. The goal was to see if this approach could ease em…

This study tested a virtual mindfulness program to help Veterans with depression and difficulty adjusting to civilian life. 36 Veterans took part. The program aimed to reduce depressive symptoms and improve community reintegration.

This study tested a program that combines talk therapy (behavioral activation) with medication adjustments to reduce depression and anxiety in adults aged 60 and older having hip or knee replacement surgery. 116 participants were split into two groups: one received the program pl…

This study tested whether an AI voice coach called Lumen can help adults with mild-to-moderate depression and anxiety. About 200 participants were randomly assigned to receive problem-solving coaching from Lumen, a human coach, or a waitlist. The goal was to see if the AI coach c…

This study tested whether weekly social groups could help older veterans who feel depressed and lonely. Eighteen veterans joined group meetings to connect with others. Researchers measured changes in mood, loneliness, and social support using questionnaires and interviews. The go…

This study tested a short program called Making Connections Intervention (MCI) to help Black adolescents with depression and suicidal thoughts engage in school-based treatment. 29 Black students in grades 6-12 participated. The program included 1-2 sessions plus digital tools to …

This study tested a personalized brain-training method called PRISM neurofeedback in 19 adults with major depression and anhedonia (loss of pleasure). Participants were randomly assigned to receive either real or sham (fake) training. The goal was to see if the therapy is safe an…

This study tested whether a special type of heated yoga (hyperthermic yoga) can help reduce symptoms of depression. 80 adults with mild to moderate depression were randomly assigned to either take yoga classes twice a week or join a waitlist. Researchers measured how acceptable a…

This small study tested whether an AI-powered virtual reality app could safely help people with inflammatory bowel disease (IBD) who also have mild to moderate anxiety or depression. Twenty-two adults with IBD used the app during a single session. The goal was to see if the appro…

This study compared two well-known talk therapies for depression: cognitive-behavioral therapy (CBT) and acceptance and commitment therapy (ACT). Both were delivered online in group sessions over 8 weeks. 116 adults with major depression took part, and researchers tracked their s…

This study tested a program called PRISM that helps teens and young adults (ages 12-24) with advanced cancer build coping skills and resilience. 195 participants were randomly assigned to receive the program or usual care. The goal was to see if PRISM could improve quality of lif…

This study tested a smartphone app that uses cognitive behavioral therapy to help people with mild-to-moderate depression. 315 adults aged 18-60 took part across 11 centers in China. The app was used for 8 weeks, and researchers measured changes in depression symptoms compared to…

This study tested a therapy called Managing Anxiety from Cancer (MAC) to help reduce anxiety in people aged 65 and older with cancer, and their caregivers. 26 participants were randomly assigned to either MAC or usual care. MAC uses a proven plan that includes the caregiver to he…

This study looked at whether adding a smartphone app that teaches cognitive behavioral therapy (CBT) skills helps veterans with depression recover better than standard CBT alone. Fifteen veterans who served in Iraq or Afghanistan took part. The goal was to see if the app improved…

This small study tested whether cannabis oil can improve sleep in people with major depression and insomnia. 14 adults took part. The goal was to see if a larger study is possible and to compare different types of cannabis oil. The study is now complete.

This study looked at whether a structured exercise program can improve physical function, mood, and quality of life for older adults (65+) while they are in the hospital. 100 participants either did exercises like walking, stretching, and resistance training or received standard …

This study looked at whether a home-based exercise program could reduce anxiety and depression in people receiving hemodialysis. 54 adults on dialysis were split into two groups: one did home exercises for 6 months, the other did not. Researchers measured changes in depression an…

This study tested a mindfulness-based stress reduction program for parents of children with autism. 96 parents took part to see if the program could lower their levels of depression, anxiety, stress, and hopelessness. The goal was to improve parents' emotional well-being through …

This study looked at whether progressive muscle relaxation exercises (tensing and relaxing different muscle groups) could help nursing students with depression, anxiety, and stress. 104 students were split into two groups: one did the relaxation exercises for 4 weeks, the other d…

This study tested a 24-week remote self-management program called TEAM-Red for depressed young African American women (ages 18-49) who also have risk factors for high blood pressure. 83 women participated, with half receiving the program and half on a waitlist. The goal was to se…

This study tested two types of internet-delivered therapy for anxiety and depression in 2477 adults. Participants received either 8 or 16 weeks of treatment, with or without a support forum. The goal was to see which approach works best to ease symptoms and improve quality of lif…

This study tested whether a humanoid robot named HUMANE could help older adults (aged 50+) living at home feel less lonely and more supported. Sixty participants used the robot for 6 weeks, and researchers measured loneliness, memory, mood, and confidence. The goal was to see if …

This study tested whether a gentle electrical current applied to the scalp (tDCS) can enhance computer-based brain training in older adults (60+) with recurrent depression. The goal was to improve thinking skills like memory and planning. The trial involved 16 participants and me…

This study tested whether adding ketamine to a standard antidepressant (milnacipran) helps reduce depression in people with severe, progressive diseases who are in palliative care. Half of the 42 participants received ketamine plus milnacipran, and the other half received a place…

This pilot study tested a 10-session behavioral activation program delivered via teletherapy to help adults with moderate-to-severe depression increase physical activity and reduce depressive symptoms. Sixty-five participants used a smartphone and Fitbit to track activity. The st…

This study looked at whether spending time in nature can help reduce anxiety and depression in teenagers. Researchers worked with 60 adolescents who did not have a psychiatric diagnosis. The study tested a nature-based therapy program and measured changes in symptoms. The goal is…

This study tested a combination of behavioral activation (a type of counseling that encourages positive activities) and medication optimization (adjusting current medicines) to reduce anxiety and depression in adults aged 60 and older undergoing surgery for cancer. 105 participan…

This study looked at 90 veterans with obesity who took GLP-1 medicines (semaglutide or tirzepatide) for six months. Researchers found that participants reported significant improvements in depression symptoms, eating disorder behaviors, and quality of life—including less pain and…

This study tested special glasses that control how much blue light reaches your eyes. The goal was to see if wearing them could improve sleep and reduce symptoms of depression. 96 adults in Ontario took part. The results may help people who struggle with both sleep problems and l…

This study tested a new way of managing depression in general practice by having a team of doctors, nurses, and mental health specialists work together to support patients. 389 adults with depression took part, and researchers measured changes in depression, anxiety, stress, and …

This study tested whether using a hand fan for 10 minutes each day for six weeks could help people with COPD feel less short of breath, and also improve how they think about their illness, and reduce anxiety and depression. 59 patients took part, with half using the fan and half …

This study tested a program called IPPI for 108 nursing home residents with dementia and signs of distress or depression. Care partners offered two short, personalized activities each week for six months. The goal was to see if the program was practical and if it helped improve m…

This study tested a Dialectical Behavior Therapy skills training group for older adults (50+) who care for a family member with Alzheimer's disease or related dementias. The goal was to reduce suicidal thoughts and feelings. Nine caregivers completed the program, and researchers …

This study tested whether training traditional birth attendants (local midwives) to provide mental health support can reduce depression in pregnant women in rural Kenya. 220 pregnant women with depression took part. The goal was to see if this approach could lower depressive symp…

This study tested whether a program of friendly, supportive phone calls (called BE WITH) could help older adults feel less lonely, depressed, and isolated. Over 670 adults aged 55 and older who received meal services took part. Some received weekly calls for 8 weeks, while others…

This study tested a program called Mood Lifters for college students struggling with depression, anxiety, or stress. Instead of one-on-one therapy with a professional, students met in peer-led groups to learn skills to boost positive feelings and reduce negative ones. The goal wa…

This study tested if expressive writing—writing about your deepest thoughts and feelings—can help reduce anxiety and depression in young adults. 160 participants wrote for 14 days, either to themselves, to a loved one, or just describing their day. The goal was to see which appro…

This study tested a 9-week kindness-focused mindfulness program for teens aged 12-17 with anxiety or depression. Half of the parents also took the program to see if it added extra benefit. The goal was to see if mindfulness could reduce symptoms and improve well-being.

This study looked at whether alternative treatments—external qigong, mindfulness meditation, or psychoeducation—can reduce anxiety and depression in college students. 55 students were randomly assigned to one of the three groups. Researchers measured changes in anxiety and depres…

This study tested a program called MindUP in 61 orphan boys aged 11-16 in Pakistan. The program teaches mindfulness and emotional skills to help reduce depression, anxiety, and stress. Teens who took part were compared to those who did not, and their mental health was measured be…

This study tested whether pramipexole, a drug used for Parkinson's disease, can help people with depression who also have anhedonia (loss of interest or pleasure). 85 adults with depression and significant anhedonia took pramipexole or a placebo alongside their usual antidepressa…

This study looked at whether doing Qigong relaxation exercises can help lower anxiety and depression in people hospitalized for depression. Seventy adults took part, with some doing Qigong and others not. Researchers measured their anxiety and depression levels using standard que…

This study tested whether an online screening tool plus a resiliency program called MINDBODYSTRONG could reduce suicide risk and depression in nurses. Nearly 850 nurses who were at moderate to high risk for suicide took part. The program taught cognitive-behavioral skills through…

This study tested a 6-week online workshop for 109 family caregivers of people with dementia. The workshop taught caregiving skills and ways to manage stress and difficult emotions. Caregivers could join from home at any time and chat with other caregivers and trained leaders. Th…

This study tested whether an internet-based mindfulness training program could help reduce depression symptoms. 116 adults with clinical depression were randomly assigned to either the online mindfulness program or their usual care. The goal was to see if the program improved dep…

This study looked at whether adding pramipexole, a drug usually used for Parkinson's disease, can safely help people with depression who have lost the ability to feel pleasure (anhedonia). 55 adults who had already been in a shorter study took pramipexole for a longer period. Res…

This study tested a new web app designed to help with depression and anxiety. The app uses a type of therapy called CBT and was made to work across different cultures. 50 adults who owned a smartphone or computer and had at least mild symptoms took part. The goal was to see if th…

This study tested a personalized form of brain stimulation called iTBS for people with major depression. Researchers used MRI scans to target a specific brain area in each of the 68 adult participants. The goal was to see if this tailored approach could reduce depression symptoms…

This study tested a combination of two talking therapies—behavioral activation and emotion-focused interventions—for adults with depression. Seven people took part, and researchers measured changes in mood, activity levels, and emotion control. The goal was to see if this approac…

This study looked at a parent training program for children aged 6-11 with ADHD and peer difficulties. The program was designed to help parents with their own ADHD or depression symptoms better connect with the training and improve their parenting skills. 33 parents took part to …

This study tested whether a sleep improvement program (CBT-I) could reduce symptoms of depression and anxiety in adults with poor sleep and high emotional distress. 51 participants received six sessions of CBT-I over eight weeks. Researchers used brain scans to see if better slee…

This study tested a digital neurotherapy (a computer-based brain-training program) in 36 adults who were either cancer survivors or on dialysis for kidney failure. The goal was to see if it could reduce depression symptoms and improve thinking and quality of life. Participants us…

This study tested a videogame called 'ACTing Minds' designed to help adults with mild to moderate depression, anxiety, or stress. 302 participants played either this game or a neutral game for one session. The goal was to see if the ACT-based game improved psychological flexibili…

This study tested a non-invasive treatment called neurofeedback in 157 teens who had attempted suicide. Participants learned to control their own brain activity in real time using an MRI scanner. The goal was to see if this training could reduce suicidal thoughts and improve emot…

This study tested whether therapy sessions over video call (FaceTime) could help people with spinal cord injury who feel depressed. 75 adults with a recent spinal cord injury and mild to moderate depression took part. They received cognitive behavior therapy from a psychologist v…

This study tested whether a personalized form of transcranial magnetic stimulation (TMS), guided by brain scans, can help people with depression who feel emotionally numb. Eighty adults with depression took part. The goal was to see if this targeted stimulation improves emotional…

This study tested a problem-solving program delivered by phone and online for 210 Hispanic caregivers of veterans who had a stroke. The goal was to reduce caregiver depression and burden, and improve problem-solving skills and quality of life. The program was adapted to be cultur…

This study tested a new way to treat depression by timing magnetic pulses (TMS) to match a person's brain waves. The idea is that delivering pulses when the brain is in an 'excited' state may work better than random timing. 34 adults with depression received either synchronized o…

This study tested whether transplanting healthy gut bacteria (fecal microbiota transplant, or FMT) could improve sleep in people with chronic insomnia. 80 adults received either FMT capsules or placebo starch capsules. Researchers measured sleep quality using sleep tests and ques…

This study tested a 9-session program that uses cognitive-behavioral techniques to help people living with HIV quit smoking by reducing anxiety and depression. 131 daily smokers who were motivated to quit took part. The goal was to see if the program led to higher quit rates comp…

This small pilot study tested a mindfulness-based therapy adapted for older Black adults (age 50+) who have both chronic pain and depression. The goal was to see if this approach could improve quality of life and reduce pain interference. The study enrolled 12 participants and me…

This study tested a special type of meditation called compassion meditation in 142 Veterans who have chronic pain along with depression or PTSD. The goal was to see if this mind-body approach could reduce how much pain interferes with daily life and improve overall well-being. Pa…

This study tested whether using a smartphone app to track sleep and daily activities, combined with coaching to keep a regular sleep-wake cycle, could help people with depression recover faster and avoid relapse after leaving a psychiatric hospital. 103 adults with major depressi…

This study tested whether adding pizotifen (a migraine drug) to escitalopram (a common antidepressant) works better than escitalopram alone for depression. 88 people with major depressive disorder took part. Researchers measured symptom changes using a standard questionnaire (PHQ…

This study tested a program that combines counseling (behavioral activation) with medication adjustments to reduce depression and anxiety in older adults (age 60+) having heart surgery. 105 participants were split into two groups: one received the program, the other got usual car…

This study tested whether a therapy delivered by phone and home visits could help people who survived respiratory failure in the ICU. The therapy combined treatment for depression with physical rehabilitation. 52 adults who had been on life support took part. The goal was to see …

This study tested magnetic seizure therapy (MST) as a gentler alternative to electroconvulsive therapy (ECT) for people with depression that hasn't improved with medication. About 239 adults with treatment-resistant depression received either MST or ECT to see if MST could ease d…

This pilot study tested a counseling program called the Friendship Bench for 106 teens aged 13-18 living with HIV who also had depression or anxiety. The program aimed to improve their mood and keep them engaged in HIV care. Researchers measured how well the program worked by loo…

This study tested a program called Tertulias (Spanish for 'conversational gatherings') for Mexican immigrant women in Albuquerque. 241 women joined either the peer support groups or a control group. The goal was to see if these culturally tailored chats could lower depression, bo…

This study looked at whether a collaborative care model, where doctors, nurses, and mental health specialists work together, helps people with depression more than usual care. 325 Danish adults with depression took part. The main goal was to see if this team approach reduces depr…

This study tested three remotely delivered programs to help 113 adults with depression, anxiety, and substance use related to COVID-19 stress. Participants either received an 8-week mindfulness course, online cognitive behavioral therapy, or standard remote monitoring and coachin…

This study looked at whether doing Zumba for 10 weeks could lower anxiety and depression in healthy adults aged 40 to 65. Forty participants were split into two groups: one did three 50-minute Zumba classes each week, while the other kept their normal routine. Researchers measure…

This study tested whether a brief online mindfulness program could reduce stress, anxiety, and depression in Indonesian university students. Over 400 students participated, and researchers also looked at whether changing negative thinking patterns helped explain the effects. The …

This study tested whether daily omega-3 supplements (fish oil) can reduce stress, anxiety, and depression while improving memory and sleep in 64 Saudi adults who were feeling highly stressed. Participants took either omega-3 capsules or a placebo for three months. Results showed …

This study tested whether a brief behavioral program called Acceptance and Commitment Therapy (ACT) could help at-risk veterans avoid persistent pain and disability after total knee replacement. About 400 veterans scheduled for knee surgery were randomly assigned to receive eithe…

This study tested three digital coping strategies—reappraisal, distraction, and relaxation—to help children aged 9-12 whose parents are separated or divorced. The goal was to reduce their risk for anxiety, depression, and other emotional problems. Researchers measured how well th…

This study tested a new group therapy program for depressed parents of children aged 6 to 10 with emotional or behavioral issues. The goal was to see if the program was practical and liked by parents. About 80 parents took part to help improve future treatments.

This study tested a 3-week program that helps cancer patients identify their personal strengths (like hobbies, social support, or personal qualities) and use them to cope better. 32 adults with different cancers took part. The program was found to be acceptable and feasible, and …

This study tested a 4-week virtual reality (VR) cognitive training program in 62 people with stable mood disorders (depression or bipolar) or psychosis spectrum disorders (like schizophrenia). The program used simulated daily-life challenges to improve thinking and daily function…

This study tested a non-drug treatment called Personalized Integrated Chronotherapy (PIC) for pregnant women with depression. PIC combines bright light therapy, sleep schedule changes, and sleep stabilization. 120 pregnant women with major depression were randomly assigned to rec…

This study tested a new medicine called JS1-1-01 in 267 adults with moderate to severe depression. The goal was to see if it safely reduces depression symptoms compared to a placebo. Participants took the drug or a dummy pill, and doctors measured mood changes using standard depr…

This study tested a program called MOSAIC Plus for pregnant women and mothers of young children who have experienced intimate partner violence. The program aims to reduce symptoms of depression and post-traumatic stress. Fifteen women took part in the 6-month program, and researc…

This study tested a type of brain stimulation called iTBS in 14 adults who have both hoarding disorder and depression. The goal was to see if it could improve depression symptoms and also help with hoarding behaviors and thinking skills. Researchers also looked at how brain conne…

This study tested whether internet-based cognitive behavioral therapy (CBT) can help reduce depression in older adults. 84 participants with depressive symptoms used an online program and were compared to a control group. The goal was to see if this approach could ease symptoms a…

This study tested two approaches for people on sick leave due to anxiety or depression: a stepped mental health program and a combined program that also included job coaching. Over 600 participants from four Danish municipalities took part. The main goal was to see if these progr…

This study tested a new, non-invasive light therapy called transcranial photobiomodulation (tPBM) for people with major depression. 50 adults received either active light or a sham treatment on their forehead three times a week for six weeks. The goal was to see if this light the…

This study tested a one-day life skills workshop for veterans with mild traumatic brain injury, chronic pain, and mental health issues like PTSD and depression. The goal was to see if the workshop could reduce distress and help veterans readjust to civilian life. 176 veterans too…

This study tested whether using a virtual reality headset to do enjoyable activities could help ease depression symptoms. 26 adults with major depressive disorder took part. Researchers compared the virtual reality approach to doing similar activities in real life to see which wa…

This study tested whether using a person's DNA to choose an antidepressant works better than standard care for cancer patients with depression or anxiety. About 99 adults with cancer took part. Researchers compared changes in mood and quality of life between those who got DNA-gui…

This study tested whether a non-invasive brain stimulation technique called rTMS can reduce pain, headaches, depression, and other symptoms in veterans with Gulf War Illness. 204 veterans who served in the Persian Gulf War region took part. The approach uses magnetic pulses to st…

This study tested a culturally adapted version of cognitive behavioral therapy (CA-CBT) for Chinese youth aged 12 to 21 in Ontario who have anxiety or depression. The goal was to see if making therapy more culturally relevant improves access and mental health outcomes. Researcher…

This study tested an 8-week text messaging program for young adults aged 18-25 with depression or anxiety who were not interested in or couldn't access in-person therapy. Participants received personalized or standard text messages, or weekly links to mental health info. The goal…

This study looked at whether adding the drug duloxetine to a supervised aerobic exercise program could help older adults with both knee osteoarthritis and depression. All 43 participants received the combined treatment to see if it was feasible and if it improved pain and mood. T…

This study tested if a non-invasive brain stimulation technique called tDCS can reduce depression symptoms. 198 adults with mild to moderate depression used a home-based device. The goal was to see if this gentle electrical stimulation could improve mood and daily function.

This study tested a digital mental health app for young adults (ages 18-25) who self-injure and are not in therapy. 90 participants were split into three groups: a self-guided app, the app with coaching, or an active control with educational content. The goal was to see if the ap…

This study tested whether adding whole-body hyperthermia (a treatment that safely raises body temperature) to standard cognitive behavioral therapy (CBT) could help adults with major depression. Thirty participants received either real or sham heat sessions alongside weekly thera…

This study tested whether special LED lights that mimic sunlight, installed in hospital rooms, could help people with major depression. Fifteen patients took part, with some getting the dynamic light and others standard light. The goal was to see if the setup was practical and co…

This study tested a short talking therapy called CALM for people with advanced cancer in Korea. The goal was to see if it was practical and could help reduce depression and distress. 90 patients took part, and the therapy focused on helping them cope with their feelings and fears…

This study looked at whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help university students in Malaysia feel better. Thirty-two students with mild to moderate anxiety, depression, or stress took part. Some received six weekly online ACT session…

This study tested a non-invasive brain stimulation technique called iTBS for treating depression. 73 adults with moderate depression received either real or fake (sham) stimulation daily for two weeks. Researchers measured changes in mood, thinking skills, and brain scans to see …

This study tested a program where older Black caregivers, their loved ones with dementia, and a support person walk together while looking at old neighborhood photos on a tablet. The goal was to see if this combination of physical activity and social reminiscing could improve car…

This study tested a brain stimulation technique called theta burst stimulation (TBS) to see if it could reduce depression symptoms in 21 adults with current depressive disorder. Some participants also received training to boost positive emotions. The main goal was to measure chan…

This study looked at whether nurses could reduce their own stress, anxiety, and burnout by pressing on specific points on their hand and wrist (acupressure) twice a day for two weeks. 160 nurses from a hospital in Taiwan took part. The results suggest that this simple self-care t…

This study looked at whether coloring mandalas (circular patterns) can help adults hospitalized for depression and anxiety feel better. Fifty-one patients took part, and researchers measured changes in their mood, stress, and quality of life. The goal was to see if this simple, l…

This study tested whether daily text messages that adapt to a person's preferences can help reduce depression symptoms. 100 adults with moderate to severe depression received either personalized messages, standard messages, or just educational links for 8 weeks. The goal was to s…

This study tested whether a meditation app called the Healthy Minds Program can reduce depression symptoms in adults. Over 1,100 people with mild to moderate depression used the app for 4 weeks, and their symptoms were compared to those who used a different app or were on a waiti…

This study tested an experimental daily pill called MAP4343 in 126 adults whose depression did not improve with standard antidepressants. The goal was to see if the drug could reduce depressive symptoms over 6 weeks. The trial was a Phase 2 study, meaning it was an early test of …

This study tested a non-medication sleep program for 88 adults with depression, bipolar disorder, or ADHD who also had insomnia. Participants received either the sleep program or standard sleep hygiene advice. The goal was to see if the program could reduce sleep problems and imp…

This study tested a technology service to help care managers in obstetrics clinics better treat depression in pregnant women and new mothers. 75 English-speaking adults with moderate to severe depression who owned a smartphone took part. The goal was to see if the tech support im…

This study adapted a behavioral activation treatment (BeatIt-2) to help minimally verbal autistic adults with depression. Nine participants and their caregivers took part. The goal was to see if the therapy was feasible and could reduce depressive symptoms using caregiver-reporte…

This study tested a simple web platform called Adhere.ly that helps therapists encourage clients to practice therapy skills between sessions (homework). 79 adults with anxiety or depression and their therapists took part. The goal was to see if using the tool improved symptoms an…

This study tested a program called ENCODE to help family caregivers of people with dementia who are in hospice. The program taught caregivers how to better manage pain and stress. 452 caregivers took part, and the study measured changes in their quality of life, anxiety, and depr…

This study tested whether training VA staff with computer simulations (called participatory system dynamics) improves how quickly and effectively veterans with PTSD, depression, or opioid use disorder receive proven treatments. About 720 staff from 24 VA health systems participat…

This pilot study tested a way to find and treat depression in teenagers at four youth-friendly health clinics in Mozambique. About 95 teens and clinic staff took part. One group received a type of talk therapy called interpersonal therapy, while the other got the usual care. The …

This study looked at whether prosthetists (the professionals who fit artificial limbs) can screen for common health problems that often go unnoticed after a leg amputation, such as poor blood flow, nerve damage, depression, and back pain. 70 adults with a below- or above-knee amp…

This completed study looked at how inflammation might change the way younger women (ages 25-44) experience reward, such as money or smiling faces, and how that relates to depression. Researchers gave 40 healthy women a mild inflammatory substance or a placebo and measured their r…

This study compared two common talk therapies for depression: Cognitive Behavioral Therapy (CBT) and Emotion-Focused Therapy. Researchers wanted to see how each therapy helps people and why some people stop treatment early. 112 adults with moderate or major depression took part. …

This study looked at whether a specific gene (BDNF) influences how well people with major depression respond to antidepressants. Researchers compared the gene variations in 188 patients who either improved or did not improve after 3 to 6 weeks of treatment. The goal is to help do…

This study looked at whether a special advance care planning tool (called POST) helps older adults get the medical care they want at the end of life. Researchers worked with 389 people aged 65 and older, including those with dementia. They checked if the care people received matc…

This study looked at whether a simple brain scan can detect signs of depression vulnerability in people who are not currently depressed. Researchers used a light-based imaging technique to measure brain activity in 90 adults, including those who had recovered from depression and …

This study looked at whether brain insulin resistance plays a role in depression during adolescence. Researchers used MRI scans to compare brain activity in teens with and without depression after giving them insulin or a placebo through the nose. The goal was to better understan…

This study looked at whether adding social support (like help with jobs and finances) to standard mental health treatment helps refugees with PTSD function better. About 200 unemployed refugees took part. The goal was to see if working closely with local social services improves …

This study followed over 18,000 Taiwanese adults to see if a vegetarian diet is linked to a lower risk of chronic diseases like dementia, depression, heart disease, stroke, gout, cataracts, gallstones, and urinary tract infections. Researchers used health insurance records to tra…

This study tested a tablet-based screening tool for substance use, depression, and anxiety in over 10,000 HIV-positive adults during routine clinic visits. The goal was to see if computerized screening could help more patients get the mental health and substance use treatment the…

This study looked at whether a short therapy program for depression could help prevent type 2 diabetes in teenage girls at high risk. The girls were ages 12-17, overweight, had mild to moderate depression, and a family history of diabetes. Researchers compared the therapy group t…

This study looked at 175 adults with both coronary heart disease and depression to understand which depression symptoms, like fatigue and loss of interest, are linked to higher heart risks. Researchers measured depression severity and heart markers to find targets for better trea…

This study tested whether healthcare providers can help low-income parents file taxes and receive tax credits by referring them to a tax filing app. Twenty-one parents with young children took part, and researchers checked if they filed taxes and how their health changed over tim…

This study tested whether a smartphone app could improve mood, sleep, and physical activity in over 1,000 medical interns. Participants used the app daily to log their mood and wore fitness trackers to measure steps and sleep. The goal was to see if the app helped, not to treat o…

This study looked at how often older adults (65+) in China feel anxious or depressed after non-cardiac surgery. Researchers tracked over 7,500 patients and used standard questionnaires to measure symptoms. The goal was to find out how common these issues are and what factors make…

This study looked at whether an electronic screening system (eScreening) helps find mental health problems like PTSD, depression, and suicide risk faster in post-9/11 veterans. Researchers compared eScreening to the usual paper-based method in 72 veterans. The goal was to see if …

This study tested a program to help mothers after a preterm birth. The program offered extra support and care coordination. Researchers wanted to see if mothers found it helpful and if it reduced stress. 67 mothers took part in the study.

This study created and tested a mobile app called VetEd for student veterans who have mental health conditions like depression, PTSD, or anxiety. The app provides academic skills, mental health management, and information on resources. 13 veterans helped researchers improve the a…

This study tested whether a gentle, non-invasive brain stimulation technique (HD-tDCS) could boost the effects of cognitive behavioral therapy (CBT) for people with depression, anxiety, or PTSD. Twenty participants received the stimulation alongside their regular therapy. The goa…

This completed study from Stanford University looked at how brain circuits relate to anxiety and depression. 167 adults with recent anxiety or depression symptoms participated. Researchers used brain scans and questionnaires to understand these conditions, and some participants a…

This study looked at whether genetic testing can help doctors choose better medicines for depression, acute pain, and chronic pain. Over 4,200 people were screened to join one of three separate trials. The goal was to see if matching drugs to a person's genes improves outcomes co…

This study looked at how healthy young adults (ages 18–35) can intentionally suppress negative memories. Using brain wave recordings (EEG) and measures like heart rate and sweat response, researchers aimed to uncover the timing and brain processes behind this ability. The goal is…

This study looked at how inflammation impacts feelings of pleasure and motivation in older adults (ages 60-80) with anxiety. Researchers used brain scans and computer tasks to measure these effects. The goal was to better understand the link between anxiety, inflammation, and los…

This study looked at how depression impacts the ability to recognize emotions on people's faces in those with multiple sclerosis (MS). Researchers compared 38 participants, including people with MS and healthy controls, using tests that involved identifying angry, happy, or neutr…

This study followed 169 elderly patients (over 60) with depression who were treated at specialized clinics in Norway. Researchers checked on them after one and three years to see how their depression progressed and whether they developed dementia. The goal was to better understan…

This study tested whether reviewing patients' electronic messages (like texts and emails) with their therapist could improve mental health care. About 110 adults with anxiety or depression took part. Researchers measured changes in quality of life and the strength of the therapis…

This early-phase trial tested the safety and how the body processes multiple doses of an experimental drug called NH102 in 40 healthy adults aged 18 to 45. Participants received either the drug or a placebo, and researchers monitored side effects, lab results, and vital signs. Th…

This study looked at whether community health workers can help screen for depression in Black churches and connect people to care. Over 500 adults took part. One group got a structured program (SBIRT) while the other got usual referrals. The goal was to see if the program increas…

This study looked at how the brain processes emotional distractions in teenage girls at risk for depression. Researchers used EEG to measure attention patterns and tested whether real-time brain feedback could reduce sad moods. The goal is to find new ways to identify and help hi…

This study looked at anhedonia—a lack of motivation or pleasure—in 123 young people with depression. Participants had brain scans, blood tests, and interviews to measure symptoms. Some also tried treatments like brain stimulation (TMS), positive thinking training, or ketamine. Th…

This study followed 125 ICU patients who needed a breathing tube and sedation for at least 48 hours. Researchers tested their memory and attention 4 months after leaving the hospital to see how many had lasting cognitive problems. The goal was to better understand the mental afte…

This study looked at 39 children with asthma to see if those with depression have different lung inflammation and respond better to a type of inhaler called ipratropium. Researchers measured lung function before and after the inhaler. The goal was to understand if depression chan…

This study looked at 136 women to see if the age they entered menopause is linked to anxiety and depression. Researchers compared women who had early menopause (before age 40) with those who had natural menopause after 40. The goal was to understand how timing of menopause affect…

This study looked at whether anxiety and depression are linked to a common tooth infection called apical periodontitis. Researchers at the University of Siena studied 120 adults, comparing those with and without the infection. They used questionnaires and dental exams to see if m…

This study looked at whether schema therapy, a type of talk therapy, can help people with depression that hasn't gotten better with standard treatments. Two patients received 30 therapy sessions over about a year. The goal was to see if this approach is practical and to learn how…

This study tested a program that combines mental health treatment with job coaching for people on sick leave due to anxiety, depression, stress, personality disorders, or functional disorders. Researchers enrolled 900 participants in Denmark to see if this combined approach helps…

This study looked at how depression changes the way mothers interact with their babies and how that affects the child's thinking, emotions, and development. About 700 English-speaking mothers (ages 20-45) with infants 4 months or younger took part in interviews, home video sessio…

This small pilot study tested whether people with major depression who eat a lot of ultra-processed foods could reduce them. 20 participants tried a personalized diet change. The goal was to see if this approach is feasible and acceptable, not to measure mood effects directly.

This study looked at whether community health workers visiting pregnant women at home in rural South Africa could improve health for both mothers and children. About 1,490 women took part, with some areas getting the home-visit program and others not. Researchers tracked things l…

This study looked at how a short course of corticosteroids (hydrocortisone) affects memory and the hippocampus, a brain region key for learning. Sixty-six healthy adults and people with depression took either the drug or a placebo for three days. Researchers used memory tests and…

This study looked at how the brain's reward system helps improve mood in people with depression. Researchers used brain stimulation and special pills to change brain signals and see how mood changed. 120 adults with depression took part to help understand these brain processes be…

This study looked at how live music experiences might help people with depression. Researchers worked with 84 participants aged 8 to 70 who had depression or were at risk for it. They measured changes in mood, resilience, and quality of life through group and individual music ses…

This study looked at 76 adults with depression to understand why some people get better with a placebo (a fake treatment). Researchers used brain scans and other tests to find clues. The goal is to help design better treatments and clinical trials in the future.

This study tested different training methods to help healthcare workers in Vietnam provide depression care. Over 1,300 adults with depression and their healthcare providers took part. The goal was to see which training approach worked best to get more people screened and treated …

This study tested a new afterschool program where college students mentored middle schoolers to help them be more active and improve their mood. The program was designed for teens with depression symptoms who might not normally join afterschool activities. The main goal was to se…

This study checked if the Cardiac Depression Scale works properly in Turkish for people with heart disease. Researchers tested 360 adults with stable heart conditions to see if the scale accurately measures depression. The goal is to give doctors a reliable way to detect depressi…

This study tested whether sending outreach messages (online, by mail, or by phone) could help more people from racial and ethnic minority groups start treatment for depression. It included 309 adults with a new depression diagnosis. The goal was to see which communication method …

This study looked at how two different speeds of magnetic brain stimulation (slow vs. fast) change brain activity in 30 healthy adults. The goal was to understand how this technique works for treating depression and schizophrenia. Participants received both types of stimulation o…

This study looked at whether a personalized meal plan with more omega-3 fatty acids (found in fish) could help breast cancer survivors manage symptoms like fatigue, pain, depression, and sleep problems. About 98 women who had finished treatment for early-stage breast cancer took …

This study followed up with 217 children (now teens) who took part in a program for anxiety and depression 5 years earlier. Researchers want to see if the program's benefits lasted, like fewer symptoms and diagnoses. The goal is to learn whether early help can prevent long-term m…

This study looked at how the COVID-19 pandemic affected the mental health of 193 Amish and Mennonite adults who already had depression, anxiety, or bipolar disorder. Participants filled out surveys about their symptoms and pandemic-related stress four times over two years. The go…

This study looked at whether using online tools like YouTube videos, TikTok, and resource links can help sexual and gender minority youth (ages 14-19) feel more comfortable seeking help for depression and anxiety. 81 participants joined a private Discord group for 4 weeks and had…

This study tested a program where local health workers screened women aged 18-49 for anxiety and depression after severe floods in rural Pakistan. Women who showed signs of mental health issues were referred to basic health centers for further help. The goal was to see if this ap…

This study tested a new way to improve thinking skills by combining brain-training games with low-oxygen air (like being at high altitude). 190 healthy adults and people with depression or bipolar disorder took part. The goal was to see if this approach could boost memory, focus,…

This study explores whether forgiving medical debt can improve people's mental health, well-being, and ability to get needed medical care. Researchers surveyed about 15,000 adults who had medical debt, some of whom had their debt forgiven by a charity. By comparing the two groups…

This study aimed to find biological markers in blood, urine, and saliva that could help explain why up to 40% of people with depression do not respond to standard antidepressant treatment. Researchers analyzed samples from 50 adults with major depression who had not taken antidep…

This study tested a program that helps low-income parents build strong parenting skills to prepare their children for school. It combined two proven methods: one where a specialist videotapes and coaches parents during doctor visits, and another offering home-based support for fa…

This study tested whether having families keep a hospital diary during their child's stay in the pediatric intensive care unit (PICU) could reduce anxiety, depression, and post-traumatic stress after discharge. Researchers followed 431 families in four Brazilian PICUs, checking t…

This study explored whether certain harmful gut bacteria are linked to anxiety, depression, and panic disorders. Researchers analyzed stool samples from 500 adults, including people with these conditions and healthy controls. The goal was to find patterns that could lead to new t…

This study looked at 15 women aged 20-50 who experienced domestic physical violence and visited a social service center in the last two years. Researchers wanted to see if their ability to do daily activities and take part in social roles was connected to how satisfied they felt …

This study measured levels of certain minerals in the blood of 100 women with fibromyalgia and compared them to healthy women. The goal was to see if these minerals are linked to disease severity, depression, or anxiety. The study was observational, meaning no treatment was given…