Sound waves to the brain: a new hope for mood disorders?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults ages 18-65 * Willing and able to undergo the MRI and LIFUP procedures and repeated LIFUP for up to 15 sessions * English language proficiency sufficient to speak to investigators and understand investigator instruction * Can visit the laboratory several times over the course of 2 to 6 weeks * Individuals with a primary affective disorder diagnosis (major depression, bipolar disorder, an anxiety disorder, or posttraumatic stress disorder on the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders Diagnosis 5th Edition * Score of 19 or greater on the general distress subscale of the 30-item Mood and Anxiety Symptom Questionnaire * Psychiatric medication(s) on a stable dosage and regimen for the past 3 months (including antidepressants, mood stabilizers, atypical antipsychotics, and sedatives/hypnotics) Exclusion Criteria: * Contraindications to LIFUP or MRI including, but not limited to, history of stroke, brain tumors, brain hemorrhages, internal wires, electrodes, pacemakers, implants, irremovable ferromagnetic objects in head that are unsafe for MRI and/or cause large distortions in imaging data, history of seizures (except febrile seizures in childhood), brain surgery, moderate-to-severe head injury or any penetrating head injury, and uncontrolled thyroid disorder. * Pregnant women or people trying to become pregnant will also be excluded due to the unknown effects of MRI on developing fetuses * Individuals with serious medical illnesses that are likely to interfere with study: cancer, autism, narcolepsy etc. * Current active suicidal/homicidal ideation (or suicide attempt in the past 3 months) * Current substance-use disorder * Current or recent (within 3 months) psychotic symptoms, or currently meeting diagnostic criteria for a manic episode * Individuals currently actively engaged in evidence-based or experimental treatments (e.g., weekly cognitive behavioral psychotherapies, transcranial magnetic stimulation, ketamine/esketamine treatment) other than psychiatric medication(s)