ANXIETY DISORDERS

This study tests whether using a person's genetic information to choose psychiatric medications leads to better recovery than standard prescribing. About 2,500 adults with mood, anxiety, or psychotic disorders will be randomly assigned to either gene-guided treatment or usual car…

This study looks at whether adding the antidepressant fluoxetine (Prozac) to standard immunotherapy can help control tumors better in people with advanced liver or gallbladder cancer who also have depression or anxiety. About 240 adults will be randomly assigned to get immunother…

This study tests whether a 4-week Resilience Training program can prevent serious mental illness in college students who already have mild psychotic experiences. 192 students aged 18-30 will be randomly assigned to either Resilience Training or a general Life Skills program. The …

This study is testing a short, 6-session group program called Resilience Training for Teens. It is designed for high school students aged 14-19 who have mild symptoms of depression, anxiety, or unusual feelings. The goal is to see if the program can help prevent them from develop…

This study tests whether adding a low or moderate dose of FDA-approved cannabidiol (Epidiolex) to cognitive behavioral therapy (CBT) helps adults with generalized anxiety disorder. Ninety participants will receive either CBD or a placebo alongside CBT, and researchers will measur…

This study tests a computer program called COGENT, designed to improve thinking skills like memory and attention in people with anxiety, depression, or PTSD. 128 adults will be randomly assigned to either the COGENT training or a sham program. Researchers will compare changes in …

This study tests a digital program called UKADO for people waiting for face-to-face psychotherapy. The program takes about 60 minutes and includes exercises to reduce symptoms of depression and anxiety. Researchers will compare different versions of the program to see which works…

This study tests whether a non-invasive brain-training technique called neurofeedback can help people with both coronary heart disease and anxiety. Participants will learn to control a part of their brain linked to stress, using real-time feedback from a headband. The goal is to …

This study compares two types of exposure training for people with spider phobia: in-person exposure with a real spider and videochat-based exposure where someone else handles the spider. 72 adults with spider fear will be randomly assigned to one of these treatments or a waiting…

This study compares a blended group therapy (online and in-person sessions) to standard in-person group therapy for adults with anxiety or depression. About 144 participants will receive 16 weeks of treatment. The goal is to see if the blended approach works as well and is accept…

This study tests a 4-week mindfulness program designed specifically for new mothers and birthing parents with anxiety disorders. Researchers will use surveys and brain scans to see if the program helps reduce anxiety, improve emotion regulation, and increase body awareness. The t…

This study tests a new telehealth program called DINOSAUR to help young children (ages 4 to 6) with autism who also have anxiety. The program teaches children and their parents strategies to reduce worry and handle uncertainty. About 70 children will take part in this 14-week onl…

This study tests whether an 8-week mindful self-compassion program can reduce symptoms of anxiety and depression. It compares attending the program in person versus through videoconference. The study involves 80 adults diagnosed with anxiety disorders or major depression who also…

This study tests whether adding a computer-based music therapy that tracks eye movements (GCMRT) to standard talk therapy (CBT) works better than CBT alone for children with anxiety. About 150 kids aged 8 to 17 with separation, generalized, or social anxiety will take part. They …

This study tests whether a brain-training technique called neurofeedback can help people with both heart disease and anxiety control their heart rate during stress. 56 adults will either receive real or fake (sham) neurofeedback while their brain activity and heart rate are measu…

This study tests if a smartphone app called Sidekick can help teenagers with anxiety disorders practice exposure exercises between therapy sessions. About 46 teens aged 13-18 will use the app alongside their usual outpatient treatment. The goal is to see if the app is practical, …

This study looks at whether qigong (a gentle mind-body practice) and multicomponent exercise can improve anxiety, balance, walking, sleep, and quality of life in people with panic disorder. About 60 adults aged 18-65 with a panic disorder diagnosis will participate. The goal is t…

This study compares two intensive cognitive behavioral therapy formats for veterans with PTSD and anxiety disorders. About 306 veterans will receive either individual therapy over two weeks, group therapy over two days, or usual care. The goal is to see which approach better impr…

This study is testing a self-help workbook designed to help people in prison manage anxiety and depression. About 96 adults with moderate to severe symptoms will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is practical, acce…

This study tests if transcranial magnetic stimulation (TMS) can reduce anxiety and depression in children and teens aged 6 to 18. About 120 youth with a doctor's diagnosis will receive TMS treatment. Researchers will measure symptom changes using questionnaires and functioning sc…

This study tests a telemedicine-delivered cognitive behavioral program (RxWell) to help adults with anxiety or depression use fewer opioids after knee or hip replacement. About 150 participants will be enrolled. The program aims to improve mood and reduce painkiller use by provid…

This study tests whether brief, online self-guided programs can help parents of children ages 2-7 better manage their child's anxiety. About 90 parents will be randomly assigned to one of three programs. The goal is to see if these programs reduce how much parents accommodate the…

This study tests a culturally adapted form of cognitive behavioral therapy (CBT) for people living with HIV who also have depression and anxiety. Fifty adults in Peshawar, Pakistan, will either receive six therapy sessions from trained HIV health workers or continue with their us…

This study tests a short, 30-minute online program for caregivers of children aged 4-10 with anxiety. The program is adapted for Latin, Haitian, and Haitian-American families. Researchers want to see if it reduces caregiver anxiety and helps them better support their child.

This study tests a new parent group program for teens aged 12-17 with autism who also have anxiety or depression. The program teaches parents skills to help their teens manage emotions. Researchers want to see if it is practical and helpful for families.

This study tests a brief group therapy designed to help people with anxiety and depression. About 100 adults will be randomly assigned to either the new therapy or standard group therapy. Researchers will measure changes in anxiety and depression symptoms after 3 months to see if…

This study tests whether adding a digital mindfulness program to usual care helps adults aged 18-65 recover from emotional disorders like depression, anxiety, OCD, PTSD, and eating disorders. Participants attend online group sessions and use a WeChat mini-program for daily exerci…

This study tests a new therapy called SoundHeal for teens aged 12-18 in juvenile detention who struggle with emotions, anxiety, or substance use. Participants sit in a special room with soothing sounds, music, gentle vibrations, and dim lights, then write about their experience. …

This study tests if an AI-guided therapy program can help adults with mild depression or anxiety. Participants will either use the AI program or receive standard care for 10 weeks. The goal is to see if AI can make therapy more accessible and reduce symptoms.

This study looks at how the brain works in children aged 8-17 with anxiety or depression. Researchers use brain scans and thinking tasks to see how two standard treatments—talk therapy (CBT) or medication (fluoxetine)—affect brain activity over one year. The goal is to understand…

This study tests whether a device called rTMS, which uses magnetic pulses to temporarily change brain activity, can alter how people with anxiety handle fear. Researchers will measure brain signals and reactions in 80 adults who recently started anxiety treatment. The goal is not…

This study is looking at whether brain scans (fMRI) can help predict how well people with depression, social anxiety, or insomnia will respond to internet-delivered cognitive behavioral therapy (iCBT). Researchers will compare brain scan data with patients' own reports to see whi…

This study looks at whether giving extra money to lower-income parents for three years can improve their children's mental health and brain function. Researchers will follow 500 children, ages 5 to 14 at the start, and measure stress, inflammation, and brain activity using scans.…

This study screens up to 16,000 people aged 3 to 99 who have mood or anxiety disorders, or are healthy volunteers. The goal is to carefully evaluate participants for other research studies and collect natural history data. Participants undergo interviews, medical exams, brain sca…

This study looks at how the brain reacts to threats in people with depression, anxiety, or both. About 165 adults will take a single dose of an anti-anxiety drug or a placebo and then have their brain activity measured with MRI and eye-blink tests. The goal is to find differences…

This study looks at how exercise might help the brain in adults with anxiety disorders. Researchers will measure certain brain chemicals from blood samples to understand the biological effects of physical activity. The goal is to learn more about the brain's response to exercise,…

This study aims to improve MRI scanning methods to see how mood and anxiety disorders affect the brain. Researchers will compare brain structure and activity in healthy volunteers and people with major depressive disorder while they perform tasks. The goal is to develop better to…

This study aims to find genetic markers that may predict which children and youth (ages 6–24) with depression, anxiety, or OCD will experience behavioral activation—a side effect like restlessness or agitation—when taking SSRI antidepressants. Researchers will compare the DNA of …

This study looks at whether a child's genes can predict if they will have certain side effects from common antidepressants (SSRIs). Researchers will collect saliva samples from 120 children and young adults aged 6 to 24 with depression, anxiety, or OCD. The goal is to find geneti…

This study explores whether a non-invasive technology called transcranial focused ultrasound (tFUS) can temporarily change how the brain handles emotional situations in people with anxiety disorders. Researchers will measure brain activity and physical responses in 40 adults who …

This study looks at whether adding patients' own goals and concerns to their mental health care plan can help them stay more engaged in treatment. About 2,400 adults with anxiety or depression who are already in collaborative care will use an enhanced questionnaire and dashboard.…

This study is testing whether an artificial intelligence (AI) tool can reliably measure the severity of depression and anxiety in adults by analyzing video interviews. Researchers will compare the AI's assessments to those made by human clinicians. The goal is to develop a more c…

This study tests whether a single session of brain stimulation (rTMS) combined with emotion regulation training can help people with mood, anxiety, or impulse disorders better control their emotions. 240 adults aged 18-55 with high emotional distress will be randomly assigned to …

This study looks at whether a non-invasive brain stimulation technique called rTMS can change heart rate in women who have had multiple pregnancy losses and also have anxiety. 55 women will receive different levels of stimulation while their heart activity is recorded. The goal i…