ANXIETY DISORDERS

This study tests whether using a person's genetic information to select psychiatric medications leads to better recovery than standard prescribing. About 2,500 adults with mood, anxiety, or psychotic disorders will be randomly assigned to either genetics-guided treatment or usual…

This study is testing a new group therapy called Resilience Training for Teens. The goal is to see if it can prevent serious mental illness in high school students who already have mild symptoms of depression, anxiety, or unusual feelings. About 70 teens aged 14-19 will take part…

This study tests whether a smartphone app called Sidekick can help teenagers (ages 13-18) with anxiety disorders practice exposure exercises between therapy sessions. About 46 teens will use the app alongside their usual outpatient treatment. The main goal is to see if this appro…

This study tests a 3-session program called Omnis Salutis that teaches veterans how to communicate their health goals to doctors and loved ones. It includes 238 veterans with PTSD, depression, anxiety, or substance use issues. The goal is to see if the program improves their soci…

This study tests whether brief, online self-guided programs can help parents of children ages 2-7 better manage their child's anxiety. About 90 parents will be randomly assigned to one of three programs and followed for 8 months. The goal is to see if these programs reduce how mu…

This study tests a 4-week mindfulness program for mothers with postpartum anxiety. It aims to reduce anxiety, improve emotion regulation, and increase body awareness using questionnaires and brain scans. About 50 mothers in their first year postpartum will participate.

This study tests a brain-training technique called neurofeedback to see if it can help people with both heart disease and anxiety control their heart rate during a stressful cold-water task. Researchers will compare real neurofeedback to a sham (fake) version in 56 adults. The go…

This study tests a new telehealth program called DINOSAUR for young children (ages 4-6) with autism who also have anxiety. The program uses cognitive-behavioral therapy to help kids cope with uncertainty and worry. Researchers will enroll 70 children to see if the program is feas…

This study tests whether a short, group-based therapy focused on understanding thoughts and feelings can help reduce symptoms of anxiety and depression. One hundred adults from community mental health services will be randomly assigned to either this new therapy or a standard gro…

This study is testing whether a treatment called transcranial magnetic stimulation (TMS) can help reduce anxiety and depression in children and teenagers aged 6 to 18. About 120 participants will receive TMS, which uses magnetic pulses to stimulate specific brain areas. The goal …

This study looks at whether adding a CBD medication (Epidiolex) to cognitive behavioral therapy helps adults with generalized anxiety disorder feel less anxious. About 90 people will take either CBD or a placebo alongside therapy sessions. The goal is to see if CBD makes the ther…

This study tests two intensive versions of cognitive behavioral therapy for veterans with PTSD and anxiety disorders. About 306 veterans will receive either individual therapy over two weeks, group therapy over two days, or usual care. The goal is to see which format better reduc…

This study tests a short, 30-minute online program for caregivers of children aged 4-10 with anxiety. The program is adapted for Latin, Haitian, and Haitian-American families. Researchers want to see if it reduces caregiver stress and improves how they help their child manage anx…

This study compares two types of exposure training for people with spider phobia: in-person contact with a spider and watching someone else handle a spider via video chat. 72 adults with spider fear will be randomly assigned to one of these treatments or a waiting list. The goal …

This study tests whether a non-invasive brain-training technique called neurofeedback can help people with stable coronary heart disease and anxiety. Participants learn to control a brain region linked to stress while listening to sounds, with the goal of lowering heart rate and …

This study tests whether a computer-based cognitive training program can improve thinking skills like memory and attention in people with anxiety, depression, or PTSD. 128 adults aged 21-55 will be randomly assigned to either the active training or a sham version. The goal is to …

This study looks at how the brain reacts to threats in people with depression, anxiety, or both. About 165 adults will take a single dose of an anti-anxiety drug or a placebo and then have their brain activity measured with MRI and eye-blink tests. The goal is to find differences…

This study tests whether a single session of brain stimulation (rTMS) combined with emotion regulation skills training can help people with mood, anxiety, or related disorders better control their emotions. 240 adults aged 18-55 with high emotional distress will be randomly assig…

This study screens up to 16,000 people aged 3 to 99 with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies at the National Institute of Mental Health. Participants undergo interviews, medical tests, and brain scans to collect…

This study aims to improve MRI scanning techniques to better understand how mood and anxiety disorders affect the brain. Researchers will scan the brains of healthy volunteers and people with major depressive disorder while they perform tasks or view images. The goal is to develo…