DEPRESSION

This study tests a program called Enhanced Friendship Bench, which combines problem-solving therapy with HIV support, for pregnant women in Malawi who have HIV and depression. Researchers want to see if it reduces depressive symptoms and helps women stay in HIV care. About 400 wo…

This study tests a 9-week online program designed to help families of LGBTQ+ youth of color become more supportive and less rejecting. Researchers will measure changes in depression, anxiety, drug use, and other risks in 180 youth aged 14-25 and their caregivers. Half the familie…

This study tests whether combining exercise with cognitive behavioral therapy (CBT) can improve blood sugar control and quality of life in Black men with type 2 diabetes and depressive symptoms. About 80 participants will receive CBT, and half will also get guided exercise sessio…

This study compares two sets of strategies to help HIV patients with depression start evidence-based treatment. Researchers will track how many patients begin depression care and whether their depression and HIV viral levels improve within a year. Ten clinics in Cape Town, South …

This study tests ways to help adults with depression take their antidepressant medication regularly. Researchers will measure if better adherence leads to fewer depression symptoms. The study involves 525 adults from Penn Medicine primary care clinics who are starting or restarti…

This study tests whether a trauma-focused group therapy (CPT-CJ) given in prison can reduce drug use, PTSD symptoms, and re-arrest after release. About 640 incarcerated adults from 10 prisons will either receive the group therapy or a self-help workbook. Researchers will also mea…

This study tests a pharmacy-led program to help low-income patients with chronic conditions like diabetes and heart disease take their medications after leaving the hospital. The program provides free medications, bedside delivery, and health coaches to help with follow-up care. …

This study tests a combined therapy for mothers with PTSD who are at risk of maltreating their children. About 160 mothers receiving preventive services will take part. The therapy blends emotional regulation skills with parent-child interaction coaching to reduce PTSD, depressio…

This study looks at whether a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) can help prevent depression from coming back. 60 adults who already improved with iTBS will receive maintenance sessions, either once a week or all in one day…

This study tests whether special reflective roof coatings can lower indoor temperatures and improve health in hot, low-income communities. About 3,200 adults in Burkina Faso, Mexico, India, Niue, and Fiji will have their roofs coated or not, and researchers will track heart rate,…

This study tests a program called MILAP that brings together young married women, their husbands, and mothers-in-law to reduce depression and intimate partner violence. About 900 families in Nepal will take part. The program includes counseling and support to improve mental healt…

This study tests a virtual reality game called E-Emotio to help children aged 10 to 16 improve how they manage their emotions. The goal is to prevent anxiety and depression by making emotional control training fun and engaging. About 160 kids will either play the emotion-training…

This study tests a program called FOREST that teaches positive emotion skills to staff at a violence prevention agency. The goal is to reduce burnout, depression, and anxiety while boosting well-being and job retention. About 100 employees will learn these skills over nine months…

This study tests a program designed to help parents support their Hispanic LGBTQ+ teenagers. The goal is to prevent or reduce drug use and symptoms of depression. About 306 teens aged 13-19 and their families will take part. The program focuses on improving family communication, …

This study tests a therapy called Positive Affect Therapy (PAT) to see if it can prevent depression in teens aged 12-16 who have experienced two or more adverse childhood events (like abuse or neglect). The therapy focuses on increasing positive feelings and reward sensitivity. R…

This study tests a new way to train youth mentors and their supervisors to deliver a proven depression prevention program to teens in rural communities. About 96 teens aged 12-17 and their parents, along with mentors and supervisors, will take part. The goal is to see if the trai…

This study tests a mindfulness-based sleep program for pregnant women with insomnia to see if it can prevent depression during and after pregnancy. About 500 pregnant women will either take the program or receive standard care. The goal is to improve sleep and reduce the risk of …

This study tests a six-session program called SER Familia for Latino immigrant families with a parent and a child aged 12-17. The program, led by community health workers, aims to reduce stress from adapting to a new culture and build resilience to prevent substance abuse, intima…

This study looks at whether cognitive-behavioral therapy, exercise training, or both can lower the risk of type 2 diabetes in teenage girls. Participants are 300 girls aged 12-17 who are at higher risk due to family history, weight, and mood symptoms. The goal is to see if these …

This study looks at whether mindfulness-based treatments can help first-generation college students in rural areas feel less anxious or depressed and stay in school. About 53 students will be randomly assigned to either mindfulness meditation or psychoeducation. Researchers will …

This study tests whether a mobile app called JoyPop can help 110 youth aged 12-17 who are on a waitlist for mental health services. Participants will either use the app or continue with usual care while they wait. The goal is to see if the app improves emotion regulation and redu…

This study tests whether estradiol (a form of estrogen) can improve symptoms of depression, psychosis, and loss of pleasure in perimenopausal women aged 44-55. Participants will receive either estradiol or a placebo and undergo brain scans to see how the treatment affects reward-…

This study tests whether a probiotic called Clostridium butyricum can improve anxiety and depression in people with functional dyspepsia (a stomach disorder with no clear cause). 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard stomach med…

This study tests an internet-based therapy program called Empower@Home for older adults (50+) who have trouble walking and feel depressed. About 64 participants will either get the online therapy with coach support or standard care. The goal is to see if the program reduces depre…

This study tests whether combining a personalized cognitive training program with a type of brain stimulation called iTBS can help treat depression in people who have had a mild traumatic brain injury (concussion). About 72 participants, including military members, veterans, and …

This pilot study is testing whether ketamine infusions, followed by a brief behavioral therapy, can help veterans with chronic low back pain and depression. The study will enroll 44 veterans and measure changes in pain interference and mood. The goal is to see if this approach is…

This study looks at whether a safe, non-invasive brain stimulation method called rTMS can help treat depression in people with spinal cord injury. Fourteen adults with a spinal cord injury and major depression will receive rTMS daily for four weeks. The main goals are to check if…

This study tests whether a computer-delivered therapy can help people who have both an anxiety disorder and alcohol use disorder. The program aims to reduce heavy drinking days and delay relapse. Researchers will enroll 256 adults in an addiction treatment program to see if this …

This study is testing whether listening to specially chosen music every day for 4 weeks can help reduce anxiety and depression in people who have recently had a stroke. About 132 participants will either receive the music therapy plus standard care, or standard care alone. The go…

This study tests two types of online therapy for Canadian public safety personnel (like police, firefighters, and paramedics) who have symptoms of PTSD, anxiety, or depression. Participants can choose which therapy they prefer. The goal is to see if online therapy helps reduce sy…

This study tests whether giving a single dose of ketamine during surgery can reduce pain, lower the need for opioids, and improve depression and PTSD symptoms in adults with serious orthopedic injuries. About 90 participants will be randomly assigned to receive either ketamine or…

This study is testing whether a focused muscle contraction exercise program can improve body composition, physical abilities, and overall well-being in U.S. veterans who suffer from chronic pain, fatigue, or depression. Participants will complete 90 exercise sessions and 4 testin…

This study tests whether an 8-session group storytelling (narrative therapy) program can reduce depressive symptoms in people aged 60 and older with mild to moderate depression. About 110 participants will be randomly assigned to either the therapy group or a waitlist. The goal i…

This study tests a special therapy called PATH-Pain for 100 older adults (60+) who have mild memory problems, chronic pain, and depression. The therapy teaches problem-solving skills to help manage pain and improve mood and thinking. Participants are compared to those receiving u…

This study tests whether heated yoga or sauna sessions, combined with a mindfulness app, can help reduce symptoms of depression. Researchers will enroll 120 adults aged 18 to 65 who have at least moderate depression. Participants will be assigned to one of the two heat-based acti…

This study tests a noninvasive, personalized brain stimulation treatment (TMS) for people aged 18-65 with chronic symptoms after a mild concussion or brain injury, such as headache, dizziness, brain fog, or anxiety. Participants will have a 66% chance of receiving active TMS and …

This study tests whether an 8-week virtual Mindfulness-Based Stress Reduction (MBSR) program can reduce fatigue in people with sarcoidosis. It also looks at effects on anxiety and depression. About 100 adults with sarcoidosis and fatigue will either join the MBSR program or a mon…

This study tests whether a special massage therapy called Tui Jing can help ease depression symptoms. Researchers will compare real Tui Jing to a fake ultrasound treatment in 64 adults with depression. The goal is to see if this therapy improves mood, sleep, and stress levels by …

This study tests whether a sleep health program designed for U.S. Marines can improve sleep quality and reduce symptoms of depression, anxiety, PTSD, and suicidal thoughts. About 860 active-duty Marines will be randomly assigned to one of five groups receiving different combinati…

This study looks at whether combining two common therapy techniques—changing negative thoughts and practicing detached mindfulness—works better than using them alone for people with anxiety or depression. About 93 adults will be randomly assigned to different treatment combinatio…

This study tests whether moderate to high doses of LSD can reduce anxiety, depression, and pain in people with advanced, life-limiting illnesses. Sixty terminally ill patients will receive either two doses of LSD or a very low-dose active placebo. The goal is to improve psycholog…

This study tests whether adding bright light therapy, methylphenidate, or melatonin to cognitive behavior therapy can improve sleep and related symptoms like fatigue, anxiety, and depression in 188 adults with advanced cancer. Participants must have poor sleep for at least 2 week…

This study tests a coaching program for Black patients with long-term muscle or joint pain and depression. The program helps patients learn about non-drug pain treatments and talk to their doctors about them. Researchers want to see if this approach reduces pain interference and …

This study tests a new approach for people with depression that hasn't improved with standard treatments. It combines a type of brain stimulation called iTBS with digital mindfulness training to improve brain function and reduce symptoms. The goal is to help 120 adults with treat…

This study tests a 10-week online group program for adults with spina bifida. Participants join weekly video sessions to build self-esteem, social skills, and reduce anxiety or depression. The goal is to improve quality of life and emotional well-being. About 35 people aged 18-75…

This study tests whether a low or moderate dose of propofol, a sleep-inducing drug, combined with brief behavioral therapy for insomnia, can improve deep sleep and reduce depression in adults aged 60 and older. Seventy participants with depression that hasn't responded to at leas…

This study tests a program called CAPABLE Transplant to help people with kidney failure who are waiting for a transplant. The program aims to solve problems like depression, physical weakness, or lack of support that keep them from being active on the waitlist. About 43 adults wi…

This study tests a virtual program called MOVIN that helps pregnant people and new parents manage depression and anxiety. About 570 participants will use an online platform to work with a care coordinator and get personalized treatment plans. The goal is to see if this approach i…

This study tests an online sleep course for adults who have trouble falling or staying asleep, and feel tired or distressed during the day. About 56 people from Saskatchewan will take part. The course teaches healthy sleep habits and thinking patterns, and researchers will check …

This study aims to see if college students can effectively deliver cognitive-behavioral therapy (CBT) to high school students in rural Pennsylvania who are dealing with depression, anxiety, or stress. About 40 teens aged 13-18 will take part. The goal is to provide a low-cost, ac…

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with talk therapy can help cancer survivors who feel depressed or anxious. Twenty adults who have finished cancer treatment and have no brain tumors will receive the drug in a controlled setti…

This study looks at whether a safe, non-invasive brain stimulation technique called TMS can help older adults (ages 60-85) who have mild memory problems and depression. Researchers want to find the best dose of TMS to improve both mood and thinking. The goal is to gather informat…

This early-stage study tests an experimental drug called SP-624 in 36 adults—some healthy and some with major depression. Participants take the drug or a placebo daily for two weeks. Researchers use EEG brain scans and AI to see if SP-624 changes brain activity or improves memory…

This study tests a 100% remote education program for 220 adults with moderate depression who recently started antidepressants. The program aims to help them stay on their medication and feel more in control of their health. Participants will use an online platform from home, and …

This study compares a standard mobile cognitive behavioral therapy (CBT) program to a personalized version that teaches skills faster. One hundred people aged 18-25 with anxiety, depression, or bipolar disorder will use the Maya app for 20 minutes a day, two days a week, for six …

This study tests a smartphone app that teaches cognitive behavioral therapy (CBT) skills to help people with depression feel better. Over 8 weeks, participants use the app for weekly lessons and homework guided by AI. The goal is to see if the app reduces depression symptoms and …

This study tests a new type of talk therapy called Identity-Based Transdiagnostic Therapy (IBTT) for young adults (ages 18-35) with anxiety or depression. The therapy focuses on how a person sees themselves and others, aiming to be more engaging and personalized than standard tre…

This study tests two resilience-building programs for cardiac arrest survivors and their caregivers. The goal is to reduce anxiety, depression, and emotional distress while improving quality of life. About 84 pairs (survivor plus caregiver) will participate in a series of session…

This study tests if teachers can be trained to provide mental health support to teenagers in rural India. About 216 students from 60 low-cost private schools will take part. The goal is to see if this approach can reduce depression and anxiety symptoms and be a sustainable way to…

This study looks at whether Parent-Child Interaction Therapy (PCIT) can help parents of children aged 2-7 who have behavioral concerns. Researchers will measure changes in anxiety, depression, stress, and even oxytocin levels using surveys and saliva samples. The goal is to see i…

This study tests whether an 8-week virtual reality adventure exergaming program can improve physical and mental health in women veterans aged 18-45. Participants will play VR games that involve physical movement, and researchers will measure changes in depression, anxiety, PTSD, …

This study tests whether a web-app based physical activity program can improve depressive symptoms in midlife Korean American women aged 40-60. Researchers will measure changes in depression, stress, and social support among 300 sedentary participants. The program is designed to …

This study tests whether a probiotic called Bacillus coagulans can improve anxiety and depression in people with functional dyspepsia (a stomach disorder with no clear cause). About 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard stomach …

This study tests whether a free online program from the World Health Organization, called Doing What Matters in Times of Stress, can help reduce anxiety and depression in employees of small and medium-sized Dutch companies. About 518 workers with elevated stress will either get t…

This study looks at whether giving both poverty relief and depression treatment helps low-income rural women in Bangladesh more than depression treatment alone. About 680 women aged 18-45 with depression and financial hardship will take part. Researchers will check depression lev…

This study tests a 6-week group program called Emotion Focused Family Therapy (EFFT) for parents of children aged 7-15 with anxiety, depression, or behavior challenges. The program teaches parents skills to support their child's emotions and behavior. Researchers will compare par…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve cognitive problems and mood in people with schizophrenia, autism, bipolar disorder, depression, or Parkinson's disease. Researchers will give TMS to the …

This study tests two different behavioral approaches to see which works better for improving mood, sleep, and reducing suicide risk in adults aged 55 and older who have depression. About 420 participants will wear a sleep tracker and complete surveys over 8 weeks. The goal is to …

This study tests a program called M-O-M-S for pregnant women living in areas hit by natural disasters. The program uses group classes led by experienced mothers (mentors) to help reduce anxiety and depression during pregnancy. Researchers will enroll 240 women and measure changes…

This study tests whether a smartphone app called Healthy Minds Program can reduce depression in teens aged 14 to 19 who have moderate to severe symptoms. About 200 participants will use the app for 20 weeks, and researchers will track changes in depression, anxiety, and overall w…

This study tests a 24-week collaborative care program for 60 adults with epilepsy who also have anxiety or depression. The program adds extra support from a care manager to usual neurology care, aiming to improve emotional well-being and quality of life. Participants must be 18 o…

This study tests a digital program on an iPad that combines brain-training games with learning practical thinking strategies. The goal is to see if it can improve mood, memory, and daily function in people who had a stroke at least 6 months ago. Researchers will enroll 70 adults …

This study tests a mobile app called WellPATH-PREVENT for adults aged 50-90 who were recently hospitalized for suicidal thoughts or a suicide attempt. The app teaches skills to better manage emotions and aims to lower suicide risk. Researchers will measure changes in brain activi…

This early-phase study tests whether a non-invasive brain stimulation technique called rTMS can help reduce both knee arthritis pain and depression in older adults. Thirty volunteers aged 50 and older with chronic knee pain and moderate-to-severe depression will receive rTMS whil…

This study looks at whether music therapy can help children with depression. Twenty kids will attend 11 music therapy sessions, and some will also go to recitals to talk about performance and creativity. The goal is to see if these activities boost resilience and reduce depressio…

This study tests whether transcranial magnetic stimulation (TMS) can reduce anxiety and depression in children and teens aged 6 to 18. About 120 participants will receive TMS treatment, and researchers will measure symptom changes using questionnaires. The goal is to see if this …

This study tests whether a keto-like supplement can change how the brain responds to positive and negative experiences in people with moderate to severe depression. 75 adults will take either the supplement or a placebo three times daily for 8 weeks, and undergo brain scans and q…

This study tests whether a proven sleep treatment (CBT-I) can improve depression and anxiety by targeting the brain's emotion control network. Researchers will use brain scans to see if better sleep changes brain activity. The study involves 120 adults with insomnia and depressio…

This study tests whether a new drug, CYB003, can safely and effectively reduce depression symptoms in adults with moderate-to-severe major depressive disorder. About 330 participants will receive either one of two doses of CYB003 or a placebo, added to their current antidepressan…

This study looks at how well different antidepressants work for teenagers aged 13 to 18 who have depression and did not get better with their first medication. Researchers will track changes in depression and anxiety scores over time. The goal is to provide clear evidence on whic…

This study tests whether a faith-based program can reduce depression symptoms in African American adults. About 50 people from Wisconsin church groups will participate. The program combines cognitive behavioral therapy with religious fellowship. Researchers will measure depressio…

This study tests whether a smartphone app called Safe Haven can help college students feel less depressed, anxious, or stressed. About 68 students will either use the app plus standard campus care, or just standard care alone. The app includes daily mood check-ins, weekly surveys…

This study tests a two-week smartphone app program designed to help people who have trouble feeling pleasure (anhedonia), along with symptoms of depression, anxiety, and stress. Participants will do three short daily exercises, such as savoring positive moments or practicing grat…

This study tests whether L-DOPA, a drug used for Parkinson's disease, can improve loss of interest and pleasure (anhedonia) in people with depression who also have high inflammation. Seventy adults aged 25-55 will receive either L-DOPA or a placebo for 8 weeks. Researchers will m…

This study tests a new method to dose repetitive transcranial magnetic stimulation (rTMS) for treating depression in people with spinal cord injury (SCI). Standard rTMS dosing requires thumb movement, which many with SCI cannot do. The study will enroll 24 adults with SCI and maj…

This study is testing a mobile app called MAYA that teaches coping skills for anxiety and depression. About 60 adults aged 40 and older with anxiety or mood disorders will use the app for 20 minutes, at least twice a week, for six weeks. Researchers want to see if people find the…

This study looks at whether doing heated yoga or regular yoga can ease depression symptoms. Researchers will track mood changes in 120 adults with moderate depression using a standard questionnaire. Participants will attend yoga sessions and report how they feel over time.

This study tests a 7-session therapeutic song-writing program for young people aged 13 to 24 with mild to moderate depression. Participants will either join the program or be placed on a waitlist. Researchers will measure changes in depression, anxiety, self-stigma, hope, and soc…

This study tests an online self-help program for current or former public safety personnel (like police, firefighters, paramedics) who experience depression, anxiety, or post-traumatic stress. About 164 participants will use a web-based cognitive behaviour therapy course from hom…

This study tests a new, single-session therapy called PATH-SS for people who have experienced sexual assault. It aims to reduce symptoms of PTSD and depression. About 45 adults in Ohio will receive the therapy and be followed for one month to see if symptoms improve.

This early-stage study tests whether adding D-serine (a supplement) to transcranial magnetic stimulation (TMS) can better relieve depression symptoms. About 60 adults with major depressive disorder will receive 30 TMS sessions plus either D-serine or a placebo pill. The goal is t…

This study tests whether taking high doses of vitamin B6 can change brain activity and reduce symptoms of anxiety and depression. Researchers will compare a group taking vitamin B6 to a group taking a placebo. The study involves 44 adults aged 18 to 40 with mild to moderate anxie…

This study tests a new drug called apimostinel, which may work quickly to lift depression with fewer side effects. About 150 adults with major depression will receive either the drug or a placebo, and some will also do a computer-based cognitive training exercise. The goal is to …

This study tests whether adding a low dose of esketamine (a fast-acting anesthetic) to standard electroconvulsive therapy (ECT) can improve depression outcomes in adolescents aged 13-17 with severe depression. About 220 participants will be randomly assigned to receive either esk…

This study tests whether a new drug called (2R,6R)-HNK can quickly improve symptoms in adults with major depression that hasn't responded to other treatments. About 50 participants will receive four infusions of the drug and four of a placebo over several weeks, with their mood a…

This early-phase study is testing whether psilocybin, a hallucinogenic drug, can safely help with depression in people with mild cognitive impairment or early Alzheimer's disease. Twenty participants will receive the drug in a supportive setting. The main goal is to see if depres…

This study looks at whether using the Calm meditation app for 10 minutes a day can help people with blood cancer who have trouble sleeping. About 276 patients will use the app for 8 weeks, and researchers will track their sleep, mood, fatigue, and signs of inflammation. The goal …

This study tests two ways of using magnetic brain stimulation (called iTBS) to treat depression in teenagers who haven't gotten better with medication. One group gets three sessions a day for a few days, while the other gets one session daily for several weeks. The goal is to see…

This study tests two self-guided online therapy courses for veterans who have depression or have had suicidal thoughts. About 472 veterans from several states will try one of the courses and report how helpful it is. The goal is to see if these online tools can reduce symptoms an…

This study tests a trauma-informed digital program designed to improve health and safety for immigrant women who have experienced violence and have symptoms of PTSD or depression. Researchers will measure changes in stress, depression, PTSD, self-protection behaviors, and empower…

This study tests whether a single low dose of ketamine, given in the emergency department, is safe and practical for adults (ages 18-65) who are having serious suicidal thoughts. Researchers will monitor side effects and ask staff about their experience. The goal is to see if ket…

This study tests whether adding social cognitive training (like understanding others' perspectives) to standard cognitive behavioral therapy (CBT) helps teens with depression more than CBT alone. About 82 teens aged 13-17 with depression will be randomly assigned to either enhanc…

This study tests a coaching program that helps young adults who have finished cancer treatment talk more easily with their friends. The goal is to reduce feelings of anxiety, depression, and loneliness. Ten survivors will try the program, and researchers will see if it works and …

This study tests whether a painless, non-invasive brain stimulation technique called rTMS can help treat depression in adults with autism. Depression is very common in people with autism, but standard antidepressants often don't work well or cause side effects. The study will enr…

This study looks at whether a single high dose of psilocybin (the active ingredient in magic mushrooms) can help people with both chronic low back pain and depression. Forty adults will receive either psilocybin or a control drug, then complete surveys and pain tests over one mon…

This study tests a program called ACT Together for parents of children with disabilities. The program includes six online lessons and weekly phone coaching sessions with a therapist. It teaches skills to handle stress and difficult emotions. Researchers want to see if the program…

This study tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can safely reduce depression in people with cancer. Researchers will enroll 86 adults with cancer-related depression. Participants will receive either electroacupuncture or a control tre…

This study tests a new digital therapy program designed to help people with anxiety or depression return to work. The program combines mental health support with work-focused strategies. Researchers will enroll 400 adults who are on sick leave and receiving mental health care. Th…

This study tests a mobile app called MAYA that provides cognitive behavioral therapy (CBT) to help adults aged 40-79 who have had a stroke and are dealing with anxiety or depression. The goal is to see if the app is easy to use and acceptable to patients. Ten participants will us…

This study tests two digital mindfulness programs—one live on Zoom and one self-paced app—to see if they can reduce depression in younger breast cancer survivors (diagnosed at or before age 50). About 402 women who finished primary cancer treatment at least 6 months ago and have …

This study tests a non-invasive brain stimulation technique called tDCS to see which brain area works better for easing depression symptoms. Fifty adults with depression will receive either stimulation to the left DLPFC or the DMPFC. The goal is to compare how each target affects…

This study is testing a digital program designed to help adolescent and young adult cancer survivors (ages 15-39) manage symptoms of depression. The program includes educational content and four evidence-based strategies. Researchers want to find out which parts of the program wo…

This study tests a mobile app called Blueprint that teaches coping skills to people who survived a serious illness in the ICU. Many survivors face depression, anxiety, and PTSD, but mental health care is hard to access. The app aims to reduce these symptoms and improve quality of…

This study tests a digital cognitive-behavioral therapy (CBT) program called Empower@Home for homebound older adults (age 50+) with depression. Participants receive either the program with support from a community layperson or enhanced usual care. The goal is to see if the progra…

This study tests a mindfulness-based program designed for older Black adults (age 50+) who have both chronic pain and mild depression. Participants will be randomly assigned to either the mindfulness program or a general health education program. The goal is to see if the mindful…

This study tests a new group program called BEAR for women who have experienced trauma and currently have suicidal thoughts. The program combines psychological skills, education about trauma, and physical self-defense training. Researchers want to see if it's possible to run this…

This study tests whether a computer-based cognitive training program can improve thinking skills like memory and attention in 128 adults with anxiety, depression, or PTSD. Participants are randomly assigned to either the active training or a sham version. The goal is to see if th…

This study tests whether a daily probiotic supplement can reduce depression in people with Parkinson's disease. Sixty adults aged 40–80 with mild to moderate Parkinson's and depression will take either a multi-strain probiotic or a placebo for 12 weeks. Researchers will measure c…

This study looks at whether a single session of whole-body heat therapy, with or without a cold water plunge, can reduce symptoms of depression. Researchers will enroll 162 adults aged 18-65 who currently have depressive symptoms. Participants will be randomly assigned to receive…

This study tests whether adding special content about loneliness to an internet-based therapy program (the Wellbeing Course) helps people with depression and anxiety feel better. About 494 adults in Saskatchewan who often feel lonely will take part. Over 8 weeks, they will comple…

This study is testing whether talking therapy (CBT) and group activities can reduce depression and improve daily life for elderly women in India. About 5,370 women aged 55 and older will take part. Some will receive home visits with counseling, some will join group activities, so…

This study looks at whether the antidepressant vortioxetine can help people who have both depression and migraine. About 31 adults with moderate to severe depression and episodic migraine will take vortioxetine for 12 weeks. Researchers will track changes in mood, anxiety, and mi…

This study tests a 6-week online psychological coaching program for NSU undergraduate students. The goal is to help reduce anxiety, depression, and stress while improving quality of life and coping skills. About 160 students will participate, and the program is free.

This study tests whether a psychedelic drug called psilocybin, given in a group retreat setting, can safely reduce anxiety and depression in people with incurable cancer. The drug is thought to help by resetting brain patterns that cause distress. The trial will enroll 18 adults …

This study tests whether advancing sleep timing (going to bed and waking up earlier) can improve depression symptoms. 150 adults with moderate to severe depression, recently discharged from a psychiatric ward, will either receive usual care or a psychotherapeutic program focused …

This study is tracking 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep problems, anxiety, depression, or epilepsy. Researchers will use standard questionnaires to measure changes in symptoms over 24 weeks. The goal is to see how well medical cann…

This study compares two forms of ketamine—one given through an IV and the other as a nasal spray—to see which works better for people with depression that hasn't improved with other treatments. About 400 adults with moderate to severe depression will receive either treatment for …

This study looks at whether sexual counseling during pregnancy can help improve sexual function, reduce depression and anxiety, and strengthen relationships. About 70 pregnant women will receive two group counseling sessions or standard care. The goal is to address common myths a…

This study tests whether a combination of buspirone (an anxiety medication) and melatonin (a sleep aid) can help with depression and thinking problems after a traumatic brain injury. Ten adults with mild or moderate brain injury who are still depressed will take the combination f…

This study tests an online program called MY-CHOICE for adults with ischemic heart disease who also have anxiety or depression. The program includes personalized online modules and optional video or phone calls with a therapist over 6-12 weeks. Researchers want to see if the prog…

This study tests three ways to treat moderate depression in adults aged 18 to 65: usual care from a family doctor, therapy from a psychologist, or a structured step-by-step medication plan from a doctor. The goal is to see which approach works best. Participants will be followed …

This study tests two types of attention training for adults with depression. One is a traditional computer task, the other is a gamified version. Researchers want to see if the gamified version works better than a placebo (sham) and is at least as good as the traditional version.…

This study tests whether a guided mental health app called SilverCloud can help teens with depression or anxiety. About 120 high school students will either use the app or get usual care. Researchers will check if symptoms improve and if the app is easy to use in schools.

This study tests a short-term group therapy that helps people understand their own and others' thoughts and feelings, called mentalization-based therapy, for adults with anxiety or depression. About 100 participants will be randomly assigned to either this new therapy or standard…

This study tests an 8-week mindfulness program designed for African American adults who have both high blood pressure and depression. Participants will learn stress management techniques like deep breathing and meditation in a group setting. Researchers want to see if the program…

This study tests whether adding motivational lifestyle coaching to usual depression care helps adults recover better. 210 people with depression will receive support to improve diet, activity, and sleep. The goal is to see if this approach reduces symptoms and boosts mental wellb…

This study tests whether using virtual reality (VR) headsets is safe and helpful for cancer patients who feel anxious, depressed, or stressed during treatment. About 24 patients will use VR to explore calming scenes like forests or oceans. The goal is to see if this can improve t…

This study tests a telemedicine program called RxWell that teaches coping skills to manage mood and pain after knee or hip replacement. About 150 adults with anxiety or depression symptoms will use the program before and after surgery. The goal is to see if it reduces the need fo…

This study is testing whether a smartphone app can help doctors better understand and treat depression by tracking symptoms every day. About 200 adults with depression will use the app or receive standard care. The goal is to see if the app leads to greater improvement in mood an…

This study tests a mobile app called Moodivate to help treat depression in people with incurable cancer. About 279 participants will either use the app or not for 12 weeks. The goal is to see if the app reduces depressive symptoms and improves quality of life. Risks include frust…

This study tests a 12-16 week online program called Parenting STAIR for military-connected mothers who have experienced trauma and have young children ages 2-10. The program helps moms manage strong emotions from past stress and improve their parenting skills. Researchers will co…

This study tests whether customizing the electrical dose of electroconvulsive therapy (ECT) for each person can better treat depression and reduce memory problems compared to a standard dose. Researchers will enroll 50 older adults with depression who are already scheduled for EC…

This study tests an online parenting program for 500 Filipino families in California. Parents take a virtual class to learn positive discipline, while children report their depression and anxiety symptoms. The goal is to see if the program improves parenting and reduces kids' emo…

This study tests whether a nutritional supplement called 'Think Tank' can help middle-aged women (40-60 years old) think better after experiencing stress. Forty healthy female daily caffeine drinkers will take either the supplement or a placebo and then complete thinking and memo…

This study tests a culturally adapted form of cognitive behavioral therapy (CBT) for people living with HIV who also have depression and anxiety. Fifty adults in Peshawar, Pakistan will either receive six therapy sessions from trained health workers or standard care. The main goa…

This study tests whether dapagliflozin, a medicine normally used for diabetes, can help reduce symptoms of depression in adults. Researchers will enroll 60 people with major depression who have not responded well to standard treatments. The goal is to see if the drug improves moo…

This study compares two group therapies for university students aged 18-28 who have moderate anxiety and depression. One therapy, Acceptance and Commitment Therapy (ACT), teaches skills to handle difficult feelings and live by personal values. The other is a supportive group that…

This study tests whether TJ0113 capsules can safely reduce depression symptoms. About 150 adults with moderate to severe depression will take either TJ0113 or a placebo daily for 8 weeks. The main goal is to see if depression scores improve more with the drug than with placebo.

This study looks at whether adding an antidepressant (escitalopram) to standard psoriasis medication (methotrexate) works better than methotrexate alone for people who have both psoriasis and depression or anxiety. About 40 adults with moderate-to-severe psoriasis and mood issues…

This study tests an internet-delivered therapy course designed to help new and expecting parents manage symptoms of anxiety and depression. Over 8 weeks, 60 participants will review online materials and complete questionnaires. The goal is to see if this approach is practical and…

This study tests whether adding metformin (a diabetes medication) to standard antidepressants can improve depression symptoms in obese adults. About 140 newly diagnosed depressed patients with a BMI over 25 will receive either metformin or a placebo alongside their antidepressant…

This study tests whether a culturally adapted skills training program called START NOW can reduce depression and anxiety in teenage refugees. About 80 participants aged 14 to 18 will be randomly assigned to either the START NOW program or standard care. Researchers will compare c…

This study tests whether a special mushroom powder (Ganoderma lucidum spores) can reduce depression in women who have had thyroid cancer surgery. Three hundred female participants will take either the mushroom supplement or a placebo for three months. The goal is to see if it imp…

This study looks at whether orthopaedic surgeons can safely screen for depression in patients recovering from a broken bone and offer medication (SSRIs or SNRIs) to treat it. About 100 adults who score at least 5 on a depression questionnaire will be offered treatment or choose n…

This study tests whether a type of talk therapy called interpersonal psychotherapy (IPT) can reduce depressive symptoms in young adults aged 18 to 24 in Porto Alegre, Brazil. The therapy is delivered in groups by a trained university student and a doctor, not a specialist therapi…

This study explores whether mindfulness training can help reduce sleep disturbances and depressive symptoms in healthcare workers and older adults. Researchers will recruit 40 participants for two four-month mindfulness sessions. The goal is to see if these practices improve well…

This study tests whether the JoyPop app can help Indigenous youth aged 18-25 in Northwestern Ontario manage emotions, depression, and anxiety while they wait for mental health services. About 110 participants will use the app or continue with usual care. The goal is to see if the…

This study explores whether immersive virtual reality (VR) nature walks can help reduce depression in people with progressive multiple sclerosis. Forty participants will use an Apple Vision Pro headset at home for short sessions over 8 weeks. The goal is to see if this approach i…

This study tests whether a type of talk therapy called Behavioral Activation, delivered via video calls at home, can improve social functioning and mood in veterans recently hospitalized for heart disease. About 132 participants will receive either 12 therapy sessions or standard…

This study tests if an artificial intelligence (AI) avatar-led program can help employees with depression. About 50-80 UK adults will either use the AI program immediately or wait and use it later. Researchers will measure changes in mood, anxiety, and work performance to see if …

This study tests a new text-message program designed to help cancer survivors who feel depressed connect with mental health care. Researchers will enroll 60 cancer survivors who have signs of depression and own a cellphone. The program sends tailored texts and a referral link to …

This study looks at whether a type of therapy called cognitive analytic therapy guided self-help (CAT-GSH) works as well as the standard cognitive behavioural therapy guided self-help (CBT-GSH) for people with anxiety or depression who are coming back for more help. About 100 par…

This study tests whether guanfacine, a medication currently used for blood pressure, can improve brain function and reduce depressive symptoms in people with depression. Researchers will enroll 162 adults aged 18-60 who are currently experiencing a major depressive episode. The g…

This study tests if dance-movement therapy can reduce depression in teenagers. About 140 teens with moderate to severe depression will take part. They will be randomly assigned to either dance therapy or usual care, and their symptoms will be tracked using questionnaires and inte…

This study tests a short, guided self-help program called Self-Help Plus for university students who are behind on at least 3 exams and feeling significant distress. About 210 students will be randomly assigned to the program or usual support. The goal is to see if the program re…

This study aims to find the best way to treat U.S. military veterans who have both insomnia and depression using digital behavioral treatments. Researchers will compare different sequences of treatment to see which order works best. The study enrolls 1,200 veterans and focuses on…

This study tests a new online, self-guided course based on dialectical behavior therapy (DBT) for adults with mild-to-moderate depression or anxiety. Up to 40 participants in Ontario will use the 8-week program and complete surveys to see if it is easy to use and helpful. The goa…

This study tests a behavioral health program called InSTILL for nursing home residents who feel depressed and their main support person. The program aims to help them cope with stress and build resilience. Researchers will compare the program to usual care and check if it is prac…

This study tests whether giving psilocybin (the active ingredient in magic mushrooms) followed by a type of brain stimulation called aiTBS is safe and can help people with depression that hasn't improved with other treatments. About 100 adults aged 22-65 with treatment-resistant …

This study aims to improve depression care in Indian primary care settings. It will involve 1,500 adults with moderate to severe depression, who will receive either a type of talk therapy (Healthy Activity Program) or antidepressant medication (fluoxetine). The goal is to see if …

This study tests whether using a personalized brain scan to guide a non-invasive treatment called iTBS works better than the standard one-size-fits-all approach for people with major depression. 210 adults will receive 6 weeks of iTBS, with half getting the standard target and ha…

This study tests whether a smartphone app called JoyPop can help young adults (ages 18-25) better manage their emotions, anxiety, and depression while they wait for mental health services. About 110 participants from Northwestern Ontario will either use the app or continue with u…

This study tests two types of talk therapy—cognitive behavioral therapy (CBT) and mindfulness-based therapy—to see which works better for treating insomnia and related depression in people who have had a mild to moderate traumatic brain injury (TBI) and also have post-traumatic s…

This study tests three versions of internet-delivered cognitive behaviour therapy (ICBT) for college and university students with mild to moderate depression or anxiety. About 200 students in Saskatchewan can choose a 5-week, 8-week, or flexible course, all with optional therapis…

This study compares two well-known therapies—cognitive-behavioral therapy (CBT) and mindfulness-based therapy (MBT)—to see which one works better for autistic adults with depression or anxiety. About 300 participants from North Carolina and Virginia will receive therapy sessions …

This study looks at whether an online program called Mom-Net can help low-income mothers with depression. The program teaches coping skills through online lessons and live coaching. Researchers want to see if Head Start agencies can deliver this program effectively and if it redu…

This study looks at two ways to decide the best treatment for anxiety and depression in 1,000 community college students. Participants will be placed into one of three care levels: self-guided online help, coach-guided online therapy, or care from a clinician. The goal is to see …

This study tests whether cariprazine, a drug already approved for adults, can safely ease depressive episodes in children aged 10 to 17 with bipolar I disorder. About 380 participants will receive either the drug or a placebo for 6 weeks, with dose adjustments based on response. …

This study tests an internet-based cognitive behavioral therapy (CBT) program called Good Days Ahead for older adults (50+) who have depression after an ICU stay. The goal is to see if treating depression can slow down memory and thinking problems. About 300 participants will be …

This study tests a new virtual reality training designed to help people with depression and low positive affect feel more joy and pleasure. 80 adults will be randomly assigned to either the VR reward training or a memory training control group for 7 weeks. The goal is to see if t…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can help adult children of genocide survivors who suffer from depression or anxiety. One hundred participants will receive the treatment in a controlled setting. The goal is to se…

This study tests a self-help workbook designed for people in prison who have moderate to severe anxiety or depression. About 96 adults will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is helpful, easy to use, and improves me…

This study tests whether an app that uses brain scans (fMRI) to give feedback can help people with mild to moderate depression. About 240 adults aged 18-80 with depression will use the app to learn about positive emotions and brain chemicals. The goal is to see if this approach i…

This study tests a program called "Mindful Moms" to see if it can improve mood and health in pregnant women with depressive symptoms. About 200 pregnant women with mild to moderate depression will either take the mindfulness program or attend group education workshops. The goal i…

This study tests a new 5-day accelerated version of TMS, a brain stimulation treatment already approved for depression and OCD. Researchers want to see if this faster approach can quickly improve symptoms and use brain scans to predict who benefits most. 500 adults with depressio…

This study tests whether a short-term therapy for depression, called Enhanced IPT-B, can help Black mothers of children with asthma feel better and possibly improve their child's asthma. About 60 mothers will receive either the therapy or standard care plus extra support. The goa…

This study is testing a 10-week online psychological treatment program for cancer survivors who are struggling with anxiety, depression, or fear of their cancer returning. It aims to find out which parts of the therapy are most helpful. The program involves 400 survivors in Swede…

This study looks at whether doulas who receive extra training in supporting mental health (called PMADs) can help pregnant women in rural Montana feel more confident, supported, and less depressed or anxious. About 75 pregnant women will be split into three groups: one with a reg…

This study explores whether teaching people emotion regulation skills tailored to their individual needs works better than a one-size-fits-all approach. Researchers will enroll 390 adults with emotional difficulties, including depression, anxiety, and PTSD. Participants will lear…

This study compares two web-based apps to see which one better helps Latinas with anxiety or depression start mental health treatment. One app uses an interactive story with a character who gives treatment advice, while the other provides standard information and resources. The g…

This study explores whether heart rate measurements from a brain-stimulating headset can help predict how well people with mild to moderate depression respond to treatment. One hundred participants will receive either real or fake brain stimulation at home for 10 days. The goal i…

This study looks at why people with bipolar disorder may think about or attempt suicide, focusing on life experiences and biology. Researchers will test a 6-week group program to help reduce suicidal thoughts and improve quality of life. About 130 English-speaking adults with bip…

This study looks at how the antidepressant fluoxetine changes the way healthy young people (ages 18-24) process anger. Participants take either fluoxetine or a placebo daily for 7 days and complete tasks involving angry faces, words, and frustrating situations. The goal is to und…

This study is developing and testing a family program adapted for Lakota 2SLGBTQ+ youth (ages 13-18) and their caregivers. The program includes 8 weekly group sessions to improve family relationships and reduce depression, anxiety, and other risks. The main goal is to see if the …

This study looks at whether people with depression, and those taking antidepressants like SSRIs or SNRIs, have different skin blood flow and sweating responses to heat compared to healthy adults. Researchers will measure these responses during a 2-hour passive heating session. Th…

This study looks at how sleep and light affect mood in women going through menopause. Researchers want to see if changing sleep timing for one night and using bright light for two weeks can help reset the body's internal clock and improve depression. Participants will provide uri…

This study looks at how the brain works during thinking tasks like remembering or paying attention. Researchers will record brain activity from 30 adults with epilepsy who are already having brain surgery for seizures. The goal is to better understand conditions like dementia, AD…

This study looks at whether cognitive remediation (brain exercises with coaching) can improve thinking skills and reduce problem behaviors in people staying in a forensic mental health unit. About 30 adults with conditions like psychosis, ADHD, or substance use will take part. Th…

This study looks at how well a program called the Trauma Resilience and Recovery program (TRRP) helps people who have been through a traumatic injury get mental health support. About 350 English- or Spanish-speaking patients from a hospital trauma center will take part. Researche…

This study looks at how a park-based afterschool program called Fit2Play affects children's physical fitness and mental health. Researchers will analyze data from about 5,000 kids to see changes in weight, blood pressure, fitness tests, and feelings of anxiety or depression. The …

This study looks at how common sexual problems are in women with multiple sclerosis (MS) and how they connect to fatigue, depression, anxiety, bladder issues, and thinking problems. Researchers will survey 140 women with relapsing-remitting MS who have a regular partner and are s…

This study aims to better understand cognitive rigidity—the tendency to get stuck in repetitive thoughts—in people with depression. Researchers will test online tasks in 2,500 adults to see how these thinking patterns relate to symptoms like loss of interest or pleasure. No treat…

This study tests if a wearable headband that uses sound waves and light can safely monitor blood flow in the brains of people who have had a stroke, as well as those with dementia, depression, or delirium. Researchers will also use artificial intelligence to analyze the data. Abo…

This study looks at how cannabis use changes brain function in teenagers who also have depression. Researchers will track 280 teens to see how their cannabis habits relate to their mood and thinking. The goal is to better understand the connection, not to test a new treatment.

This study aims to create a realistic social media task for brain scans to better understand how social media use and emotional health affect each other in teens. About 60 teens aged 13-17 with depressive symptoms will complete brain scans, daily surveys, and follow-up questionna…

This study aims to understand why people with depression have a higher risk of heart attacks. Researchers will analyze the function and composition of HDL ("good") cholesterol in 90 adults with depression compared to healthy controls. The goal is to uncover how depression may aff…

This study looks at existing medical records from over 156,000 people who received NeuroStar TMS for depression, OCD, or anxiety. Researchers want to find out which patient traits and treatment settings lead to the best results. No new treatments or visits are required—just analy…

This study uses a special PET scan to measure levels of an enzyme called PDE4B in the brains of people with major depressive disorder (MDD) and healthy volunteers. Researchers want to see if people having a depressive episode have lower PDE4B levels. The study involves up to 5 vi…

This study aims to understand how ketamine works in the brain to quickly treat depression. Researchers will use brain scans, blood tests, and other measures in 150 adults with major depression and healthy volunteers. The goal is to find out why a single dose works fast but briefl…

This study looks at how severe childhood stress may change the brain and increase the risk of depression. Researchers will use brain scans to measure chemical changes and brain activity in 160 women aged 20 to 32. The goal is to understand why some people stay mentally healthy de…

This study follows up with 1,000 adults who previously took part in mood disorder research at the National Institute of Mental Health. Participants complete online surveys and optional phone interviews about their current symptoms, treatments, and well-being. The goal is to under…

This study looks at whether a training program that teaches emotional intelligence can help secondary school teachers and students in Dhaka feel less anxious and depressed and improve their overall well-being. About 80 participants will be split into two groups: one gets the trai…

This online registry tracks 550 pregnant women with migraines to see if a nerve-stimulation device (CEFALY) is safe and helpful during and after pregnancy. Participants keep their usual treatments and fill out six short surveys over 12 months. No clinic visits are needed.

This study aims to help families with food insecurity and mothers with depression. Researchers will provide resources like food, rent help, and mental health support to see if it improves the bond between mother and child. The study includes 2,000 caregivers of young children in …

This study looks at how a type of talk therapy for depression changes the gut microbiome, immune system, and brain activity in 150 adults living with both HIV and depression. Participants will receive either the therapy or standard care, and researchers will use brain scans and o…

This study looks at whether teaching mothers with depression to encourage positive emotions in their young children can increase the child's brain response to rewards. About 180 mother-child pairs (children aged 4-6) will take part. Mothers will receive either coaching on positiv…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will use interviews, blood tests, brain scans, and sleep monitoring to compare four groups: people with recent suicidal thoughts or attempts, those with past suicida…

This study looks at whether online cannabis ads that claim to help with anxiety or depression make people buy more or stronger products. About 2,000 light-to-moderate cannabis users with mild to severe anxiety or depression will shop in a realistic online store. The goal is to se…

This study tests a program called FRAME that helps heart failure patients talk about mental health with their doctors and family. About 7,300 adults with heart failure or at risk for it will take part. The goal is to see if the program makes it easier for patients to get mental h…

This study looks at whether community-based mental health services can improve depression, anxiety, and PTSD. About 1,000 adults with mild to moderate psychological distress will receive these services and be tracked over time. The goal is to see if this approach works in real-wo…

This study is testing a 9-session group program called Changing Lives and Changing Outcomes-9 for people with serious mental illness who have been in trouble with the law. The goal is to help them understand their mental health better and reduce their chances of future legal prob…

This study aims to find out which support strategy Latino teens with depression and their families prefer to help them attend therapy. Researchers will interview 15 teens, 15 parents, and 5 healthcare providers. The goal is to identify the most acceptable approach, such as peer s…

This study is testing whether cameras, microphones, and wearable sensors can help doctors measure how severe a person's depression is. Researchers will record interviews with 300 hospitalized patients and analyze facial expressions, voice, movement, heart rate, and brain activity…

This study screens up to 16,000 people aged 3 to 99 with mood or anxiety disorders, as well as healthy volunteers, to see if they qualify for other research studies at the National Institute of Mental Health. Participants undergo interviews, medical exams, brain scans, and lab te…

This study looks at what 'visual frailty' means for people aged 60 and older who have age-related macular degeneration (AMD). Researchers will measure vision, reading ability, daily function, mental health, and other health conditions to create a new assessment tool. The goal is …

This study uses smartphone tracking and brain scans to see how your daily emotions, thoughts, and actions are linked. About 100 adults will answer quick surveys and let a GPS app run for four months. The goal is to understand these connections better, not to test any treatment.

This study follows 300 adults who had a surgical site infection after orthopedic surgery (like hip, knee, or spine procedures). Researchers want to see how often depression and related problems like malnutrition occur over one year. The goal is to better understand and prevent th…

This study aims to better understand how brain activity relates to mood in people with depression and epilepsy. Researchers will use precise brain recordings and artificial intelligence to analyze mood changes. The goal is to improve treatments for depression and other mental hea…

This study looks at how a natural brain chemical called allopregnanolone affects depression in women going through menopause. Researchers will give a related substance (pregnenolone) to 80 healthy women aged 40-60 who have depressive symptoms. The goal is to understand the brain …

This study looks at whether the brain activity of a therapist and a client with mild-to-moderate depression becomes synchronized during a therapy session. 45 college students will attend one session of either behavioral activation or psychoeducation while their brainwaves are mea…

This study will review the medical records of about 12,000 people who received mental health treatments for depression, OCD, or anxiety. Researchers want to compare how well two treatments—NeuroStar TMS and esketamine—work in real-world settings by looking at changes in symptom s…

This study looks at how depression affects decision-making, especially when choices are hard. Researchers will use brain stimulation (TMS or TI) while participants play game-like tasks. The goal is to learn which brain regions are involved, not to treat depression. About 500 peop…

This study looks at why depression and heart disease often happen together in women going through menopause. Researchers will measure stress-related chemicals and heart rate in 30 women aged 44-55. The goal is to find clues that could lead to better prevention and treatment.

This study aims to understand what causes depression in teenagers and how the brain changes with it. It will compare teens with depression to those without, and offer free talk therapy and optional medication for up to 25 weeks. The study is for depressed teens aged 11-17 in the …

This study tests two school-based programs designed to help teenagers sleep better, with the goal of improving mental health and school performance. About 3000 students aged 13-19 in Swedish high schools will take part, and their results will be compared to students who receive u…

This study looks at how physical activity fights depression by affecting the brain's reward system, inflammation, and motivation. Researchers will compare aerobic exercise to stretching in 250 adults with moderate depression. The goal is to understand why exercise works, so progr…

This study aims to understand how cannabis use and withdrawal affect depression and suicide risk in teenagers aged 12-18 who use cannabis daily or near-daily. Researchers will use smartphone surveys multiple times a day to track mood, cannabis use, and suicidal thoughts in real t…

This study is collecting information from 4,500 people who have had brain surgery for conditions like aneurysms, tumors, or epilepsy. The goal is to find out what factors help predict recovery, such as thinking skills and emotional health. By standardizing how outcomes are measur…

This study looks at how the brain reacts to threats in people with depression, anxiety, or both. About 165 adults will take a single dose of an anti-anxiety drug or a placebo and then have their brain activity measured with MRI and eye-blink tests. The goal is to find differences…

This study looks at how depression affects brain activity and whether a special brain scan method can track recovery during a 5-day TMS treatment. About 20 adults with major depression will get MRI scans before and after treatment. The goal is to understand individual brain chang…

This study follows 415 people with difficult-to-treat depression for 5 years after their original genetic testing. Researchers will review medical records and registry data to see how patients are doing, including suicide attempts and depression course. The goal is to learn which…

This study is testing a mobile phone app called TrueBlue that helps monitor depression and anxiety. It includes 125 adults who are at least 12 weeks pregnant or up to 12 weeks after giving birth. The goal is to see if the app is safe, easy to use, and agrees with standard mood qu…

This study in Goa, India, tests whether adding community-based support to a brief psychological treatment for depression helps more people seek and complete care. About 784 adults with depression will either receive only the brief therapy or the therapy plus community outreach. T…

This study looks at how a gentle, non-invasive brain stimulation technique called temporal interference (TI) might improve social reward processing in people with depression. Researchers will use brain scans and electrical recordings to see how stimulation changes brain activity …

This study is testing whether brain scans can predict how well people with depression, insomnia, or social anxiety will respond to internet-delivered cognitive behavioral therapy (iCBT). Researchers will compare brain scan data with patients' own expectations to see which is bett…

This study follows 540 adults with solid cancers to track how anxiety and depression change over time. Researchers will look at factors like age, cancer type, and coping style to predict who needs extra support. No new treatment is given—the goal is to learn and improve care.

This study aims to see if it is possible to measure brain activity patterns related to thinking and attention in people with chronic pain or depression, compared to healthy volunteers. Participants will complete computer tasks while their brain activity is recorded, and receive m…

This study looks at how stress, pain, and the immune system interact in people living with HIV who also have cannabis use disorder and depression. Researchers will measure stress hormones, pain levels, and heart rate during a pain stress task. The goal is to better understand the…

This study tests whether a web-based app called PST-Aid helps therapists use problem-solving treatment more effectively for depression in community health centers. About 410 therapists and their patients will take part. The goal is to see if the app improves how well therapists a…

This study looks at whether screening for social needs (like housing or food) with a focus on antiracism can help reduce chronic diseases such as high blood pressure, diabetes, and asthma. About 68,000 adults and children in primary care will take part. The goal is to see if this…

This study looks at whether mindfulness and meditation techniques can help mothers of premature babies in the NICU produce more breastmilk and feel less stressed. About 40 mothers will learn mindfulness practices and researchers will measure milk volume, stress hormones, and bond…

This study looks at how the brain, nervous system, and blood vessels interact in 80 adults having heart surgery. Researchers will measure brain activity, heart rate control, and blood flow to see how these systems work together. The goal is to better understand why some people de…

This study looks at how a 9-week therapy called Engage & Connect changes brain activity related to social rewards in adults aged 50-80 who have depression and suicidal thoughts. Researchers will use brain scans to measure changes in areas linked to positive feelings. The goal is …

This study uses brain scans to see how transcranial magnetic stimulation (TMS) affects the brain in healthy people and those with depression. About 97 adults aged 18-65 will have MRI scans while receiving single and repeated TMS pulses. The goal is to understand how TMS changes b…

This study looks at how chronic stress changes brain and immune function in people with HIV who use stimulants. Researchers will use brain scans and interviews to understand these changes, with the goal of finding better ways to treat depression and reduce stimulant use. The stud…

This study looks at whether thinking about death can increase feelings of depression and anxiety in healthy adults. Researchers will ask some participants to write about their own death and others to write about dental pain, then compare their emotional responses. The goal is to …

This study looks at whether a program called Coffee and Family Education and Support (CAFES2) helps refugee families from Arabic-speaking countries feel less depressed, anxious, or stressed. About 74 families in Chicago will take part. The program is led by trained peers and focu…

This study looks at how ketamine, a fast-acting antidepressant, works in the brain. Researchers want to see if blocking a specific receptor (AMPA) changes ketamine's effects. About 70 adults with treatment-resistant depression will stay at the clinic for 5 weeks, receive ketamine…

This study looks at how a device that stimulates the vagus nerve (used for depression or epilepsy) changes how the stomach works. Researchers will measure stomach emptying and capacity in 16 adults who already have the device. The goal is to understand the connection, not to test…

This study is testing a type of talk therapy called Emotion Regulation Therapy (ERT) delivered online. It aims to help adults in New York State who struggle with worry, rumination, or self-criticism. The study will track changes in attention, emotional control, and mood over 6 th…

This study looks at a telephone service called SUSTAIN that helps older adults (65+) manage depression, anxiety, or chronic pain. Researchers want to find out what factors make the program more effective and whether its benefits last over time. About 4,000 participants will be fo…

This study compares two programs—Mindfulness-Based Cognitive Therapy and a general wellness program—to see which one better helps people with mild depression control their emotions. About 76 adults with low-level depression symptoms will complete surveys, interviews, and computer…

This study uses special PET scans to see if inflammation in the brain is higher in people with major depressive disorder (MDD) during a depressive episode compared to healthy volunteers. Researchers will scan about 64 adults aged 18-70, including those with MDD and healthy contro…