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Could a simple drug boost ECT for depressed teens?

NCT ID NCT07247968

Symptom relief Sponsor: Min Su Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a low dose of esketamine (a fast-acting anesthetic) to standard electroconvulsive therapy (ECT) can improve depression outcomes in adolescents aged 13-17 with severe depression. About 220 participants will be randomly assigned to receive either esketamine or a placebo alongside ECT. The main goal is to see if more teens respond to treatment in the esketamine group.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 220 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

13 to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Inpatients diagnosed with Major Depressive Disorder according to the International Classification of Diseases,11th Revision(ICD-11),and scheduled for Modified Electroconvulsive Therapy(MECT); * Aged 13 to 17 years,regardless of gender; * Educational attainment of primary school or higher; * Normal hearing and vision,including color perception; * Voluntary participation in the study with signed informed consent; * American Society of Anesthesiologists(ASA)physical status classification I-II. Exclusion Criteria: * Severe cardiovascular disease,significant arrhythmias,or other cardiac conditions; * Inability to complete the assessment scales; * History of substance abuse; * Received electroconvulsive therapy(ECT)within 6 months prior to the study; * Severe cerebrovascular disease,severe hypertension,intracranial hypertension,or presence of intracranial electrodes; * Severe allergy or contraindication to propofol or succinylcholine; * Comorbid with other psychiatric disorders.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adolescent Depression ECT Esketamine

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The First Affiliated Hospital of Chongqing Medical University

    NOT_YET_RECRUITING

    Chongqing, China

  • The First Affiliated Hospital of Chongqing Medical University

    RECRUITING

    Chongqing, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.