DEPRESSION

This study is testing whether a brain stimulation treatment called tDCS works just as well when done at home compared to in a hospital. It will involve 66 adults with moderate to severe depression. The main goal is to see if home treatment is as effective at reducing depression s…

This study is testing whether adding the antihistamine clemastine to standard antidepressant treatment can improve brain structure and help depression treatment work better in adults over 60. Researchers will compare two groups—one receiving antidepressants with clemastine and on…

This study is testing a new oral medication, JS1-1-01, to see if it can help reduce symptoms in adults with moderate to severe depression. About 180 participants will be randomly assigned to receive either the real tablet or a placebo (a dummy pill that looks the same) to compare…

This study is testing a self-help version of a proven PTSD therapy, both alone and combined with a peer support program, to see if it helps women veterans. The goal is to create a more accessible treatment option that can reduce PTSD and depression symptoms while improving overal…

This study is creating a new tool to help therapists decide how to adjust standard mental health treatments to better match the cultural values and experiences of Latine youth. The goal is to improve treatment engagement and outcomes for young people dealing with anxiety, depress…

This study is testing if applying a special sunlight-reflecting coating to roofs can help keep homes cooler during extreme heat in Colima, Mexico. Researchers will enroll 800 people to see if these 'cool roofs' improve physical health (like heart rate and blood sugar), mental wel…

This study tests whether adding sleep-focused treatments to standard depression care can quickly and lastingly reduce suicide risk in young adults. Researchers will compare three different sleep intervention approaches in 90 suicidal college students receiving outpatient treatmen…

This study aims to roll out and test a smartphone app called CONEMO to help adults manage symptoms of depression, anxiety, and insomnia. It will involve over 12,000 people who use primary healthcare services in two Brazilian cities. The goal is to see how well this proven digital…

This study aims to test a new model for connecting young people to mental health care. It involves a mobile app co-designed with youth and supported by trained peer and family navigators in schools and clinics. The goal is to see if this approach helps more teens and young adults…

This study is testing a specially designed visual safety plan to help autistic teenagers manage suicidal thoughts and self-harm. Researchers will recruit 90 autistic teens who have recently had suicidal thoughts and randomly assign them to receive either the new visual plan plus …

This study is testing a faster version of a non-invasive brain stimulation treatment for depression. It aims to see if giving 30 treatment sessions over just 5 to 14 days is effective and tolerable for patients. Researchers will enroll up to 150 people with depression to measure …

This study is testing a new way to find depression in people with a chronic stomach condition. Since talking about mental health can be difficult, researchers want to see if a simple, painless ultrasound scan of a foot artery can act as an objective clue. They will check if this …

This study is creating and testing a special version of a proven mental health program for parents expecting or raising a baby with Down syndrome. The goal is to prevent depression by helping parents process feelings of grief and connect with a supportive community. Researchers w…

This study is testing a smartphone app designed to prevent anxiety and depression in adults who don't currently have these conditions. Researchers will enroll about 2,600 people in Spain and Chile to try one of two versions of the app, which offers personalized plans based on ris…

This study aims to test if a personalized smartphone app can prevent people from developing depression or anxiety. It will enroll 9,000 adults in Spain who do not currently have these conditions. Participants will use the app, which creates a custom plan focusing on areas like ex…

This study is testing a self-help workbook designed to help cancer patients manage feelings of anxiety and depression. It aims to see if using this book, with some guidance, can improve patients' mood and quality of life without needing regular therapy sessions. The trial will in…

This study aims to see if a gardening-based therapy program can help teenagers with depression who engage in non-suicidal self-harm. It will involve 66 adolescents who will participate in structured gardening activities like planting and caring for plants. Researchers will measur…

This study is testing whether a mobile app that provides short weekly mindfulness and breathing exercises can help first-time expecting mothers and fathers manage stress and emotions during pregnancy. Researchers want to see if using the app reduces signs of depression and improv…

This study is testing a new smartphone app designed to help people with early psychosis. The app uses phone sensors to try to detect moments of high stress or negative mood. When it senses these moments, it can suggest brief mental health exercises, like mindfulness, to help peop…

This study is testing whether community health workers can effectively deliver a mental health support program to Spanish-speaking Latine parents experiencing depression, anxiety, or traumatic stress. Researchers will enroll 52 parents and randomly assign them to receive the 14-w…

This study is testing if a gentle, non-invasive electrical stimulation of a nerve in the ear can help reduce anxiety and depression around the time of breast cancer surgery. About 232 patients will be randomly assigned to receive either the real stimulation or a fake version duri…

This study aims to see if following a culturally-adapted Mediterranean diet can help reduce symptoms of depression in adults in Hong Kong. Researchers will enroll 90 participants with moderate depression and a low-quality diet, randomly assigning them to either follow the diet pl…

This study is testing a new, easy-to-use mindfulness program delivered by daily text messages. It aims to help people who have finished treatment for early-stage breast, prostate, or colorectal cancer and are experiencing mild to moderate depression. The goal is to see if this br…

This study is testing whether a specific type of acupressure, timed according to the body's natural daily rhythms, can improve sleep quality for older adults living in a nursing home. Researchers will compare this timed acupressure to a sham (fake) acupressure treatment in 80 res…

This study is testing a new talk therapy program designed to help people with type 2 diabetes who are also struggling with their mental health. The program teaches skills to manage stress, negative thoughts, and the emotional challenges of living with a chronic illness. Researche…

This study is testing a workplace program designed to help low-wage hospital workers manage depression symptoms and become more physically active. The program includes phone counseling sessions, work coaching, help with basic needs like food and housing, and text message support.…

This study is testing whether eight weekly online music therapy sessions can help improve quality of life and reduce symptoms of depression and anxiety in adults who have both an autoimmune disease (like Type 1 diabetes or Hashimoto's) and depression. Researchers will work with a…

This study is testing if a gentle, non-invasive electrical stimulation on the ear during heart surgery can help prevent post-surgery confusion (delirium) and reduce feelings of anxiety and depression. About 270 patients scheduled for elective heart surgery will be randomly assign…

This study is testing a new way to deliver therapy for anxiety and depression by combining traditional face-to-face sessions with a smartphone app. Researchers want to see if this 'blended' format is practical for patients and doctors in primary care, and if it helps reduce sympt…

This study is testing if a single oral dose of a drug related to psilocybin (the psychedelic compound in 'magic mushrooms') can help reduce symptoms of depression and anxiety. It will involve 40 adults with major depressive disorder who haven't gotten enough relief from their cur…

This study will test whether EMDR group therapy helps adults who experienced the 2025 Silivri earthquake in Turkey. Researchers will compare 40 participants who receive the therapy to those on a waitlist, measuring changes in PTSD, depression, anxiety, sleep, and quality of life.…

This study is testing a short, 3-5 minute educational message called PEACE. It aims to see if this message can reduce anxiety, depression, and trauma symptoms while improving public attitudes toward the reintegration of former Boko Haram members. The pilot will involve 74 adult r…

This study is testing a self-paced, online program called WeACT, designed to help family members caring for a relative with dementia. The program teaches skills to manage difficult thoughts and feelings, aiming to reduce stress, depression, and anxiety. Researchers want to see if…

This study is testing whether a virtual reality (VR) game that combines music and movement can help young adults feel less depressed and anxious and more socially connected. Researchers will compare three groups: one playing a social VR game with others, one playing a solo VR gam…

This study is testing a pilot program that coaches young adult cancer survivors on how to communicate better with their friends and peers. The goal is to see if improving these conversations can help reduce feelings of anxiety, depression, and social isolation after cancer treatm…

This study is testing whether reading a personal narrative book helps women of childbearing age better manage their emotions, anxiety, and fears before having a hysterectomy. Researchers will compare the usual pre-surgery information and support to the same care plus the storyboo…

This study is testing whether craniosacral therapy, a gentle hands-on treatment, can help reduce pain, depression, and improve quality of life for primary caregivers of individuals with special needs. Thirty female caregivers will be assigned to either receive the therapy session…

This study is testing a smartphone app called the Living Well Program, which provides mental health support and phone coaching. It aims to see if using the app can reduce anxiety and depression in breast cancer patients and, as a result, lower their overall healthcare costs. The …

This study is testing a new program called BRIDGES, designed with teenagers, to help young people with depression become more physically active. It involves 18 sessions over 3 months with a specialized physical therapist who provides guidance and connects participants with local …

This study is testing whether a brief psychological support program before lung cancer surgery can help reduce patients' anxiety and depression. It will involve 138 adults scheduled for surgery, comparing those who receive four weekly therapy sessions to those who do not. The mai…

This study is testing whether a specific hand pressure technique, guided by a stress and coping model, can improve quality of life and mental well-being in women going through perimenopause. Sixty women aged 40-54 will learn and practice the hand application daily for two weeks. …

This study is testing a self-help program designed for post-9/11 veterans experiencing depression or PTSD symptoms who are not currently in therapy. The program teaches healthy coping skills and guides veterans toward support services if they choose to seek them later. Researcher…

This study aims to see if a special sleep health program can help U.S. Marines sleep better and improve their mental health. Researchers will test three different sleep programs by randomly assigning 860 active-duty Marines to one of five groups. They will use surveys and wearabl…

This study will test if a 4-week online group therapy program delivered over Zoom can help reduce symptoms of anxiety and depression in international students studying in Malaysia. Researchers will compare 128 students who receive the therapy with students on a waiting list to se…

This small pilot study is testing whether a mobile phone app can effectively deliver depression treatment. Eight African American adults with depression will attend six weekly 90-minute mental health classes through the app and complete regular surveys. The goal is to see if this…

This study is testing whether metformin, a medication typically used for diabetes, can help treat depression in people living with HIV. Researchers will enroll 600 HIV-positive adults in Uganda who have depression but aren't currently taking antidepressants. The trial will compar…

This study is testing if giving a low dose of the drug esketamine during surgery can help reduce anxiety and depression in breast cancer patients who already have mild to severe depression. It will involve 142 women undergoing breast cancer surgery. Researchers will compare those…

This study is testing whether a chatbot powered by artificial intelligence can help new mothers in their recovery after childbirth. Researchers want to see if the chatbot can provide helpful pelvic floor health information and reduce feelings of loneliness. About 130 first-time m…

This study tests whether connecting dementia caregivers with trained peer mentors and personalized community resource lists can improve their well-being. Over 330 caregivers will receive education, resource information, and ongoing text message support for 12 months. Researchers …

This study is testing if giving a low, continuous dose of a drug called esketamine (related to ketamine) during breast cancer surgery can help reduce the anxiety and depression many patients feel around their operation. It will involve about 218 patients and will measure their em…

This study is testing whether using virtual reality (VR) can help reduce depression symptoms and improve quality of life in teenage girls. It will involve 48 girls aged 13-18 who have been diagnosed with mild to moderate depression. Researchers will measure changes in depression …

This study is testing whether a new smartphone app can help teenagers who hurt themselves on purpose (nonsuicidal self-injury). The app uses a chatbot to teach coping skills and provide support. Researchers want to see if the app is easy to use and acceptable to teens before laun…

This study aims to see if giving the drug esketamine during surgery can help reduce anxiety and depression symptoms in breast cancer patients who also have severe depression. It will involve about 240 female patients undergoing breast cancer surgery. Researchers will compare thos…

This study is testing whether using virtual reality (VR) headsets during a breast biopsy can help reduce patients' feelings of depression, anxiety, and stress. 80 patients in Palestine will be randomly assigned to either use a calming VR environment during their procedure or rece…

This study is testing whether a program combining yoga, meditation, and mindful eating can help university students feel less stressed, anxious, and depressed. About 60 students will attend weekly sessions for one semester, practicing physical postures, breathing exercises, and l…

This study is testing a phone and text message support program designed to help low-wage hospital service workers who are experiencing depression. The program includes therapy sessions, work coaching, help with basic needs like housing or food, and encouragement for physical acti…

This study is testing whether a dietary supplement called GynMDD helps reduce depression symptoms when taken alongside weekly talk therapy. Researchers will compare adults with mild to moderate depression who receive either the supplement or a placebo pill along with their therap…

This study is testing whether adding a special smartphone app to remote therapy sessions helps reduce depression in adults aged 50-80 better than therapy alone. The app uses a smart algorithm to help people stick with their therapy homework. Researchers will compare the two appro…

This study aims to see if teaching mindfulness skills can help reduce depression, anxiety, and stress in pregnant women who are hospitalized because they are at risk of delivering their baby too early. It will involve 60 participants who will either receive weekly mindfulness coa…

This small pilot study is testing whether adding brief daily mindfulness practice to an existing brain stimulation treatment helps people with depression. Twenty participants receiving standard brain stimulation therapy will use a mindfulness app during their treatment days. Rese…

This study is testing whether listening to a short daily audio recording of positive self-affirmation statements can help reduce pain, depression, anxiety, and stress in women recovering from mastectomy surgery. It will compare 42 patients who listen to the recording against thos…

This study is testing whether a group therapy retreat using psilocybin, the active compound in 'magic mushrooms,' can safely help reduce anxiety and depression in adults with advanced cancer. Participants will take a single dose of psilocybin in a controlled setting, supported by…

This study investigates how online cannabis ads that claim to help with anxiety and depression affect what people buy. Researchers will have 2000 adults with symptoms of anxiety or depression use a simulated online cannabis store. They will test if these therapeutic claims make p…

This study aims to understand how different patterns of non-invasive brain stimulation affect mood and brain function in adults with major depression. Researchers will compare three stimulation types and use brain scans to see how they work with antidepressant treatments. The goa…

This study aims to better understand why people with depression often struggle with motivation and effort. Researchers will measure brain activity, heart rate, breathing, and energy use in 90 people (some with depression, some without) while they walk on a treadmill and make choi…

This study is testing if data collected from a person's smartphone can predict when their depression symptoms might return. Researchers will enroll 320 adults who have recently recovered from depression. Half will use a special app that collects phone data, while the other half r…

This study aims to understand if specific patterns of harmful gut bacteria are linked to anxiety, depression, and panic disorders. Researchers will compare stool samples from 500 adults with these conditions to samples from healthy individuals. The goal is to gather new evidence …

This study aims to understand how physical activity levels are connected to posture, sleep quality, feelings of depression, and muscle or joint pain among university health science teachers. It will involve about 73 staff members who will fill out questionnaires about their habit…

This study aims to understand how the brain changes in people who have lost or have a distorted sense of smell, often after illnesses like COVID-19 or the flu. Researchers will follow 80 adults with smell disorders and healthy volunteers for one year, using brain scans, smell tes…

This study aims to understand how common anxiety and depression are among medical students and interns at Assiut University. Researchers will survey about 289 students to identify what factors might increase their risk and how mental health relates to their academic performance. …

This study aims to understand the connections between a teen's heart rate patterns, their ability to manage emotions, and the quality of their relationship with a parent. Researchers will enroll 74 adolescents diagnosed with depression. Participants will wear a Fitbit at night fo…