DEPRESSION

This study will see if painting roofs with a special reflective coating can lower indoor temperatures and improve health for 800 people in Tavua, Fiji. Researchers will measure things like heart rate, blood sugar, mood, and sleep quality. The goal is to find a simple, low-cost wa…

This study will test whether special reflective roof coatings, called cool roofs, can lower indoor temperatures and improve health for people living in hot areas of Colima, Mexico. About 800 households will take part, and researchers will measure things like heart rate, blood sug…

This study is testing a program called Mothers and Babies adapted for parents of infants with Down syndrome (MBDS). The goal is to prevent depression by helping parents cope with grief and build social support. About 72 expectant and new parents (including fathers and nonbinary p…

This study tests two smartphone app programs designed to prevent anxiety and depression in adults who do not currently have these conditions. About 2,600 participants from Spain and Chile will use the app for one year. The goal is to see if personalized tips and tracking can redu…

This study tests a personalized smartphone program designed to prevent depression and anxiety in adults who do not currently have these conditions. About 9,000 people in Spain aged 18-55 will use an app that creates a custom prevention plan based on their personal risk factors. T…

This study tests whether listening to positive self-affirmation recordings can help reduce pain, depression, anxiety, and stress in women who have had a mastectomy. Forty-two participants will be split into two groups, with one group listening to the affirmations daily. The goal …

This study tests whether using a virtual reality headset during a breast biopsy can lower feelings of depression, anxiety, and stress. About 80 Palestinian women will either wear a VR headset showing a calming scene for 15-30 minutes or receive standard care. Their emotional stat…

This study tests whether a mild electrical pulse to a nerve in the ear, given during heart surgery, can lower the chances of postoperative delirium (sudden confusion) and reduce anxiety or depression after the operation. About 270 adults having planned heart surgery will be rando…

This study looks at whether EMDR group therapy can help adults who survived the April 2025 Silivri earthquake in Turkey. Forty participants will be randomly assigned to either the therapy group or a waitlist. Researchers will measure changes in PTSD, depression, anxiety, sleep qu…

This study tests whether metformin, a common diabetes drug, can help treat depression in people living with HIV. Depression is common in this group and can make it harder to stick with HIV treatment. The trial has three parts, starting with dose testing, then a placebo comparison…

This study tests whether a single oral dose of CYB003, a drug similar to psilocybin (found in magic mushrooms), can help relieve symptoms of depression and anxiety. Forty adults with major depressive disorder and moderate-to-severe anxiety will receive either CYB003 or a placebo.…

This study looks at whether using virtual reality can help reduce depression in teenage girls. About 48 girls aged 13 to 18 with mild to moderate depression will use VR and fill out questionnaires about their mood and quality of life. The goal is to see if VR can be a helpful, dr…

This study tests a guided self-help program for veterans with moderate depression. It uses coaching sessions to help them follow a self-help workbook based on behavioral activation. The goal is to see if this approach can improve access to mental health care in VA primary care cl…

This study looks at whether reading a personal narrative book can help women of childbearing age manage anxiety, depression, and negative thoughts before a hysterectomy. About 156 women will either receive standard care or also get a book to read. The goal is to see if the book i…

This study looks at whether adding a digital mental health app to remote therapy sessions helps reduce depression in adults aged 50 to 80. About 60 people with mild to moderate depression will take part. The goal is to see if the app makes the therapy more acceptable and effectiv…

This study tests a structured psycho-social program (PSP) for adults aged 30-40 with type 2 diabetes who have mild-to-moderate mental health issues. The program uses counseling techniques to help people manage negative thoughts, stress, and coping related to their diabetes. Resea…

This study tests whether a new tablet called JS1-1-01 can safely reduce depression symptoms in adults with moderate to severe depression. About 180 people aged 18 to 65 will receive either the drug or a placebo. The main goal is to see if the drug lowers scores on a standard depr…

This study tests a daily digital mindfulness program designed to reduce depressive symptoms in people who have finished treatment for early-stage breast, prostate, or colorectal cancer. About 76 participants will listen to short audio exercises each day for several weeks. The goa…

This study is testing a new workplace program for hospital service workers who have depression and are not very active. The program includes phone therapy, coaching, help with social needs, and text message support. The goal is to see if the program is practical and liked by work…

This study tests a brain stimulation technique called TMS to help female athletes who have both depression and a concussion. About 35 women aged 18-65 will receive the treatment to see if it eases their symptoms. The goal is to improve mood and concussion recovery without medicat…

This study tests whether a special type of acupressure, given at times that match the body's natural daily rhythms, can improve sleep in older adults living in nursing homes. Eighty people aged 60 and older will receive either this circadian-based acupressure or a fake version fo…

This study explores whether 8 weekly telehealth music therapy sessions can improve quality of life and reduce depression and anxiety in adults with autoimmune endocrine diseases (like Type 1 diabetes or Hashimoto's) and depression. Ten participants will have video sessions with a…

This study tests a computer-based therapy program designed to help caregivers of veterans who feel mild to moderate depression. About 20 caregivers aged 18 to 65 will use the program and report how it affects their mood and daily life. The goal is to see if this approach is pract…

This study tests a program designed to help low-wage hospital workers who feel depressed and are not very active. The program includes phone therapy, work coaching, help with social needs, and text messages to support mood and exercise. About 60 workers will take part to see if t…

This study looks at whether a program combining yoga, meditation, and mindful eating can lower stress, anxiety, and depression in university students. About 60 students will attend weekly sessions for a semester and fill out questionnaires before and after. The goal is to see if …

This study tests whether a friendly AI chatbot can help new mothers learn about pelvic floor health and feel less lonely after childbirth. About 130 first-time moms will be randomly assigned to either standard care or standard care plus the chatbot for 4 weeks. Researchers will c…

This study tests whether using a gentle brain stimulation technique (tDCS) at home works as well as receiving it in a hospital for people with moderate to severe depression. Sixty-six adults will either perform the sessions at home with nurse support or in the hospital. The goal …

This study tests a digital program called Living Well, which includes a smartphone app and coaching calls, to see if it can lower anxiety and reduce healthcare costs for people with breast cancer. About 50 adults with stage II to IV breast cancer and moderate-to-severe anxiety wi…

This study looks at whether adding a peer support program to a self-help version of cognitive processing therapy can help women veterans with PTSD feel better. The goal is to reduce PTSD symptoms and improve well-being, while making treatment easier to access. About 100 women vet…

This study tests whether a trained peer mentor, along with personalized resource lists and text messages over 12 months, can reduce loneliness and help caregivers of people with dementia find end-of-life resources. About 330 caregivers will take part. The goal is to ease the burd…

This study will develop and test a digital mental health program called 'VIBE in the Parks' for teens and young adults (ages 13-24) who use Chicago Park District programs. About 268 participants will be split into two groups: one gets the VIBE program, the other gets a digital wo…

This study will test a smartphone app called CONEMO to help adults with depression, anxiety, and insomnia. The app has already shown promise for depression. Researchers will invite 12,400 people from 28 health clinics in Brazil to use the app and track their symptoms. The goal is…

This study tests an 8-week digital program that helps migrants in Sweden improve their mental health through better sleep, diet, physical activity, and social connections. 240 adults with moderate stress, anxiety, or depression will be randomly assigned to the program or a waitli…

This pilot study will test if a mobile phone app can help reduce depression symptoms in African American adults. Eight participants will attend six weekly 90-minute classes through the app and complete surveys over four months. The goal is to see if this digital approach is effec…

This study tests a new program called BRIDGES, designed to help teenagers with depression become more physically active at their own pace. About 60 teens receiving outpatient care will be randomly assigned to either the BRIDGES program or standard care. The goal is to see if this…

This small pilot study will test whether adding brief guided mindfulness meditation (using a smartphone app) to standard accelerated brain stimulation therapy can help ease depression symptoms. Twenty adults with major depression who are already scheduled for brain stimulation wi…

This study looks at whether a safe, mild brain stimulation technique called tDCS can help adults with moderate depression sleep better and feel better. Participants will use a home-based device and track their sleep and mood changes. The goal is to see if better sleep leads to fe…

This study tests a new way to treat emotional disorders like anxiety and depression by combining face-to-face therapy sessions with a smartphone app. About 45 adults will try this blended approach, standard therapy, or a waitlist. Researchers want to see if the app makes therapy …

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help treat depression. About 50 adults with depression will receive psilocybin alongside therapy. Researchers will use MRI brain scans to see how the drug changes brain activity and mood over time.

This study is testing whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can help healthcare workers who feel depressed and have lost meaning in their work. About 72 doctors, nurses, and other clinicians will take part in small group retreats with…

This study tests a 6-week program that combines group reading discussions with simple mouth exercises for adults aged 55 and older. The goal is to see if this non-drug approach can reduce depression, improve physical and oral health, and boost mental toughness. 60 participants wi…

This study tests whether playing a virtual reality music and movement game can improve social connection and mental well-being in young adults aged 18-25 with mild to moderate depression or anxiety. Participants will be placed into one of three groups: a VR game with social inter…

This study looks at whether community health workers (CHWs) can effectively deliver a mental health program to Spanish-speaking Latine parents who have symptoms of depression, anxiety, or traumatic stress. About 52 parents will either get the program right away or after a 5-month…

This study looks at whether giving esketamine during breast cancer surgery can help reduce severe depression and anxiety in patients. About 242 women with severe depression will be randomly assigned to receive esketamine or a placebo during their operation. Researchers will measu…

This study tests if a mild electrical pulse on the ear during breast cancer surgery can reduce anxiety, depression, and pain after the operation. About 232 women will receive either real or fake stimulation to see if it helps them feel better and recover faster. The goal is a sim…

This study tests whether a self-paced online program called WeACT can help family caregivers of people with dementia feel better mentally and emotionally. The program teaches skills to handle difficult thoughts and feelings. About 40 adult caregivers with mild to moderate depress…

This study tests whether four weekly counseling sessions before lung cancer surgery can lower anxiety and depression. About 138 adults awaiting lung cancer surgery will be split into three groups: those who get the counseling, those who refuse it, and healthy volunteers. Research…

This study looks at whether teaching mindfulness skills to pregnant women who are at risk of delivering early (before 37 weeks) can help lower their stress, anxiety, and depression. About 60 women admitted to the hospital will take part in mindfulness sessions for four weeks. The…

This study tests whether a Mediterranean diet, adapted for Chinese tastes, can reduce depression symptoms in 90 Hong Kong adults with moderate to severe depression. Participants will follow the diet and report their mood and diet quality using frequent phone surveys. The study al…

This study tests if electroacupuncture (a type of acupuncture with mild electric pulses) can reduce a group of common symptoms—pain, tiredness, sleep trouble, anxiety, depression, and brain fog—in breast cancer survivors. About 228 women who have finished active cancer treatment …

This study looks at whether a mindfulness-based stress reduction program can help nursing students better manage stress, anxiety, and depression. About 93 students will take part, learning techniques like breath awareness and yoga to improve their emotional well-being. The goal i…

This study tests whether a gentle hand-application method called Jin Shin Jyutsu can help perimenopausal women feel better emotionally and physically. Sixty women aged 40-54 will practice the technique daily for two weeks. Researchers will measure changes in quality of life, stre…

This study looks at whether craniosacral therapy, a gentle hands-on technique, can help reduce pain, depression, and improve body awareness and quality of life in primary caregivers of people with special needs. About 30 female caregivers will either receive the therapy or be in …

This study looks at whether adding the dietary supplement GynMDD to weekly talk therapy can help adults with mild to moderate depression feel better. About 168 people aged 18 to 65 will take either the supplement or a placebo daily for 8 weeks. Researchers will track mood changes…

This study is testing a faster version of a brain stimulation treatment called iTBS for people with depression. Instead of the usual schedule, participants will receive 30 short sessions over 5 to 14 days. The goal is to see if this quicker approach works well and is tolerable in…

This study tests whether internet-based group cognitive behaviour therapy (GCBT) delivered over Zoom can reduce symptoms of anxiety and depression in international students studying in Malaysia. 128 participants will be randomly assigned to either the therapy program or a waitlis…

This study looks at whether therapeutic gardening can help teenagers with depression who harm themselves. Participants will take part in gardening activities like planting and caring for plants. The goal is to see if this reduces self-harm, improves mood, and helps with sleep and…

This study looks at whether giving esketamine continuously during breast cancer surgery can help reduce anxiety and depression in patients who already have mild-to-severe depressive symptoms. About 142 women will take part, and their mood and sleep quality will be tracked before …

This study tests whether clemastine, a common antihistamine, can improve brain white matter and make antidepressants work better in older adults (over 60) with depression. About 80 participants will receive either clemastine or a placebo alongside their antidepressant. The goal i…

This study tests whether adding sleep-focused treatments to standard psychiatric care can lower suicide risk in young adults with depression and sleep problems. About 90 college students in an intensive outpatient program will be randomly assigned to one of three sleep interventi…

This study tests whether adding allopurinol, a medicine usually used for gout, can help people with major depression who don't get better with standard antidepressants alone. About 70 adults with moderate to severe depression will receive either allopurinol or a placebo alongside…

This study tests a web-based program designed to help people with advanced cancer manage symptoms like depression, pain, fatigue, and sleep problems, while also supporting their caregivers. About 40 patients and their partners will use the program to track symptoms and get person…

This study tests a smartphone app designed to help teenagers aged 14 to 18 who hurt themselves on purpose and are not currently in therapy. The app provides support and information to help them cope with difficult feelings. The goal is to see if the app is easy to use and helpful…

This study tests whether short weekly exercises delivered through a mobile app can help first-time parents manage their emotions and stress during pregnancy. Expecting mothers and fathers in Singapore will use the app, wear a Fitbit, and complete surveys about their well-being an…

This study tests a guided self-help CBT manual called 'Khushi or Khatoon' for cancer patients with anxiety and depression. About 108 adults with cancer and moderate to severe distress will use the manual and be compared before and after treatment. The goal is to see if it improve…

This study will test whether a 16-week Pilates program done at home via video calls can improve walking, balance, fatigue, and pain in people with multiple sclerosis (MS). About 50 adults with mild to moderate MS will be assigned to either the Pilates group or a waitlist. Researc…

This study tests whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression after the operation. About 218 adults having breast cancer removal will be randomly assigned to receive esketamine or a placebo during anesthesia. Re…

This study tests a visual safety plan designed for autistic teenagers aged 13-18 who have had recent suicidal thoughts or self-harm. About 90 participants will either get the visual plan plus standard care or standard care alone. Researchers will check if the plan is easy to use,…

This study tests if combining a gentle electrical brain stimulation (tDCS) with computer-based memory games can improve thinking and memory in adults over 60 with recurrent depression. Participants will be assigned to one of three groups to compare active stimulation plus targete…

This study aims to understand how brain function changes in people with smell disorders, such as loss of smell or distorted smell. Researchers will use brain scans, smell tests, and questionnaires to track these changes over one year. The study involves 80 adults, including healt…

This study looks at whether data from phones and smartwatches can help predict how well treatment for depression during and after pregnancy works. About 250 women in their last trimester or first 12 weeks after giving birth will receive standard therapy and wear devices for 4 wee…

This study looks at how heart rate variability (a measure of nervous system health) relates to emotional control and parent-teen relationships in 74 adolescents aged 12-18 with major depression. Participants wear a Fitbit while sleeping for a week and fill out questionnaires. The…

This study will test a mobile app and peer navigators to help youth ages 13-22 get connected to mental health services in schools and clinics. The app was designed with input from young people and community partners. Researchers will track how many youth complete mental health sc…

This study will survey 289 medical students and interns at Assiut University to find out how many experience anxiety and depression. Researchers will also look for risk factors and see if mental health affects grades. The goal is to better understand the problem, not to test a tr…

This study explores whether data from your smartphone (like activity or usage patterns) can predict when depression symptoms might return. Researchers will track 320 adults who have been treated for depression and are currently well. If successful, this could lead to an app that …

This pilot study tests a brief 3-5 minute communication tool called PEACE, designed to improve mental wellbeing and public attitudes toward reintegrating former Boko Haram members in Nigeria. Researchers will enroll 74 adults to see if the intervention is acceptable and reduces a…

This study will create and test a tool called CRAFTT that helps therapists tailor mental health treatments to the cultural background of Latine youth (ages 5-15). The goal is to improve how well these treatments work for anxiety, depression, trauma, and behavior issues. About 64 …

This study looks at whether a self-help program can improve daily functioning and mental health for post-9/11 veterans who have depression or PTSD symptoms but are not in therapy. Two hundred veterans will use the self-help materials or standard resources and complete 6 check-ins…

This study looks at how different types of non-invasive brain stimulation change mood and brain activity in 200 adults with major depression. Participants will receive three types of stimulation and have MRI scans while taking antidepressants. The goal is to understand how brain …

This study aims to understand why cognitive-behavioral therapy (CBT) helps people reduce repetitive negative thinking, a common issue in anxiety and depression. Researchers will track 500 adults over 16 weeks to see which parts of CBT are most effective. The goal is to improve fu…

This study looks at why people with depression find it hard to put in effort. Researchers will have 90 participants (some with depression, some without) walk on an inclined treadmill while their brain activity and body responses are measured. The goal is to better understand the …

This study tests whether smartphone sensors can detect moments of low mood in people with early psychosis and deliver brief mental health exercises at the right time. Ten adults with psychosis and mild depression or anxiety will use a special app for 10 weeks. The goal is to see …

This study looks at how much physical activity health science professors and lecturers get and how it relates to their posture, sleep quality, mood, and muscle or joint pain. Researchers will survey 73 university staff members using questionnaires. The goal is to understand these…

This study looks at whether simple, non-invasive artery tests can identify depression in people with chronic atrophic gastritis (CAG), a long-term stomach condition. Many patients with CAG have undiagnosed depression because they feel embarrassed to talk about it. The study will …