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Brain zaps for athletes: new TMS study targets depression and concussion

NCT ID NCT07507214

Symptom relief Sponsor: University of Florida Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 19, 2026 · Updated 2 times

Summary

This study tests a brain stimulation treatment called TMS to help female athletes with both depression and concussion symptoms. About 35 women aged 18-65 who have had a concussion and have moderate to severe depression will receive the treatment. The goal is to see if TMS can improve mood and reduce concussion-related issues like sleep problems and poor athletic performance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 35 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female athletes, both recreational and professional * ages 18-65 years old * Concussion as determined by clinical history (at least 72 hours post-diagnosis) and Post-Concussion Symptom Scale (PCSS) score above 7 OR more than 4 total symptoms present * Depression as determined by Patient Health Questionnaire - (PHQ-9) score of 10 or greater indicating moderate depression or greater * Treatment-resistant depression as determined by previously taken or currently taking an oral antidepressant for at least 6 weeks Exclusion Criteria: * Pregnant or breast-feeding individuals * History of seizures or epilepsy * Implanted devices (such as cochlear implants, brain stimulators, aneurysm clips or stents) * Participants undergoing treatment with ototoxic medications (aminoglycosides, cisplatin) * History of bipolar disorder * Pacemakers or implanted defibrillators * Allergy or other contraindications to d-cycloserine * Other contraindications as determined by PI * Unable to provide informed consent due to language or other barriers * Incarceration * Biological male gender

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Conditions

The condition(s) this trial relates to.

Brain Concussion Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Concussion Depression

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • UF World Equestrian Center

    Ocala, Florida, 34482, United States

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