Brain inflammation in depression: new imaging study seeks clues
NCT ID NCT04582916
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 32 times
Summary
This study uses PET scans to measure levels of COX-1 and COX-2, enzymes linked to inflammation, in the brains of people with major depressive disorder (MDD) during a depressive episode. Researchers will compare these levels between MDD participants and healthy volunteers. The goal is to understand if brain inflammation is higher in depression, not to test a new treatment.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
11C-MC1 and 11C-PS13 (radioactive tracers injected for PET imaging)
What this could lead to
If successful, this could help researchers understand the role of brain inflammation in depression, potentially pointing toward new treatment targets.
What could go wrong
This is a very early Phase 1 imaging study with only 64 participants. It is not testing a treatment, so it may not lead directly to any new therapy.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.