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MRI-Guided brain zaps aim to ease depression

NCT ID NCT05577481

Symptom relief Sponsor: Xijing Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a personalized form of brain stimulation called iTBS for people with major depression. Researchers used MRI scans to target specific brain areas in 68 participants. The goal was to see if this tailored approach could improve depression symptoms more than a sham treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intermittent theta burst stimulation (iTBS) combined with antidepressants
What this could lead to
If successful, this could lead to a more effective, personalized brain stimulation treatment for depression, potentially improving symptom relief.
What could go wrong
This is a small, early-phase study (68 participants) that may not show clear benefits over sham. The approach is complex and may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

68 people

The number who actually took part.

Started

Jul 2023

Finished

Feb 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 to 60 years old * Meet the criteria of the Diagnostic and Statistical Manual of Mental Disorder- V of MDD, single or recurrent * Meet the threshold on the total HAMD17 score of \>17 at both screening and baseline visits * Able to provide informed consent Exclusion Criteria: * any other current or past psychiatric axis-I or axis-II disorders * severe physical illnesses * psychotic symptoms, alcohol or drug abuse * A history of neurological disorders including seizure, cerebral trauma * MRI evidence of structural brain abnormalities * Contraindications to MRI and rTMS * Acute suicide * Female that is pregnant or breastfeeding

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression

Contacts and locations

Locations

  • XijingH

    Xi'an, Shaan'xi, 710032, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.