Brain scan spots depression risk before symptoms appear
NCT ID NCT05427578
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether a simple brain scan can detect signs of depression vulnerability in people who are not currently depressed. Researchers used a light-based imaging technique to measure brain activity in 90 adults, including those who had recovered from depression and those with a family history of the condition. The goal was to identify brain markers that might predict future depression risk.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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90 people
The number who actually took part.
- Started
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Aug 2021
- Finished
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Nov 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
rMDD group: People who had major depressive disorders now fully remitted HCr group: Healthy control group with a high risk of depression, refer to as healthy volunteers who have a 1st-degree relative with MDD in this study. HCnr group: Healthy control group with a low risk of depression, refer to as healthy volunteers who have no a 1st-degree relative with MDD in this study.
- Ages
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18 to 35 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Mini-mental state examination (MMSE) \> 24 Exclusion Criteria: * Current diagnosis of psychiatric disorders, such as depression, anxiety, schizophrenia, or autism * current or past diagnosis of neurological disorders, such as head injuries, strokes, encephalitis, epilepsy, Parkinson's, or Alzheimer's
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The Hong Kong Polytechnic University
Hong Kong, Hong Kong
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Other studies related to the condition(s) this trial covers.
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