Upper respiratory tract disorder

This trial tests whether a combination of the immunotherapy drug pembrolizumab, chemotherapy, and radiation can control advanced larynx cancer while preserving the voice box. Adults with stage III or IV larynx cancer who are candidates for organ preservation receive three cycles …

This phase 3 trial is testing an experimental mRNA vaccine called mRNA-1345 to see if it can protect against respiratory syncytial virus (RSV) in adults who are at high risk of severe illness. The study includes two groups: adults aged 18 to 59 with chronic health conditions like…

This study tested a new inhaler that combines three medicines (CHF 5993) against a two-medicine inhaler (CHF 1535) in over 3,400 people with COPD. The goal was to see if the triple combination improves lung function and reduces serious breathing attacks over 52 weeks. Participant…

Researchers are testing an experimental antibody drug called verekitug in adults with chronic rhinosinusitis with nasal polyps, a condition where inflamed tissue grows inside the nasal passages and causes congestion. Participants receive either verekitug or a placebo injection wh…

This study tests a nasal spray called OPN-375 in about 72 teenagers (ages 12-17) who have nasal polyps—growths inside the nose that cause stuffiness and breathing trouble. The spray is given twice a day for 16 weeks, and some participants receive a placebo (inactive spray) for co…

This study looks at the long-term safety of a drug called itepekimab for people with chronic obstructive pulmonary disease (COPD). About 700 adults who already completed earlier itepekimab studies will receive the drug every 2 or 4 weeks for up to 52 weeks, plus a 20-week follow-…

This Phase 2 trial tests whether rademikibart, an injected drug, can help adults with COPD who are having a sudden flare-up and have a specific type of inflammation (type 2). The study will compare the drug to a placebo in 160 participants, looking at whether it reduces treatment…

This trial compares two common steroid treatments for chronic cough that occurs with nose or sinus symptoms, known as upper airway cough syndrome. Adults with chronic cough and signs of rhinitis or sinusitis are randomly assigned to either an inhaled steroid (budesonide) or a ste…

This study tests a new fixed-dose combination of two drugs (ensifentrine and glycopyrrolate) given via nebulizer twice daily for 28 days in 480 adults with COPD. The goal is to see if the combination improves lung function more than either drug alone or placebo. The trial is curr…

Researchers are testing lebrikizumab, an antibody given by injection every four weeks, in adults with chronic obstructive pulmonary disease (COPD) who have had recent flare-ups. The trial compares lebrikizumab with a placebo in people already using standard inhaled steroids and b…

Researchers are testing whether an automated oxygen delivery system called O2matic keeps blood oxygen levels in a safe range better than manual adjustment for patients hospitalized with a COPD flare-up. The device continuously measures oxygen saturation and uses an algorithm to c…

This phase 2 trial tests whether adding inhaled corticosteroids to standard COPD treatment improves blood vessel function in the lungs. Thirty adults with COPD, aged 40-80, will take either Bevespi or Bretzri for four weeks. Researchers will measure how well lung blood vessels wi…

This trial tests an experimental drug called FLX475, given alone or with the immunotherapy pembrolizumab, in people with advanced cancers that have not responded to standard treatments. The study aims to find the safest dose and to see whether the combination can shrink tumors. P…

This pilot study tests whether injecting a corticosteroid called dexamethasone directly into the salivary glands can prevent dry mouth in people receiving radiation therapy for head and neck cancer. Researchers will enroll 10 adults with certain types of throat cancer who are sch…

This study tests whether a fine-mist inhaler can deliver salbutamol deeper into the lungs than standard inhalers. People with COPD, asthma, and healthy volunteers inhale salbutamol in different particle sizes, some tagged with a radioactive tracer to track where the drug lands. R…

This phase 1 trial tests an experimental drug called MRG003 in people with advanced solid tumors, including colorectal cancer, head and neck squamous cell carcinoma, and nasopharyngeal carcinoma. The study aims to find a safe dose and to see whether the drug can shrink tumors. Pa…

This study tested whether giving the immunotherapy drug durvalumab alongside radiation works better than the standard cetuximab plus radiation for people with advanced head and neck cancer who cannot take the usual chemotherapy drug cisplatin. A total of 196 adults took part. The…

This study looks at whether dupilumab, an injectable medication, can improve lung function and reduce symptoms in adults with COPD who have a specific type of inflammation. The researchers are reviewing medical records from patients who received dupilumab as part of routine care,…

This trial tests whether mepolizumab, an injectable biologic, can reduce the number of moderate or severe flare-ups in people with chronic obstructive pulmonary disease (COPD) who have high levels of eosinophils (a type of white blood cell linked to inflammation). Participants re…

This trial tests whether artificial intelligence can help acupuncturists hit a deep facial point, called the Xinwu point, more accurately when treating allergic rhinitis (hay fever-like nasal allergies). Sixty adults will be randomly assigned to receive either AI-guided needling …

This trial tests whether a home breathing support program, guided by respiratory therapists, is practical and helpful for people with severe COPD who do not have high carbon dioxide levels. Participants use a bilevel positive airway pressure device at home for at least 6 hours a …

This trial tests two aggressive radiation therapy schedules for people with advanced head and neck cancer that cannot be removed with surgery. One approach uses a very intense radiation schedule combined with chemotherapy, while the other uses a very accelerated radiation schedul…

This trial tests whether a non-invasive device that sends electrical pulses through the skin to stimulate the diaphragm can help people hospitalized with a severe COPD flare-up. The goal is to see if this technique improves diaphragm function and reduces the need for invasive mec…

This study looks at whether using a breathing machine (non-invasive ventilation) at home, with remote monitoring, can help people with advanced COPD avoid hospital visits. It tracks how often patients need unplanned hospital care and whether the monitoring data can predict proble…

This trial tests whether using a blood test that measures procalcitonin—a marker of bacterial infection—can safely guide decisions about antibiotics in people hospitalized for a COPD flare-up. Participants are randomly assigned to either usual care or procalcitonin-guided treatme…

This trial tests whether adding the beta-blocker metoprolol to standard care can reduce a combined risk of death, COPD flare-ups, and heart-related hospitalizations in people with COPD who do not have known heart disease. About 1,700 adults with COPD will receive either metoprolo…

This early-stage trial is testing an experimental inhaled medication called TQC3721 in people with moderate to severe chronic obstructive pulmonary disease (COPD). The study aims to see how safe and tolerable the drug is, how it moves through the body, and what effects it has on …

This trial compares two widely used combination inhalers—Foster (beclomethasone plus formoterol) and Seretide (fluticasone plus salmeterol)—in people with chronic obstructive pulmonary disease (COPD). The goal is to see if Foster works better at improving lung function right afte…

This trial tests whether a series of allergy shots, called PURETHAL Mites, can reduce symptoms like sneezing, runny nose, and congestion in adults with moderate to severe house dust mite allergies, with or without asthma. Participants receive either the active treatment or a plac…

This pilot study investigates whether an 8-week ketogenic diet—high in fat and very low in carbs—can improve lung function, reduce inflammation, and boost exercise capacity in men aged 40–75 with mild-to-moderate COPD. Participants are randomly assigned to either the ketogenic di…

This trial tests whether implanting small valves in the airways—a procedure called lung volume reduction—can improve heart and skeletal muscle function in people with severe chronic obstructive pulmonary disease (COPD). Participants will undergo the procedure and be followed for …

This trial tests whether a standardized respiratory physiotherapy program, delivered in primary care over six months, can improve quality of life and key health measures in adults aged 40 to 74 with mild COPD. Participants are randomly assigned to either the physiotherapy program…

This study looked at how dupilumab, a drug that blocks certain immune signals, improves smell in adults with chronic sinusitis and nasal polyps. Researchers measured changes in inflammation in the smell region using CT scans, endoscopy, and mucus samples over three months. The go…

This trial tests whether adding a procedure to shrink the inferior turbinates—small structures inside the nose—during adenoidectomy gives children aged 9 to 18 better relief from nasal blockage and sleep-disordered breathing than adenoidectomy alone. Participants have both adenoi…

This trial asks whether animated video lessons can help people with asthma or COPD manage their condition at home better than traditional paper brochures. Participants receive a home-based pulmonary rehabilitation program in either format, and researchers compare how well each gr…

This study tested whether giving lower doses of radiation after surgery for head and neck cancer could reduce long-term side effects like dry mouth and trouble swallowing, while still keeping the cancer from coming back. About 200 patients with certain stages of oral, throat, or …

This trial tests whether treating gum disease can reduce bacteria that cause lung infections in people with bronchiectasis. Participants with both conditions will receive either basic cleaning, deep cleaning, or deep cleaning plus light therapy. Researchers will measure bacteria …

This trial tests an experimental drug, BI 1291583, in adults with bronchiectasis who produce sputum and have a history of flare-ups. Participants are randomly assigned to one of three doses of the drug or a placebo, taken once daily for at least 24 weeks. The study measures how l…

This phase 3 trial tests whether Jinhua Qinggan Granules, a traditional Chinese herbal medicine, can eliminate symptoms of acute upper respiratory infections (like fever, sore throat, and congestion) within three days. About 273 adults with early-stage cold or flu will receive ei…

This trial tests whether a pharmacist, at the time of hospital admission, can review a patient's prescribed inhaler for insurance coverage and clinical appropriateness. The goal is to see if this simple check helps patients get the most cost-effective inhaler and reduces the chan…

This study tests an investigational drug called tozorakimab in about 1,454 adults with symptomatic COPD who have had at least two moderate or one severe flare-up in the past year. Participants continue their usual inhaled medications and receive either tozorakimab or a placebo as…

This trial investigates whether custom-made stents, designed using 3D computer modeling and printing, can safely treat complex airway narrowing that standard stents cannot fit. Ten adults with symptomatic, anatomically complex airway stenosis will receive a personalized stent and…

This phase 3 trial tests whether mepolizumab, an injectable drug, can reduce nasal polyp size and improve symptoms like nasal blockage in adults with chronic rhinosinusitis and nasal polyps. Participants receive either mepolizumab or a placebo every four weeks for a year. The stu…

This phase 3 trial tests whether mepolizumab, an injectable antibody that calms a type of immune cell, can reduce nasal polyp size and improve breathing when added to standard nasal spray therapy. About 400 adults with severe bilateral nasal polyps will receive either mepolizumab…

This phase 3 trial tested a new triple-combination inhaler (beclometasone, formoterol, and glycopyrrolate) against a standard two-drug inhaler in 1,368 adults with severe COPD. The study measured changes in lung function and breathlessness over 52 weeks. The goal was to see if th…

This study looks back at health records from over 46,000 people in Denmark and Sweden with allergic rhinitis (hay fever), some of whom also have asthma. It compares those who used SQ sublingual immunotherapy (SLIT) tablets — a daily tablet placed under the tongue containing grass…

This phase 3 trial tested whether a triple-combination inhaler (CHF 5993) works better than a standard dual inhaler (Symbicort) for people with chronic obstructive pulmonary disease (COPD). Over 700 adults aged 40 and older with a history of smoking took part. The main goal was t…

This trial compares two approaches to voice care after surgery for benign vocal cord lesions like polyps or cysts. One group stays completely silent for five days, while the other uses soft, low-effort whispering. Both groups then receive the same voice therapy. The study measure…

This study tests a drug called tozorakimab in people with chronic obstructive pulmonary disease (COPD) who have a history of flare-ups and high levels of eosinophils (a type of white blood cell). The trial involves 98 participants who receive either tozorakimab or a placebo every…

This study tested a new device that uses electrical pulses (IRE) to shrink enlarged tonsils in children, aiming to improve breathing without traditional surgery. Thirty-one children aged 3-18 with tonsil hypertrophy and airway obstruction took part. Researchers measured pain reco…

This study tests whether giving doctors a personalized infographic showing a COPD patient's predicted lung function decline over 15 years can increase smoking cessation counseling and medication prescriptions. The tool uses individual patient data like age, sex, and lung function…

This study investigates whether eccentric cycling—where the pedals resist the rider's effort, similar to walking downhill—can improve exercise capacity in people with heart or lung conditions. Unlike normal cycling, eccentric cycling demands less oxygen, which may allow patients …

This phase I study is testing a subcutaneous (under the skin) injection of toripalimab, an immunotherapy drug, for people with advanced nasopharyngeal carcinoma. The trial compares the new injection to the standard intravenous (IV) version, looking at safety, tolerability, and ho…

This study tests whether virtual or in-person care transition programs are better at helping people with COPD avoid emergency room visits and hospital readmissions within 30 days of discharge. The trial enrolls hospital sites across the U.S., not individual patients, and compares…

This phase 2 trial investigates the safety and tolerability of EP395, an oral capsule taken once daily for 12 weeks, in people with chronic obstructive pulmonary disease (COPD). The study includes 61 adults aged 45 and older and compares EP395 against a placebo. Researchers monit…

This study compares two common substances—hydrogen peroxide and adrenaline—for controlling bleeding during tonsillectomy in children and teens aged 5 to 18. Surgeons apply one of the two to the surgical site and measure how quickly bleeding stops and how much blood is lost. The g…

This study tests whether combining semi-occluded vocal tract exercises (like phonating through a pipette) with breathing exercises (pursed-lip, segmental, and diaphragmatic breathing) can improve how long conservatory students can sustain a note and their overall lung function. P…

This completed study followed 152 COPD patients who started using a triple-combination inhaler (BGF) as part of their routine care. Researchers measured changes in symptoms and quality of life after 12 and 24 weeks. The goal was to see if the inhaler helps patients feel better an…

This study tested a drug called tozorakimab in over 1,700 people with COPD who had a history of flare-ups. The goal was to see if it could safely reduce severe breathing attacks over the long term. Participants who completed earlier trials were given either tozorakimab or a place…

This study tested whether a natural hormone called DHEA can improve exercise ability in adults with COPD and high blood pressure in the lungs. 51 participants took either a low or high dose of DHEA or a placebo daily for one year. The main goal was to see if DHEA helped them walk…

This study tested whether a daily dose of the hormone DHEA can help adults with COPD who also have high blood pressure in their lungs. Sixty participants took either DHEA or a placebo for one year. Researchers measured how far they could walk in six minutes and checked heart and …

This study tested a program to help smokers at high risk for COPD reduce their smoking. Over 4,200 adults aged 35 and older who smoked or had recently quit took part. The program included health checks, digital tools, and education to support quitting or cutting back. The goal wa…

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This completed study tested whether omega-3 fatty acids and vitamin D supplements can improve weight, muscle mass, and fatigue in 45 people with COPD who also have cachexia (severe muscle wasting). Participants took the supplements twice daily for six weeks. The goal was to see i…

This study tested a new type of breathing machine that automatically adjusts its settings to match each person's breathing in real time. Fifteen people with severe COPD who already use a ventilator at home tried the device for six weeks. The goal was to see if the smart ventilato…

This study tested a community-based program for adults at high risk for COPD who also have other health issues like high blood pressure, diabetes, or mental health concerns. Over 9,300 participants in Xishui County were assigned to either the program or usual care. The program in…

This study tested a device called NEUROMARK in 80 adults with chronic rhinitis (long-term stuffy or runny nose). The device uses radiofrequency energy to disrupt nerves in the nose that trigger symptoms. The goal was to see if it safely reduces nasal symptoms like congestion and …

This phase 3 trial tested whether a new inhaler (beclometasone/formoterol) works as well as an existing one (budesonide/formoterol, Symbicort) for people with chronic obstructive pulmonary disease (COPD). Over 24 weeks, 750 Chinese adults with moderate-to-severe COPD used one of …

This study tested whether mepolizumab, an asthma drug, can reduce lung inflammation and flare-ups in people with COPD who have high levels of eosinophils (a sign of asthma-like inflammation). Thirty-one participants received mepolizumab every 4 weeks for a year and had MRI scans …

This phase 2 trial tested a drug called KL-A167 in 153 adults with recurrent or metastatic nasopharyngeal carcinoma (a type of throat cancer). Participants received the drug by IV every two weeks. The main goal was to see how many patients' tumors shrank or disappeared. The study…

This study looked at 200 people with moderate to severe COPD who started taking the triple-combination inhaler BREZTRI. Researchers tracked changes in symptoms and lung function over 24 weeks in routine doctor visits. The goal was to see how the medicine performs outside of stric…

This study tested a 12-week internet-based aftercare program for people with COPD, starting right after they finished inpatient pulmonary rehabilitation. The program included activity tracking, online exercise training, educational modules, and therapist support via phone. Resear…

This early-stage trial tested whether EP395, an oral capsule, can reduce lung inflammation in healthy adults. All 49 participants inhaled a substance that causes temporary airway inflammation, mimicking a key feature of COPD. Researchers measured inflammation levels and collected…

This study tested whether a drug called mepolizumab, given after a severe COPD flare-up that required hospital care, could prevent future hospital stays or death. It involved 238 adults with eosinophilic COPD (a type with high levels of certain white blood cells). Participants re…

This completed study tested whether adding a daily statin (atorvastatin 20 mg) to standard treatment for six months could reduce airway inflammation and improve lung function in 80 people with severe COPD. Researchers measured blood markers of inflammation and breathing tests. Th…

This phase 3 trial tested whether giving only radiation therapy works as well as radiation plus chemotherapy for people with intermediate-risk nasopharyngeal cancer. The study enrolled 338 participants and used modern intensity-modulated radiation therapy (IMRT). The goal was to …

This study tested whether an inhaled antibiotic (tobramycin), taken alone or with an oral antibiotic (ciprofloxacin), can permanently clear Pseudomonas aeruginosa infections from the lungs of people with bronchiectasis. The trial involved 371 adults and compared these treatments …

This study tested two doses of a drug called tozorakimab in over 1,100 adults with COPD who had frequent flare-ups. Participants received either the drug or a placebo as a shot, while continuing their usual inhalers. The main goal was to see if the drug could reduce the number of…

This study tested a new medicine called tozorakimab in over 1,100 adults with COPD who had frequent or severe flare-ups. Participants received either a low or high dose of the drug or a placebo as a shot under the skin, while continuing their usual inhalers. The main goal was to …

This study tested a drug called itepekimab in over 1,200 people with moderate-to-severe COPD who were either former or current smokers. The goal was to see if it could reduce the number of serious flare-ups and improve lung function compared to a placebo. The drug works by blocki…

This study tested a new antibody drug called itepekimab in over 1,100 former smokers with moderate-to-severe COPD. The goal was to see if it could reduce the number of sudden worsening episodes (exacerbations) and improve breathing. Participants received either the drug or a plac…

This study looked at the safety and how the body processes two doses of nirsevimab, a medicine to prevent RSV, given 5 to 6 months apart. It included 33 Japanese infants up to 12 months old with heart or lung disease, weak immune systems, Down syndrome, or who were born early. Re…

This study tested whether switching to a stronger, extrafine triple inhaler (CHF5993) could improve lung function in 25 people with advanced COPD. Participants were current or former smokers aged 40 or older. The study used special lung imaging to measure changes in airway volume…

This study tested a new drug combination (TQB2618 plus penpulimab) in 47 people with advanced nasopharyngeal carcinoma that had come back or spread. Some participants had already tried standard treatments, while others were new to therapy. The goal was to see if the combination w…

This Phase 3 study tested a new inhaler called HL231 in 487 Chinese adults with moderate to very severe COPD. Participants used either HL231 or the active comparator Ultibro once daily for 52 weeks. The main goal was to see if HL231 improved lung function (FEV1) after 26 weeks co…

This study tested a new implant designed to release trapped air in the lungs of people with severe emphysema or COPD. Up to 48 participants received up to two procedures to place the implants. Researchers checked if the device was safe and if it improved breathing over 12 months.

This study followed 212 adults with moderate to severe COPD in Greece who were prescribed a triple-combination inhaler (Trixeo Aerosphere). Researchers tracked why patients switched from dual therapy and how their symptoms and quality of life changed over 52 weeks. The goal was t…

This study followed 250 adults with COPD who were starting a new triple-combination inhaler (budesonide/glycopyrronium/formoterol, or BGF) in routine Italian clinics. Researchers measured how patients felt about their health after 12 weeks and up to a year. The goal was to see re…

This study tested whether giving live vaccines (BCG and MMR) to people with COPD can train their immune system to produce less harmful inflammation. Sixty adults with COPD received either the vaccines or a placebo. Researchers measured changes in immune cell activity over four mo…

This early-phase trial tested whether the immunosuppressant drug everolimus could help people with idiopathic subglottic stenosis, a rare condition where scarring narrows the airway. Eight participants took everolimus for 42 days after a dilation surgery to open the airway. The g…

This phase 2 trial tested whether infusions of PROCHYMAL, a stem cell product, are safe and can help people with moderate to severe COPD. 62 participants received either stem cells or a placebo. The main goal was to check for side effects, and researchers also looked at changes i…

This phase II trial tested whether adding sorafenib to cetuximab works better than cetuximab alone for patients with advanced head and neck cancer that has come back or spread. Fifty-five adults with various types of head and neck cancer took part. The study measured how long pat…

This study looked at whether using a HEPA air purifier at home can improve lung health in adults with a type of COPD called eosinophilic COPD. 178 people took part, with half getting real purifiers and half getting fake ones. The main goal was to see if the purifiers helped with …

This study tested an experimental drug called ENV-101 (taladegib) in 20 adults with advanced solid tumors that have a specific genetic mutation (PTCH1 loss-of-function). The drug works by blocking a growth pathway in cancer cells. Researchers measured how many patients' tumors sh…

This large study in rural India trained village health workers to diagnose and treat common illnesses like high blood pressure, diarrhea, pneumonia, malaria, asthma, and COPD. Over 72,000 adults aged 16-60 from 80 tribal villages took part. The goal was to reduce deaths by at lea…

This study tested a type of allergy immunotherapy (Clustoid® Max Forte) in 140 people aged 5 to 65 with dust mite allergies. The goal was to see if it reduces allergy and asthma symptoms and the need for medication over one year. Results were measured by symptom scores and medica…

This study tested a drug called astegolimab in over 1,300 people with COPD who have frequent flare-ups. The goal was to see if adding this drug to standard care could reduce the number of moderate to severe COPD attacks over a year. Participants were current or former smokers wit…

This study tested a dietary supplement containing immune-supporting nutrients and postbiotics in 40 children aged 5–12 with asthma and/or allergic rhinitis. The goal was to see if the supplement could improve symptom control over 6 months. Researchers also looked at changes in im…

This study looked at how well endoscopic stenting and suturing work to close holes or tears in the esophagus. Researchers reviewed 150 patients treated at a large referral center. The goal was to see which technique leads to better healing.

This completed French registry tracked 155 adults with severe emphysema or COPD who received Zephyr Valves, tiny devices placed in the lungs to help them work better. The goal was to see if the treatment safely improves breathing over 12 months. Researchers measured lung function…

This study compared two surgical methods for removing adenoids in 128 children: the traditional cold curettage and a newer coblation technique using endoscopes. The goal was to see which method leaves less leftover tissue and causes fewer complications. The coblation method uses …

This study tested a new way to give radiation for head and neck cancer. Instead of treating the whole neck, doctors used artificial intelligence to focus radiation only on the cancer spots. 67 patients took part to see if this approach could reduce side effects without increasing…

This phase 3 trial tested tezepelumab, a biologic drug given as a shot, in 416 adults with severe chronic sinusitis and nasal polyps. Participants received either tezepelumab or a placebo, plus a standard nasal steroid spray. The study measured changes in polyp size and nasal con…

This study tested a personalized approach for people with severe COPD. Doctors used a simple blood test (eosinophil count) to decide whether to reduce inhaled steroids, and some patients also received the antibiotic azithromycin. The goal was to see if this strategy could reduce …

This study tested whether inhaling a solution containing ectoin, a natural substance, can reduce inflammation in the lungs and help prevent further loss of lung function. It involved 36 postmenopausal women aged 75–80 with mild airway obstruction and signs of inflammation. Partic…

This study tested a surgery that reconnects nerves in the throat to help people with both vocal cords paralyzed. The goal was to improve breathing and voice without causing swallowing problems. Four adults who had not gotten good results from earlier treatments took part. Results…

This study tested a new combination of two inhaled drugs, ensifentrine and glycopyrrolate, in 33 adults with COPD. The goal was to see how the drugs move through the body, how well they open airways, and if they are safe. Each person received single doses of the combination and e…

This study tested an inhaled mixture of bacteria-killing viruses (phages) in 48 adults with bronchiectasis and chronic Pseudomonas lung infections. Participants received either the phage therapy or a placebo by inhalation. The goal was to see if the phages could safely reduce the…

This study tested whether high-flow nasal oxygen therapy works as well as standard noninvasive ventilation for people with a moderate COPD flare-up. Fifty-one patients were randomly assigned to one of the two treatments for the first 24 hours. The main goal was to see how each me…

This large Phase 3 trial tested whether a daily pill called brensocatib can reduce the number of lung infections (called pulmonary exacerbations) in people with non-CF bronchiectasis, a chronic lung condition. Over 1,700 adults and adolescents took either 10 mg, 25 mg of brensoca…

This study tested two ways to pull the upper jaw forward in 40 children aged 7-13 with underbite. One method used a traditional face mask attached to teeth, the other used tiny screws placed in the cheekbone. Both followed a special expansion protocol. The goal was to see which a…

This study looked at how well the Trimbow inhaler works for people with COPD when used in everyday life, not just in a lab. 362 adults with COPD used the inhaler for 12 weeks. Researchers measured changes in a COPD symptom questionnaire to see if patients felt better. The goal wa…

This study looked at whether monitoring COPD patients' home ventilators from a distance can help them use the machines more regularly and reduce hospital visits. 54 adults with COPD who were new to home ventilation took part. Some received standard care with in-person checkups ev…

This phase 3 trial tested a biologic drug called depemokimab in 276 adults with chronic sinusitis and nasal polyps. Participants received either the drug or a placebo as an injection under the skin. The study measured changes in polyp size and nasal blockage over 52 weeks to see …

This study tested whether having a pharmacist teach people with COPD about their medications could reduce sudden worsening of symptoms. 174 adults with moderate to severe COPD were given a 20-minute education session either at the hospital or at their local pharmacy, plus a 10-mi…

This study looked at 65 people with advanced head and neck cancer that had spread to lymph nodes. It compared two approaches: having surgery to remove affected lymph nodes before chemo-radiation, versus chemo-radiation alone. The goal was to see if upfront surgery could reduce tr…

This study tested a once-daily inhaler called Trelegy Ellipta in 80 adults hospitalized for a COPD flare-up. The goal was to see if it reduces the need for extra rescue breathing treatments and shortens hospital stays. Participants took the inhaler daily along with short-term ste…

This phase II trial tested whether adding the targeted drug cetuximab to standard chemotherapy and radiation could help prevent head and neck cancer from coming back after surgery. The study enrolled 53 patients with certain high-risk features. The main goal was to see how many p…

This study tested whether a bacterial vaccine called MV130, taken daily under the tongue for 12 months, can reduce the number and severity of COPD flare-ups in adults with moderate to severe COPD. A total of 198 participants were randomly assigned to receive either MV130 or a pla…

This study tested whether a mobile telerehabilitation app could help people with COPD keep the benefits they gained from a short pulmonary rehab program. 200 patients were randomly assigned to use the app or receive standard care for one year. The main goal was to see if the app …

This study tested whether using HEPA air cleaners at home along with phone-based motivational interviewing could improve breathing and quality of life in smokers with COPD. 144 current smokers with COPD were randomly assigned to receive either active air cleaners and counseling o…

This study compared two types of sinus surgery for people with chronic sinusitis and nasal polyps that involve a type of inflammation called eosinophilic. One surgery (MRESS) removes more tissue, including the middle turbinate, while the standard surgery (FESS) preserves it. The …

This study followed over 1,300 people with moderate to severe COPD whose symptoms were not controlled by standard dual inhalers. Researchers measured how Trimbow, a triple-combination inhaler, affected their quality of life and lung function over six months. The goal was to see i…

This Phase 3 trial tested a biologic drug called depemokimab in 264 adults with chronic sinusitis and nasal polyps. Participants received either the drug or a placebo as a shot under the skin. The study measured changes in polyp size and nasal blockage over 52 weeks. The goal is …

Researchers are studying whether volumetric high-resolution CT scans can give a detailed picture of lung damage in people with stable chronic obstructive pulmonary disease (COPD). The study enrolls 75 patients with COPD confirmed by breathing tests. Participants receive both a sp…

This study is testing a computer algorithm that uses health records to predict whether a person has COPD. Many people with COPD are not diagnosed until the disease is advanced, while others are wrongly told they have it. The goal is to see if the algorithm can correctly identify …

This study explores whether wearable motion sensors can improve screening for fall risk in people with chronic conditions like osteoarthritis, Parkinson's disease, COPD, and obesity. Participants will perform two standard walking tests while wearing small sensors that measure mov…

This study is testing a new blood test (called BÜHLMANN BAT) to see if it can help diagnose allergies to peanuts, insect venom, dust mites, hazelnut, and cat dander. About 60 people aged 1.5 years and older who are already being checked for allergies will give one extra tube of b…

This study investigates whether patterns in speech and breathing can indicate the presence of obstructive respiratory diseases like COPD. Researchers will collect short voice recordings from patients with and without lung disease and compare them to standard lung function tests. …

This study tests whether a simple lung ultrasound can accurately detect heart failure in people with chronic obstructive pulmonary disease (COPD) who come to the emergency room with shortness of breath. Heart failure is a common but often missed cause of worsening COPD symptoms. …

This study tested a new scoring tool (GLORI-COPD) to see how well it can identify COPD patients at risk of serious complications, like lung infections. Researchers studied 462 smokers or former smokers aged 35 and older who had not been previously diagnosed with COPD. The goal is…

This study looked at whether a blood test for circulating tumor cells (CTCs) can help detect lung cancer earlier in people at very high risk: smokers and ex-smokers with COPD. Researchers combined this blood test with low-dose CT scans over three yearly screenings in 683 particip…

This study tested a new rapid test called SPOTFIRE ST for people with sore throats in urgent care. The test uses PCR to find up to 13 different viruses and bacteria in about 20 minutes. Researchers wanted to see if doctors find it useful, how accurate it is, and whether patients …

This study tested a new way to find small cancer spots in neck lymph nodes of people with nasopharyngeal cancer. Researchers combined MRI scans with a special ultrasound that uses a contrast agent. They aimed to create a better rule for spotting these tiny metastases. 348 patient…

This study tested a special breathing technique during PET scans to get clearer images of lung tumors. 103 people with small lung nodules (under 35 mm) had both a standard PET scan and an extra scan where they held their breath. The goal was to see if this reduces blurring from b…

This study tested two medications, roflumilast and azithromycin, in over 1,000 people with severe COPD and chronic bronchitis. The goal was to see which drug better prevents hospitalizations or death. Participants were current or former smokers aged 40 or older who had been hospi…

This study tested whether giving families educational materials, alcohol-based hand sanitizers, and surgical face masks could reduce the spread of colds and flu among household members. Researchers followed 2,788 people in 450 households in Northern Manhattan for 15 months. They …

This early-phase study tested a vaccine called CIMAvax-EGF in 20 people at high risk for lung cancer or survivors at risk of recurrence. The vaccine works by helping the body make antibodies against a protein that can fuel cancer growth. Researchers checked for side effects and m…

This study tested how well two different 2023-2024 updated COVID-19 vaccines (Novavax and Pfizer mRNA) protect adults from getting sick with COVID-19. About 1,200 adults who had already received at least two mRNA vaccine doses were randomly assigned to get either the Novavax or P…

This study tested a small clip attached to the breathing tube used during anesthesia to see if it could prevent sore throat, voice changes, and trouble swallowing after surgery. 100 adults having surgery with general anesthesia took part. The clip is designed to reduce pressure o…

This study tests a new treatment called GNR-127 for people with seasonal allergies to birch pollen. The treatment is a protein that aims to reduce allergy symptoms like sneezing, runny nose, and itchy eyes. The trial involves 150 adults and will check for safety and how well it w…

Researchers are testing whether an inhaled dual bronchodilator (umeclidinium/vilanterol) can improve heart function during exercise in people who have COPD, lung hyperinflation, and mild heart failure. About 60 adults aged 40 to 85 with these conditions will take either the drug …

Researchers are testing an experimental drug called IRL201104 in adults with seasonal allergic rhinitis triggered by grass pollen. Participants receive six intravenous doses over 10 weeks. The trial measures how the skin reacts to a controlled allergen challenge, comparing IRL201…

Researchers are testing whether adding neuromuscular electrical stimulation (NMES) to chest physiotherapy helps older adults with severe COPD walk farther and gain muscle strength. Sixty participants receive either chest physiotherapy alone or chest physiotherapy plus NMES applie…

Researchers at Pamukkale University are testing whether adding virtual reality cycling to standard pulmonary rehabilitation helps people hospitalized for a COPD flare. Fifty participants with moderate COPD receive either the virtual reality add-on or standard rehab alone. The tri…

This study tests whether a program combining resistance training and a Mediterranean diet is practical and helpful for people with head and neck cancer undergoing radiation. Forty participants will receive supervised exercise sessions and pre-made meals, plus dietary coaching. Th…

Researchers are testing whether injecting dexamethasone, a steroid, into the soft palate during tonsillectomy reduces uvula swelling and improves recovery. The study includes 74 adults aged 18 to 44 having tonsillectomy for recurrent tonsillitis. Half receive the steroid injectio…

Shots and blood draws cause pain and anxiety in children, and numbing creams take time to work. Researchers are testing a device that uses cold, vibration, and distraction to block needle pain. The trial compares this device with standard numbing cream in children aged 4 to 15 at…

Researchers are studying how a three-week inpatient pulmonary rehabilitation program affects breathing in people with COPD whose blood oxygen drops during exercise. Participants train while breathing normal air, air that mimics moderate altitude, or extra oxygen. A wearable senso…

Researchers are studying whether a pulmonary rehabilitation program at moderate altitude changes airway resistance in adults with COPD. Participants complete an endurance training cycle, with some sessions using extra oxygen through a nasal tube and others breathing regular room …

Researchers are testing whether breathing extra oxygen during exercise training helps people with COPD who have normal oxygen levels at rest but drop low during activity. The trial enrolls 54 adults in a three-week inpatient rehab program. Participants cycle and walk while breath…

This early-stage study tests a new inhaled drug called HRS-9821 in 160 people. First, healthy volunteers get a single dose to check safety. Then, people with COPD receive multiple doses. The main goal is to see what side effects occur and how the drug moves through the body. This…

This study tests whether a daily probiotic blend can improve quality of life for adults with persistent allergies to dust mites, cats, or dogs. For 12 weeks, 98 participants will take either the probiotic or a placebo and track their symptoms and antihistamine use. The goal is to…

Researchers are testing a nasal spray called PG-011 in adults with moderate to severe seasonal allergic rhinitis. The trial compares two strengths and dosing schedules of the spray against a placebo to see which might best reduce nasal symptoms like runny nose, sneezing, congesti…

This study tested a device called NEUROMARK that uses radiofrequency energy to disrupt nerves in the nose. It included 36 adults with moderate to severe chronic rhinitis. The goal was to see if the procedure safely reduces symptoms like runny nose and congestion over 3 months.

This trial tests whether a spray made from lavender and ginger oils can ease sore throat, thirst, and nausea after kidney stone surgery. About 110 adults who have the surgery under general anesthesia will receive the aromatic spray, a placebo, or standard care. Researchers will m…

This study tested a new drug called BLU-808 in 21 adults with ragweed allergies. The goal was to see if it is safe and helps reduce sneezing, runny nose, and itchy eyes caused by ragweed pollen. Participants were exposed to ragweed in a special chamber to measure the drug's effec…

This study tests whether a web-based training program helps people with COPD who use a noninvasive ventilator (NIV) at home stick to their therapy and sleep better. Participants receive online lessons on using the device, and researchers measure their compliance and insomnia seve…

This pilot study tests whether four sessions of cognitive-behavioral therapy (CBT) can help teenagers with vocal cord dysfunction. The therapy teaches teens to identify triggers, self-monitor symptoms, and use breathing and relaxation techniques to reduce symptom reactivity. Rese…

This Phase 2 trial tests whether an injection called DM-101PX can reduce nasal symptoms caused by birch pollen allergy. About 100 adults with birch pollen allergic rhinitis or rhinoconjunctivitis will receive either the drug or a placebo. The main goal is to see if the treatment …

This study tests an injection called SHR-1819 in 100 adults with seasonal allergic rhinitis (hay fever). Participants will receive either the drug or a placebo to see if it reduces daily nasal symptoms like sneezing and stuffiness. The trial is double-blind, meaning neither patie…

This trial tests whether adding virtual reality to standard pulmonary rehabilitation can reduce depression in people with COPD. Adults aged 45 to 85 with COPD and mild or worse depression will be randomly assigned to receive either pulmonary rehab with virtual reality or rehab al…

This trial explores whether an internet-based cognitive behavioral therapy (CBT) program, combined with COPD education, can improve mental health, disease knowledge, and quality of life in adults with chronic obstructive pulmonary disease (COPD). Participants complete the 8-10 we…

This trial tests a device called RheOx that delivers controlled heat pulses to the airways to reduce excess mucus-producing cells, which are a hallmark of chronic bronchitis. The study enrolls adults aged 35 to 80 with moderate-to-severe COPD and chronic bronchitis symptoms. Part…

This trial tests whether a device called Simeox, which uses pulsed air to help loosen and clear mucus from the airways, can improve lung function and quality of life in people with bronchiectasis who produce excess mucus. About 50 adults with the condition will use either Simeox …

This trial tests whether progressive muscle relaxation and deep breathing exercises can help people with COPD feel less tired and sleep better. About 90 participants will be split into three groups: one practicing muscle relaxation, one doing deep breathing exercises, and a contr…

This trial tests whether two nasal pump sprays made from diluted seawater can safely ease symptoms of colds, rhinitis, sinusitis, and other upper respiratory infections. Participants, from 3 months old, will use one of the sprays for 7 days while doctors track symptom severity an…

This trial tests whether a program of breathing exercises—like diaphragmatic breathing, pursed lip breathing, and incentive spirometry—can improve lung function and ease breathlessness in people with chronic airway diseases such as COPD and asthma. Participants will undergo pulmo…

This trial tests whether a mouthwash containing lithium can prevent or reduce oral mucositis (painful mouth sores) and dysgeusia (taste changes) in people receiving radiation for head and neck tumors. Participants will rinse with either a lithium mouthwash or a placebo during the…

This study looks at whether watching a short, AI-created story video at home can help children aged 4 to 10 feel less anxious and scared before their first skin prick test for allergies. About 100 kids will be split into two groups: one watches the video, the other gets standard …

This trial investigates whether Su Jok therapy, a complementary technique that stimulates specific points on the hands, can reduce dyspnea (breathlessness) and fatigue in people with chronic obstructive pulmonary disease (COPD). The study will include 30 hospitalized adults with …

This trial tests whether a continuous infusion of the local anesthetic ropivacaine, delivered through small catheters placed near the breastbone, can improve recovery after cardiac surgery. The study focuses on patients at higher risk of respiratory complications, such as older a…

This trial compares two breathing techniques—Active Cycle of Breathing Technique (ACBT) and Pursed-Lip Breathing (PLB)—to see which better improves lung function, reduces breathlessness, and enhances quality of life in people with moderate to severe COPD. Forty adults aged 40 to …

This trial tests whether taking zinc supplements for five days before a Botox injection into the vocal cords can extend the treatment's benefits for people with spasmodic dysphonia, a condition that causes involuntary voice spasms. Participants will take a 50 mg zinc gluconate pi…

This trial tests whether low-intensity body weight exercises combined with blood flow restriction (BFR) are safe and acceptable for people with COPD. Participants perform simple moves like sit-to-stand and knee raises at home, wearing inflatable cuffs on their thighs. The study f…

This study tests whether a device called oscillatory positive expiratory pressure (OPEP) therapy can reduce cough symptoms and improve lung mechanics in people with COPD. Participants use the device at home twice daily for four weeks. Researchers compare lung function and symptom…

This study is testing a hypertonic seawater aerosol spray (a saltwater mist) to see if it helps relieve nasal symptoms, improve sleep, and thin mucus in people with colds, sinus infections, or similar upper respiratory infections. About 110 adults and children aged 2 and older wi…

This phase 3 trial tests whether a once-daily pill combining desloratadine (an antihistamine) and betamethasone (a corticosteroid) relieves nasal allergy symptoms better than desloratadine alone. About 70 adults with moderate-to-severe allergic rhinitis will take either the combo…

This study tested whether a simple balloon-blowing exercise, combined with deep breathing, could increase oxygen levels in people with mild to moderate COPD. 46 adults performed the exercises twice daily for 7 days. The results showed that those who did both balloon blowing and d…

This study tested a small vibrating device worn on the neck to see if it could make speaking easier for people with spasmodic dysphonia, a rare voice disorder. Forty participants used the device at home for 20 minutes a day over 8 weeks. They reported how much effort it took to s…

This study tested two types of radiation therapy for nasopharyngeal cancer (a cancer in the upper throat). One group received standard photon radiation plus carbon ion therapy, and the other received proton radiation plus carbon ion therapy. The main goal was to see which approac…

This study tests whether a probiotic gummy containing Weizmannia coagulans BC99 can reduce symptoms of allergic rhinitis (hay fever) in children aged 4 to 14. Over 8 weeks, half the children receive the probiotic gummy and half receive a placebo. Researchers track changes in nasa…

This study compared two ways to remove tonsils in 66 people with chronic tonsillitis: using a harmonic scalpel (ultrasonic energy) versus traditional cold steel instruments. The main goal was to see if the harmonic scalpel causes less pain three days after surgery. Researchers al…

This study tested a special lollipop containing the painkiller diclofenac to help children aged 4 to 12 manage pain after having their tonsils removed. Fifty children received a weight-adjusted dose every 8 hours for the first day after surgery. The goal was to see if the lollipo…

This study looked at 100 adults with COPD who needed a breathing tube and a ventilator. It compared two approaches: giving sedation with daily breaks versus giving no sedation at all. The goal was to see which method leads to more days off the ventilator and fewer complications i…

This study looked at whether taking a probiotic called LP28 can help older adults fight off colds and feel better. 102 people who had at least two colds in the past year took part. Researchers measured cold symptoms and immune cell levels to see if the probiotic made a difference…

This study compared two types of breathing tubes (Air-Q and Proseal LMA) in 97 elderly patients aged 65-90 undergoing surgery. The goal was to see which device works better and causes fewer side effects like sore throat. Researchers measured how well each tube sealed the airway a…

This study tested whether a home-use light device (rhinophototherapy) can reduce nasal inflammation and allergy symptoms as well as a standard steroid spray. Thirty-five adults with allergic rhinitis used either the light device for 4.5 minutes three times daily or a steroid spra…

This study looked at whether a 4-week program of breathing muscle training, aerobic exercise, or both could improve breathing strength, walking ability, and well-being in women with stable COPD. 68 women aged 48-65 with mild-to-moderate COPD took part. The researchers also checke…

This study tested a new type of botulinum toxin injection (DAXI) for people with adductor spasmodic dysphonia, a condition that causes the voice to spasm and sound strained. 22 adults who had previously been helped by standard Botox injections received a single DAXI injection int…

This study tested whether adding a decongestant nasal spray for the first 5 days to standard steroid spray treatment helps children with persistent allergic rhinitis feel better faster. 76 children aged 4-18 were randomly assigned to receive either steroid spray alone for 4 weeks…

This study looked at whether a nose spray medicine called midazolam can help calm preschool children (ages 2-6) before they have surgery to remove their tonsils and adenoids. The goal was to make the children less anxious and more comfortable before anesthesia. The study included…

This study tested whether sleeping with the head and trunk raised (using an adjustable bed backrest) improves sleep quality in people with chronic obstructive pulmonary disease (COPD). Twenty-four adults with severe COPD and sleep difficulties each tried the raised position and t…

This study tested whether a home-based exercise program using an exergaming (video-game exercise) system, supervised remotely by a physiotherapist, could improve physical fitness and quality of life in people with COPD. 92 participants were randomly assigned to either the exergam…

This study tested whether placing a throat pack soaked in the steroid dexamethasone could reduce sore throat after septoplasty (nose surgery). 65 adults were randomly assigned to receive either a dexamethasone-soaked pack, a saline-soaked pack (placebo), or no pack. The main goal…

This study tested whether a gentle brain stimulation technique called tDCS could improve voice quality and range in 45 healthy singers. Participants received either real stimulation to the motor cortex or cerebellum, or a sham (fake) stimulation, during voice training over 10 day…

This phase 3 trial tested whether ulinastatin, a drug that blocks certain enzymes, can reduce severe mouth sores caused by chemoradiotherapy in 179 patients with advanced nasopharyngeal cancer. Patients received either standard care or ulinastatin alongside their cancer treatment…

This study tested whether taking a daily arginine supplement (Bioarginine) for 6 weeks can improve breathing and daily activities in people with COPD. 153 participants were randomly assigned to receive the supplement or a placebo on top of their usual inhaled medications. The goa…

This completed trial tested whether a probiotic called Bifidobacterium longum ES1, or its heat-treated version, could reduce symptoms of allergic rhinitis (hay fever) in 72 adults with moderate-to-severe dust mite allergies. Participants took daily capsules for several weeks and …

This study tested whether singing and vocal exercises could improve lung function in people with chronic obstructive pulmonary disease (COPD). Five adults with COPD took part in virtual singing sessions twice a week for four weeks, guided by a music therapist. Researchers measure…

This study tested a new breathing support method (HVNI) against standard non-invasive ventilation (NIV) in 66 COPD patients with dangerously high carbon dioxide levels. The goal was to see if HVNI could safely lower carbon dioxide and reduce the need for a breathing tube. Results…

This study tested whether specific osteopathic techniques (rib rising and thoracic lymphatic pump) combined with a manual diaphragmatic release could improve breathing in 66 people with stable moderate-to-severe COPD, aged 60-75. Participants received the hands-on therapy, and re…

This study tested a program called PRISM, which teaches skills like stress management and goal setting, to see if it helps racial minority patients with serious illnesses feel more resilient and communicate better with their healthcare providers. The study enrolled 28 seriously i…

This study tested whether using a pre-inflated tracheal tube cuff during intubation reduces sore throat after surgery. 250 adults with non-difficult airways were randomly assigned to either the pre-inflated cuff method or the standard deflated cuff method. The goal was to see if …

This study tested an investigational treatment called PQ Grass 27600 SU in 119 adults with seasonal grass pollen allergies (hay fever). The goal was to see if it could reduce allergy symptoms and the need for relief medications during peak grass pollen season. Participants receiv…

This study tested an experimental nasal spray called INI-2004 in 78 adults with ragweed allergies. Participants received either the spray or a placebo once a week for four weeks, then spent time in a room filled with ragweed pollen to see if symptoms improved. The goal was to che…

This study tested a new device that uses high-voltage electric pulses to shrink enlarged tonsils without cutting. Twenty-four adults with grade 2 or higher tonsil hypertrophy received the treatment. The goal was to reduce tonsil size and pain, with results measured at 3 months.

This study looked at whether taking a grass pollen tablet (SLIT) together with the drug dupilumab for 2 years can help adults with moderate to severe hay fever tolerate grass pollen better, even after stopping treatment. About 199 participants were involved. The main goal was to …

This study looked at two types of vibrating devices—one that sends vibrations into the airways and one that vibrates the chest wall—to see if they could help people with COPD breathe better and sleep more soundly during a sudden worsening of their condition. 33 adults with severe…

This study tested whether giving children montelukast before and after tonsillectomy reduces their pain and need for strong painkillers. 116 kids aged 3-8 took part, receiving either montelukast or a placebo. Researchers measured pain scores and how often families contacted docto…

This study tested whether an eight-week online yoga program could improve breathing, exercise ability, and quality of life in adults with non-cystic fibrosis bronchiectasis, a chronic lung condition. Seventy participants were split into a yoga group (three supervised sessions per…

This study looked at whether adding balance exercises to standard lung rehab can help prevent falls in people over 80 with COPD. 21 participants were split into two groups: one did the usual rehab, the other added balance training. The goal was to see if balance improved and fall…

This study tested whether an online program for insomnia could help veterans with COPD sleep better and feel better. 13 veterans were randomly assigned to either the online insomnia treatment or online education about sleep. The goal was to see if the treatment improved sleep qua…

This study tested whether a six-week program of breathing exercises using a device called an incentive spirometer could help older adults (65+) with COPD who were also frail. 66 participants were split into two groups: one did the breathing exercises, the other did not. After six…

This study looked at whether a combination inhaler (tiotropium/olodaterol) can improve exercise capacity in people with COPD who have overinflated lungs. 44 adults used the inhaler for 4 weeks, and researchers measured changes in oxygen use during exercise, heart function, and qu…

This study tested whether an internet-based walking program with a pedometer could help veterans with COPD who cannot attend hospital rehab become more active. 146 veterans took part, and their daily step counts were measured. The goal was to see if this approach improves physica…

This study tested whether using a special high-flow oxygen device during exercise training helps people with COPD breathe easier and exercise more. Thirty patients completed 12 rehab sessions, and those using the device could walk at a steeper incline on the treadmill. The approa…

This study tested two breathing techniques—Wim Hof method and box breathing—in 60 people with mild COPD. The goal was to see if these exercises could reduce anxiety and breathlessness and improve lung function. Participants practiced one of the two techniques, and researchers mea…

This study tested whether a 10-week digital pulmonary rehabilitation program, done at home via video calls and a smartphone app, could improve lung function, thinking skills, and sleep quality in people with chronic obstructive lung disease (COPD). Sixty stable COPD patients aged…

This study tested how well the over-the-counter medication Mucinex works for people with stable chronic bronchitis when used over 12 weeks. 82 adults aged 40 and older took part, tracking their symptoms, satisfaction, and any side effects. The goal was to see if long-term use hel…

This study tested a new type of radiation therapy that adjusts the treatment beam each day based on the patient's current anatomy. The goal was to see if this daily adaptive approach could reduce chronic dry mouth (xerostomia) compared to standard radiation in 50 people with head…

This completed trial tested the NEUROMARK device, which uses radiofrequency to disrupt nerves in the nose, against a sham (fake) procedure in 132 adults with chronic rhinitis. The goal was to see if the device could reduce symptoms like runny nose and congestion by at least 30% a…

This study tested whether teaching COPD patients breathing exercises through short videos could reduce shortness of breath, increase activity, and improve sleep. Sixty adults with COPD followed a 30-day program of pursed-lip and diaphragmatic breathing, guided by a 5-7 minute vid…

This study tested whether using virtual reality (VR) headsets for balance exercises could help people with mild-to-moderate COPD. Fifty participants did VR training three times a week for eight weeks. Researchers measured balance, walking ability, and lung function to see if VR t…

This study tested whether using virtual reality (VR) glasses for 30 minutes each evening could improve sleep quality, reduce anxiety, and stabilize vital signs in intensive care patients with COPD. Fifty patients were split into two groups: one received VR sessions for a week, th…

This study tested Xolair (omalizumab) in 50 teenagers aged 12 to 17 with severe seasonal allergic rhinitis (hay fever) that standard treatments couldn't control. Researchers tracked side effects and how much symptoms improved. The goal was to see if Xolair is safe and effective i…

This small study tested whether acupuncture can relieve nasal congestion in people with allergic rhinitis. Eleven adults received either acupuncture or a standard nasal spray for 6 weeks. The goal was to see if acupuncture offers a safe, side-effect-free option for stuffy noses.

This study tested whether a 3-week home exercise program before lung cancer surgery could help patients recover more quickly. 90 patients with lung cancer and COPD were split into two groups: one received only chest physiotherapy, the other added home exercise training. Researche…

This study compared two surgical techniques for removing tonsils in 60 adults with chronic tonsillitis. Coblation uses low-temperature energy to remove tissue, while cold dissection uses traditional cutting. The goal was to see which method causes less pain and fewer infections a…

This study tested a triple-combination inhaler (BGF) in 171 adults with moderate-to-severe COPD. Participants received BGF, a dual-combination inhaler (BFF), or placebo in random order. The goal was to see if BGF improves breathing capacity and exercise endurance compared to the …

This Phase 2a study tested an inhaled drug called JKN2304 in 42 adults with moderate-to-severe COPD. Participants received either JKN2304, a placebo, or an active comparator (formoterol) for 14 days. The main goal was to check safety, and researchers also measured changes in lung…

This study tested whether one-on-one training from a nurse could help people with asthma or COPD use their inhalers correctly. One hundred adults who already used inhalers took part. The goal was to see if the training improved their technique, knowledge, and how well they stuck …

This study looked at whether acupuncture can reduce dry mouth (xerostomia) caused by radiation therapy in people with head and neck cancer. A total of 258 participants were randomly assigned to receive acupuncture or usual care. The main goal was to see if acupuncture improved dr…

This study tested four different anesthesia drugs in 100 children aged 3-10 having tonsil surgery. The goal was to see which drug best prevents confusion and restlessness after waking up. Researchers measured pain, agitation, and recovery quality in the recovery room.

This completed study tested a 6-week self-management program for people with COPD. The program included education, breathing exercises, walking, strength training, and relaxation techniques. Researchers measured quality of life, exercise capacity, and mood in 42 participants aged…

This study tested whether adding a propolis mouth rinse to standard oral care could prevent or reduce mouth sores in 60 COPD patients in the intensive care unit. Half the patients received propolis care for 15 days, while the other half got standard care only. Researchers checked…

This study tested a newer, potentially safer nerve block (MTP block) against the standard one (thoracic paravertebral block) for pain after chest surgery. 180 adults having lung surgery through a large chest incision were included. The goal was to see if the newer block provides …

This small study tested whether gentle electrical stimulation of the vagus or trigeminal nerve could ease severe breathlessness in people with advanced COPD. Eight participants tried both active and sham stimulation during exercise. The main goal was to see if such a study is eve…

This study tested a new device called the COMBO Endoscopy Oropharyngeal Airway in 104 adults undergoing a sedated lung procedure (fiberoptic bronchoscopy). The device combines oxygen delivery, airway support, and breathing monitoring into one tool. The goal was to see if it could…

This study tested whether a supplement called GCWB1001 can help adults with mild breathing symptoms like cough, phlegm, and chest tightness. 120 people took either the supplement or a placebo for 12 weeks. The goal was to see if symptoms improved and if it was safe.

This study followed 661 Italian adults with moderate to severe COPD who were prescribed the Trimbow inhaler. Researchers measured changes in health status using the COPD Assessment Test (CAT) and how well patients stuck to their medication over 12 months. The goal was to see if t…

This completed study looked at how two different Robitussin cough syrup regimens affect quality of life in 244 adults with coughs from the common cold. One group used a single daytime/nighttime syrup, while the other used separate daytime and nighttime syrups. Researchers measure…

This study tested the safety and effectiveness of Allegra D (fexofenadine plus pseudoephedrine) in 203 people aged 12 and older with allergic rhinitis. Participants took the medication for up to 13 days, and researchers tracked side effects and symptom improvement using nasal and…

This study tested a new ventilator mode called NAVA for people with chronic obstructive pulmonary disease (COPD) who need a breathing machine. NAVA uses the patient's own diaphragm signals to control the machine, aiming to improve comfort and reduce time on the ventilator. The st…

This study looked at whether applying an ice compress to the neck before botulinum toxin injections can reduce pain for people with spasmodic dysphonia, a chronic voice disorder. 116 adults received either ice or no ice before their injection and then filled out a pain questionna…

This study tested whether a digital multimedia education program could help older adults (60+) with COPD better manage their condition. Participants used an e-book on their phones or computers, guided by a nurse, over 8 weeks. The goal was to improve disease knowledge, self-care …

This study looked at two different breathing exercises for people with COPD, a long-term lung disease. 58 adults were split into two groups: one used a device that creates vibrations while breathing out, and the other used a special breathing technique. The goal was to see which …

This study compared two types of exercises for adults with long-term neck pain. After six weeks, those who did cervical stabilization exercises had greater improvements in pain, daily function, head posture, and voice efficiency than those who did traditional exercises. Both grou…

This study tested whether Ectoin allergy nasal spray and eye drops can relieve symptoms of hay fever (runny nose, sneezing, itchy eyes) better than a placebo. 46 adults with ragweed allergies were exposed to pollen in a special chamber. Researchers measured symptom scores and nas…

This study tested a new automatic setting (Auto-EPAP) on a ventilator to see if it could better manage airway blockages during sleep compared to the standard manual setting. It involved 23 adults with conditions like sleep apnea, COPD, or obesity-related breathing problems who al…

This study looked at whether giving the drug salbutamol (often used in asthma inhalers) through a nebulizer helps people with severe COPD who are having a flare-up and need a breathing machine. The trial included 43 adults and compared the drug to a placebo. The main goal was to …

This study tested whether giving the breathing drug salbutamol through a high-flow nasal device works as well as the usual mask method for people with COPD. 25 adults with COPD took part. The goal was to see if the new method is not worse at improving lung function.

This study followed 10 people with moderate to severe COPD in Romania who started taking the inhaler TRIXEO AEROSPHERE. Researchers measured changes in their health status and treatment satisfaction over 3 and 6 months. The goal was to see how the medication works in everyday lif…

This study tested a digital platform designed to help patients recover physically and mentally after major surgery for esophageal or laryngeal cancer. The platform offered short daily exercise sessions. The study included 30 patients and focused on whether they would use the tool…

This study tested whether L-menthol, a minty compound, can reduce breathlessness and improve exercise ability in people with COPD. Twenty adults with stable COPD cycled while researchers measured their breathing discomfort and endurance. The goal was to see if a simple, natural s…

This study tested two methods to strengthen leg muscles in 102 people with severe COPD: electrical stimulation (using pads on the skin) and stationary cycling. Both were part of a 3-4 week hospital rehab program. The goal was to see which better improves leg function and exercise…

This study tested whether adding a special breathing exercise (inspiratory muscle training) to a standard 3-week pulmonary rehab program helps reduce shortness of breath more than rehab alone. It included 38 COPD patients with normal breathing muscle strength. The goal was to see…

This study tested a medication called STALORAL Birch 300 IR in 553 children aged 5 to 17 with birch pollen allergies. The goal was to see if it safely reduces symptoms like sneezing, runny nose, and itchy eyes during pollen season. Participants received the treatment or a placebo…

This pilot study tested a 15-minute controlled breathing routine (REST) in 20 adults with COPD who reported high stress. Participants learned three yoga breathing techniques and practiced them twice daily for a week with remote guidance. The study aimed to see if the routine was …

This study tested whether a health coach can help low-income patients with COPD or asthma get better access to lung specialists and follow their advice. 328 patients from public clinics were randomly assigned to either usual care or a health coach who prepared them for specialist…

This study tested a steroid nasal spray (mometasone furoate) in 130 children aged 3-12 who snore and have sleep-disordered breathing. The goal was to see if the spray could relieve symptoms enough to avoid surgery to remove tonsils or adenoids. Children used the spray daily for 6…

This study tested whether a home-based pulmonary rehabilitation programme could help people with COPD in areas with limited healthcare resources. 128 participants either received the 8-week home programme (exercise, education, and phone support) or standard care. Researchers meas…

This Phase 3 trial tested whether a single pill containing paracetamol (pain reliever/fever reducer), fexofenadine (antihistamine), and phenylephrine (decongestant) works better than a placebo for treating cold and flu symptoms. 567 adults in Brazil took the combo pill or a place…

This study tested whether a low dose of IL-2 (a protein that helps regulate the immune system) could reduce nasal symptoms in people with birch pollen allergy. Twenty-four adults with a history of seasonal allergies received either the drug or a placebo over several months. The g…

This study tested a wearable vest called ELECTROVEST that vibrates and gently stimulates muscles to help clear mucus from the lungs. It included 21 adults with COPD, cystic fibrosis, bronchiectasis, or asthma. The vest was compared to a standard chest-vibration device to see if i…

This study tested whether using a hand fan for 10 minutes daily over six weeks could reduce shortness of breath, anxiety, and depression in people with COPD. Fifty-nine patients from a hospital in Turkey took part, with half using the fan and half receiving standard care. The goa…

This study looked at whether taking oral corticosteroids (prednisone) for 5 days can help people with COPD who are having a flare-up. The trial involved 189 adults aged 40 and older who were treated in general practice. Researchers tracked treatment failure, including emergency v…

This study tested whether taking the allergy drug fexofenadine for two days before ragweed season can reduce symptoms like sneezing and runny nose. 95 adults with ragweed allergies were randomly given either fexofenadine or a placebo. Researchers measured nasal symptoms over six …

This study tested two types of exercise programs in 36 people with COPD: one focused on breathing muscles and the other on core (abdominal and back) muscles. The goal was to see which better improves diaphragm function, breathing strength, exercise ability, and quality of life. P…

Researchers are testing whether high-definition transcranial direct current stimulation (HD-tDCS) changes brain blood flow and breathing muscle strength in adults with chronic obstructive pulmonary disease (COPD). Twenty participants receive three 20-minute sessions of brain stim…

Researchers measure levels of the protein periostin in the blood and adenoid tissue of children with enlarged adenoids. They compare children scheduled for adenoid removal with children who have only mild enlargement and no symptoms. The study asks whether periostin is linked to …

This study compares two oral formulations of pranlukast, a drug used for asthma and allergic rhinitis, to see if they are equivalent. Sixty healthy adults will receive a single dose of each version in random order under fasting conditions. The main goal is to measure drug levels …

Researchers are studying how chronic obstructive pulmonary disease (COPD) relates to sensorimotor function, thinking skills, pain sensitivity, and muscle quality. The study compares adults aged 40 to 65 with COPD at different disease stages against healthy adults of the same age.…

Researchers are studying blood and tumor tissue from people with squamous cell cancer of the larynx, pharynx, or oral cavity who have no history of smoking, heavy drinking, or workplace exposure to substances like asbestos or wood dust. The goal is to learn how DNA changes and bi…

Researchers are testing two ways to train VA primary care clinicians to hold goals of care conversations with veterans who have serious illnesses such as cancer, heart failure, or dementia. One approach gives clinicians written materials and online training. The other adds team f…

This study follows 236 smokers or ex-smokers who have respiratory symptoms but normal spirometry, a standard test for COPD. Researchers measure a different lung function called DLCO, which checks how well oxygen moves from the lungs into the blood. Participants are split into two…

This trial tests whether a new formulation of budesonide and formoterol inhalation powder delivers the same amount of medication into the body as the approved Symbicort Turbuhaler. Healthy adults aged 18 to 45 will receive a single dose of each inhaler in random order, with a 4-d…

This study follows a large group of COPD patients over many years, using routine clinic visits and standard tests. Researchers aim to describe how the disease changes over time, identify different patterns of progression, and see how various treatments affect those patterns. The …

This pilot study from the University of Aberdeen is looking at how dietary protein (from plants and animals) relates to sarcopenic obesity—a condition where muscle loss and obesity happen together—in 30 women aged 55+ with COPD. Researchers will also check lung function and infla…

This study looked at how itepekimab, an experimental drug, affects airway inflammation in 49 adults aged 40-70 with COPD who smoke or used to smoke. Participants stayed on their usual COPD medications while receiving itepekimab for 12 weeks. The goal was to understand the drug's …

This study explores how emotional, practical, and social support affects the ability of people with COPD to manage their own health. Researchers will survey 111 adults aged 40 and older with COPD, and interview 20 of them in depth. The goal is to understand what helps or hinders …

This study evaluates the 6-minute stepper test as a way to measure exercise capacity in people with COPD or interstitial lung disease. Participants will perform the stepper test, a standard walk test, and a cycling test to see if the results match. The study also checks whether t…

This study investigates whether allergic sensitivity, known as atopy, is associated with more frequent exacerbations in people with chronic obstructive pulmonary disease (COPD). Researchers will measure markers of allergy, such as IgE levels and skin prick test responses, in 100 …

This study is testing whether a simple lung ultrasound can tell the difference between a sudden COPD flare-up and stable disease. It will compare ultrasound images, breathing tests, and exercise ability in about 60 people—those with an acute exacerbation, those with stable COPD, …

This large observational study is investigating whether nitrate, nitrite, and phosphate—compounds found naturally in food and water and used as additives—are linked to chronic diseases like gastrointestinal cancers, heart disease, and respiratory conditions. Researchers will foll…

This study looks back at tissue samples from patients with nasopharyngeal carcinoma who took part in an earlier treatment trial. Researchers are using advanced genetic testing and protein analysis to look for markers linked to how long patients survive. The goal is to better unde…

This study is testing a simple questionnaire to see how well it measures allergic rhinitis (hay fever) control in children aged 5 to 11. The goal is to give doctors a reliable way to track symptoms and adjust treatments. About 135 children will fill out the questionnaire during a…

This study aims to find the lowest concentrations of ragweed and birch pollen that cause allergy symptoms in people with seasonal allergic rhinitis. Participants sit in a special chamber where pollen levels are carefully controlled, and their nasal symptoms are measured. The goal…

This study tracks how often swallowing difficulties (dysphagia) and voice changes (dysphonia) happen after anterior cervical spine surgery — a common procedure to treat a narrow spinal canal. Researchers will follow 36 patients for one year after surgery, using questionnaires and…

This study tested whether showing older hospitalized patients their own activity levels on a bedside screen could encourage them to move more. 130 adults aged 60+ with conditions like COPD, heart failure, or Parkinson's wore a small sensor and saw real-time feedback on time spent…

This study looked at how doing a mental task while standing affects balance in people with chronic lung disease (COPD). Researchers compared 36 adults with COPD to healthy volunteers to see if their balance got worse when they had to think at the same time. The goal was to better…

This study looked at whether people with COPD have trouble controlling their knee muscles during everyday tasks that require precise, gentle force. Researchers compared 36 participants (COPD patients and healthy volunteers) as they performed small, controlled leg contractions. Th…

This study investigates how the immune system responds to COVID-19 in people with chronic lung conditions like asthma, COPD, or cystic fibrosis, compared to those without lung disease. Researchers collect blood, sputum, and nasal samples to measure immune signals and gene activit…

This study looks at whether chronic lung inflammation from bronchiectasis raises the risk of heart disease and accelerates aging. Researchers will measure heart function, artery stiffness, bone density, muscle mass, and blood markers in 110 adults aged 40 to 80 with confirmed bro…

This study looks at how regular winter swimming—bathing in cold open water during winter—affects blood cells, blood flow, and stress-fighting enzymes in healthy men. Researchers compare winter swimmers to a control group who never swim in cold water and have a sedentary lifestyle…

This study tested a drug called suzetrigine, which blocks a specific nerve channel (NaV1.8) involved in pain signaling. In 67 healthy volunteers, tiny amounts were injected into the skin alongside a placebo and lidocaine. Participants received six different types of brief pain (e…

This completed observational study looked at 4500 patients admitted to internal medicine wards with heart failure, COPD, or chronic kidney disease. Researchers aimed to identify which other chronic conditions tend to cluster with these diseases, and how those clusters affect pati…

This study looks at how the community of bacteria, fungi, and viruses in the lungs changes when a person with COPD has a severe flare-up that requires intensive care. Researchers collect sputum samples from patients to analyze the genetic material of these microbes. The goal is t…

This study looked at how the nasal immune system of people with COPD reacts to a live flu vaccine (FluMist). Researchers compared those who have frequent COPD flare-ups to those who do not, to see if differences in immune response or viral replication might explain the flare-ups.…

This study looks at how mucus from the airways of people with bronchiectasis affects a new inhaled antibody treatment. Researchers will collect sputum samples from 30 adults with stable bronchiectasis and test how well the antibodies can reach and bind to bacteria in the lab. The…

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This study investigates whether spores from birch rust fungi trigger seasonal allergies in autumn. Researchers will compare 30 people with suspected birch rust allergy to 15 non-allergic controls, tracking symptoms and spore levels. The goal is to understand a possible cause of a…

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This study tested a skin sensor that measures carbon dioxide (CO2) levels continuously during exercise, comparing it to standard blood tests. Researchers included 140 healthy volunteers and people with lung or heart conditions. The goal was to see if the sensor could accurately t…

This study tested a new sensor placed inside the nose to measure carbon dioxide levels in 21 people with breathing conditions like COPD or obesity-related breathing problems. The goal was to see if the sensor is safe, easy to use, and gives accurate readings compared to standard …

This study looked at two ways to help patients breathe during throat surgery: a newer method called flow-controlled ventilation and a standard method. Researchers measured how well each method worked in 71 adults having elective throat surgery. The goal was to see if the newer me…

This study looks at how exercise training affects the growth and maturation of tiny blood vessels in the leg muscles of people with COPD. Researchers will compare healthy volunteers and COPD patients doing different exercise intensities for 5 to 10 weeks. The goal is to understan…

This early study tested a single dose of the experimental drug GSK3862995B in 30 healthy adults of Chinese, Japanese, and European ancestry. The goal was to see if the drug is processed similarly across these groups, so that future global COPD studies can include diverse particip…

This study explores whether certain blood cells called fibrocytes play a role in the airway remodeling seen in chronic obstructive pulmonary disease (COPD). Researchers will compare blood samples and lung function between people with COPD and healthy volunteers, including smokers…

This study looks at fibrocytes—cells involved in scarring—in the lungs and blood of 50 people with COPD compared to healthy controls. Researchers want to understand how these cells contribute to airway remodelling, the abnormal tissue repair that makes COPD worse. The goal is to …

This study looked at whether specific cells from the blood, called fibrocytes, are involved in muscle wasting (sarcopenia) in people with COPD. Researchers compared thigh muscle samples from 22 COPD patients with and without muscle loss. The goal was to understand why muscle loss…

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This study tested whether using a device that sends mild electrical pulses to the leg muscles (NMES) could help older adults recover strength and mobility after being hospitalized for a COPD flare-up or pneumonia. Seven participants used the device in the hospital and at home for…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study tested whether a virtual reality (VR) room called VR CAVE can teach community health nursing skills as effectively as a physical mock home. 150 final-year nursing students practiced home visits for patients with COPD and tuberculosis in both settings. Results showed bo…

This study looked at how people with COPD experience physical activity. Researchers interviewed 54 participants and had them wear activity monitors to compare standard activity levels with personalized intensity measures. The goal was to better understand how to tailor activity r…

This completed observational study included 123 adults with COPD or asthma. Researchers measured breathing muscle strength using a special device and then tried to predict those results from simpler tests like spirometry and body composition. The goal was to see if doctors could …

This study looked at how well people with COPD can learn to use three different inhaler devices: Diskus, Breezhaler, and Respimat. Twenty-four participants were taught to use each device and then checked for mistakes. The goal is to find better ways to train patients so they get …

This study looked at how using high-flow nasal oxygen during laryngeal surgery affects the heart and blood vessels. Twenty relatively healthy adults were monitored for changes in heart function compared to standard breathing support. The goal was to understand potential risks, no…

This study tested whether taking two common blood thinners (aspirin and clopidogrel) for two weeks can improve blood flow in the lungs of smokers with COPD. Fifteen current or former smokers with and without COPD participated. The goal was to see changes on a special CT scan, not…

This study looked at whether using computer-assisted navigation during sinus surgery helps people with nasal polyps. Researchers compared surgery with and without this technology in 40 patients. They tracked how often polyps came back and how many complications occurred.

This study looked at whether three blood proteins (pre-albumin, retinol binding protein, and transferrin) can help detect early malnutrition in people with advanced nasopharyngeal cancer undergoing chemoradiotherapy. Researchers tracked 60 patients to see if these proteins change…

This study tested how easy and acceptable the P-STEP mobile app is for people with chronic conditions like asthma, COPD, heart disease, or diabetes. 178 adults in Leicester, UK used the app for 12 weeks to track their walking and get air quality updates. The main goal was to meas…

This completed study used artificial intelligence to examine electronic health records from 10,000 head and neck cancer patients. The goal was to create models that can predict the risk of cancer coming back or progressing, and to identify which patients might live longer after i…

This study looked at how a new medicine called EP395, being developed for COPD, interacts with other common drugs. It involved 37 healthy adults aged 18 to 55. The goal was to see if EP395 changes how other drugs work in the body, which helps doctors use it safely in the future.

This study looked at how one night of no sleep affects shortness of breath and exercise ability in 20 people with COPD. Participants did exercise tests after a normal night and after a sleepless night to compare. The goal was to understand if sleep loss makes breathing harder dur…

This completed study from Mansoura University looked at how low fat-free mass (muscle) affects the outlook for people with COPD. Researchers studied 90 adults aged 40 and older with confirmed COPD. They used breathing tests, a 6-minute walk test, CT scans, and the BODE index to m…

This study looked at how a breathing technique called ELTGOL affects air distribution in the lungs of people with COPD and healthy volunteers. Participants lay on their side while researchers measured lung activity using a special imaging method. The goal was to understand how ma…

This study looked at 41 people who had early-stage vocal cord cancer and were treated with either surgery or radiation. The goal was to see which treatment led to better voice quality five years later. Patients filled out a questionnaire about their voice, and doctors also measur…

This completed study followed 360 adults and children with chronic respiratory and other medical conditions to see how their immune systems responded to COVID-19 vaccines over 18 months. Researchers measured antibody, T cell, and B cell levels before vaccination and every 3 month…

This study tested whether adding a brief pause at the end of each breath (end-inspiratory pause) during mechanical ventilation could help remove carbon dioxide more efficiently in patients with COPD. Fourteen deeply sedated, intubated adults with COPD were given two 30-minute ven…

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This study looked at 80 people who had a lung transplant to see if measuring neural respiratory drive (a breathing signal) and a protein called Pro-BNP could predict when their condition might get worse. The goal is to catch problems like infection or rejection early so treatment…

This completed study looked at whether substances in nasal fluid can help doctors objectively measure the severity of respiratory conditions like asthma, COPD, hayfever, and sinusitis. Researchers collected samples from 111 adults (including healthy volunteers) using a small nasa…

This study explored why some people with COPD lose muscle mass and strength (sarcopenia). Researchers measured exercise ability, frailty, and breathing in 42 adults with COPD. The goal was to find which factors most affect muscle loss, helping guide future care.

This study looked at 37 people with COPD who were having a lung-attack (sudden worsening of breathing). Researchers compared two treatment strategies: using only short-acting rescue inhalers versus adding long-acting inhalers. They used a safe, easy breathing test called oscillom…

This study tested a wearable smart textile sensor system called SimpleSense in 334 people. The device uses special sensors in a harness to record heart signals, breathing, and body movement. Researchers compared its readings to standard hospital monitors to see if it works just a…

This study looked at how breathing and swallowing interact in people with severe COPD who were in the hospital for a sudden worsening of their condition. Researchers wanted to see if using a non-invasive breathing machine (NIV) changes this interaction. Sixteen patients were obse…

This study looked at how people who had their voice box removed due to throat cancer produce a new voice. Researchers used a special high-speed camera to record vibrations in the throat and compared them to sound recordings. The goal was to better understand these substitute voic…

This completed study looked at 289 children to understand what factors increase the risk of serious complications from pharyngitis (sore throat), such as abscesses or severe neck infections. Researchers compared children hospitalized for these complications with those who had pha…

This study looked at how the lungs move chloride, sodium, and bicarbonate in 42 patients with idiopathic bronchiectasis (widened airways of unknown cause). Researchers measured electrical signals in the airway lining during bronchoscopy and took nasal and bronchial samples. The g…

This study tested whether home automation and remote monitoring can help elderly people (65+) with multiple chronic conditions live safely at home. Over 500 participants had their homes equipped with sensors that tracked health signs and sent alerts to doctors. The main goal was …

This study looked at gene activity in cells from the nose and lungs of 44 healthy and allergic adults. The goal was to understand how allergies change these cells and why the nose and lungs react differently. Researchers hope this knowledge will lead to better treatments for alle…

This study tested whether a large language model (like GPT-4) could help doctors follow official treatment guidelines for COPD. 78 hospitalized COPD patients were randomly assigned to either receive standard care or have their discharge treatment reviewed by the AI. The goal was …

This study tested a machine learning algorithm to predict if a patient being cared for at home would deteriorate. Researchers used data from over 500 patients to train the algorithm and compared its alerts to traditional vital sign alarms. The goal is to catch problems earlier an…

This study looked at data from 372 patients to see if a computer program could predict who would need to be readmitted to the hospital within 30 days. Researchers used information like age and health history to train the computer model. The goal was to find patterns that could he…

This study uses a special MRI technique with inhaled helium-3 gas to measure how fast air moves through the windpipe and lungs. Researchers will compare airflow in healthy volunteers and people with COPD or constrictive bronchitis. The goal is to gather real-world data to improve…

This study looked at how over 1,600 people's bodies react to different breakfasts, like whole grain vs. refined grain and high-fat vs. high-carb. Researchers measured blood sugar, fats, and other markers after meals to understand why responses vary. The goal is to pave the way fo…

This completed early-phase study tested a new way to study Strep A bacteria, which causes strep throat and can lead to serious heart disease. Researchers safely exposed 40 healthy adults aged 18-40 to a specific strain of Strep A under controlled conditions. The goal was to see h…

This study tested a program called ED GOAL that helps older adults with serious illnesses like heart failure or cancer discuss their end-of-life wishes with doctors and family, starting in the emergency department. Researchers enrolled 141 patients and measured whether the progra…

This study looked at whether a home visit by an environmental counselor can improve the quality of life for children with asthma or allergic rhinitis. Researchers checked the children's health at the start and again six months after the visit using standard questionnaires. The st…

This study tested three different oximeters (Masimo, Nellcor, Nonin) at various oxygen targets in 40 patients with and without COPD. The goal was to see how the choice of oximeter and target affects the amount of oxygen needed. Results could help guide safer oxygen therapy.

This early-stage study tested a single dose of an inhaled drug called DBM-1152A in 44 healthy Chinese adults. The main goal was to see if the drug is safe and how the body processes it. No treatment was given for any disease; the study simply gathered safety information to guide …

This completed Phase 1 study tested whether two substances in the blood (sST2 and miR-223) can help predict how well patients with dust mite allergies respond to a six-month course of under-the-tongue immunotherapy (SLIT). Fifty-four patients with moderate-to-severe allergic rhin…

This early-phase trial tested the safety and tolerability of an inhaled drug called DBM-1152A in 20 healthy Chinese adults. Participants received either the drug or a placebo once daily for 7 days at different dose levels. The study focused on side effects and how the drug moves …

This study looked at how nutritional supplements affect energy use in people with chronic lung disease who are already in a pulmonary rehab program. Researchers measured resting energy needs in 35 adults aged 45-80. The goal was to better understand how to support their recovery …

This study looked at 8 people with a FLNA gene mutation to see how many also had emphysema, a lung condition that damages air sacs. Participants had a chest scan, breathing tests, and a checkup with a lung doctor. The goal was to confirm if this rare genetic change is linked to u…

This completed study analyzed over 230,000 adults in France who had lower respiratory tract infections like pneumonia, bronchitis, or flu. Researchers used anonymous electronic health records from 2015 to 2024 to describe patient characteristics, how often antibiotics were prescr…

This study analyzed health records from over 3,500 people with COPD who had a severe flare-up and were later treated with the medication BGF. Researchers tracked how many additional flare-ups and heart-related events occurred over time. The goal was to understand real-world outco…

This study tested a decision support program for people with advanced COPD and their family members. The goal was to help them feel more confident and less conflicted about end-of-life care choices. 226 patients and their families took part, and researchers measured how the progr…

This study looked at whether using a Spiritual Needs Questionnaire helps identify and address the spiritual needs of patients in palliative care. About 100 patients with cancer, heart failure, COPD, or ALS took part. The goal was to see if this approach is practical and beneficia…

This study looked at 53 adults having ear surgery (tympanoplasty) with their head turned to the side. Doctors used ultrasound to measure the optic nerve sheath diameter, which can indicate pressure inside the skull. The goal was to see if the sideways head position changes that p…

This study tested a program to help doctors prescribe antibiotics more appropriately for common childhood infections like earaches, sore throats, and sinusitis. Over 1,000 doctors took part, receiving online training, personalized feedback on their prescribing habits, and support…

This study looked at 150 children and adults who had their tonsils removed using one of three surgical methods: BiZact, coblation, or bipolar. Researchers measured pain after surgery, how long the operation took, when patients could eat solid food again, and how much the devices …

This study looked at whether doing virtual reality exercises with other people (multi-player) is more motivating than doing them alone. It included 86 participants: healthy teens, children with motor disorders, and older adults with conditions like stroke or COPD. Researchers mea…

This pilot study tested whether it is possible to collect and analyze small RNA molecules from a person's breath. Researchers took breath samples from 25 volunteers (healthy people and a few with lung disease) at rest and after intense exercise. They successfully extracted and se…

This study looked at 622 veterans with chronic lung disease who had COVID-19. Researchers tracked their health outcomes, recovery, and need for rehabilitation services. The goal was to understand which factors lead to more severe illness and what support patients need after recov…

This study looked at 150 adults with COPD to see if a drop in exercise ability during pulmonary rehabilitation could predict when a flare-up (exacerbation) might happen. Researchers tracked changes in physical performance and compared them to hospital visits for COPD attacks. The…

This study looks at whether low vitamin D levels in early pregnancy are linked to breathing problems in children ages 5 to 6. Researchers measured airway resistance in 142 children whose mothers had vitamin D levels checked during the first trimester. The goal is to understand if…

This study interviewed 26 older adults (75+) with chronic illnesses who take many medications. Researchers wanted to understand how patients feel about being cared for by the same doctor over time, and what happens when they lose that regular doctor. The goal was to learn about t…

This study looked at 250 people to understand why some smokers develop a rare lung condition called combined pulmonary fibrosis and emphysema (CPFE). Researchers compared telomere length and genetic mutations in patients with CPFE, those with only fibrosis or emphysema, and healt…

This study followed 216 people with COPD and other health conditions for up to 38 months. Participants used a mobile app to log daily symptoms and other health data. The goal was to find patterns that could predict when a person might have a flare-up or get worse, so doctors can …

This study looked at 65 people with COPD to see if a simple six-minute stepper test can give similar information as a standard, more complex exercise test. The goal is to make it easier for patients to get assessed for pulmonary rehabilitation, especially in places where the stan…

This study looked at 750 people hospitalized for a COPD flare-up to find out how many also had a pulmonary embolism (a blood clot in the lung). Doctors used a standard set of tests, including a blood test and special scans, to check for clots. Participants were followed for 3 mon…

This study observed 100 people with COPD who were sedated for a stomach and colon exam. Researchers wanted to see if certain risk factors, like symptom severity or past hospital stays, could predict breathing problems during the procedure. They also tested a new monitor called th…

This study looks at whether the six-minute stepper test can reliably measure changes in exercise tolerance during a 3-week pulmonary rehabilitation program for people with COPD. Researchers will compare results from the stepper test with the standard six-minute walk test. The goa…

This study tested how a single session of one-leg cycling affects blood vessels and muscles in 26 people with COPD. The goal was to see if this type of exercise could improve oxygen use and artery health. The results may help design better exercise programs for COPD patients.

This study looked back at the medical records of 718 adults with COPD in Spain who started taking the triple-combination inhaler Trixeo. Researchers wanted to see how many lung flare-ups (exacerbations) patients had in the year after starting the drug. The goal was to understand …

This study looked at whether a special planning tool, called a POST form, helps older adults (65+) get the medical care they prefer at the end of life. Researchers worked with 389 people, including those with dementia, to see if their treatment matched their wishes. The goal was …

This study measured breathing patterns in 163 adults with asthma or COPD to help computers predict how much of an inhaled drug actually reaches the lungs. Researchers used these real-world breathing measurements to improve simulations of aerosol drug deposition. The goal is to ma…

This study looked at how a molecule called IL-5 affects different cells in the sinuses of people with nasal polyps and a related condition called aspirin-exacerbated respiratory disease. Researchers analyzed tissue samples from 30 participants to understand how IL-5 contributes t…

This study tested a new self-administered questionnaire called DYSLIM to measure shortness of breath and its impact on daily life in people with chronic respiratory diseases like COPD, cystic fibrosis, and pulmonary hypertension. Researchers enrolled 199 participants to check if …

This study looked at whether providing nutritional support to people being treated for tuberculosis (TB) improves their outcomes. Researchers compared TB patients in Benin, who receive food baskets and meals, to similar patients in Togo, who do not get systematic nutritional supp…

This completed study used chest MRI scans to look at blood flow in the lungs of 30 people with COPD. The goal was to learn how blood vessels adapt during exercise and how this relates to disease progression. By better understanding these changes, researchers hope to improve care …

This study looked at 100 people with advanced COPD to see if the fungus aspergillus in their sputum is linked to their quality of life and symptoms. Participants provided sputum samples and filled out questionnaires at the start, then again by phone after 1 and 3 months, and in p…

This study tested whether a questionnaire called VQ11 can accurately measure changes in quality of life for people with COPD who start taking a long-acting bronchodilator. Fifty-seven stable COPD patients filled out the VQ11 before and after three months of treatment. The goal wa…

This study tested whether giving doctors automated reports on their antibiotic prescribing habits could improve how often they follow official guidelines. Researchers looked at over 26,000 patients with pneumonia, ear infections, or sore throat. They compared antibiotic use befor…

This study observed how private pediatricians in France manage allergic rhinitis (hay fever) in children under 18. Over 1,000 children participated, and researchers collected data on current treatment practices, including how many kids might be eligible for allergy immunotherapy.…

This study followed 31 adults with COPD for 12 weeks to track how their inflammation levels, lung function, and symptoms change over time. Researchers measured daily lung function and symptoms, along with weekly or biweekly blood and sputum tests. The goal was to better understan…

This study followed 240 people with head and neck cancer to see how their swallowing changed from diagnosis to 18 months after their first treatment. Researchers used a questionnaire called the Deglutition Handicap Index (DHI) to measure patients' own experience of swallowing pro…

This study looked at how the body handles short-chain fatty acids (SCFAs) in people with COPD compared to healthy adults. Researchers measured SCFA metabolism and body composition in 63 participants. The goal was to understand if SCFA production is lower in COPD, which could affe…

This study reviewed medical records of 59 adults with COPD to see if a standard pulmonary rehabilitation program is safe and effective for those who also have pulmonary hypertension (high blood pressure in the lungs). Researchers compared how much walking distance improved in peo…

This study analyzed electronic medical records of nearly 920,000 Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers compared care before and during the pandemic, looking at visits…

This study looked at whether doing two 6-minute walk tests at the end of a pulmonary rehabilitation program gives a more accurate measure of exercise capacity in people with COPD. Researchers compared the distance walked in the first and second tests to see if there was a meaning…

This study tested two different ways of using a breathing machine at night to help people with COPD get off the machine faster. Nineteen patients were randomly assigned to one of two ventilation modes during sleep. Researchers measured how long it took to wean off the ventilator …

This completed study tested whether a dissolved allergy tablet (Itulazax) can be used as a nasal spray to diagnose birch pollen allergy. 89 participants received either the dissolved tablet or a saltwater spray, and their nasal symptoms and airflow were measured. The goal was to …

This completed Phase 1 study in 30 healthy volunteers looked at how cyclosporine, a drug that blocks certain transporters, affects the amount of CHF6001 (Tanimilast) in the blood. Participants took CHF6001 alone first, then again after taking cyclosporine. The goal was to see if …

This completed study tested a French version of a swallowing questionnaire for people who had their throat and voice box removed due to cancer. Researchers wanted to see if the translated survey works well for French-speaking patients. The study involved 225 adults who could read…

This completed study looked at how a special form of vitamin B3 (nicotinamide) is processed in 28 patients with low tryptophan levels due to respiratory infections or inflammatory bowel disease. Participants took either 500 mg or 1000 mg of the supplement daily for four weeks. Th…