Could a simple saltwater spray ease your next cold?
NCT ID NCT07267689
First seen Jun 25, 2026 · Last updated Jul 24, 2026 · Updated 3 times
Summary
This study is testing a hypertonic seawater aerosol spray (a saltwater mist) to see if it helps relieve nasal symptoms, improve sleep, and thin mucus in people with colds, sinus infections, or similar upper respiratory infections. About 110 adults and children aged 2 and older will use the spray twice daily for 7 days at home. The goal is to check if the spray is safe and effective for easing symptoms.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- hypertonic seawater aerosol solution
- What this could lead to
- If it works, this could provide a simple, drug-free option to relieve cold and sinus symptoms at home.
- What could go wrong
- This is a small, non-comparative study with no placebo group, so results may not prove the spray works better than doing nothing. It only tracks symptoms for 7 days.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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110 people
The number who actually took part.
- Started
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Apr 2026
- Finished
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May 2026
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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2 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adult subject voluntarily given informed consent to investigation participation in writing encompassing consent to data recording and verification procedures. 2. Minor subjects (7-17 years old) given informed assent to investigation participation in writing encompassing consent to data recording and verification procedures 3. Male and female subjects, aged from 2 years old; 4. Subject diagnosed with URTIs such as rhinopharyngitis, rhinitis, acute rhinosinusitis or cold based on the medical examination done by the doctor. 5. Subject willing to adhere to the requirements of the protocol, including availability for follow-up visits 6. Subject who agrees to no use decongestants, corticosteroids, antibiotics, allergen-specific immunotherapy, antihistamines, non-steroidal anti-inflammatory drugs (NSAIDs), local nasal antiseptics, other nasal saline solutions or irrigations, nasal sprays, nasal creams or gels, systemic analgesics or antipyretics (except paracetamol if needed); 7. Subject who is able to comply with the study requirements, at the Investigator's appreciation. 8. For minor (\<18) subjects, parents/guardians willing and able to sign written consent 9. Subject able and willing to use an internet-enabled device (computer, tablet, or smartphone) to complete study procedures (online questionnaires) and have regular access to a device with internet connectivity (personal or household device) for the duration of the study. Exclusion Criteria: 1. Person with hypersensitivity to seawater 2. Subject who previously undergone bronchospasm 3. Children under 2 years of age 4. Pregnant and breastfeeding women 5. Onset of URTI symptoms \> 48 hours 6. Subject with COVID or flu 7. Subject presenting alarm symptoms (periorbital oedema/erythema, displaced globe, double vision, ophthalmoplegia, reduced visual acuity, severe headache, frontal swelling, signs of sepsis, sign of meningitis, neurological signs) at the day of inclusion 8. Subject known to have allergy to the components of the masks that is used with the inhalation device; 9. Subject with asthma, 10. Subject presenting infection or pathology of the inferior respiratory tracts; 11. Subject with chronic nasal obstruction (polypes) 12. Subject who used any decongestants, corticosteroids, antibiotics or allergen-specific immunotherapy within 4 weeks prior to inclusion; 13. Subject who used any antihistamines, non-steroidal anti-inflammatory drugs (NSAIDs) or local nasal antiseptics within 7 days prior to inclusion; 14. Subject who used any nasal saline solutions or irrigations, nasal sprays, nasal creams or gels, systemic analgesics or antipyretics within 24 hours prior to inclusion; 15. Subject with drug or alcohol abuse 16. Subjects who is deprived for their freedom by administrative or legal decision 17. Subject living in a social or sanitary establishment. 18. Subject being in an exclusion period for a previous study or with a current or recent (\<3 months) participation in another investigational study involving a drug or combined device with drug. 19. Other condition preventing the subject to participate the study in the investigator's opinion: subject deemed unreliable or incapable of understanding and complying with the study assessment or unrealistic expectations of treatment results
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centrum Medyczne PZU Zdrowie
Kielce, 25-017, Poland
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Centrum Medyczne Zdrowie
Kielce, 25-713, Poland
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Centrum Nowoczesnych Terapii "Dobry Lekarz"
Krakow, 31-011, Poland
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Krajmed Centrum Medyczne
Warsaw, 02-743, Poland
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