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Can mushroom and apple compounds boost your immune system?

NCT ID NCT05190432

Knowledge-focused Sponsor: University of Southampton Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study is testing whether two natural dietary supplements—taxifolin (found in apples and onions) and ergothioneine (found in mushrooms)—can improve immune function in healthy adults aged 50 to 65. Researchers will measure how well immune cells engulf and destroy threats. The goal is to understand if these compounds can help counter age-related immune decline.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Taxifolin (dihydroquercetin) and ergothioneine dietary supplements
What this could lead to
If successful, this study could point toward dietary strategies to support immune function in aging adults.
What could go wrong
This is a small, early pilot study in healthy volunteers, not designed to prove any health benefit. Results may not apply to the general population or lead to any treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

90 people

The number who actually took part.

Started

Nov 2021

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age 50-65yr * BMI 18.5-30kg/m2 * Willing to avoid consumption of foods rich in Taxifolin/DHQ and Ergothioneine during the study period * Willing to avoid taking any other food supplements or high doses of vitamins during the study period * Able to provide written informed consent. Exclusion Criteria: * Use of prescription medication which may influence immune function, such as anti-inflammatory or immunosuppressant medication * Diabetes requiring any medication * Liver cirrhosis * A history of drug or alcohol misuse * Asplenia or other acquired or congenital immunodeficiencies * Any autoimmune disease including connective tissue diseases * Malignancy * Laboratory confirmed SARS-CoV-2 infection within last 3 months * self-reported symptoms of acute or recent infection (including use of antibiotics within the last 3 months)

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease common cold Inflammation inflammatory disease influenza

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Antioxidative stress COLD Inflammation Influenza

Contacts and locations

Locations

  • NIHR Southampton Biomedical Research Centre

    Southampton, Hampshire, SO16 6YD, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.