Smart ventilator adjusts breath support automatically for COPD patients
NCT ID NCT04848012
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a new type of breathing machine that automatically adjusts its settings to match each person's breathing in real time. Fifteen people with severe COPD who already use a ventilator at home tried the device for six weeks. The goal was to see if the smart ventilator helps them use the therapy longer and more comfortably compared to their usual machine.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Auto-titrating non-invasive ventilator
- What this could lead to
- If successful, this could make nightly breathing therapy more comfortable and easier to stick with for people with severe COPD, potentially reducing hospital visits.
- What could go wrong
- This is a small, early-stage study with only 15 participants, so results may not apply to everyone. The device may not improve adherence or could cause discomfort.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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15 people
The number who actually took part.
- Started
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May 2021
- Finished
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Dec 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Patient Inclusion Criteria: * Age ≥ 18 years * BMI \<30 kg/m¬2 * Confirmed diagnosis of COPD * Currently using domiciliary NIV with average reported compliance of at least 3hours * Ability to provide informed consent * Medical stability confirmed by recruiting physician * Free of exacerbations for at least 2 weeks prior to enrolment * Presence of expiratory flow limitation on forced oscillation technique criteria Exclusion Criteria: * Current acute illness as determined by recruiting physician e.g. upper respiratory tract infection * Presence of major medical comorbidity, e.g. severe heart failure (LVEF \<30%), active malignancy, end-stage renal failure (CKD 4), and neuromuscular disease * Subjects who have had surgery of the upper airway, nose, sinus, or middle ear within the previous 90 days. * Psychosocial factors that would prevent compliance with study protocol Healthy participant inclusion criteria: * Age ≥ 18 years * No expiratory flow limitation on forced oscillation testing * No acute illness on study day * Ability to provide informed consent
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Guys and St Thomas NHS Foundation Trust
London, London, SE1 7EH, United Kingdom
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