New Botox-Like shot may give voice disorder patients months of relief
NCT ID NCT05158166
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a new type of botulinum toxin injection (DAXI) for people with adductor spasmodic dysphonia, a condition that causes the voice to spasm and sound strained. 22 adults who had previously been helped by standard Botox injections received a single DAXI injection into their voice box muscles. The goal was to see if DAXI could provide longer-lasting voice improvement, potentially reducing the need for repeat injections every few months.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
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22 people
The number who actually took part.
- Started
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Oct 2023
- Finished
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Mar 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * greater than 18 * diagnosis of adductor spasmodic dysphonia * previous successful treatment with BotoxA * stabilized dose for last 3 treatments Exclusion Criteria: * age less than 18 * exclusively having other neurologic conditions such as: * abductor spasmodic dysphonia * ALS * Multiple sclerosis * Parkinson's disease * Essential tremor
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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UCSF
San Francisco, California, 94118, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Could a simple zinc pill make botox last longer for voice spasms?
- Wearable biofeedback could help voice therapy stick in daily life
- Could magnetic pulses to the brain ease a rare voice disorder?
- Vibrating neck device may help rare voice disorder
- Simple straw exercise may help soothe tired voices