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Simple breathing pause may help clear CO2 in COPD patients on ventilators

NCT ID NCT07207967

Knowledge-focused Sponsor: Sanatorio Anchorena San Martin Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding a brief pause at the end of each breath (end-inspiratory pause) during mechanical ventilation could help remove carbon dioxide more efficiently in patients with COPD. Fourteen deeply sedated, intubated adults with COPD were given two 30-minute ventilation patterns—one with the pause and one without. The researchers measured blood gases and lung mechanics to see if the pause improved CO2 clearance without causing lung overinflation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
end-inspiratory pause (a breathing pattern adjustment during mechanical ventilation)
What this could lead to
If this approach works, it could help doctors ventilate COPD patients more efficiently, potentially reducing the risk of complications from high carbon dioxide levels.
What could go wrong
This was a very small, short-term study (14 patients, 30-minute test periods). Results may not apply to all COPD patients or to longer-term ventilation. The technique could still cause lung overinflation in some cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

14 people

The number who actually took part.

Started

Oct 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * deeply sedated and intubated adults with COPD exacerbation, PaCO2 ≥ 45 mmHg and no signs of respiratory effort * sign the informed consent Exclusion Criteria: * Persistent air-leaks, severe hemodynamic instability, pregnancy or intracranial hypertension were exclusion criteria.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease COPD, severe early onset Positive-Pressure Respiration, Intrinsic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COPD (chronic obstructive pulmonary disease)

Contacts and locations

Locations

  • Sanatorio Anchorena San Martín

    San Martín, Buenos Aires, B1650, Argentina

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