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Bee product mouthwash may prevent painful mouth sores in ICU patients

NCT ID NCT07426198

Symptom relief Sponsor: TC Erciyes University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding a propolis mouth rinse to standard oral care could prevent or reduce mouth sores in 60 COPD patients in the intensive care unit. Half the patients received propolis care for 15 days, while the other half got standard care only. Researchers checked their mouths on days 1, 7, and 15 to see how the sores developed.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
propolis
What this could lead to
If it works, this could offer a simple, natural mouth rinse to help prevent painful mouth sores in ICU patients with COPD.
What could go wrong
This is a small, completed trial with only 60 patients, so results may not apply to everyone. Propolis can cause allergic reactions in people allergic to bees.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Jan 2025

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18 years or older, * diagnosed with COPD, * no oral mucositis at the start of the study, * no known allergy to bees or bee products, * able to speak and understand Turkish and communicate effectively, * conscious, * without any psychiatric illness, * without any mental or physical disability that would prevent them from answering questions, * individuals who volunteered to participate in the study were included in the study. Exclusion Criteria: * individuals with a cancer diagnosis, * individuals receiving immunosuppressive therapy, * individuals receiving mechanical ventilation support, * individuals with altered consciousness or acute confusion, * individuals who did not volunteer to participate in the study were excluded from the research.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease stomatitis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Oral mucositis

Contacts and locations

Locations

  • Erciyes University

    Talas, Kayseri, 38039, Turkey (Türkiye)

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