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Could a single steroid shot ease tonsillectomy recovery?

NCT ID NCT03079453

Symptom relief Sponsor: Bezmialem Vakif University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time

Summary

Researchers are testing whether injecting dexamethasone, a steroid, into the soft palate during tonsillectomy reduces uvula swelling and improves recovery. The study includes 74 adults aged 18 to 44 having tonsillectomy for recurrent tonsillitis. Half receive the steroid injection and half receive a saline injection. The team compares swelling, pain, swallowing difficulty, speech problems, and breathing discomfort over the first five days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexamethasone, a steroid given as a local injection during tonsillectomy
What this could lead to
If it works, a single injection during tonsillectomy could become a simple way to reduce throat swelling and make recovery more comfortable.
What could go wrong
This is a small, single-center study of 74 adults. The injection may not meaningfully reduce swelling or pain, and steroids can carry risks like delayed healing or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

74 people

The number who actually took part.

Started

Jul 2018

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 44 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Adults aged 18-44 years Scheduled for elective bilateral tonsillectomy Indication for surgery: recurrent tonsillitis Exclusion Criteria: Age \<18 years Obstructive sleep apnea Concomitant surgical procedures Acute tonsillitis or peritonsillar abscess at the time of surgery Perioperative systemic corticosteroid use ASA physical status III or higher

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Conditions

The condition(s) this trial relates to.

Edema tonsillitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Edema Tonsillar surgery complications

Contacts and locations

Locations

  • Bezmialem Vakif University

    Istanbul, Fatih, 34093, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.