New oxygen method tested for COPD emergencies
NCT ID NCT03488628
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether high-flow nasal oxygen therapy works as well as standard noninvasive ventilation for people with a moderate COPD flare-up. Fifty-one patients were randomly assigned to one of the two treatments for the first 24 hours. The main goal was to see how each method affected blood gas levels and safety.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- High-flow nasal oxygen therapy
- What this could lead to
- If this works, it could offer a more comfortable breathing support option for COPD flare-ups, potentially reducing the need for face masks.
- What could go wrong
- This is a small pilot study with only 51 patients, so results may not apply to everyone. It also does not test long-term outcomes or survival.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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51 people
The number who actually took part.
- Started
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Jun 2018
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age \> 18 * Known Chronic Obstructive Pulmonary disease (COPD) * respiratory rate or presence of accessory respiratory muscles activity on physical exam * moderate exacerbation of COPD as defined by an arteria pH between 7.25 and 7.35 and an arterial carbon dioxide partial pressure (PaCO2) equal or above 45 mm Hg Exclusion Criteria: * Age below 18 * Pregnancy * Known sleep apnea syndrome * Patent treated by noninvasive ventilation at home * Not affiliated to French scial security * Contraindication to aither Noninvasive ventilation or to High-Flow Nasal Oxygen therapy * Previous inclusion in the study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHR d'Orléans
Orléans, 45067, France
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