Centre Hospitalier Régional D'orléans

This study is testing two different ways to remove a breathing tube from patients in the intensive care unit (ICU). Researchers want to know if using suction to clear the tube right before removal helps patients breathe better afterwards compared to not using suction. About 120 a…

This study is testing whether carefully raising patients with severe lung failure (ARDS) to a more upright position in bed is safe and practical. It will compare this 'verticalization' technique to the standard 'prone' (face-down) position to see if it helps patients get similar …

This study aims to find out if a simple calf measurement with a tape measure works as well as a special X-ray scan for diagnosing sarcopenia (serious muscle loss) in hospitalized people aged 75 and older. Researchers will compare the two methods in 298 participants to see if the …

This study is testing if blood drawn from a patient's existing central line (a tube in a large vein) gives the same accurate result for a common blood-thinner test as the standard, often painful, needle stick in the arm. Researchers will compare two different flushing methods for…

This study is testing whether getting ICU patients who are on breathing machines to sit in a chair helps them recover strength and function better than staying in bed. Researchers will compare two groups: one that sits in a chair and one that stays sitting up in bed. They want to…

This study aims to find the best way to reduce pain from monthly injections of HIV medication. It will test if using a virtual reality headset as a distraction or injecting in a different spot on the buttock helps. About 120 adults with well-controlled HIV will try all four combi…

This study is testing whether a special training program using your own voice, hearing, and body movements can help reduce the distress caused by chronic tinnitus (ringing in the ears). Researchers are enrolling 56 adults with bothersome tinnitus to see if this training improves …

This small, early study is testing whether using a robotic arm to hold an ultrasound device helps doctors give steroid injections for carpal tunnel syndrome. It will compare the robot-assisted method to the standard manual method in 20 patients to see if it's safe, accurate, and …

This study is testing whether daily breathing muscle training can help reduce daytime sleepiness in adults with obstructive sleep apnea. Researchers will compare a group doing the breathing exercises with a group receiving standard care. The goal is to see if this simple training…

This study aims to find out if measuring oxygen levels with a standard facemask is accurate enough for critically ill patients who need a breathing tube placed. Researchers will compare the facemask readings to a more precise measurement taken through a small tube in the nose and…

This study aims to understand how long the protective antibodies from COVID-19 and Monkeypox vaccines or treatments last in the body. Researchers will follow 30 adults for up to 5 years, collecting blood and nasal samples to measure antibody levels over time. The goal is to gathe…

This study aims to understand how taking probiotic supplements and/or starting an exercise program affects body composition and general health in healthy women. Researchers will enroll 120 non-athletic female university students and randomly assign them to take either probiotics …

This study aims to compare two different ways of giving extra oxygen to healthy volunteers before a breathing tube placement procedure. Researchers will measure oxygen levels in the body using two monitoring methods to see which oxygen delivery technique works better. The study i…

This is a laboratory study to understand how different compounds from the cannabis plant affect immune cells. Researchers will take a small extra blood sample from 100 patients with chronic inflammatory diseases like rheumatoid arthritis, lupus, or Crohn's disease. In the lab, th…

This study aims to understand how HIV affects the body's cellular cleanup system called autophagy, even in patients whose virus is well-controlled with medication. Researchers will compare blood samples from 180 HIV-positive adults on different treatment paths with samples from h…

This is a long-term observational study aiming to understand why medical students experience high rates of depression and anxiety. Researchers will follow up to 10,000 students over many years, comparing those in medical school to those who were not accepted. The goal is to ident…

This study aims to find out if simple body measurements can help predict how well someone will recover after a stroke. Researchers will measure muscle mass and composition in 250 stroke patients shortly after their stroke. They will then check if these measurements are linked to …

This study aims to understand if and how much CBD passes from mothers into breast milk and their babies. Researchers will recruit 60 breastfeeding mothers in France who use CBD and measure CBD levels in their blood, milk, and their infants' urine. The goal is to gather basic safe…

This study aims to see if food allergy skin tests give the same results when using fresh food versus food that has been frozen or stored for a while. Researchers will test 100 adults with diagnosed food allergies by performing skin prick tests with both fresh and stored samples o…

This study aims to understand how chronic kidney disease affects the immune system, particularly why patients with advanced disease are more vulnerable to serious infections. Researchers will compare blood samples from 100 people across three groups: those with end-stage kidney d…