Centre Hospitalier Régional D'orléans

This study looks at 600 adults with infections caused by a hard-to-treat bacteria called Pseudomonas aeruginosa. Researchers want to see which antibiotic works best to cure the infection and prevent it from coming back. The goal is to improve treatment for people with these stubb…

This study compares using a tape measure around the calf to a standard X-ray method for diagnosing sarcopenia (age-related muscle loss) in hospitalized patients aged 75 and older. Researchers will enroll 298 participants to see if the simple calf measurement is accurate enough to…

This study tests a training program where people with chronic tinnitus use their own voice and movements to create sounds that mask or quiet the ringing. Researchers will compare how much tinnitus bothers participants who do the training versus those who don't, using questionnair…

This study tests whether a new device using cold helium plasma is safe and tolerable for people with chronic wounds, such as leg ulcers or pressure sores. About 40 adults with wounds that have not healed for over 4 weeks will receive the treatment. The goal is to see if cold plas…

This study tests whether a continuous apomorphine pump can reduce muscle stiffness and improve comfort for people with advanced Parkinson's disease who are nearing the end of life. The trial will enroll 80 patients receiving home hospital care. The goal is to ease suffering and i…

This study looks at two ways to reduce pain from HIV injections: changing the injection site (from the buttock to the hip area) and using a virtual reality headset during the shot. About 120 people with well-controlled HIV will try all four combinations of site and VR use. The go…

This study looks at whether safely sitting up patients with severe lung injury (ARDS) can improve oxygen levels as well as the standard face-down position does. Researchers will test this in 32 adults who are already on a breathing machine. The goal is to see if the sitting-up me…

This study tests whether using a robotic arm to guide an ultrasound probe makes carpal tunnel injections more accurate and less painful than the standard manual method. Twenty adults with moderate to severe carpal tunnel syndrome will receive a corticosteroid injection either by …

This study tests whether a special breathing exercise program (inspiratory muscle training) can reduce daytime sleepiness in adults with obstructive sleep apnea who already use a CPAP machine. About 58 participants will be randomly assigned to add the breathing exercises or conti…

This study looks at whether moving patients who are on breathing machines out of bed and into a chair helps them regain strength and function better than staying in bed. About 150 adults in the ICU will be randomly assigned to either chair sitting or bed sitting. The goal is to s…

This study follows up to 10,000 medical students in Orleans, France, for up to 22 years to understand what leads to depression and other mental health problems. Researchers will compare students who enter medical school with those who don't, using yearly questionnaires. The goal …

This study aims to confirm that a French translation of the Foot Health Status Questionnaire (FHSQ) is accurate and reliable. Researchers will test the questionnaire with 150 adults visiting a podiatry clinic in France. The goal is to ensure the survey correctly measures foot hea…

This study looks at how HIV affects a natural cell cleanup process called autophagy, which helps keep cells healthy. Researchers will compare HIV patients on different treatment schedules and healthy volunteers to see if this process is broken. The goal is to better understand wh…

This study is looking at how well antibodies in the blood and nose can neutralize the viruses that cause COVID-19 and monkeypox. Researchers will follow 30 adults who have received vaccines or antibody treatments for these diseases. The goal is to understand how long this protect…

This study looks at whether suctioning the breathing tube before removing it helps ICU patients maintain better oxygen levels. About 120 adults who have been on a breathing machine for over 48 hours will take part. Researchers will compare oxygen levels three hours after tube rem…

This study looks at whether using frozen or stored foods for skin prick tests gives the same results as using fresh foods. About 100 adults with known food allergies will be tested with both fresh and preserved versions of the same foods. The goal is to see if clinics can reliabl…

This study looks at whether measuring oxygen in exhaled air through a facemask is reliable for critically ill patients who need a breathing tube. Low oxygen is a common complication during this procedure. The researchers will compare facemask readings to a more direct measurement…

This study looks at how chronic kidney disease affects the immune system, specifically T-cells, which help fight infections. Researchers will analyze blood samples from 100 patients to understand immune weakness. They will also test a new lab technique to engineer T-cells that mi…

This study looks at whether blood taken from a central venous catheter (a large tube placed in a vein) can give accurate readings of the blood thinner heparin, compared to the standard method of drawing blood from a vein in the arm. About 30 intensive care unit (ICU) patients on …

This study looks at how natural cannabis compounds (like CBD and THC) affect immune cells from 100 people with chronic inflammatory diseases such as rheumatoid arthritis, lupus, and inflammatory bowel disease. Researchers will take a blood sample and expose the cells to different…

This study looks at whether taking probiotics, doing physical activity, or both can change body composition (like muscle mass) in healthy women. About 120 female university students who don't currently exercise will be split into four groups: probiotics with exercise, probiotics …

This study looks at how much CBD (a legal, non-addictive substance) passes from a mother's blood into her breast milk and whether it can be found in her baby's urine. Researchers will measure CBD levels in mothers' blood and milk at different times after birth. The goal is to und…

This study looks at how runners' emotions and coping strategies change during an 80-kilometer ultra-endurance race and how these factors affect their performance and fatigue. Researchers will track 80 healthy adult participants before, during, and after the race using surveys and…

This study looks at how runners' minds handle a very long, 120-kilometer race. Researchers want to understand how people's emotional habits and coping styles affect their feelings, tiredness, and performance during the race. About 80 healthy adults who are already signed up for t…

This study explores whether simple body measurements, like muscle size and electrical properties, can help predict how well someone will recover after a stroke. Researchers will measure the thickness and surface area of a jaw muscle and use a special scale to assess body composit…