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New drug shows promise in cutting COPD attacks

NCT ID NCT05037929

Disease control Sponsor: Genentech, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called astegolimab in over 1,300 people with COPD who have frequent flare-ups. The goal was to see if adding this drug to standard care could reduce the number of moderate to severe COPD attacks over a year. Participants were current or former smokers with a history of at least two flare-ups in the past two years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

1,334 people

The number who actually took part.

Started

Oct 2021

Finished

Jul 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Documented physician diagnosis of COPD for at least 12 months * History of frequent exacerbations, defined as having had two or more moderate or severe exacerbations occurring within a 12-month period in the 24 months prior to screening * Post-bronchodilator FEV1 \>=20 and \<80% of predicted normal value at screening * Modified Medical Research Council (dyspnea scale) (mMRC) score \>=2 * Current or former smoker with a minimum of 10 pack-year history * History of one of the following combinations of optimized, stable, standard-of-care COPD maintenance therapy for at least 4 weeks prior to screening, with no anticipated changes in therapy prior to initiation of study drug and throughout the study: Inhaled corticosteroid (ICS) plus long-acting beta-agonist (LABA); Long-acting muscarinic antagonist (LAMA) plus LABA; ICS plus LAMA plus LABA Exclusion Criteria * Current documented diagnosis of asthma according to the Global Initiative for Asthma guidelines or other accepted guidelines within 5 years prior to screening * History of clinically significant pulmonary disease other than COPD * History of long-term treatment with oxygen at \>4.0 liters/minute * Lung volume reduction surgery or procedure within 12 months prior to screening * Participation in or planned participation in a new pulmonary rehabilitation program. Patients who are in the maintenance phase of a rehabilitation program are eligible * History of lung transplant * Occurrence of moderate or severe COPD exacerbation, COVID-19, upper or lower respiratory infection, pneumonia, or hospitalization of 24 hours duration within 4 weeks prior to initiation of study drug * Treatment with oral, IV, or IM corticosteroids within 4 weeks prior to initiation of study drug * Initiation of a methylxanthine preparation, maintenance macrolide therapy, and/or PDE4 inhibitor within 4 weeks prior to screening * Unstable cardiac disease, myocardial infarction, or New York Heart Association Class III or IV heart failure within 12 months prior to screening

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic obstructive pulmonary disease

Contacts and locations

Locations

  • AZ Delta

    Roeselare, 8800, Belgium

  • AZ Sint-Maarten

    Mechelen, Antwerpen, 2800, Belgium

  • Aalborg Universitetshospital

    Aalborg, 9000, Denmark

  • Alfredo Berrocal Kasay Reuma Sociedad de Responsabilidad Limitada

    Lima Cercado, 000000, Peru

  • Allianz Research Institute Inc

    Westminster, California, 92683, United States

  • American Health Research Inc.

    Charlotte, North Carolina, 28277, United States

  • Amphia Ziekenhuis

    Breda, 4819 EV, Netherlands

  • Aotearoa Clinical Trials Trust

    Auckland, 2025, New Zealand

  • Asklepios MVZ Bayern GmbH

    Landsberg, 86899, Germany

  • Assuta Ashdod Medical Center

    Ashdod, 7747629, Israel

  • Barzilai Medical Center

    Ashkelon, 7830604, Israel

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • Blessing Health Hannibal

    Hannibal, Missouri, 63401, United States

  • Bluewater Clinical Research Group

    Sarnia, Ontario, N7T 4X3, Canada

  • Box Hill Hospital

    Box Hill, Victoria, 3128, Australia

  • Bradford Royal Infirmary

    Bradford, BD9 6RJ, United Kingdom

  • Burlington Lung Clinic

    Burlington, Ontario, L7N 3V2, Canada

  • CARE - Centro de Alergia y Enfermedades Respiratorias

    CABA, C1414AIF, Argentina

  • CARE Clinical Research

    St Louis, Missouri, 63141-6823, United States

  • CHU UCl Namur asbl - Site Godinne

    Yvoir, 5530, Belgium

  • CHU de Nice

    Nice, 06001, France

  • CHUS H Clinico U de Santiago

    Santiago de Compostela, LA Coruna, 15706, Spain

  • CICUM San Miguel

    Guadalajara Centro, Jalisco, 44100, Mexico

  • CIMS-Studienzentrum Bamberg,

    Bamberg, Germany

  • Cadena Care Institute, LLC

    Poway, California, 92064-2021, United States

  • Cambridge University Hospitals NHS Foundation Trust

    Cambridge, CB2 0QQ, United Kingdom

  • Canterbury Respiratory Research Group

    Christchurch, 8011, New Zealand

  • Cardio-Pulmonary Associates

    Chesterfield, Missouri, 63017-3627, United States

  • Carolina Research Center

    Shelby, North Carolina, 28150-3803, United States

  • Catholic Univ. of Incheon St.Mary's Hospital

    Incheon, 21431, South Korea

  • Centro Integral de Medicina Respiratoria (CIMER)

    San Miguel de Tucumán, T4000CBC, Argentina

  • Centro Medico IPAM

    Rosario, Santa Fe Province, S2001SBK, Argentina

  • Centro Médico Dra de Salvo

    Buenos Aires, C1426ABP, Argentina

  • Centro Médico Respire

    San Fernando, B1646EBJ, Argentina

  • Centro Respiratorio Quilmes

    Quilmes, B1878FNR, Argentina

  • Centro de Especialidades Medicas Lobos

    Lobos, B7240AAN, Argentina

  • Centro de Investigacion Medico Biologico y Terapia Avanzada, S.C.

    Guadalajara, Jalisco, 44130, Mexico

  • Centro de Investigacion del Maule

    Talca, Chile

  • Centro de Investigacion y Atencion Integral Durango CIAID

    Durango, 34080, Mexico

  • Centro de Investigaciones Clínicas Belgrano

    Buenos Aires, 7240, Argentina

  • Centro de Investigaciones Medicas Mar Del Plata

    Mar del Plata, 7600, Argentina

  • Centro de Investigaciones Medicas Respiratorias

    Providencia, Región-MetropolitanadeSantiago, 7500000, Chile

  • Centro de Investigación Curico

    Curicó, 3340000, Chile

  • Centrum Alergologii Teresa Hofman

    Poznan, 60-214, Poland

  • Centrum Medyczne ALL-MED

    Krakow, 30-033, Poland

  • Centrum Medyczne Bydgoszcz- PRATIA - PPDS

    Bydgoszcz, 85-796, Poland

  • Chonbuk National University Hospital

    Jeonju, 54907, South Korea

  • Clinica Internacional

    Lima, Lima 01, Peru

  • Clinica Providencia (Inverconsult Sociedad Anonima)

    Lima, 32, Peru

  • Clinica Ricardo Palma

    Lima, Lima 27, Peru

  • Clinical Research of Gastonia

    Gastonia, North Carolina, 28054-7481, United States

  • Clinical Research of Rock Hill

    Rock Hill, South Carolina, 29732-1160, United States

  • Clinical Site Partners - Leesburg Suite 101 - HyperCore - PPDS

    Leesburg, Florida, 34748-5077, United States

  • Clinical Site Partners - Winter Park - HyperCore - PPDS

    Winter Park, Florida, 32789-4681, United States

  • Clinical Trial Systems

    City of Tshwane, 0186, South Africa

  • Diamond Clinic

    Krakow, 31-559, Poland

  • Dobrostan Gabinety Lekarskie

    Wroclaw, 53-301, Poland

  • Dr A.C Wilhase practice-Reimed

    Ekurhuleni, 1459, South Africa

  • Dr. Victor Babes Foundation

    Bucharest, 030303, Romania

  • EMED Centrum Uslug Medycznych Ewa Smialek

    Rzeszów, 35-205, Poland

  • ETG Lodz

    Lódz, 90-302, Poland

  • ETG Lublin

    Lublin, 20-412, Poland

  • ETG Siedlce

    Siedlce, 08-110, Poland

  • ETG Warszawa- PPDS

    Warsaw, 02-793, Poland

  • Enroll SpA - PPDS

    Providencia, 7500587, Chile

  • Exordia Medical Research, Inc.

    Fall River, Massachusetts, 20723, United States

  • Flinders Medical Centre

    Bedford Park, South Australia, 5042, Australia

  • Florida Institute for Clinical Research, LLC

    Orlando, Florida, 32825-4454, United States

  • Fundacion Cidea

    Buenos Aires, C1121ABE, Argentina

  • Fysikalisk Medicin i Stockholm AB

    Lidingö, 181 29, Sweden

  • Gemeinscharftspraxis Dres Jung - Deggingen

    Deggingen, 73326, Germany

  • Gentofte Hospital

    Hellerup, 2900, Denmark

  • Glenfield Hospital

    Leicester, LE3 9QP, United Kingdom

  • Hospital Carlos Van Buren

    Valparaíso, 2340000, Chile

  • Hospital General Universitario Gregorio Maranon

    Madrid, 28007, Spain

  • Hospital Universitario Fundacion Jimenez Diaz.

    Madrid, 28040, Spain

  • Hospital Universitario Marques de Valdecilla

    Santander, Cantabria, 39008, Spain

  • Hospital Universitario Virgen de Las Nieves

    Granada, 18012, Spain

  • Hospital Universitario Virgen de la Victoria

    Málaga, 29010, Spain

  • Hospital de Merida

    Mérida, Badajoz, 06800, Spain

  • Hospital de San Pedro de Alcantara

    Cáceres, 10003, Spain

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, 000000, Spain

  • Hvidovre Hospital

    Hvidovre, DK-2650, Denmark

  • Hôpital de La Croix Rousse

    Lyon, 69004, France

  • INSARES

    Mendoza, M5500CCG, Argentina

  • Indywidualna Specjalistyczna Praktyka Lekarska lek.

    Kielce, 25-751, Poland

  • Inst. of Healthcare Assessment, Inc.

    San Diego, California, 92120, United States

  • Instituto Ave Pulmo

    Mar del Plata, B7602DCK, Argentina

  • Instituto De Enfermedades Respiratorias E Investigacion Medica

    San Juan Bautista, CP 1888, Argentina

  • Instituto Jalisciense de Investigacion Clinica S.A. de C.V.

    Guadalajara, Jalisco, 44100, Mexico

  • Instituto Medico Fundacion Grupo Colaborativo Rosario Investigacion y Prevencion Medica

    Rosario, S2013OJN, Argentina

  • Instituto de Investigaciones Clinicas-Mar del Plata

    Buenos Aires, B7600FZN, Argentina

  • Instituto de Medicina Respiratoria, IMeR

    Córdoba, X5003DCE, Argentina

  • Investigaciones en Patologias Respiratorias

    San Miguel de Tucumán, 4000, Argentina

  • Isala Klinieken

    Zwolle, 8011 JW, Netherlands

  • Jasper Summit Research LLC

    Jasper, Alabama, 35501, United States

  • KASMED s.r.o.

    Tábor, 390 02, Czechia

  • KPPK Studienzentrum Kroker-Schmidt

    Bendorf, 56170, Germany

  • Kaplan Medical Center

    Rehovot, 76100, Israel

  • Konkuk University Medical Center

    Seoul, 05030, South Korea

  • Korea University Anam Hospital

    Seoul, 02841, South Korea

  • Lakeview Hospital

    Ekurhuleni, 1501, South Africa

  • Langeberg Clinical Trials

    Kraaifontein, 7570, South Africa

  • Leon Daniello Pneumophthisiology Clinical Hospital

    Cluj-Napoca, 400371, Romania

  • Lowcountry Lung and Critical Care

    North Charleston, South Carolina, 29406, United States

  • MECS Research GmbH

    Berlin, 12203, Germany

  • MIRES/MYF estudios clinicos

    Ñuñoa, 7750495, Chile

  • MUDr. Ilona Pavlisova s.r.o.

    Miroslav, 671 72, Czechia

  • MediTrial s.r.o.

    Jind?ich?v Hradec, 377 01, Czechia

  • Medical Center Hera EOOD

    Sofia, 1510, Bulgaria

  • Medical Center New rehabilitation center EOOD

    Stara Zagora, 6003, Bulgaria

  • Medical Centre "Asklepii", OOD

    Dupnitsa, 2600, Bulgaria

  • Medical Centre Respiro OOD

    Razgrad, 7200, Bulgaria

  • Medical center Medconsult Pleven OOD

    Pleven, 5800, Bulgaria

  • Medical center Unimed EOOD

    Plovdiv, 4023, Bulgaria

  • Medisphere Medical Research Center, Llc

    Evansville, Indiana, 47714, United States

  • Meditek Ltda

    Santiago, 8320000, Chile

  • Medizentrum Essen Borbeck

    Essen, 45355, Germany

  • Metroplex Pulmonology & Sleep Center

    McKinney, Texas, 75069, United States

  • Midwest Chest Consultants

    Saint Charles, Missouri, 63301, United States

  • Midwest Clinical Research LLC

    St Louis, Missouri, 63141, United States

  • National Jewish Health

    Denver, Colorado, 80206, United States

  • Neomed Out-Patient Treatment and Diagnosis Medical Center SRL

    Brasov, 500283, Romania

  • Niepubliczny Zaklad Opieki Zdrowotnej Centrum Medyczne ProMiMed sp z o.o. sp.k.

    Krakow, 31-637, Poland

  • Ninewells Hospital

    Dundee, DD1 9SY, United Kingdom

  • Northern Pines Health Center PC

    Buckley, Michigan, 49620, United States

  • Northwestern Center for Clinical Research

    Chicago, Illinois, 60611, United States

  • Nouvel Hôpital Civil

    Strasbourg, 67091, France

  • Odense Universitetshospital

    Odense, 5000, Denmark

  • Office of Marc De Meulemeester

    Thuin, 6534, Belgium

  • Ostrowieckie Centrum Medyczne Spolka Cywilna Anna Olec-Cudzik

    Ostrowiec Swietokrzysk, 27-400, Poland

  • PULMAG Grzegorz Gasior Marzena Kociolek Spolka Cywilna

    Sosnowiec, 41-208, Poland

  • PharmaSite

    Malmö, 211 52, Sweden

  • Plicni Ambulance Kralupy nad Vltavou

    Kralupy nad Vltavou, 278 01, Czechia

  • Pneumologie Varnsdorf S.r.o.

    Nový Bor, 473 01, Czechia

  • Praxis Dr med Claus Keller

    Frankfurt am Main, 60389, Germany

  • Praxis Dr. Med Evelin Liefring

    Berlin, 13187, Germany

  • Private Practice Dr Jean Benoit Martinot

    Erpent, 5101, Belgium

  • ProbarE i Lund AB

    Lund, 222 22, Sweden

  • ProbarE i Stockholm AB

    Stockholm, 113 29, Sweden

  • Pulmonary Associates of Mobile PC

    Mobile, Alabama, 36608-3135, United States

  • Queen Anne Street Medical Centre

    London, London, City of, W1T6AH, United Kingdom

  • Revive Research Institute

    Lathrup Village, Michigan, 48076, United States

  • SEC Clinical Research LLC - Dothan 2 - ClinEdge - PPDS

    Dothan, Alabama, 36305, United States

  • Salvus-Klinische Studien GmbH

    Leipzig, 04207, Germany

  • Sf. Ioan cel Nou Emergency County Hospital

    Suceava, 720237, Romania

  • Shaare Zedek Medical Center

    Jerusalem, 9103102, Israel

  • Shamir Medical Center Assaf Harofeh

    Beer Jacob, 0073100, Israel

  • Sheba Medical Center - PPDS

    Tel Litwinsky, 52621, Israel

  • Sherman Clinical Research - ClinEdge - PPDS

    Sherman, Texas, 75092, United States

  • Sierra Clinical Research - ClinEdge - PPDS

    Las Vegas, Nevada, 89106-4159, United States

  • Sociedad Médica SyG SpA

    Providencia, 7500000, Chile

  • South Texas Medical Research Institute, Inc., dba TTS Research ? ClinEdge ? PPDS

    Boerne, Texas, 78006-1993, United States

  • Southeastern Research Center

    Winston-Salem, North Carolina, 27103-4029, United States

  • Spartanburg Medical Center

    Spartanburg, South Carolina, 29303, United States

  • Specialized Hospital for Active Treatment of Pneumophthisiatric Diseases - Haskovo EOOD

    Haskovo, 6300, Bulgaria

  • Specialized Hospital for Active Treatment of Pneumophthisiatric Diseases-Dr.Nikola Penchev-Paza

    Pazardzhik, 4400, Bulgaria

  • Specialized Hospital for Active Treatment of Pneumophthisiatric Diseases-Vratsa

    Vratsa, 3000, Bulgaria

  • Specialized Hospital for Active Treatment of Pulmonary Diseases- Pernik EOOD

    Pernik, 2300, Bulgaria

  • Spitalul Clinic de Pneumoftiziologie Constanta

    Constanța, 900002, Romania

  • St Augustines Hospital

    Durban, 4001, South Africa

  • St. Joseph's Healthcare Hamilton- Charlton Campus

    Hamilton, Ontario, L8N 4A6, Canada

  • Studienzentrum Dr Med Schlenska

    Peine, 31224, Germany

  • Sygehus Lillebælt, Vejle

    Vejle, 7100, Denmark

  • Tel Aviv Sourasky Medical Center PPDS

    Jerusalem, 90000, Israel

  • Temple University Hospital

    Philadelphia, Pennsylvania, 19140, United States

  • TrialsWest Pty Ltd

    Spearwood, Western Australia, 6163, Australia

  • Tuen Mun Hospital

    Hong Kong, Hong Kong

  • Twoja Przychodnia Centrum Medyczne Nowa Sol

    Nowa Sól, 67-100, Poland

  • UZ Antwerpen

    Edegem, 2650, Belgium

  • Unidad Medica de Occidente

    Guadalajara, Jalisco, 44220, Mexico

  • Unidad de Investigacion Clinica En Medicina (Udicem) S.C.

    Monterrey, Nuevo León, 64718, Mexico

  • University Multiprofile Hospital for Active Treatment Sveti Georgi EAD

    Plovdiv, 4001, Bulgaria

  • University Multiprofile Hospital for Active Treatment and Emergency Medicine N. I. Pirogov EAD

    Sofia, 1606, Bulgaria

  • University of Cape Town Lung Institute

    Cape Town, 7700, South Africa

  • University of Saskatchewan, Royal University Hospital

    Saskatoon, Saskatchewan, S7N 0W8, Canada

  • Universitätsklinikum Gießen und Marburg GmbH

    Giessen, 35392, Germany

  • Velocity Clinical Research Spartanburg PPDS

    Spartanburg, South Carolina, 29303-4225, United States

  • Westmead Hospital

    Westmead, New South Wales, 2145, Australia

  • Zentrum fuer Pneumologie, Onkologie und Schlafmedizin am Diako

    Augsburg, 86150, Germany

  • Zentrum fuer ambulante pneumologische Forschung Marburg GbR

    Marburg, 35037, Germany

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