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Which works better to stop bleeding during tonsil surgery: hydrogen peroxide or adrenaline?

NCT ID NCT07675278

Disease control Sponsor: Rawalpindi Medical College Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study compares two common substances—hydrogen peroxide and adrenaline—for controlling bleeding during tonsillectomy in children and teens aged 5 to 18. Surgeons apply one of the two to the surgical site and measure how quickly bleeding stops and how much blood is lost. The goal is to find which method is more effective and safer for routine use.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hydrogen peroxide and adrenaline (epinephrine)
What this could lead to
If one agent works better, it could become the preferred method for controlling bleeding during tonsillectomy, reducing blood loss and surgery time.
What could go wrong
This is a small, early-stage study with only 64 participants, so results may not apply to all patients. Both substances have risks, such as tissue irritation or heart effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

64 people

The number who actually took part.

Started

Feb 2024

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

5 to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients aged 5-18 years. 2. Scheduled for elective tonsillectomy. 3. Diagnosis of chronic or recurrent tonsillitis. 4. Normal coagulation profile. 5. Medically fit for general anesthesia. 6. Provided informed consent (from participant, or parent/legal guardian for pediatric participants). Exclusion Criteria: 1. Patients with a coagulation or bleeding disorder. 2. Patients taking blood-thinning medications (e.g., aspirin or other antiplatelet agents). 3. Presence of an acute tonsillar infection at the time of surgery. 4. Known reaction or allergy to adrenaline or hydrogen peroxide. 5. Known or suspected tonsillar malignancy. 6. Concurrent adenoid hypertrophy requiring adenoidectomy.

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Conditions

The condition(s) this trial relates to.

Intraoperative Complications tonsillitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic tonsillitis Tonsillar hypertrophy, tonsillitis Tonsillectomy

Contacts and locations

Locations

  • Rawalpindi Teaching Hospital

    Rawalpindi, Punjab Province, 46000, Pakistan

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