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Lung microbiome secrets may explain COPD emergencies

NCT ID NCT03641235

Knowledge-focused Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how the community of bacteria, fungi, and viruses in the lungs changes when a person with COPD has a severe flare-up that requires intensive care. Researchers collect sputum samples from patients to analyze the genetic material of these microbes. The goal is to understand which germs are present and how they might contribute to serious breathing problems.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If patterns are found, this could point toward new ways to predict or treat severe COPD attacks.
What could go wrong
This is a small observational study, so findings may not apply to all COPD patients and won't directly lead to treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

29 people

The number who actually took part.

Started

Sep 2018

Finished

Mar 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patient above 18 admitted in ICU, admitted for COPD exacerbation defined by sustained (\> 2 days) worsening of respiratory symptoms considering Anthonisen's criteria with life-threatening condition.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient above 18 admitted in ICU * Admitted for COPD exacerbation defined by sustained (\> 2 days) worsening of respiratory symptoms considering Anthonisen's criteria with life-threatening condition. * Needing mechanical ventilation (noninvasive ventilation or oro-tracheal intubation) * COPD condition will be presumed according to patient's respiratory history or previous lung function testing * Able to consent or with the patient's family consent * Affiliated to a social insurance scheme No inclusion Criteria: * COPD patient admitted for another cause than respiratory failure * person under tutorship or curatorship * living further than 100 kilometers away from the ICU * expected survival inferior to 1 week Exclusion Criteria \- Lung function testing not consistent with COPD at steady-state visit

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic obstructive pulmonary disease

Contacts and locations

Locations

  • University Hospital, Bordeaux

    Bordeaux, 33000, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.