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Night ventilation showdown: which mode helps COPD patients wean faster?

NCT ID NCT01573481

Knowledge-focused Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested two different ways of using a breathing machine at night to help people with COPD get off the machine faster. Nineteen patients were randomly assigned to one of two ventilation modes during sleep. Researchers measured how long it took to wean off the ventilator and how well patients slept.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
pressure support ventilation and pressure controlled ventilation
What this could lead to
If successful, this could point toward better nighttime ventilation strategies to shorten weaning time and improve sleep for COPD patients on ventilators.
What could go wrong
This is a very small, early-stage study with only 19 participants, so results may not apply broadly. The interventions are already standard modes, so no dramatic breakthrough is expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

19 people

The number who actually took part.

Start date

Jan 2012

Finished

Jan 2015

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The patient and/or legal representative of the patient has provided a written informed consent before inclusion in the study * The patients is hospitalized in respiratory and critical care unit (university hospital of AMIENS, FRANCE) * the patient is mechanically ventilated (ventilator model : puritan-bennett B840) * Pulmonary disease,chronic obstructive (Spirometry and Blood Gas Analysis in chronic state before admission) * stable cardiovascular status (cardiac frequency \< 140 beats/min and systolic blood pressure : 90-160 mmHg without catecholamines) * midazolam \< 0,05mg/kg/h * sufentanyl \< 0,05µ/kg/h * the disorder that caused respiratory failure and prompted mechanical ventilation is treated * the clinician suspects the patient may be ready to begin the weaning process * inspiratory oxygen fraction (FiO2) \< 50% * positive end-expiratory pressure \< or equal 8cmH2O * during the day, the patient tolerate pressure support ventilation (pressure support level \< 15cmH2O * respiratory frequency (FR) \< 35 breaths/min * tidal volume (VT) \> 5ml/kg * PaO2/FiO2 \> 200 mmHg * FR/VT \< 105 breaths/min/L Exclusion Criteria: * sleep apnea, central * narcolepsy * Encephalopathy, Metabolic AND Encephalitis

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COPD exacerbation Weaning failure

Contacts and locations

Locations

  • Pneumologie et Réanimation Respiratoire

    Amiens, 80000, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.