Type 2 diabetes mellitus

Researchers are testing an experimental oral drug called MBX-2982 in adults with type 2 diabetes. The trial compares three daily doses of MBX-2982 against a placebo and sitagliptin, a standard diabetes drug, over four weeks. Participants are treatment-naive or taking a single ora…

Researchers are testing whether a 24-month weight-loss program delivered by trained health coaches through an electronic medical record patient portal can help Black adults with obesity and type 2 diabetes or prediabetes. The study enrolls 352 people aged 40 to 70 in Louisiana pr…

Researchers test whether adding doxycycline to sitagliptin helps control blood sugar and heart health in adults over 40 with newly diagnosed type 2 diabetes. Participants receive both drugs, and the team tracks changes in fasting blood sugar and HbA1c. The trial also measures hea…

This study tests whether acetyl L-carnitine, a dietary supplement, can help reduce pain, inflammation, and improve blood sugar control in obese, diabetic, postmenopausal women with osteoarthritis. One hundred women will take either the supplement or a placebo for 12 weeks, alongs…

This study tests whether a cookie made from Golden Rice and red betel leaf can improve cholesterol and triglyceride levels in adults with type 2 diabetes. Over 28 days, 102 participants will eat the cookies daily, and their blood fat levels will be measured before and after. The …

This study looked at whether delivering healthy food to the homes of rural adults with type 2 diabetes and food insecurity could improve their blood sugar control and diet. Over 400 participants either received standard care alone or standard care plus free healthy food deliverie…

Researchers test whether a connected pillbox with pre-filled trays and automated text or phone reminders helps people with type 2 diabetes, high blood pressure, or high cholesterol take their medications as prescribed. The study enrolls about 50 adults who have struggled to stay …

This pilot study tests whether having a pharmacist oversee continuous glucose monitoring (using a FreeStyle Libre device) can improve blood sugar control and health behaviors in people with type 2 diabetes. Forty participants will use the monitor for 12 weeks, and their results w…

This early-stage study tests an experimental drug called MK-1403 in people with type 2 diabetes. The main goals are to check if the drug is safe and tolerable, and to see how it behaves in the body. Researchers will also measure its effect on a marker of inflammation (hsCRP). Abo…

This study looks at how different exercise programs (moderate or high-intensity) and a diet plan affect appetite, blood sugar, and body fat in people with type 2 diabetes. About 146 adults will take part in a 12-week program. The goal is to find the best combination to improve he…

This phase 3 study tested a new once-daily pill called orforglipron against an existing oral semaglutide in nearly 1,700 adults with type 2 diabetes whose blood sugar was not well controlled on metformin. The main goal was to see how well orforglipron lowers blood sugar levels ov…

This study tests an experimental drug called NT-0796 in 176 obese adults, some with type 2 diabetes. Participants take the drug or a placebo alongside a reduced-calorie diet and increased physical activity for 6 months. The goal is to see if the drug helps with weight loss and re…

Researchers compare three weekly GLP-1 receptor agonists, dulaglutide, semaglutide, and tirzepatide, in 159 obese adults, 84 with diabetes and 75 without. Participants receive one of the drugs for 24 weeks. The trial measures changes in body weight, BMI, blood sugar, cholesterol,…

Researchers test whether continuous glucose monitors (CGM) can help hospitalized adults with type 2 diabetes reach a tighter average blood sugar target of 90 to 130 mg/dL without causing dangerous low blood sugar. Participants are randomly assigned to standard care (target 140 to…

This study tests whether combining a shared decision-making checklist during doctor visits with mobile text reminders helps people with type 2 diabetes take their medications as prescribed. About 378 patients from community health centers in Michigan are taking part. The goal is …

This early study is testing a new magnetic device that creates a shortcut in the digestive system to help people with obesity and type 2 diabetes lose weight and control blood sugar. Ten adults aged 18-65 with a BMI between 30 and 35 will have the device placed using a scope, wit…

This study tests a new magnetic system (MagDI) that creates a connection between two parts of the small intestine to help with weight loss and blood sugar control. It involves 25 adults with obesity and type 2 diabetes. The goal is to see if the device is safe, works as intended,…

This Phase 2 trial tests whether tirzepatide, a drug already used for diabetes and weight loss, can improve kidney health in 140 people with obesity and chronic kidney disease (with or without type 2 diabetes). Researchers will use MRI scans to measure changes in kidney fat and b…

Researchers are testing whether adding an SGLT2 inhibitor to the usual treatment for type 2 diabetes improves blood sugar control and other metabolic measures. The trial enrolls about 482 adults with type 2 diabetes who are not already taking these drugs. Participants will be com…

This Phase 2 trial tests a once-weekly injection called petrelintide in 221 people with overweight or obesity and type 2 diabetes. Participants receive either petrelintide or a placebo for several weeks. The main goal is to see how much weight they lose and whether blood sugar im…

This study tested a new investigational medicine called CagriSema, which combines two drugs (cagrilintide and semaglutide) in one weekly injection. It was given to 274 adults with type 2 diabetes who were already taking daily insulin, with or without metformin. The goal was to se…

This study tests a new investigational medicine called CagriSema against an approved drug, tirzepatide, in people with type 2 diabetes whose blood sugar is not well controlled by current pills. About 1,023 adults will receive either CagriSema or tirzepatide once a week for up to …

Researchers are testing whether lanifibranor, a drug for fatty liver disease, can improve blood sugar control in adults with NASH and type 2 diabetes. They are also studying whether combining lanifibranor with empagliflozin, a diabetes medication, works better than lanifibranor a…

Researchers test whether shared decision making helps adults with type 2 diabetes who have poor blood sugar control. Participants are randomly assigned to receive either shared decision making sessions or routine health education. The trial measures changes in self-efficacy, heal…

This study tested whether a short period of intensive insulin therapy, followed by a combination of basal insulin, metformin, and vildagliptin, could help people with poorly controlled type 2 diabetes simplify their long-term treatment. The goal was to see if more participants co…

This phase 3 study tested an experimental once-daily pill called orforglipron (LY3502970) against a placebo in 1613 adults who are overweight or have obesity and type 2 diabetes. The goal was to see if the drug helps with weight loss and improves blood sugar control. Participants…

This study tested a new investigational drug called CagriSema against a currently available medicine, tirzepatide, in over 1,000 adults with type 2 diabetes. The goal was to see which works better at lowering blood sugar and body weight. Participants received weekly injections of…

This study tests whether choosing diabetes medications based on a person's genetic profile helps control blood sugar better than standard treatment. About 500 adults with type 2 diabetes that is not well controlled will be randomly assigned to either gene-guided or standard care.…

This early-stage trial tests an investigational drug called MWN105, given as an injection under the skin, in healthy Chinese volunteers aged 18 to 45. The study aims to check the drug's safety, how the body processes it, and whether it triggers an immune response. Researchers wil…

This trial tests an oral medication called MWN109 in Chinese adults with type 2 diabetes, overweight, or obesity. Researchers want to see if the amount of water taken with the pill and the timing of the next meal change how much drug enters the blood. The study also checks safety…

This study tested a once-daily pill called orforglipron in 559 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. The pill was compared to a placebo (a dummy pill) over about 54 weeks to see if it safely lowers blood sugar levels. Th…

This study looks at whether the amount of effort you put into strength training can improve blood sugar control and mental health in people with type 2 diabetes. About 48 adults with type 2 diabetes will do resistance exercises at different effort levels. Researchers will track b…

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes by reducing depression and insulin resistance. 120 teens aged 12-17 with overweight, a family history of diabetes, and elevated depression symptoms took part. They were randomly as…

This early trial tests montbretin A, a compound extracted from crocosmia plant bulbs, in people with type 2 diabetes and in healthy volunteers. The main goal is to find a safe dose and see if it causes fewer stomach side effects than standard diabetes medications. Participants ta…

This study tested whether providing medically tailored meals (10 ready-to-eat meals per week for 6 months) plus phone-based lifestyle coaching could improve blood sugar control in adults with type 2 diabetes who also face food insecurity. 215 participants were randomly assigned t…

This study tested a 4-month online program that encourages a very low-carbohydrate breakfast for adults with poorly controlled type 2 diabetes. Researchers measured how satisfied participants were, how well they stuck to the diet, and changes in blood sugar, weight, and medicatio…

This study tests whether adding culturally tailored heart-health education to medically tailored meal programs helps people with type 2 diabetes and high blood pressure eat better and improve their blood sugar and blood pressure. About 176 adults from low-income New York City nei…

This pilot study tests a 12-week text message program called AYUDA for younger Latinx adults recently diagnosed with type 2 diabetes who are also caring for a child. Participants receive twice-weekly texts with diabetes education and self-management resources. Researchers compare…

This trial asks whether eating tinned mackerel twice a week can improve blood sugar control in South Asian adults with type 2 diabetes. Participants with diabetes will either keep their usual diet or replace some red meat or poultry with mackerel for 16 weeks. Researchers will me…

Researchers at the University of Aberdeen are testing whether a buckwheat beverage can reduce blood sugar spikes after meals. The study includes healthy adults and people with type 2 diabetes whose condition is managed by diet or metformin. Participants drink the beverage and hav…

This trial tests whether personalized education, guided by a risk assessment for six major diabetes complications, can improve blood sugar control in adults with type 2 diabetes. Participants receive education focused on their highest predicted risk, such as kidney disease or str…

This trial tests a multimodal program for adults aged 65 and older with type 2 diabetes who are frail or prefrail. The program combines a 16-week exercise routine, educational sessions on diabetes self-care, and adjusted blood sugar and blood pressure goals. Researchers compare t…

This study tested a family-focused diabetes education program delivered in Marshallese faith-based organizations. Over 300 adults with type 2 diabetes and their family members took part. The goal was to see if group education in a familiar community setting could improve blood su…

This study looks at whether deep cleaning for gum disease can improve kidney health in people with uncontrolled type 2 diabetes. 46 adults with both conditions will either get gum treatment right away or after a delay. Researchers will measure kidney markers like creatinine and u…

This study tested whether a daily pill called oral semaglutide helps children and teenagers (ages 10 to under 18) with type 2 diabetes control their blood sugar better than a placebo. All participants also took standard diabetes medicines like metformin or insulin. The trial last…

This study tests whether ketorolac, an anti-inflammatory eye drop, can reduce inflammation in the eyes of people with diabetic retinopathy and slow the disease. About 164 adults with type 2 diabetes will use either the active drop or a placebo for up to 3 years. Researchers will …

This study is testing whether giving people with type 2 diabetes a Fitbit and sending them personalized text messages from an AI chatbot can help them become more active and improve their health. Thirty-six sedentary adults will wear the Fitbit daily for 12 weeks and receive week…

This Phase 3 trial is testing whether a once-daily 50 mg semaglutide tablet can help East Asian adults with overweight or obesity lose weight. Participants will take either the active tablet or a placebo for 68 weeks, alongside lifestyle counseling on diet and physical activity. …

This study looked at whether aspirin or a diabetes drug called an SGLT2 inhibitor (like dapagliflozin) can improve liver health in people with type 2 diabetes and non-alcoholic fatty liver disease. Researchers measured liver enzymes, cholesterol, and liver stiffness (using FibroS…

This trial tests an experimental oral drug called HTD1801 in adults with nonalcoholic steatohepatitis (NASH), a serious liver condition, along with liver fibrosis and type 2 diabetes or prediabetes. Participants receive either HTD1801 or a placebo to see if the drug can improve l…

This study tested a new insulin called icodec that is injected just once a week, compared to standard daily insulin shots, in over 1,000 adults with type 2 diabetes who had never used insulin before. The goal was to see if the weekly shot controls blood sugar just as well as dail…

This Phase 3 trial tested whether HTD1801 (berberine ursodeoxycholate) can help people with type 2 diabetes who aren't well controlled on metformin alone. Over 500 participants received either the drug or a placebo for 24 weeks. The main goal was to see if the drug lowered blood …

This completed study compared the effectiveness of once-daily oral semaglutide (Rybelsus) to other oral diabetes medications in 1020 adults with type 2 diabetes who were already taking metformin. Participants were randomly assigned to receive either Rybelsus or another diabetes p…

This trial investigates whether a traditional herbal drug, NOSHIN SHAHD, can improve insulin resistance and reduce inflammation and oxidative stress in people with type 2 diabetes. Participants will take the herbal drug or a placebo for about six weeks, and researchers will measu…

This pilot study tests whether having older Black men with diabetes lead support groups can help other older Black men better manage their type 2 diabetes. All 48 participants receive standard diabetes education, and half also get 6 months of monthly peer-led support sessions. Th…

This trial tests whether a 12-week calorie-restricted diet, combined with the weight-management drug Contrave, can help people with type 2 diabetes and obesity achieve remission. Remission means blood sugar levels drop below the diabetes threshold without needing glucose-lowering…

This study tested a new medicine called survodutide (BI 456906) to see if it helps people with overweight or obesity and type 2 diabetes lose weight. Over 750 adults received either the drug or a placebo injection once a week for about 76 weeks, along with diet and exercise advic…

This study tests whether three diabetes medications—liraglutide, empagliflozin, and linagliptin—can help reverse mild cognitive impairment (early memory and thinking problems) in people with type 2 diabetes. About 396 participants will take one of the drugs for 48 weeks, with an …

This study tests a new procedure called ReCET that uses gentle electrical pulses to regenerate the lining of the small intestine. Combined with a diabetes drug (semaglutide), the goal is to help people with type 2 diabetes stop using insulin. The study involves 32 adults and comp…

This trial asks whether cooking with refined high-oleic palm oil can improve cholesterol and blood sugar levels as effectively as olive oil. Healthy adults will be randomly assigned to use one of the two oils in their daily cooking for four months. Researchers will measure change…

This study looks at whether involving family members can help people with type 2 diabetes in rural Kentucky eat healthier and exercise more. Researchers will work with 75 participants and their families to create a personalized nutrition and physical activity plan for 6 months. T…

This study tested a new drug called HTD1801 (berberine ursodeoxycholate) against the standard diabetes drug dapagliflozin in 367 adults with type 2 diabetes whose blood sugar was not well controlled by metformin alone. The main goal was to see how well HTD1801 lowers blood sugar …

This Phase 3 trial tested whether HTD1801, a new drug made from a modified natural compound, can lower blood sugar in people with type 2 diabetes who struggle to control it with diet and exercise alone. The study enrolled 408 adults and compared the drug to a placebo over 24 week…

This trial tests whether a smartphone app called Kiplin, which uses games, telecoaching, and social support, can increase daily physical activity in people with obesity or type 2 diabetes. It compares the app to a standard three-month face-to-face exercise program. The main goal …

This Phase 3 trial tests retatrutide, a once-weekly injection, in 1000 adults with type 2 diabetes who are overweight or obese. The study also looks at a subset of participants with obstructive sleep apnea. Over 89 weeks, researchers will measure weight loss, changes in sleep apn…

This pilot trial tests whether a single infusion of pegloticase, a drug that breaks down uric acid, can improve markers of heart and kidney health in young men aged 18–25 with youth-onset type 2 diabetes. High uric acid is common in this group and linked to later complications. T…

This trial tests whether a mobile health system that sends real-time text messages—prompting users to take a walk or stand up after sitting too long—can increase physical activity in people with prediabetes or type 2 diabetes. Participants receive a Fitbit tracker and brief advic…

This study looks at whether offering financial rewards, along with nurse coaching and home monitoring, helps adults with type 2 diabetes improve their blood sugar control. About 450 participants will be randomly assigned to receive either nurse coaching and home monitoring alone,…

This study tests whether a 12-week low-calorie meal replacement diet can improve heart function and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) who are also obese. 63 adults will be randomly assigned to either the diet or standard care. …

This study tests whether a connected smartphone app called Health2Sync helps adults with type 2 diabetes who use basal insulin achieve better blood sugar control. The app syncs blood glucose readings and shares them with doctors, who can then adjust insulin doses. Researchers com…

This study investigates whether a 12-week program combining aerobic and resistance exercise can improve blood sugar control and cognitive function in adults aged 65-79 with type 2 diabetes and mild memory issues. Participants follow a supervised exercise routine that gradually in…

This study tests a support program for people with type 2 diabetes and chronic kidney failure who struggle to take their medications regularly. Participants receive an electronic pill bottle that tracks when they open it, plus short motivational interviews with a pharmacist. The …

This study investigates whether taking two medications—finerenone and empagliflozin—together can better slow kidney function decline in people with chronic kidney disease and type 2 diabetes compared to taking either drug alone. Participants are randomly assigned to receive the c…

This study tracks the long-term safety of dorzagliatin, a drug for type 2 diabetes, in over 2,000 patients over 52 weeks. Researchers monitor side effects and how well the drug controls blood sugar. The goal is to ensure the drug remains safe for everyday use.

This study tests whether community health workers (CHWs) who screen patients for social needs like food, housing, or transportation and connect them to resources can improve blood sugar and blood pressure control. About 3,120 adults with uncontrolled diabetes or hypertension from…

This study tests a program called 'Disfrutando' designed to help people with type 2 diabetes, especially those in high-burden communities, better manage their condition. The program focuses on practical self-management skills and addressing social factors that make diabetes harde…

This study tests whether walking with a wearable hip exoskeleton can improve blood sugar control after meals in people with type 2 diabetes. Participants walk for 30 minutes after a meal, either without assistance or wearing the exoskeleton in two different support modes. The goa…

This large study looks at real-world data from 60,000 people with type 2 diabetes and obesity to compare four diabetes drugs—dulaglutide, semaglutide, tirzepatide, and sitagliptin—in preventing heart attacks, strokes, and death. Researchers are analyzing insurance claims to see w…

This study looks at whether a low-carb, high-protein diet can help people with type 2 diabetes control their blood sugar and lose weight better than a standard diabetes diet. About 100 overweight or obese adults with type 2 diabetes will follow one of the two diets for 12 months.…

This study tests whether a 3-month community program combining nutrition education, cooking classes, and exercise can improve health outcomes for people with Cardiovascular Kidney Metabolic (CKM) syndrome—a cluster of conditions including diabetes, high blood pressure, high chole…

This completed trial tested whether laser acupuncture could improve body shape index (ABSI) in 50 women aged 40-50 with uncontrolled type 2 diabetes and obesity. Participants received either real or sham laser acupuncture twice a week for 12 weeks, plus a low-glycemic diet. The s…

This large phase 3 trial compares two injectable diabetes medications, tirzepatide and dulaglutide, to see which one better prevents major heart problems like heart attacks, strokes, or death from cardiovascular causes. The study includes over 13,000 adults aged 40 and older with…

This study investigates whether giving endocrinologists (diabetes specialists) a one-week intensive training program helps them manage type 2 diabetes more effectively. The training includes a hospital stay experience and hands-on patient management. Researchers will compare bloo…

This Phase 3 trial tested CagriSema, a once-weekly injection combining two medicines (cagrilintide and semaglutide), in 2734 adults with type 2 diabetes. The goal was to see if the combo lowers blood sugar and body weight better than either drug alone or a placebo. All participan…

This study tests whether combining two diabetes drugs—semaglutide and empagliflozin—can reverse liver damage from NASH (a severe form of fatty liver disease) in people with type 2 diabetes. Participants will receive either the combo, empagliflozin alone, or a placebo for 48 weeks…

This study investigates whether a passive stretching program can reduce muscle and tendon stiffness in people with type 2 diabetes. Diabetes can cause muscles and tendons to become stiffer, making walking harder and increasing energy use. The trial compares stiffness in people wi…

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This study tests the long-term safety of an experimental oral drug called orforglipron in adults with type 2 diabetes whose blood sugar is not well controlled by diet, exercise, or other diabetes pills. Participants take the drug once daily for about a year, and researchers monit…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This completed study tested whether a customizable texting program could help veterans with type 2 diabetes improve their blood sugar control. 366 veterans were randomly assigned to receive either standard daily diabetes texts or a more interactive version with check-ins, medicat…

This study tested a 6-week diabetes self-management program for ethnic minority elderly (aged 60+) in rural Thailand. The program included weekly group sessions on diet, exercise, medication, and emotional coping, plus two home visits. Researchers measured changes in blood sugar …

This study tested an electronic glucose management system (eGMS) designed to help doctors decide insulin doses for hospitalized patients with type 2 diabetes. The trial compared the eGMS to the usual insulin ordering protocol in 140 patients. The goal was to see if the eGMS could…

This study tested whether personalized dietary advice helps people with early-stage type 2 diabetes control their blood sugar better than standard advice or usual care. About 255 participants were split into three groups: personalized diet, standardized diet, or usual care. Resea…

This study tested whether adding mindful eating training to a low-carb diet education helps people with type 2 diabetes follow the diet better. About 125 adults were randomly assigned to get either diet education alone or diet education plus mindful eating sessions. The main goal…

This completed study tested whether resveratrol, a natural compound found in grapes and berries, can improve blood vessel health and blood sugar control in people with type 2 diabetes. 48 adults took either a resveratrol pill or a placebo daily for 12 weeks. Researchers measured …

This study tested a culturally tailored program called Together Overcoming Diabetes (TOD) for American Indian families in Ojibwe communities. Adult caregivers with type 2 diabetes and their youth (ages 10-16) worked with local health coaches to set health goals. The program inclu…

This study tested whether making U.S. dietary guidelines more culturally relevant for African Americans could improve diet quality and reduce type 2 diabetes risk. 63 overweight or obese African American adults with at least three diabetes risk factors attended weekly classes for…

This study tested whether adding a smartphone app with short videos on mental health, diet, exercise, and insulin adjustment to standard care could improve blood sugar control and birth weight in pregnant women with diabetes. Over 600 women participated. The goal was to see if th…

This early-phase study tested whether a single infusion of donor stem cells could help repair damaged blood vessels in 26 adults with type 2 diabetes and symptomatic heart disease. Researchers measured blood vessel function and looked for signs of repair in the lab. The goal was …

This study tested two drugs—hydralazine-ISDN and metformin—in 1100 people with chronic heart failure and reduced heart function. Some participants also had diabetes or insulin resistance. The goal was to see if these drugs could lower the risk of death or hospital stays due to wo…

This study tested a new insulin called icodec, taken just once a week, against a standard daily insulin (degludec) in 588 adults with type 2 diabetes who had never used insulin before. Participants received either weekly icodec plus a daily placebo, or daily degludec plus a weekl…

This study tested a new once-a-week injection called IcoSema, which combines insulin and semaglutide, against semaglutide alone in 683 adults with type 2 diabetes. The goal was to see if IcoSema improves blood sugar levels more effectively. Participants received weekly shots for …

This study tested a new once-weekly injection called MET097 in 133 adults with obesity or overweight and type 2 diabetes. The goal was to see if it helps with weight loss and blood sugar control compared to a placebo. Participants received either the drug or a placebo for 28 week…

This study tested whether dapagliflozin, a drug used for type 2 diabetes, can lower blood pressure in people who have received a kidney transplant. Fifty-two participants took either the drug or a placebo for 12 weeks. The goal was to see if the drug helps control blood pressure …

This study tested a new once-weekly injection called IcoSema, which combines two diabetes drugs (insulin icodec and semaglutide), against daily insulin glargine in 485 adults with type 2 diabetes whose blood sugar was not well controlled on oral medications. The goal was to see i…

This completed trial tested a new automated insulin delivery system called twiist in 307 adults with insulin-treated type 2 diabetes. The system combines an insulin pump, a continuous glucose monitor, and a smart algorithm to automatically adjust insulin. The main goal was to see…

This study looked at whether starting tirzepatide, a once-weekly injection for type 2 diabetes, before Ramadan helps people manage their blood sugar safely while fasting. 166 adults with uncontrolled diabetes who planned to fast took part. Researchers measured changes in blood su…

This study tested a smart insulin system called Control-IQ+ in 319 adults with type 2 diabetes who use insulin. The goal was to see if the technology helps control blood sugar better than standard care. Participants used the system for a period, and researchers measured changes i…

This study looked at whether eating only within a 10-hour window each day helps overweight adults aged 50 to 75 with prediabetes lose fat and improve their metabolism. 57 participants either followed the 10-hour eating plan or their usual 13-hour eating pattern, while tracking th…

This study looked at whether gastric bypass surgery or the best medical care is more effective for obese people with poorly controlled type 2 diabetes. Researchers tracked 66 participants to compare death rates, weight loss, blood sugar control, quality of life, and costs. The go…

This completed phase 3 trial tested three doses of the oral drug HRS-7535 against a placebo in 284 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. The main goal was to see if HRS-7535 could lower HbA1c (a measure of average blood …

This study tested whether using activity trackers, text reminders, and short exercise videos could help people with type 2 diabetes reduce the time they spend sitting at work. Forty-six adults with type 2 diabetes who had mostly desk jobs took part. The goal was to see if these m…

This study tested whether a daily postbiotic capsule (a substance that helps good gut bacteria) could improve blood sugar control in adults with type 2 diabetes. 106 participants took either the postbiotic or a placebo for 12 weeks. Researchers also analyzed genetics and gut bact…

This study tested a weekly injection of semaglutide (2.4 mg) to help adults with overweight or obesity lose weight. About 242 people took part, comparing the drug to a placebo over roughly one year. The main goal was to see how much weight they lost and how many lost at least 5% …

This pilot study tested whether using an automated insulin delivery (AID) system for just 10 days can help people with type 2 diabetes safely adjust their long-acting insulin doses. 23 adults who already used insulin injections took part. The goal was to see if the device was saf…

This study tested whether adding pioglitazone to the standard two-drug therapy (metformin and empagliflozin) helps people with type 2 diabetes who still have high blood sugar. Over 600 adults took part in this Phase 3 trial. The main goal was to see if the extra drug lowers HbA1c…

This study looked at whether a DASH-style diet (modified for diabetes) combined with lower salt intake can lower blood pressure in adults with type 2 diabetes and high blood pressure. 105 participants ate specially prepared meals for 5-week periods. The goal was to find a practic…

This study looked at how the diabetes drugs glyburide and metformin work in pregnant women with gestational diabetes. 177 women between 20 and 32 weeks pregnant took part. The goal was to find the right dose and understand how these drugs control blood sugar and improve insulin f…

This study tested a new once-weekly injection called UBT251 in 211 adults with type 2 diabetes. Participants received either UBT251, a placebo, or the existing drug semaglutide for 24 weeks. The main goal was to see how well UBT251 lowers blood sugar (HbA1c) and to find the right…

This pilot study tested a mobile app and wearable devices to give personalized diet and activity advice to 27 adults with type 2 diabetes or prediabetes. The goal was to see if the app could help them improve their blood sugar levels and make healthier food choices. The study als…

This study looked at whether dapagliflozin, a diabetes medication, can improve how the heart uses sugar and blood flow in people with type 2 diabetes and stable coronary artery disease. 25 adults took either the drug or a placebo for 4 weeks. The goal was to see if the drug helps…

This study looked at how well adults with obesity or complicated overweight could stick to different very low-calorie ketogenic diets (VLCKD) in a real-world clinic. Participants chose one of four diet plans, ranging from all-natural foods to all meal replacements, and followed a…

This study tested whether a dietary supplement called phosphatidylserine can improve blood flow in people with type 2 diabetes. 36 adults took either the supplement or a placebo for 4 weeks. Researchers measured blood flow in the leg and arm to see if the supplement helped blood …

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study tested a new approach for people with type 2 diabetes: a once-weekly insulin injection (insulin icodec) combined with a flash glucose monitor, a small sensor worn on the arm that tracks blood sugar continuously. The goal was to see if this combination helps control blo…

This early study tested a single dose of the drug rongliflozin in 32 Chinese adults with type 2 diabetes who had normal, mildly, or moderately reduced kidney function. Researchers measured how the drug moved through the body and how it affected blood sugar and urine glucose. The …

This pilot study tested a 12-week phone program for 60 African American women aged 40-64 with type 2 diabetes and multiple caregiving responsibilities. Half received extra support for their caregiving stress plus diabetes education, while the other half got standard diabetes educ…

This study tested whether a form of vitamin B6 called pyridoxamine can improve the health of small blood vessels in people with type 2 diabetes. The researchers gave 40 participants either pyridoxamine or a placebo for a period, then switched treatments to compare effects. They m…

This study tested whether empagliflozin, a diabetes medication, lowers blood pressure more than other diabetes pills in adults with type 2 diabetes and high blood pressure. 300 participants took either empagliflozin or another diabetes drug for 12 weeks. Researchers measured bloo…

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This study looked at whether a 3-month supervised exercise program can improve blood sugar, body fat, and fitness in sedentary men aged 35-65 with type 2 diabetes, prediabetes, or overweight. Participants exercised at a fitness center under supervision. The goal was to see how di…

This study tested a program designed to help women with type 2 diabetes become more physically active. 86 women aged 30-65 took part. The program included a video, a pamphlet, and regular check-ins to encourage exercise. The goal was to see if this approach could increase daily a…

This study looked at whether time-restricted eating (TRE) — eating only during a set daily window — can help control blood sugar and weight in adults with type 2 diabetes. 115 overweight or obese adults who take metformin were asked to follow TRE for 24 weeks. The goal was to see…

This study tested whether a nurse-led mobile app could improve diabetes management in 112 adults with type 2 diabetes. The intervention group received structured education and reminders via the app for 6 months, while the control group got standard care. The main goal was to see …

This study tested a new investigational medicine called CagriSema in 189 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. Participants received either CagriSema or a placebo injection once a week for about a year. The main goal was…

This study tested whether wearing a continuous glucose monitor (CGM) and watching AI-generated health education videos could help 30 adults with prediabetes control their blood sugar. Participants wore a CGM that tracked glucose levels without showing them the readings during the…

This study looked at two different ways to manage blood sugar in pregnant women with MODY2 diabetes, a genetic condition that affects insulin release. The goal was to see if using ultrasound to guide insulin treatment could prevent the baby from growing too large. 46 women took p…

This study tested whether taking low-dose aspirin (150 mg) daily, starting in the first trimester, could reduce pregnancy complications in women with type 1 or type 2 diabetes. The trial included 137 women and looked at outcomes like preeclampsia, early preterm birth, low birth w…

This study tested a program called AMENUCED for adults with type 2 diabetes in Mexico. The program combines medical care, nutrition advice, and education to help manage the disease. Only 5 people took part to see if they would accept and stick with the program. The goal was to ch…

This study tested whether personalized text messages can improve medication adherence in adults with type 2 diabetes. 28 participants received either tailored or generic daily texts for 6 months. The goal was to see if custom messages help people take their diabetes pills more co…

This pilot study tested a web-based version of the DECIDE program, called eDECIDE, which teaches problem-solving skills to help African Americans manage type 2 diabetes. The study involved 36 participants and compared the online program to the traditional in-person group sessions…

This study tested whether adding pioglitazone or dapagliflozin to standard diabetes pills (alogliptin and metformin) helps control blood sugar better in adults with type 2 diabetes. A total of 133 participants took one of the two extra drugs for 26 weeks. The main goal was to see…

This completed study looked at how two common diabetes drugs, dapagliflozin and empagliflozin, affect weight, cholesterol, and inflammation in 260 obese adults newly diagnosed with type 2 diabetes. Over six months, researchers measured changes in body weight, blood fats, and mark…

This study tested a personalized dietary program for 30 adults with type 2 diabetes. The program was designed to help participants better manage their blood sugar and potentially achieve remission. Researchers measured changes in HbA1c and other health markers to see if the diet …

This study looked at whether giving vitamin D supplements to adults with type 2 diabetes who also have low vitamin D levels can improve their blood sugar control. 119 participants took a high dose of vitamin D once a month for three months. Researchers measured blood sugar and ot…

This study tested whether a daily supplement of overripe banana powder can improve blood sugar control in adults with type 2 diabetes. Sixty participants took either the banana supplement or a standard formula for 12 weeks. Researchers measured changes in fasting blood sugar, HbA…

This study tested a continuous glucose monitor (CGM) that sends real-time blood sugar data to a cloud-based dashboard, allowing a remote team to manage high-risk type 2 diabetes patients in the hospital. Over 500 participants were assigned to either the active CGM system or usual…

This study tested whether eating tuna-based nuggets for three months could improve health in 120 people with heart disease and related conditions like obesity and diabetes. The nuggets were given as a source of selenium. Results showed improvements in some markers of inflammation…

This study tested whether a program that combines technology (like a monitoring system) with diabetes education and skills training can help African American adults with poorly controlled type 2 diabetes. About 200 participants used the system for 12 months, and researchers measu…

This pilot study tested a new computer algorithm that uses continuous glucose monitor (CGM) readings to automatically suggest the right dose of long-acting insulin for people with type 2 diabetes. Thirty adults already using basal insulin were followed for 18 weeks to see if the …

This study compared two common diabetes drugs—dapagliflozin and metformin—in over 2,000 people with early type 2 diabetes (diagnosed less than 4 years). The goal was to see which drug better prevents serious complications like death, heart attack, stroke, heart failure, kidney di…

This study looked at 100 liver transplant patients with diabetes to see if dapagliflozin or sitagliptin is better at reducing liver fat and improving body composition. Participants took one of the two drugs for 12 months. The goal was to find a safer and more effective way to man…

This study tested the drug dapagliflozin (a diabetes medicine) against a placebo in 220 people on dialysis for kidney failure, with or without diabetes. The goal was to see if the drug could improve heart structure and be safe. Participants took the drug or placebo for a period, …

This study tested whether a longer intestinal bypass during stomach cancer surgery improves diabetes control better than the standard method. It included 94 adults with early-stage gastric cancer and type 2 diabetes. Researchers measured blood sugar and hormone levels one year af…

This pilot study tested two approaches to improve metabolic health in Black adults with stage 1 obesity and conditions like high blood pressure or prediabetes. Participants received either weight-focused or weight-neutral health coaching for 7 weeks. The goal was to see if a larg…

This study tested whether providing six months of diabetes-tailored meals and nutrition counseling can improve blood sugar control and reduce food insecurity in adults with type 2 diabetes. 281 participants received either the food support plus counseling or usual care. The main …

This study tested a home-based behavioral program called Home DM-BAT for low-income seniors with type 2 diabetes. Two hundred Black or Hispanic seniors aged 65 and older took part. The program involved 8 weekly in-home sessions and monthly booster calls to help improve blood suga…

This study tested whether the drug dapagliflozin (Forxiga) works better than standard treatments for people with type 2 diabetes whose blood sugar is not well controlled on metformin alone. Over 600 adults took either dapagliflozin plus metformin or usual care (like sulfonylureas…

This study tested whether people with type 2 diabetes and kidney damage can safely participate in a clinical trial from home. Twelve participants took the drug empagliflozin, and depending on their response, some added or switched to finerenone. The goal was to see if remote data…

This completed study tested an AI-based system called X-Life that gives personalized lifestyle advice to adults with type 2 diabetes. The system uses glucose levels and wearable data to guide diet and activity. 124 participants were split into two groups: one using X-Life and the…

This study compared several common diabetes medications when added to metformin in 7,850 adults with type 2 diabetes. The goal was to see which combination best kept blood sugar under control over time. Results help doctors and patients choose the most effective treatment plan.

This study tested whether a 12-week Ayurveda-inspired program combining a special diet, yoga, and breathing exercises was practical for adults with type 2 diabetes. Seventeen people started, and twelve completed the program. Participants followed the plan at least five days a wee…

This study tested whether a virtual weight control program combined with a continuous glucose monitor could help adults with type 2 diabetes lower their blood sugar levels. 152 overweight or obese adults with type 2 diabetes participated. The program used the WW (Weight Watchers)…

This completed phase 4 trial compared two common diabetes drugs, dapagliflozin and empagliflozin, added to metformin in 108 adults with type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). Participants took one of the two drugs daily for six months. Researchers used live…

This study tested whether a simplified approach to starting automated insulin delivery works safely in adults with type 2 diabetes. 56 participants used the Omnipod M System with a continuous glucose monitor, starting with either a lower or higher insulin dose. The goal was to se…

This completed study looked at over 28,000 people with type 2 diabetes and a type of heart failure called HFpEF. Researchers compared two drugs, tirzepatide and semaglutide, to see which one better reduces the risk of death or hospitalization for heart failure. The study used rea…

This study tested a new medicine called CagriSema, which combines two drugs (cagrilintide and semaglutide) in one weekly injection, for weight loss in 1200 adults who are overweight or obese and have type 2 diabetes. Participants received either CagriSema or a placebo for about 1…

This completed study tested whether a health behavior program designed with input from immigrant communities can improve diabetes management in first-generation immigrants with type 2 diabetes. Researchers compared the culture-sensitive program to standard care in 202 participant…

This study tested a once-weekly injection of semaglutide (2.4 mg) to help people with overweight or obesity lose weight. About 375 adults took part, some receiving the drug and others a placebo, along with lifestyle advice. The main goal was to see how much weight they lost over …

This completed study tested whether a new consultation method called M2-PRIME, which uses simple analogies like the 'Garbage and Lorry' model, could help people with type 2 diabetes on insulin improve their blood sugar control. 106 participants received three analogy-based consul…

This study tested a new device, DyaMX, that uses an endoscope to regenerate the lining of the upper small intestine in people with type 2 diabetes. The goal was to see if the procedure is safe and can help improve blood sugar control. 65 adults with diabetes took part. The main f…

This study tested whether a daily semaglutide tablet helps Chinese adults with overweight or obesity lose weight. About 200 participants took either the drug or a placebo for 44 weeks, along with guidance on diet and exercise. The main goals were to measure the percentage of weig…

This early-phase trial tested the safety and tolerability of a new drug called ZT002 in 32 healthy volunteers. Participants received either a single or multiple doses of ZT002 or a placebo by injection. The study aims to see if the drug is safe enough to move into larger trials f…

This study tested whether adding social gaming (earning points and supporting each other) to a weight loss app helps adults with overweight or obesity and at least 3 risk factors for type 2 diabetes lose more weight over 12 months. About 240 adults used a mobile app to track food…

This early-phase study tested a special form of cannabidiol (CBD) called DehydraTECH, alone or combined with GLP-1 drugs (like Ozempic), in 148 overweight or obese adults with prediabetes or type 2 diabetes. The main goal was to check safety and how the body processes the drugs, …

This study tested a new medicine called AZD5004 in 406 adults with type 2 diabetes. The goal was to see if it helps lower blood sugar better than a placebo or an existing diabetes drug. Participants had to have had diabetes for at least 6 months and be on diet, exercise, or stabl…

This study looked at whether weight-loss surgery (vertical sleeve gastrectomy) can improve kidney, heart, and pancreas function in teens aged 12-21 with type 2 diabetes and obesity. Researchers measured blood flow to the kidneys, kidney filtering ability, and insulin production b…

This study looked at whether a mobile app called 'Dose Check' helps people with type 2 diabetes control their blood sugar when used with the insulin Tresiba. 179 adults in Saudi Arabia used the app alongside their regular insulin for about 6-7 months. Researchers measured changes…

This study tested a new weekly injection called CagriSema, which combines two drugs (cagrilintide and semaglutide), to help Chinese adults with obesity or overweight lose weight. About 300 participants received either CagriSema, semaglutide alone, or a placebo for around one year…

This study looked at whether adding canagliflozin to an existing GLP-1 medication is safe and helpful for people with type 2 diabetes. 71 adults took the combination for 52 weeks. Researchers tracked side effects, blood sugar levels, weight, and blood pressure. The goal was to se…

This study looked at the long-term safety and effectiveness of adding canagliflozin to insulin therapy in adults with type 2 diabetes. A total of 139 people who had completed a previous 16-week study took part. Researchers tracked side effects, blood sugar control, and weight cha…

This study tested a new medication, TA-7284, in 1,299 adults with type 2 diabetes over 52 weeks. The goal was to see if the drug is safe and helps control blood sugar when used alone or with other diabetes medicines. Results focused on side effects, blood sugar levels, and weight…

This study tested a program that combines diabetes coaching, small financial rewards, and continuous glucose monitoring to help adults with type 2 diabetes improve their blood sugar management. 26 participants used a continuous glucose monitor and received motivational interviews…

This study tested whether a 12-week low-carbohydrate diet program, delivered through a smartphone app with remote coaching, could help people with type 2 diabetes improve their blood sugar and lose weight. 115 adults recently diagnosed with type 2 diabetes and who were overweight…

This pilot study tested a 6-month program combining group classes, personal coaching, and a low-carb diet to help people with early type 2 diabetes lose weight and possibly reverse their condition. It involved 35 overweight adults in low-income Memphis neighborhoods. The goal was…

This phase 2 trial tested HRS-7535, a new drug, in 281 adults with type 2 diabetes and diabetic kidney disease. Participants received either the drug or a placebo for 16 weeks. The main goal was to see if HRS-7535 could reduce protein in the urine, a sign of kidney damage, and he…

This study tested the long-term safety and blood sugar control of the drug MP-513 (Teneligliptin) in 240 Japanese adults with type 2 diabetes. Some participants took MP-513 alone, while others took it together with another diabetes medicine called glimepiride. The study lasted 52…

This study followed 50 adults with type 2 diabetes who were already prescribed oral semaglutide (Rybelsus) by their doctor. Researchers tracked changes in blood sugar (HbA1c) and body weight over about 8-10 months. Participants also filled out a questionnaire about how they took …

This study followed 244 adults with type 2 diabetes in Japan who were already prescribed Xultophy by their doctor. Researchers tracked blood sugar levels and low blood sugar episodes over 26 weeks to see how well the treatment works in everyday life. The goal was to understand re…

This completed study looked at how well oral semaglutide (Rybelsus) works for Thai adults with type 2 diabetes in everyday medical practice. Researchers reviewed medical records of 209 patients over 6 months to measure changes in blood sugar (HbA1c) and body weight. The goal was …

This study looked at whether alerts from continuous glucose monitors (CGMs) help hospital patients with type 1 or 2 diabetes manage their blood sugar better. Over 500 adults who needed intensive insulin therapy took part. The main goal was to see if alerts increased the time bloo…

This early study tested a device that uses mild electric pulses to regenerate the lining of the upper small intestine in 20 adults with type 2 diabetes. The goal was to see if the procedure is safe and could help lower blood sugar. Participants were on 2-3 diabetes pills and had …

This study compared a new version of the Omnipod insulin pump (SmartAdjust 2.0) to the current Omnipod 5 in 132 people with type 1 or type 2 diabetes, ages 2 to 70. Participants used each system for about a month to see if the new one is safe and helps keep blood sugar in a healt…

This study tested a new insulin called icodec that is injected just once a week, compared to a standard daily insulin (degludec), in 526 adults with type 2 diabetes. The goal was to see if the weekly insulin controls blood sugar as well as the daily one over 26 weeks. Participant…

This study tested whether an AI-powered health coach and gamification could help people with type 2 diabetes better manage their blood sugar. 88 participants in rural areas received weekly automated coaching calls and goal-setting. The main goal was to see if this approach is fea…

This completed study tested whether canagliflozin, a diabetes drug, can reduce scarring in the heart muscle of people with type 2 diabetes who are at high risk for heart problems. 45 participants were randomly assigned to take either canagliflozin or sitagliptin daily. Researcher…

This study tested whether higher doses (25 mg and 50 mg) of once-daily oral semaglutide work better than the standard 14 mg dose in people with type 2 diabetes. Over 1,600 adults took part, gradually increasing their dose over 68 weeks. The main goals were to see changes in blood…

This study looked at whether semaglutide, a type 2 diabetes medicine, can reduce the risk of major heart problems like heart attacks, strokes, or heart-related death. About 9,600 adults with type 2 diabetes and existing heart disease took either semaglutide tablets or a placebo d…

This early study tested whether a protein called apelin can improve how the body uses insulin in people with type 2 diabetes. Nine volunteers received both apelin and a placebo infusion to compare effects. The goal was to see if apelin increases the amount of sugar the body can p…

This study tested whether providing medically tailored meals, with or without weekly group support sessions, helps Black adults with high blood pressure, type 2 diabetes, obesity, or metabolic syndrome improve their health. 75 participants received either meals alone, meals plus …

This study looked at how well the diabetes pill Rybelsus (oral semaglutide) works in everyday life for adults with type 2 diabetes in Canada. About 194 people took the medication as prescribed by their doctor and filled out questionnaires over 8-10 months. The main goal was to se…

This study tested a new insulin called icodec that is injected just once a week, compared to a standard daily insulin (glargine), in 582 adults with type 2 diabetes. Participants also used mealtime insulin as needed. The goal was to see if the weekly insulin controls blood sugar …

This study looked at whether regular follow-up visits with nurses and dietitians help people with type 2 diabetes manage their condition better. 398 adults with type 2 diabetes first received a week of education on diet and exercise. Then half were assigned to frequent check-ins …

This study tested whether drinking an extra 1.5 liters of water daily for a year could lower blood sugar in adults with signs of dehydration and high blood glucose. Nearly 800 participants were split into two groups: one received lifestyle advice plus extra water, the other only …

This study tested a new once-weekly injection called IcoSema, which combines insulin icodec and semaglutide, against once-weekly insulin icodec alone in over 1,200 people with type 2 diabetes. The goal was to see if the combo improves blood sugar control more effectively. Partici…

This study tested a new insulin called icodec that is injected just once a week, compared to a standard daily insulin (glargine), in nearly 1,000 adults with type 2 diabetes who had never used insulin before. The main goal was to see if the weekly insulin could control blood suga…

This study tested whether a culturally tailored diabetes education program, called Compañeros en Salud, combined with a continuous glucose monitor (CGM) helps Latinx adults with type 2 diabetes control their blood sugar better than education alone. 120 adults aged 18-60 with an A…

This study tested whether a weekly injection of semaglutide (2.4 mg) can improve heart failure symptoms and reduce body weight in 617 people with obesity-related heart failure with preserved ejection fraction and type 2 diabetes. Participants received either semaglutide or a plac…

This study tested whether taking sodium butyrate tablets for 12 weeks, along with a modestly reduced-calorie diet, helps overweight or obese adults (with or without type 2 diabetes) lose more weight and improve blood sugar and fat levels compared to a placebo. 46 participants wer…

This study tested whether it's possible to use the diabetes drug empagliflozin in 60 veterans with prediabetes. Participants took the drug or received standard lifestyle advice for 12 weeks. The main goal was to see if people would join and stay in the study, not to prove the dru…

This study tested an automated insulin delivery system (the Omnipod 5) in 130 hospitalized adults with type 1 or type 2 diabetes. Patients were randomly assigned to use the automated system or standard insulin injections plus a continuous glucose monitor. The goal was to see if t…

This study tested whether using mobile monitoring devices along with nurse support can help people better manage type 2 diabetes and high blood pressure. 220 adults with poor diabetes control took part. The program focused on teaching self-management skills like tracking blood su…

This study compared two diets for people with type 2 diabetes: a very low-carbohydrate (keto) diet and a plate-method diet. Over 12 months, researchers tracked blood sugar control and body composition in 182 participants. The goal was to see which approach better improves diabete…

This study tested a once-daily pill called orforglipron in 546 adults with type 2 diabetes whose blood sugar was not well controlled despite using insulin (with or without other diabetes medications). The goal was to see if adding orforglipron could safely lower blood sugar level…

This study tested a program called ENACTS to help Native Hawaiian and Pacific Islander adults with high blood pressure or type 2 diabetes lower their blood pressure. The program included support for healthier eating, more physical activity, and working with grocery stores to labe…

This study tested a new once-daily pill called orforglipron against an existing drug, dapagliflozin, in adults with type 2 diabetes whose blood sugar was not well controlled with metformin alone. About 962 participants took either orforglipron or dapagliflozin for roughly 46 week…

This study tested whether using wireless continuous glucose monitors (CGM) in the hospital can help manage blood sugar levels for people with type 1 or high-risk type 2 diabetes. 157 patients wore the monitors, which sent real-time glucose readings to a care team that could adjus…

This study looked at how well once-daily oral semaglutide (Rybelsus) works for adults with type 2 diabetes in everyday medical practice in Israel. Researchers tracked changes in blood sugar and body weight over about 8-10 months. The goal was to see if the pill helps lower blood …

This study looked at whether a special nutritional drink called Resource Diabet Plus can improve blood sugar and cholesterol levels in people with type 2 diabetes who are malnourished or at risk of malnutrition. Researchers reviewed medical records of 59 patients in Spain who too…

This study followed 291 adults with type 2 diabetes whose blood sugar was not well controlled on their current medication (DPP4i). Participants switched to an oral version of semaglutide, a drug that helps lower blood sugar and may aid weight loss. Over about 5-6 months, research…

This study tested the Omnipod 5, a wearable device that automatically delivers insulin, in 343 adults with type 2 diabetes. Participants used the system for 13 weeks to see if it improved blood sugar levels. The goal was to make diabetes management simpler and more effective.

This study followed 145 adults with type 2 diabetes who took once-daily oral semaglutide (Rybelsus) as part of their normal care. Researchers measured changes in blood sugar (HbA1c) and body weight over 8-10 months. The goal was to see how well the medication works in everyday li…

This study looked at how well the diabetes pill Rybelsus (oral semaglutide) works in real life for adults with type 2 diabetes in Sweden. Researchers tracked blood sugar levels and weight changes over 8-10 months in 194 people who were already prescribed the medication by their d…

This study looked at how well once-daily oral semaglutide (Rybelsus) works for adults with type 2 diabetes in everyday UK clinics. Researchers tracked blood sugar levels and weight changes over 8-10 months in 336 participants. The goal was to see if the pill helps lower blood sug…

This study followed 99 adults with type 2 diabetes in Denmark who were already prescribed once-daily oral semaglutide (Rybelsus). Researchers tracked changes in blood sugar (HbA1c) and body weight over 8-10 months, along with patient questionnaires. The goal was to see how well t…

This study tested whether taking moringa leaf powder capsules for 8 weeks could improve metabolic syndrome in Mexican adults. 36 participants were randomly assigned to receive either moringa or a placebo. Researchers measured changes in weight, blood pressure, waist size, and blo…

This study tested a medication called tirzepatide in children and teenagers aged 10 to 17 with type 2 diabetes. Participants were already taking metformin or insulin but still had high blood sugar. The goal was to see if tirzepatide could safely lower blood sugar levels better th…

This completed study looked at how well once-daily oral semaglutide (Rybelsus) works for adults with type 2 diabetes in real-world clinics across Spain. Researchers tracked changes in blood sugar (HbA1c), body weight, and how satisfied patients were with their treatment over 8-10…

This completed study in Italy looked at how well once-daily oral semaglutide (Rybelsus) works for adults with type 2 diabetes in everyday medical practice. Researchers tracked changes in blood sugar and body weight over 8-10 months in 458 participants. The goal was to see if this…

This study looked at how well once-daily oral semaglutide (Rybelsus) works for adults with type 2 diabetes in everyday clinical practice in Saudi Arabia. Researchers tracked changes in blood sugar (HbA1c) and body weight over 8-10 months in 194 participants. The goal was to see i…

This study followed 650 adults with type 2 diabetes in Japan who were already prescribed oral semaglutide (Rybelsus) by their doctors. Researchers tracked changes in blood sugar levels and body weight over 8-10 months, along with any side effects. The goal was to see how the medi…

This study tested a long-acting insulin called insulin glargine U300 in 570 Chinese adults with type 2 diabetes whose blood sugar was not well controlled. Some participants had never used insulin before, while others switched from another basal insulin. The main goal was to see h…

This early study tested a small implant placed under the skin that steadily releases a drug called exenatide, similar to popular weight-loss and diabetes medications. The goal was to check safety and how the drug behaves in the body. Twenty-four overweight but otherwise healthy a…

This study tested a long-acting insulin called glargine (brand name Toujeo) in 228 adults with type 2 diabetes whose blood sugar was still too high despite taking oral diabetes medications. The main goal was to see how safe the insulin was, including any low blood sugar episodes.…

This phase 2 trial tested the safety and effectiveness of metformin extended release (XR) in 12 adults with type 2 diabetes and mild to moderate chronic kidney disease (stages 1 to 3). Participants took metformin XR tablets for 6 to 12 weeks, and researchers monitored their blood…

This study tested whether a digital app combined with a 12-week very low-calorie diet (800 calories per day) could help adults with type 2 diabetes lose weight and achieve remission. One hundred participants were randomly assigned to either the digital program or standard care. T…

This completed study looked at whether the diabetes drug empagliflozin (Jardiance) can help repair heart damage in diabetic patients who had a major heart attack. 200 participants took either 10 mg or 25 mg of the drug daily for 6 months. Researchers measured changes in heart siz…

This study looked at whether drinking diet beverages (like diet soda) instead of water affects blood sugar control in adults with type 2 diabetes. 181 participants who regularly drank diet beverages were randomly assigned to keep drinking them or switch to plain water for 24 week…

This completed Phase 4 study tested Soliqua 100/33, a once-daily injectable combining insulin and a GLP-1 drug, in 124 adults with very uncontrolled type 2 diabetes (HbA1c ≥9%) who were not yet on insulin. The goal was to see if the drug increased the time their blood sugar staye…

This Phase 3 trial tested a drug called relacorilant in 137 people with hypercortisolism caused by adrenal adenomas or hyperplasia. The goal was to see if it could improve blood sugar control and lower high blood pressure. Participants received either relacorilant or a placebo fo…

Researchers are evaluating four blood glucose meters and four HbA1c point-of-care devices to see how accurately they measure blood sugar and long-term glucose control compared with standard lab methods. The study includes people with diabetes, both adults and teenagers, some of w…

This pilot study explores whether three different home sleep apnea testing devices—NightOwl, SleepImage, and Nox T3—are practical and user-friendly for adults with type 2 diabetes. Participants will wear each device at home for three nights and answer questionnaires about their e…

Researchers at Assiut University are investigating whether the ratio of two blood proteins, fibrinogen and albumin, is linked to diabetic kidney disease in people with type 2 diabetes. The study compares 50 patients who have both type 2 diabetes and kidney disease with 50 patient…

This study investigates whether hearing problems are an under-recognized complication of diabetes. Researchers will screen 172 adults with type 1 or type 2 diabetes using hearing tests and a questionnaire. If a hearing issue is found, a more detailed assessment will be done to de…

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study looked at new markers in blood and urine to detect and predict the severity of drug-associated acute pancreatitis in adults. Researchers compared these markers in 175 patients with drug-induced pancreatitis, other pancreatic diseases, and healthy volunteers. The goal i…

This study looked at whether two blood tests, eLIFT and FibroMeter, can accurately detect liver fibrosis (scarring) in people with type 2 diabetes. The researchers compared these blood tests to standard methods like FibroScan and liver biopsy. The goal is to find a simpler, less …

This study looked at over 5,000 adults coming to the emergency room to see how many had undiagnosed type 2 diabetes or pre-diabetes. Researchers used a standard HbA1c blood test, already taken for other reasons, to screen patients. The goal was to find out how common hidden diabe…

This study tested whether adding a special 'pre-session'—which includes education about diabetes risks, motivational interviewing, and help solving barriers—could encourage more people to attend a national diabetes prevention program. The trial involved 483 adults at risk for dia…

This study tested a program to prevent type 2 diabetes in Chinese immigrants with prediabetes. Participants received weekly videos on diabetes prevention and fresh, culturally appropriate produce. The goal was to see if this approach could help people lose weight and build health…

This study follows people at high risk for diabetes who previously took part in a program testing intensive lifestyle changes or the drug metformin. The goal is to see if these approaches can prevent or delay diabetes and reduce long-term health problems like heart disease and ca…

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This completed study tested a 24-month program that combined face-to-face counseling with digital tools to help families prevent and manage type 2 diabetes and high blood pressure. Over 1,200 adults and their children from Albania, Bulgaria, Greece, and Spain took part. The progr…

This study tested a six-month home-based exercise program using elastic bands to prevent frailty in 120 adults aged 50-85 with type 2 diabetes and chronic kidney disease. The program aimed to improve muscle strength and daily functioning. Researchers measured changes in frailty s…

This study tested a special version of the Diabetes Prevention Program designed specifically for men. 301 men with pre-diabetes or high risk took part to see if the program helped them lose weight and prevent type 2 diabetes. The program focused on lifestyle changes and was deliv…

This completed study tested a 6-month program that taught nutrition and exercise to mothers and their children (ages 7-12) in the Yaqui Valley, Mexico. The goal was to improve lifestyle habits and prevent food insecurity, malnutrition, and related health problems like heart disea…

This study tested a new way to prevent type 2 diabetes in people with pre-diabetes. Participants wore a continuous glucose monitor (CGM) on their arm and received AI-generated educational videos on their smartphone. The goal was to see if this combination could help lower average…

This completed study compared two versions of the Diabetes Prevention Program in 304 overweight adults with prediabetes. One group followed the standard lower-calorie, lower-fat diet, while the other tried a very low-carbohydrate diet. Researchers measured changes in blood sugar …

This study tested whether letting people with prediabetes set their own health goals (NDPP-Flex) works better than the standard diabetes prevention program. About 200 adults from Denver Health took part. The goal was to see if this flexible approach could lower blood sugar and he…

This study tested whether watching calming VR videos or squeezing a stress ball could reduce pain, anxiety, and improve satisfaction during insulin injections in older adults (65+) with type 2 diabetes. 90 participants were split into three groups: VR, stress ball, or usual care.…

This study tests whether a 6-week program of non-weight bearing exercise can help diabetic foot ulcers heal faster than standard wound care alone. Forty adults with type 2 diabetes and a foot ulcer will be randomly assigned to exercise plus standard care or standard care only. Re…

Researchers are testing whether a two-week course of functional magnetic stimulation applied to the sole of the foot can improve feeling, foot strength, balance, and walking in adults with type 2 diabetes and diabetic peripheral neuropathy. Participants are randomly assigned to r…

Researchers are testing whether cognitive behavioral therapy for insomnia (CBT-I) can improve blood sugar control in older Chinese adults with type 2 diabetes and insomnia. The trial compares CBT-I to usual care in 214 participants aged 60 and older. They will measure changes in …

People with type 2 diabetes often face higher rates of anxiety and depression than the general public. Researchers at Dasman Diabetes Institute are testing whether six weeks of guided breath awareness, practiced inside a pyramid-shaped structure, can reduce those symptoms. The pi…

This study tests whether a new medicine called CagriSema can reduce nerve pain in people with type 2 diabetes. About 142 adults with painful diabetic neuropathy will receive either CagriSema or a placebo for around 10 months. The main goal is to see if the drug lowers weekly pain…

This small study in Uganda looks at how meals made with local fruits and vegetables affect blood sugar and fat levels in people with type 2 diabetes. Eight participants will eat five different test meals over five weeks, with blood samples taken over three hours after each meal. …

This study looked at whether quercetin, a natural substance found in foods like apples and onions, can change how the body absorbs sugar. Researchers gave 24 obese adults (some with type 2 diabetes) either quercetin or a placebo during a sugar-drink test. They measured blood suga…

This early-phase study looks at whether older adults (65+) with type 2 diabetes and mild cognitive impairment can better manage their blood sugar by sharing continuous glucose monitor data with a care partner via a mobile app. Fourteen participants and their care partners will us…

This study asks whether using a continuous glucose monitor (CGM) — a small sensor worn under the skin that tracks blood sugar levels in real time — can improve quality of life for adults with type 2 diabetes. Participants will use the device for 12 months and complete questionnai…

This study tests whether a walking program that uses FitBit tracking and personalized coaching can help people who recently had a leg amputation due to diabetes or peripheral artery disease become more physically active. Participants will use a FitBit to monitor their steps and r…

This study tested whether a 12-week Pilates program could improve erectile function in 60 men aged 40-60 with type 2 diabetes and erectile dysfunction. Participants did Pilates three times a week for 60 minutes each session. The study measured blood flow in the penis and used a q…

This study tested whether semaglutide, a diabetes medicine, improves walking ability in people with type 2 diabetes and peripheral artery disease (narrowed leg arteries). About 792 adults received weekly injections of semaglutide or a placebo for 59 weeks. The main goal was to se…

This study tested a non-invasive ear-clip device that gently stimulates the vagus nerve to see if it can reduce pain in people with diabetic peripheral neuropathy. 185 adults with type 2 diabetes and chronic nerve pain used the device or a sham version twice daily for 12 weeks. T…

This study tested whether using electrical stimulation on the thigh muscles could improve how the body uses insulin in people with type 2 diabetes. Eighteen adults with type 2 diabetes who were overweight and on oral medication received a single session and then six days of daily…

This small study tested whether gummy candies made with maqui berry could help overweight adults control their blood sugar after eating a carb-rich meal. Ten participants ate white bread alone, or with maqui berry gummies, and had their blood sugar and antioxidant levels measured…

This study tested whether adding spiritual care to standard diabetes care helps adults with type 2 diabetes. 80 participants received either usual care or usual care plus a structured spiritual program. Researchers measured changes in psychological resilience, distress, and blood…

This study tested a new approach called HypnoDiaCare, which combines hypnosis with diabetes education, to see if it helps adults with type 2 diabetes manage their condition and feel better. Fifty-four participants were split into three groups: one received hypnosis-based educatio…

This study tested a mindfulness program for 30 teens aged 12-18 with prediabetes or type 2 diabetes. The goal was to see if the program was practical and liked by teens, and to explore any effects on health measures like blood sugar. The approach involved group sessions and quest…

This study tested whether mindfulness training helps people with type 2 diabetes better manage food cravings and stick to a low-carb diet. Sixty adults participated, learning skills to notice cravings without automatically eating. The goal was to improve long-term diet adherence …

This study tested a phone-based coaching program for veterans with type 2 diabetes who feel stressed or overwhelmed by daily self-care tasks like checking blood sugar and taking insulin. The program gave personalized advice and support to help reduce that stress and improve blood…

This study tested whether an online mindfulness program could help adults with type 1 or type 2 diabetes lower their blood sugar. Over 300 participants with high stress and poor glucose control were randomly assigned to either an 8-week Mindfulness-Based Stress Reduction course o…

This study tested whether shivering from cold exposure can improve 24-hour blood sugar levels in people with prediabetes or type 2 diabetes. Twenty-four participants underwent two cold sessions at different shivering intensities. The goal was to see if muscle activation from shiv…

This completed study looked at insurance claims data from 70,000 people with type 2 diabetes and established heart disease to compare the heart-related risks of three diabetes drugs: tirzepatide, dulaglutide, and semaglutide. The goal was to see if any of these drugs was linked t…

This study looked at how different types of aerobic exercise (moderate continuous training vs. high-intensity interval training) and diet counseling affect cell health in people with type 2 diabetes. Researchers measured changes in mitochondria (the cell's power plants) and oxida…

This completed study looked at 1759 adults aged 18-55 to uncover why some people develop type 2 diabetes. Researchers measured how the body handles sugar, uses energy, and stores fat, and also collected genetic samples. The goal was to find genetic and lifestyle factors that lead…

Researchers are examining the medical records of 12,000 people with type 2 diabetes who visited a large diabetes care center in Southern India during 2022 and 2023. The study aims to estimate how many of these patients have kidney insufficiency, a complication that past estimates…

Researchers at the University at Buffalo are studying whether insulin can reduce inflammation by suppressing toll-like receptors, which are part of the body's immune alarm system. The trial compares insulin infusion with dextrose and saline infusions in three groups: lean healthy…

This study uses computer simulations to compare two treatment strategies for people with chronic kidney disease and type 2 diabetes. Researchers will model whether adding empagliflozin to finerenone reduces heart failure, hospitalizations, and cardiovascular death more than finer…

This completed study in Kazakhstan looked at 240 adults recently diagnosed with diabetes. Researchers measured blood sugar, insulin resistance, and immune markers to understand how different forms of diabetes develop. The goal is to help doctors diagnose and treat adult-onset dia…

This study looks at American Indians with type 2 diabetes who had early kidney disease and took a drug called losartan years ago. Researchers want to see if the benefits of that treatment still help protect their kidneys today. About 141 people who were in the earlier study or th…

Researchers in Belgium are studying adults with type 2 diabetes to understand how often they develop non-alcoholic fatty liver disease (NAFLD) and what that condition looks like. Participants will undergo a liver scan, provide blood samples, and answer questionnaires about their …

This study compares two diets in people with overweight and early signs of blood sugar problems: a low-carbohydrate diet and a Mediterranean diet, both designed to produce similar weight loss. Each participant follows both diets for four weeks, in random order, with a break in be…

Researchers are using ultrasound to measure the thickness of ankle cartilage in people with type 2 diabetes who have nerve damage, and comparing it with healthy adults. Diabetic polyneuropathy may change how the lower limbs move, which could affect the ankle joint. The study incl…

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This completed Phase 1 study looked at how vitamin E is absorbed and used in the bodies of normal-weight and obese women, and whether vitamin C helps. Fifty women aged 18 to 40 took part, including some with type 2 diabetes. Researchers gave different doses of vitamin E (by mouth…

This study looks at how body weight influences physical activity, balance, and quality of life in 50 adults with type 2 diabetes. Researchers will measure body composition, muscle strength, walking ability, and balance using simple tests and questionnaires. The goal is to better …

This study tests whether a non-invasive device called Gastric Alimetry can detect changes in stomach muscle activity caused by semaglutide (Ozempic). Researchers will measure stomach electrical signals and symptoms in people with and without diabetes before and after taking the w…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This observational study looks at records from Israel's National Insurance Institute to understand how often diabetes is linked to permanent disability. It will compare disability rates and severity across different regions and over time, from 2020 to 2025. No treatments or tests…

This study follows adolescents with youth-onset type 2 diabetes, along with obese and lean peers, into young adulthood to see how their kidneys change over time. Using advanced imaging and kidney function tests, researchers aim to understand early signs of diabetic kidney disease…

This study is looking at whether peripheral artery disease (PAD) is linked to lower levels of regenerative cells in the blood. Researchers will compare blood samples from adults with PAD to those without the condition, measuring the number of certain progenitor cells and markers …

This study looks at how fasting and temporarily stopping the diabetes drug dulaglutide affect how much food and liquid stays in the stomach after a meal. About 20 people with type 2 diabetes will have their stomachs checked with ultrasound after eating. The goal is to understand …

This study looks at whether a substance in the blood called neurofilament light chain (NfL) is linked to how severe nerve damage is, how well people balance, and their risk of falling. Researchers will measure NfL levels in 80 adults with type 2 diabetes, some with and some witho…

This study explores whether compounds in cannabis, like THC and CBD, can reduce inflammation and improve how the body responds to insulin. Researchers will measure blood markers of inflammation and insulin sensitivity in people across the weight spectrum, both after a single use …

This Phase 1 trial tests two experimental drugs (L03RD1 and L03RD2) in 48 healthy adults to see how safe they are and how the body processes them. Participants take the drugs alone or together in a single dose. The study does not aim to treat diabetes, but to gather information f…

This study will assess the diet, heart health, body composition, mental wellbeing, and physical performance of 600 U.S. Army soldiers. Researchers aim to gather detailed data on nutrition and health, similar to a national survey but tailored for the military. The goal is to bette…

This study looks at whether drinking a beverage with artificial sweeteners (erythritol or xylitol) changes how blood platelets clump together, which could affect heart attack or stroke risk. Researchers will measure platelet activity and blood levels of these sweeteners in 50 hea…

This study tested two strategies to improve how often people with type 2 diabetes are referred to and attend diabetes self-management education (DSMES) classes. Researchers gave providers alerts in the electronic health record and offered peer support to patients. The goal was to…

This study investigates how the liver processes nutrients after a meal in healthy individuals and in patients with fatty liver disease or cirrhosis. Researchers will take blood samples and liver biopsies after fasting or eating a standardized meal, and after a glucagon injection.…

This study tested whether training healthcare providers to prescribe continuous glucose monitors (CGMs) increases their use among patients with type 2 diabetes. Researchers trained clinic staff at three community health centers serving a mostly Hispanic/Latino population. They th…

This study tests whether a lifestyle program held at senior centers can help older adults (age 60+) with type 2 diabetes improve their physical function and quality of life. About 20 participants will take part in the program, which includes education and activity sessions. The m…

This study analyzed health records from over 450,000 adults with obesity and type 2 diabetes to see if adding a GLP-1 or SGLT2 drug early improves survival and kidney health. Researchers compared those who added the other drug class within 90 days to those who added a different d…

This early-stage study tested different oral versions of the drug AZD5004 in 65 healthy adults. The goal was to see how the body absorbs and processes each version, and whether taking it with food changes those effects. The study is complete, but results are not yet available.

This completed study in India looked at 362 hospital patients to understand how common high blood sugar (hyperglycemia) is and how it affects their hospital stay. Researchers measured blood sugar levels, checked for diabetes, and looked at body composition and certain blood marke…

This study looked at how gut bacteria affect the development of type 2 diabetes and help personalize treatment. Researchers followed 100 adults newly diagnosed with type 2 diabetes who had not taken diabetes medication before. They analyzed stool samples and blood tests, then ass…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study looked at how quickly bringing high blood sugar under control, combined with moderate treadmill walking, affects certain proteins linked to bone health in people with type 2 diabetes. The goal was to understand why some patients develop a rare but serious joint conditi…

This study looked at the genes of 40 adults with type 2 diabetes to find DNA differences that might explain why some develop Charcot foot, a serious joint problem. Half of the participants had Charcot foot, and half did not. Researchers compared their exomes (the part of DNA that…

This study looked at how a single dose of HR17031 moves through the body in people with mild, moderate, severe, or end-stage kidney disease compared to those with normal kidneys. A total of 24 adults with type 2 diabetes took part. The goal was to understand how kidney function a…

This study looked at how much blood sugar levels go up and down during the day in frail or disabled patients over 75 with diabetes who use basal insulin. Researchers used a continuous glucose monitor for 5 days to compare two types of insulin: human NPH and long-acting analogues.…

This early-stage study tested a new drug (HL1113) in 37 healthy adults to see how the body processes it. The drug combines two existing medicines for high blood pressure and type 2 diabetes. Participants took the drug in different ways to compare safety and drug levels. The resul…

This completed study looked at 126 people with different fat distribution patterns—including those with lipodystrophy (abnormal fat loss or distribution), obesity, and normal weight—to understand how fat tissue relates to insulin resistance and immune signals. Researchers measure…

This study looked back at medical records of 2,740 adults with type 2 diabetes who were admitted to the ICU for septic shock, a life-threatening infection. Researchers wanted to see if those who were already taking metformin (a standard diabetes pill) before getting sick had a lo…

This completed study looked at 172 people with and without HIV to understand why those with HIV have a higher risk of diabetes. Researchers examined fat tissue and immune cells to see if chronic immune activation in fat contributes to insulin resistance. The goal was to learn how…

This early-stage trial looked at how a single 50mg dose of pyroglutamate rongliflozin capsules behaves in 32 adults with mild or moderate liver damage and type 2 diabetes, compared to healthy volunteers. Researchers measured drug levels in the blood and tracked side effects to un…

This study looked at how different levels of exercise change the bacteria in the gut of people with type 2 diabetes. Forty adults with type 2 diabetes did either moderate or high-intensity endurance and strength training for 16 weeks. Researchers compared changes in blood sugar a…

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study looked at how inherited gene variants influence the body's response to two common type 2 diabetes medications, metformin and glipizide. Over 1,000 participants took each drug and had their glucose and insulin levels measured. The goal was to understand why some people …

This study looks at how the body processes HRS9531, an experimental diabetes drug, in people with different levels of kidney function. Researchers gave a single dose to 32 volunteers—some with healthy kidneys and some with mild impairment—and measured drug levels over time. The g…

This study analyzed data from over 16,500 adults with chronic heart failure who were part of a remote monitoring program in France. Researchers looked at how having diabetes, other health conditions, and short-term weight changes were linked to survival. The goal was to better un…

This completed trial tested whether electronic alerts in the emergency room can improve care for people with type 2 diabetes. The alerts prompted doctors to order an A1c test when blood sugar was very high, and to consider admitting the patient for better diabetes management. Res…

This completed study from Denmark looked at 101 people to see if nerve damage from type 2 diabetes is linked to memory and thinking problems. Researchers compared people with and without diabetes using tests of thinking skills, nerve function, and brain scans. The goal was to und…

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This completed Phase 1 trial tested how four diabetes medications (HRS-1780, henagliflozin, metformin, and HRS-7535) affect each other's levels in the body. Twenty-four healthy men took the drugs in a fixed order, and researchers measured drug concentrations and side effects. The…

This pilot study tested whether taking metformin 30 or 60 minutes before a meal affects carbohydrate absorption in people with obesity and prediabetes or type 2 diabetes. One participant completed three oral glucose tolerance tests—one without metformin, one with metformin taken …

This completed early-phase study tested different doses of fatty acids (Intralipid) in 9 healthy volunteers to find the dose that causes mild insulin resistance. The goal was to create a reliable model for future diabetes research. Participants received low or medium doses of fat…

This completed study analyzed electronic health records from over 6,500 patients in China who started taking finerenone for chronic kidney disease and type 2 diabetes. Researchers tracked kidney function, potassium levels, and side effects like high potassium. The goal was to see…

This study looked at how the amount of salt in the diet changes the effects of the diabetes drug ertugliflozin on blood pressure and kidney function. Overweight adults with type 2 diabetes followed either a low-salt or high-salt diet while taking the drug or a placebo. The goal w…

This study looked at data from 348 people with type 2 diabetes in Germany who use the myTherapy app. Researchers wanted to see how many had high levels of a protein called albumin in their urine, which is a sign of kidney damage. They also tracked how these levels changed over a …

This study combines data from four earlier trials to track 262 adults with type 2 diabetes and obesity for up to 13 years. Researchers want to see if bariatric surgery keeps blood sugar under control longer than medical or lifestyle changes. Participants were originally in random…

This study looks at whether metformin, a standard diabetes medicine, can improve thinking and memory in older adults with type 2 diabetes by altering their gut bacteria. Fifty participants aged 55 to 80 will be followed for a year, with half taking metformin for six months. Resea…

This small pilot study looked at whether aprepitant, a drug used for nausea, can reduce aldosterone (a hormone that raises blood pressure) in people with type 2 diabetes and low-renin hypertension. Five participants took either aprepitant or a placebo for two weeks, then switched…

This completed study looked at how the hormone GIP changes blood flow in the gut after a sugary drink in 10 people with type 2 diabetes. Researchers used a GIP-blocking drug to see what happens when GIP is stopped. The goal was to better understand GIP's role in digestion and met…

This study tested a personalized medicine approach in 239 people with type 2 diabetes who use multiple daily insulin injections. Researchers used blood tests (C-peptide and GAD antibodies) to see if some patients could safely stop their mealtime insulin and switch to other diabet…

This study looked at whether giving a carbohydrate drink (yogurt with honey) before elective abdominal surgery is safe and helpful for people with type 2 diabetes. 120 patients were split into three groups: non-diabetic controls, non-diabetic with the drink, and diabetic with the…

This study looks at why dapagliflozin, a diabetes drug, can raise 'bad' cholesterol levels. Researchers will track how the body makes and clears cholesterol in 28 adults with type 2 diabetes over 6 months. Half the participants will get dapagliflozin, the other half a placebo. Th…

This study looked at 1500 people with obesity (BMI 25 or higher) to find out what helps diabetes go away and other health issues improve after weight-loss surgery. Researchers collected health data before and after surgery, including weight, blood sugar, and quality of life. The …

This study tested whether special communication training for pharmacists and general practitioners helps them involve older patients in decisions to stop or lower medications for heart disease and diabetes. Researchers enrolled 310 patients aged 75 and older who were taking certa…

This completed study looked at how people change their eating habits after starting GLP-1 drugs like Ozempic or Mounjaro for weight or diabetes. Researchers tracked 37 adults using dietary records and questionnaires to see if it's feasible to study diet changes this way. The goal…

This study looked at over 133,000 adults with newly diagnosed type 2 diabetes who were smokers. Researchers wanted to see if switching from regular cigarettes to e-cigarettes could lower the risk of heart problems and diabetes complications. The study used health records to compa…

This study looked at how quickly the drug BGM0504 enters the blood and how long it stays in the body. Researchers compared 34 people with normal kidney function to those with mild or moderate kidney problems. The goal is to understand if kidney function changes how the drug shoul…

This study looked at how brown adipose tissue (brown fat) works in people with type 2 diabetes. Researchers used special PET scans with a fat-based tracer to measure brown fat activity more accurately than before. The study included 6 participants and aimed to better understand h…

This study looked at how diabetes changes the way certain fats (arachidonic acid) are processed in fatty plaques that build up in the carotid artery. Researchers compared plaque samples from 204 diabetic and non-diabetic patients undergoing surgery for carotid stenosis. The goal …

This study looked at how semaglutide, a diabetes medicine, affects the kidneys in people with type 2 diabetes and chronic kidney disease. 106 participants received either semaglutide or a placebo injection once a week for about a year. Researchers used MRI scans, blood and urine …

This study looked at a recently discovered hormone called 26RFa in 62 women who were obese, some with type 2 diabetes and some without. Researchers measured the hormone levels before and after weight-loss surgery (sleeve gastrectomy) and compared them to healthy-weight volunteers…

This study explored whether personality type (A or B) and stress levels differ between people with type 2 diabetes who have foot wounds and those who do not. Researchers used questionnaires to measure personality, stress, depression, and quality of life in 66 participants. The go…

This study looked at whether a special education program could help people with diabetic foot (a serious complication of type 2 diabetes) become more prepared for disasters like earthquakes or floods. 68 patients took part, with some receiving the education and others getting usu…

This study looked at whether GLP-1 agonists, a class of diabetes drugs, can reduce fat buildup in the heart muscle of people with type 2 diabetes. Researchers used MRI scans to measure heart fat before and after 6 months of treatment in 42 adults over 50. The goal was to understa…

This completed study looked at healthcare claims data from over 58,000 people to see if it could reproduce the results of the STEP-HFpEF DM trial, which tested semaglutide for heart failure with preserved ejection fraction in people with type 2 diabetes. Researchers compared new …

This completed study looked at whether information from healthcare claims (like insurance records) can be used to get similar results as a real clinical trial. Researchers compared people with type 2 diabetes and heart failure who started taking tirzepatide to those who started t…

This study looked at how well 60 adults with type 2 diabetes could follow a Mediterranean diet for 12 months. Researchers wanted to see what makes it hard or easy to stick with this healthy eating plan. The goal is to find ways to help more people with diabetes adopt this diet.

This study examined whether type 2 diabetes influences how well a dental procedure called pulpotomy works in adults. Researchers compared 70 diabetic and non-diabetic patients who had a molar treated for irreversible pulpitis. They checked the tooth's health, symptoms, and X-ray …

This study looked at how low blood sugar (hypoglycemia) affects the body's ability to control heart rate in people with well-controlled type 2 diabetes. Fourteen adults underwent two sessions of low blood sugar while their heart rate regulation was measured. The goal was to under…

This study gathered information from 1,061 adults in Saudi Arabia about their weight, blood sugar, heart health, and lifestyle. The goal was to understand how common heart disease is in people with obesity. Participants filled out a questionnaire during a routine doctor visit, an…

This study looked at 80 pregnant women with type 2 diabetes who used continuous glucose monitors (CGMs) to track their blood sugar. Researchers wanted to see if how well blood sugar was controlled during pregnancy was linked to health problems in newborns, such as preterm birth, …

This study looked at whether a nutrition and behavior change program could help reduce sleep apnea in people who are overweight or obese. About 400 adults took part, and researchers measured changes in sleep apnea risk, daytime sleepiness, and weight loss. The goal was to see if …

This study looked at whether a generative AI simulation can improve how medical students communicate a type 2 diabetes diagnosis. 120 students were split into two groups: one used the AI tool, the other used traditional methods. Researchers measured changes in communication skill…

This study looked at whether viral infections and diabetes in pregnant women are linked to congenital heart defects in their babies. Researchers analyzed blood and stool samples from 114 women to detect viruses and immune responses. The goal was to gather knowledge for future lar…

This study looked at how a new combination diabetes drug, CKD-383, moves through the body compared to taking the individual drugs separately. It involved 30 healthy adults who received a single dose of each treatment in a random order. The goal was to measure drug levels and chec…

This early-stage study looked at how a new combination diabetes drug, CKD-383, is processed by the body and whether it is safe. Thirty healthy adults took the drug as two tablets together or separately in a random order. The goal was to compare the two ways of taking the medicati…

This study looked at 186 pregnant women with type 1 or type 2 diabetes to understand how fats in the blood relate to baby birth weight. Researchers measured blood fats, diet, and placenta genes. The goal is to find new ways to prevent babies from being born too large, which can c…

This study looked at how well the Pfizer COVID-19 vaccine triggers an immune response in 196 adults with weakened immune systems (due to conditions like kidney transplant, cancer, or HIV) compared to healthy adults. Researchers measured antibody levels and their ability to neutra…

This study looked at how common and severe fatty liver disease is in people with type 2 diabetes. Researchers used advanced MRI scans to measure liver fat, inflammation, and scarring. 317 patients were checked twice, three years apart, to see how the disease changes over time. Th…

This study looked at whether chemicals in the breath (VOCs) match blood sugar levels in people with type 2 diabetes. Twenty adults with diabetes had their breath and blood sugar measured after drinking sugar water and receiving insulin. The goal was to see if a breath test could …

This study looked at 202 adults with type 2 diabetes and early-stage diabetic eye disease (non-proliferative diabetic retinopathy). Researchers used non-invasive eye scans to find markers that could predict if the disease would get worse or lead to sight-threatening problems. The…

This study looked at fat cells from bone marrow and belly fat in 45 post-menopausal women having knee replacement surgery for osteoarthritis. Researchers measured gene activity to see if bone marrow fat releases more joint-damaging factors. The goal is to understand how fat contr…

This study looked at whether a person's genes can help predict their risk of diabetic ketoacidosis (DKA) when taking SGLT2 inhibitors, a common class of diabetes drugs. Researchers collected DNA from 63 adults with type 2 diabetes who were either hospitalized with DKA while on th…

This completed study followed 1,290 adults with type 1 or type 2 diabetes for two years. Researchers tracked mental health issues like depression, anxiety, and eating problems alongside daily blood sugar levels using smartphone surveys and continuous glucose monitors. The goal wa…

This study looked at whether special rocker sole shoes cause balance problems in people with type 2 diabetes and nerve damage in their feet. 25 adults completed the trial. Researchers measured how much people swayed while standing still in the special shoes.

This study tested whether a single, standardized MRI scan can reliably measure body composition and the health of multiple organs—like the liver, pancreas, heart, and kidneys—in people with type 2 diabetes and healthy volunteers. 43 participants were scanned twice on the same mac…

This study followed 245 people with type 2 diabetes and high heart risk for two years to see how many develop heart failure. Researchers collected data from doctor visits and phone calls to track heart health over time. The goal was to better understand who is at risk and how the…

This study looked at nearly 242,000 adults with type 2 diabetes to compare different glucose-lowering medications and their effects on heart health. The goal was to help patients and doctors choose the best treatment based on age, sex, race, and kidney function. The main focus wa…

This study looked at whether giving a carbohydrate drink 2 hours before surgery is safe for people with well-controlled type 2 diabetes. 76 adults were split into two groups: one got the drink, the other fasted as usual. Researchers measured blood sugar and checked stomach conten…

This study tested whether it is possible to run diabetes education workshops for inmates at Paris' La Santé prison. 22 men with type 1 or type 2 diabetes took part in group classes covering diet, foot care, and medication. The main goal was simply to see if prisoners would attend…

This study looked at 500 women who had gestational diabetes during pregnancy. They took a glucose test 4 to 12 weeks after giving birth to see how many had type 2 diabetes, impaired glucose tolerance, or impaired fasting glucose. The goal was to compare women diagnosed with gesta…

This study looked at how stress, behavior, and social factors affect weight loss and heart health in people from disadvantaged backgrounds. 15 adults with overweight or obesity took part. Researchers measured weight, waist size, and heart health over time to understand what helps…

This study looked at how drinking orange juice compared to a sugar-sweetened beverage affects risk factors for heart disease and type 2 diabetes. Fifty-six adults drank either orange juice or a sugary drink for four weeks. Researchers measured changes in cholesterol, blood sugar,…

This completed trial tested whether an on-screen electronic alert in the doctor's computer system could increase testing for chronic kidney disease (CKD) in people with type 2 diabetes. About 400 patients who hadn't had a key kidney test in the past year took part. The alert remi…

This study looked at real-world medical records from over 887,000 people with type 2 diabetes, overweight, and heart risk to compare two drugs: tirzepatide and semaglutide. The goal was to see which one better prevents serious heart problems like heart attack, stroke, or death. T…

This completed study tested whether healthcare claims data can predict the results of a major heart trial (SURPASS-CVOT) comparing two diabetes drugs, tirzepatide and dulaglutide. Researchers analyzed records from over 44,000 people with type 2 diabetes and heart disease to see i…

This study tested a clinical decision support tool called PREVENT to help nurses prioritize which patients need homecare most urgently after leaving the hospital. Researchers studied nearly 2,000 adults with conditions like diabetes, heart failure, and lung disease to see if the …

This study tracked over 1,000 adults with type 2 diabetes in Vietnam who were prescribed dapagliflozin (Forxiga) as part of routine care. Researchers monitored side effects and serious events over 24 weeks to confirm the drug's safety in real-world use. The goal was to support th…

This study tested whether simple electronic reminders in doctors' computer systems could reduce unnecessary tests and treatments for older adults. Researchers focused on three common issues: testing for bacteria in urine without symptoms, PSA tests for older men without prostate …

This study looked at how raising ketone levels in the blood affects heart function and sugar use in 41 adults with type 2 diabetes and mild-to-moderate heart failure. Researchers used MRI and PET scans to measure heart pumping and energy use. The goal was to understand the body's…

This study looked at whether people with type 2 diabetes need to attend all sessions of a diabetes self-management education program to see benefits. 120 participants were split into groups that attended 100%, 60%, 10%, or no education. Researchers measured changes in self-care, …

This completed study looked at 97 men with type 2 diabetes to see if a non-invasive skin test for advanced glycation end-products (AGEs) could be linked to erectile dysfunction. AGEs build up due to high blood sugar and may damage blood vessels. Researchers used a device called A…

This completed study looked at gut bacteria in 90 adults with obesity, type 2 diabetes, or neither. Researchers collected samples from the small intestine and colon during routine endoscopies. They compared these to stool samples to see which bacteria are linked to metabolic heal…

This completed study followed 24 adults with type 2 diabetes who use insulin pumps. Participants wore a continuous glucose monitor for 14 days at home to track blood sugar levels. The goal was to see how glucose levels relate to insulin doses and meals in everyday conditions. It …

This study looks at 55 adults with diabetes who are either allergic to insulin or not, to better understand and diagnose insulin allergy. Researchers will test a step-by-step diagnostic approach and study the immune system's role. The goal is to make it easier to identify the exa…

This completed study looked at whether people with type 2 diabetes who show signs of premature aging (like shortened telomeres) are more likely to develop heart muscle disease. Researchers used heart scans and blood tests in 150 adults aged 40-55 with diabetes but no heart sympto…