Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a daily pill help teens control type 2 diabetes?

NCT ID NCT04596631

Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Aug 21, 2026 · Updated 2 times

Summary

This study tested whether a daily pill called oral semaglutide helps children and teenagers (ages 10 to under 18) with type 2 diabetes control their blood sugar better than a placebo. All participants also took standard diabetes medicines like metformin or insulin. The trial lasted about 66 weeks and involved 132 participants. The main goal was to see if semaglutide lowered HbA1c (a measure of blood sugar control) more than the placebo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
oral semaglutide
What this could lead to
If it works, this could provide a new daily pill option to help children and teenagers better manage their type 2 diabetes.
What could go wrong
This is a relatively small trial in a specific age group, and the drug may not work better than placebo or could cause side effects. Long-term benefits and risks are still unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

132 people

The number who actually took part.

Started

Nov 2020

Finished

Feb 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

10 to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Informed consent from parent(s) or legally acceptable representative (LAR) and child assent from the subject obtained before any trial-related activities. Trial-related activities are any procedures that are carried out as part of the trial, including activities to determine suitability for the trial. * Male or female, aged 10 to below 18 years at the day of randomisation * HbA1c 6.5%-11.0% (47-97 mmol/mol) (both inclusive) * Diagnosed with type 2 diabetes mellitus according to the American Diabetes Association criteria and treated with: * stable metformin dose (stable metformin dose is defined as at least 1000 mg daily or the maximum tolerated dose for 56 days or longer prior to screening) or * stable metformin dose and a stable dose of basal insulin (stable dose of basal insulin is defined as basal insulin treatment equal to or more than 30 days prior to screening, compared to the dose at screening, dose adjustments of ± 25% are allowed) or * stable dose of basal insulin Exclusion Criteria: * Diagnosis of type 1 diabetes * Maturity onset diabetes of the young (MODY) * Positive insulinoma associated-protein 2 (IA-2) antibodies or anti-glutamic acid decarboxylase (anti-GAD) antibodies.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Diabetes mellitus type 2 are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes mellitus type 2

Contacts and locations

Locations

  • "AHEPA" University General Hospital of Thessaloniki

    Thessaloniki, 54636, Greece

  • "Verum clinic" LLC

    Kyiv, 03039, Ukraine

  • All India Institute of Medical Sciences

    New Dehli, New Delhi, 110029, India

  • Athens Paediatric Center

    Athens, 15125, Greece

  • Barry J. Reiner, MD LLC

    Baltimore, Maryland, 21229, United States

  • Birmingham Children's Hospital

    Birmingham, B4 6NH, United Kingdom

  • CHU - UCL Namur - Site Sainte Elisabeth_Namur_1

    Namur, 5000, Belgium

  • CNPE "City Clinical Hospital #9 Dnipro City Council"

    Dnipro, 49023, Ukraine

  • Chang Gung Memorial Hospital Linkou-Dept of Pediatrics

    Taoyuan, 333, Taiwan

  • Children's Healthcare Atlanta

    Atlanta, Georgia, 30329, United States

  • Children's Hospital Los Angeles - Endocrinology

    Los Angeles, California, 90027, United States

  • Chronic Care Center

    Hazmiyeh, 21211, Lebanon

  • City Clinical Hospital #9 (Dnipro) - Endocrinology department

    Dnipro, 49023, Ukraine

  • Cliniques Universitaires Saint-Luc - Serv. Pédiatrie

    Brussels, 1200, Belgium

  • Columbus Research Foundation

    Columbus, Georgia, 31904, United States

  • Consultorio de Endocrinología y Pediatría

    Puebla City, 72190, Mexico

  • De Kinderkliniek

    Almere Stad, 1315 RC, Netherlands

  • Diabet Center SRL

    Brasov, 500260, Romania

  • Dr P V Rao - Diabetes Research Centre

    Hyderabad, Telangana, 50082, India

  • EUROMEDICA Gen Clinic The/ki, Endocrin,Metabolism,Diabetes

    Thessaloniki, 54645, Greece

  • Emergency County Hospital Constanta

    Constanța, 900591, Romania

  • Endolife Specialty Hospitals

    Guntur, Andhra Pradesh, 522001, India

  • Eternal Heart Care Centre

    Jaipur, Rajasthan, 302017, India

  • Excel Endocrine Centre

    Kolhāpur, Maharashtra, 416008, India

  • Fakultní Nemocnice Ostrava

    Ostrava-Poruba, 708 00, Czechia

  • GFHI Omsk Region "Regional Children's Clinical Hospital"

    Omsk, 644001, Russia

  • General Hospital of Lamia

    Lamia, 35100, Greece

  • General Hospital of Lamia

    Lamia, GR35100, Greece

  • Gosford Hospital

    Gosford, New South Wales, 2250, Australia

  • Henry Dunant Hospital Center,2nd Internal Medicine Clinic

    Athens, 11526, Greece

  • Henry Dunant Hospital Center,2nd Internal Medicine Clinic

    Athens, GR-11526, Greece

  • Hospital Putrajaya

    Putrajaya, 62250, Malaysia

  • Hospital da Luz Lisboa, S.A.

    Lisbon, 1500-650, Portugal

  • Hôpital d'Enfants

    Rabat, 10000, Morocco

  • Iatriko Athinon (Athens Medical Canter)

    Athens, 15125, Greece

  • Indiana Uni School of Med-Ped

    Indianapolis, Indiana, 46202, United States

  • Jeroen Bosch Zkh

    's-Hertogenbosch, 5223 GZ, Netherlands

  • Jothydev's Diabetes & Research Center

    Thriruvananthapuram, 695 032, India

  • Kharkiv Regional Children's Clinical Hospital - Endocrinological department

    Kharkiv, 61093, Ukraine

  • Komisarenko Institute of Endocrinology and Metabolism of NAMSU - Department of paediatric endocrine pathology

    Kyiv, 04114, Ukraine

  • Liggins Institute

    Grafton, 1023, New Zealand

  • Masarykova nemocnice v Usti nad Labem, o.z. - Detska klinika

    Ústí nad Labem, 40011, Czechia

  • Monash Children's Hospital

    Clayton, Victoria, 3168, Australia

  • Monument Health Clinical Rsrch

    Rapid City, South Dakota, 57701, United States

  • Murdoch Children's Research Institute

    Parkville, Victoria, 3052, Australia

  • NE Clin Res of San Antonio

    San Antonio, Texas, 78233, United States

  • NSMU paediatric clinic

    Novosibirsk, 630048, Russia

  • Nemours Children's Health

    Pensacola, Florida, 32514, United States

  • Nemours Chld Clnc Jacksonville

    Jacksonville, Florida, 32207, United States

  • P D Hinduja National Hospital and Medical Research Centre

    Mumbai, Maharashtra, 400016, India

  • PHI University Clinic for Children's Diseases-Skopje

    Skopje, 1000, North Macedonia

  • Pediatric Endo UVHS

    Charlottesville, Virginia, 22908, United States

  • Pennington Biomed Res Ctr

    Baton Rouge, Louisiana, 70808-4124, United States

  • Pentelis Children's Hospital - Pediatric Clinic

    Penteli, Athens, 15236, Greece

  • Perth Children's Hospital

    Nedlands, Western Australia, 6009, Australia

  • Ponce Med School Found Inc

    Ponce, 00716, Puerto Rico

  • RMAPE

    Moscow, 125373, Russia

  • Rambam MC - Department of Pediatrics A

    Haifa, 31096, Israel

  • Ramdev Rao Hospital

    Hyderabad, Telangana, 500072, India

  • Republic Children's Hospital of Ministry of Health of Udmurt

    Izhevsk, 426009, Russia

  • SAHI Sverdlovsk Reg "Regional Children's Clinical Hospital"

    Yekaterinburg, 620149, Russia

  • SPSBHI City Children out-patient clinic #44

    Saint Petersburg, 191144, Russia

  • SSKM

    Kolkata, West Bengal, 700020, India

  • Siberian State Medical University

    Tomsk, 634050, Russia

  • Soroka MC - Pediatric Endocrinology

    Beersheba, 84101, Israel

  • Spitalul Clinic de Urgenta pentru Copii "M.S.Curie"

    Bucharest, 041451, Romania

  • Spitalul Judetean de Urgenta Targoviste

    Targoviste, Dâmbovița County, 130083, Romania

  • Taipei Mackay Memorial Hospital

    Taipei, 104, Taiwan

  • Texas Tech University HSC

    Amarillo, Texas, 79106, United States

  • U.G.H. "Attikon", Pediatric Endocrinology Outpatient Clinic

    Athens, 12462, Greece

  • UAB Ped Endo Children's Hosp

    Birmingham, Alabama, 35233, United States

  • UBMD Peds-Div of Endo/Diabetes

    Buffalo, New York, 14203, United States

  • ULS De Gaia/Espinho_H.Santos Silva_Pediatria

    Vila Nova de Gaia, 4400-129, Portugal

  • UPMC Child Hosp-Pittsburgh

    Pittsburgh, Pennsylvania, 15224, United States

  • UZ Brussel

    Brussels, 1090, Belgium

  • Ukrainian scientific and practical center of endocrine surgery of MOH - department of paediatric endocrinology

    Kiev, 01021, Ukraine

  • Unidade De Santa Maria E.P.E. - Hospital de Santa Maria

    Lisbon, 1649-035, Portugal

  • Univ Gen Hospital Larisa

    Larissa, 41110, Greece

  • Univ Gen Hospital Larisa, Endocrinology & Metabolic Disease

    Larissa, GR-41110, Greece

  • Univ Of Texas Hlth Science Cntr

    San Antonio, Texas, 78207, United States

  • University General Hospital of Ioannina, Endocrinology

    Ioannina, 45500, Greece

  • University Hospital of Athens ATTIKON

    Athens, Attica, 12462, Greece

  • University Hospital of Athens ATTIKON

    Haidari-Athens, Attica, GR-12462, Greece

  • University Malaya Medical Centre

    Kuala Lumpur, Kuala Lumpur, 59100, Malaysia

  • University Malaya Medical Centre

    Lembah Pantai, Kuala Lumpur, 59100, Malaysia

  • University Malaya Medical Centre

    Kuala Lumpur, 59100, Malaysia

  • University Of Louisville Research Foundation

    Louisville, Kentucky, 40202, United States

  • University of Mississippi Medical Center

    Jackson, Mississippi, 39216, United States

  • University of South Florida Diabetes Center

    Tampa, Florida, 33612, United States

  • Universitätsklinik für Kinder und Jugendheilkunde Haus E

    Salzburg, 5020, Austria

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Vinnytsia Regional Clinical Endocrinological Centre - Therapeutic department #2

    Vinnytsia, 21010, Ukraine

  • Virginia Commonwealth Univ

    Richmond, Virginia, 23298, United States

  • Virginia Commonwealth University_Richmond

    Richmond, Virginia, 23298, United States

  • Westmead Children's Hospital- The Clinical Research Centre

    Westmead, New South Wales, 2145, Australia

  • Women's & Children's Hospital

    North Adelaide, South Australia, 5006, Australia

  • Yale School Of Medicine

    New Haven, Connecticut, 06520, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.