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Weekly shot could replace daily insulin for type 2 diabetes

NCT ID NCT06269107

First seen Nov 01, 2025 · Last updated Apr 29, 2026 · Updated 26 times

Summary

This study tested a new once-weekly medicine called IcoSema (a mix of two diabetes drugs) against a daily insulin shot in 485 adults with type 2 diabetes whose blood sugar was not well controlled on oral pills. The goal was to see if the weekly shot works as well or better at lowering blood sugar. Participants were randomly assigned to receive either IcoSema once a week or insulin glargine daily for about 11 months.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • "Laiko" General Hospital of Athens

    Athens, 11527, Greece

  • "Thermi" Private Hosital

    Thessaloniki, 57001, Greece

  • 'G. Gennimatas' General Hospital of Athens

    Athens, 115 27, Greece

  • A.O.U. Policlinico Umberto I

    Rome, Lazio, 00161, Italy

  • AMC Community Endocrinology

    Albany, New York, 12203, United States

  • ASL Avezzano Sulmona L'Aquila - Ospedale San Salvatore - UOC Diabetologia

    L’Aquila, Abbruzzo, 67100, Italy

  • Advanced Clinical Research LLC

    Bayamón, 00959, Puerto Rico

  • Advanced Medical Research

    Maumee, Ohio, 43537, United States

  • Akdeniz University Tip Fakultesi Hastanesi

    Antalya, 07058, Turkey (Türkiye)

  • Akdeniz Üniversitesi Hastanesi- Endokrinoloji

    Antalya, 07058, Turkey (Türkiye)

  • Albuquerque Clin Trials, Inc.

    Albuquerque, New Mexico, 87102, United States

  • Amarillo Med Spec LLP

    Amarillo, Texas, 79106, United States

  • Atlanta Diabetes Associates

    Atlanta, Georgia, 30318, United States

  • Azienda Ospedaliera di Perugia;Ospedale S. Maria della Misericordia

    Perugia, 06129, Italy

  • BSES MG hospital

    Mumbai, Maharashtra, 400058, India

  • BYL Nair Hospital and T N Medical College Department of endo

    Mumbai, Maharashtra, 400008, India

  • Başakşehir Çam ve Sakura Şehir Hastanesi

    Istanbul, 34480, Turkey (Türkiye)

  • Beijing Friendship Hospital, Capital Medical University-Endocrinology

    Beijing, Beijing Municipality, 100050, China

  • Casa Sollievo della Sofferenza reparto endocrinologia

    San Giovanni Rotondo, FG, 71013, Italy

  • Casa della Salute di Ceccano - Ambulatori Campus Biomedico

    Ceccano (Frosinone), 03023, Italy

  • Cedar-Crosse Research Center

    Chicago, Illinois, 60607, United States

  • Centrum Terapii Wspolczesnej J.M. Jasnorzewska S.K.A.

    Lodz, 90-338, Poland

  • Chellaram Diabetes Institute

    Pune, Maharashtra, 411021, India

  • Chongqing University Three Gorges Hospital

    Chongqing, Chongqing Municipality, 404000, China

  • Clinhouse Centrum Medyczne

    Zabrze, 41-807, Poland

  • Clinical Research Institute of South Africa

    KwaDukuza, KwaZulu-Natal, 4449, South Africa

  • Clinical Research of Cent FL

    Winter Haven, Florida, 33880, United States

  • Clinical Trials Research_Sacramento

    Lincoln, California, 95821, United States

  • Consano Clinical Research, LLC

    Shavano Park, Texas, 78231, United States

  • Cotton-O'Neil Diab & Endo Ctr

    Topeka, Kansas, 66606, United States

  • Desert Oasis Hlthcr Med Group

    Palm Springs, California, 91355, United States

  • Desert Oasis Hlthcr Med Group

    Palm Springs, California, 92262, United States

  • Diab & Endo Assoc of Stark Co

    Canton, Ohio, 44718, United States

  • Diabetes and Thyroid Ctr of FW

    Fort Worth, Texas, 76132, United States

  • Diabetes, Thyroid and Endocrine Centre

    Jaipur, Rajasthan, 302006, India

  • Dr Pillay's Rooms

    Durban, KwaZulu-Natal, 4450, South Africa

  • Dr R Dulabh

    Johannesburg, Gauteng, 1812, South Africa

  • Elite Clinical Trials

    Blackfoot, Idaho, 83221, United States

  • Endeavor Health

    Skokie, Illinois, 60077, United States

  • Endo Res Solutions Inc

    Roswell, Georgia, 30076, United States

  • Evangelismos Hospital

    Athens, 10676, Greece

  • First Valley Med Grp Lancaster

    Lancaster, California, 93534, United States

  • Flourish Research

    San Antonio, Texas, 78229, United States

  • Fmc Science, Llc

    Lampasas, Texas, 76550, United States

  • Fukuwa Clinic_Internal Medicine

    Tokyo, 104-0031, Japan

  • Gabinet Lekarski Malgorzata Saryusz-Wolska

    Lodz, 90-132, Poland

  • General Hospital of Kalamata - B Internal Medicine Department

    Kalamata, 24100, Greece

  • Grande Ospedale Metropolitano Niguarda

    Milan, 20162, Italy

  • Grazyna Pulka Specjalistyczny Osrodek "All-Med"

    Krakow, 30-033, Poland

  • Heiwadai Hospital_Internal Medicine

    Miyazaki, Miyazaki, 880-0034, Japan

  • Holston Medical Group

    Kingsport, Tennessee, 37660, United States

  • Huizhou Central People's Hospital-Endocrinology

    Huizhou, Guangdong, 516001, China

  • I.N.R.C.A. Istituto Nazionale di Riposo E Cura Per Gli Anziani

    Ancona, 60127, Italy

  • IPGME&R and SSKM Hospital

    Kolkata, 700020, India

  • Jinan Central Hospital

    Jinan, Shandong, 250013, China

  • Juntendo University Hospital_Diabetes, endocrinology and metabolism

    Tokyo, 113-8431, Japan

  • Langeberg Clinical Trials

    Cape Town, Western Cape, 7572, South Africa

  • Madras Diabetes Research Foundation

    Chennai, Tamil Nadu, 600086, India

  • Methodist Phys. Clinic

    Omaha, Nebraska, 68114, United States

  • Mysore Medical College and Research Institute

    Mysore, Karnataka, 570001, India

  • NBR Polska Tomasz Klodawski

    Warsaw, 00-710, Poland

  • NZOZ Specjalistyczny Osrodek Internistyczno-Diabetologiczny Małgorzata Arciszewska

    Bialystok, Podlaskie Voivodeship, 15-435, Poland

  • New Venture Medical Research

    Wadsworth, Ohio, 44281-9236, United States

  • Newtown Clinical Research

    Johannesburg, Gauteng, 2001, South Africa

  • North Texas Endocrine Center

    Dallas, Texas, 75231, United States

  • Northeast Research Institute

    Fleming Island, Florida, 32003, United States

  • Oodouri Diabetes, Internal medicine Clinic_Internal Medicine, Diabetes Internal Medicine

    Hokkaido, 060-0001, Japan

  • Oyama East Clinic_Internal Medicine

    Tochigi, 323-0022, Japan

  • PANSTWOWY INSTYTUT MEDYCZNY MSWiA

    Warsaw, 02-507, Poland

  • Peking University People's Hospital-Endocrinology

    Beijing, Beijing Municipality, 100044, China

  • Physician's East Endocrinology

    Greenville, North Carolina, 27834, United States

  • Polo Ospedaliero di Chiavari

    Chiavari (genova), 16043, Italy

  • Post Graduate Institute of Medical Education & Research

    Chandigarh, 160012, India

  • Quality Research Inc

    San Antonio, Texas, 78209, United States

  • Ramaiah Memorial Hospital

    Bangalore, Karnataka, 560054, India

  • Roodepoort Medicross Clinical Research Centre

    Roodepoort, Gauteng, 1724, South Africa

  • SMS Medical College & Hospital

    Jaipur, Rajasthan, 302004, India

  • SNZOZ Lege Artis

    Bialystok, 15-404, Poland

  • Scripps Whittier Diabetes Inst

    La Jolla, California, 92037, United States

  • Seth GS Medical College & KEM Hospital

    Mumbai, Maharashtra, 400012, India

  • Seyrantepe Hamidiye Etfal Egitim ve Arastirma Hastanesi

    Istanbul, 34371, Turkey (Türkiye)

  • Shanghai Pudong New Area People's Hospital-Endocrinology

    Shanghai, Shanghai Municipality, 201200, China

  • Southgate Medical Group, LLP

    West Seneca, New York, 14224, United States

  • T.C. Saglik Bakanligi Pendik Egitim ve Arastirma Hastanesi

    Istanbul, 34899, Turkey (Türkiye)

  • TPMG Clinical Research

    Newport News, Virginia, 23606, United States

  • Tekirdağ Namık Kemal Üniversitesi Hastanesi- Dahiliye

    Tekirdağ, 59030, Turkey (Türkiye)

  • The Affiliated Hospital of Jiangsu University

    Zhenjiang, Jiangsu, 212001, China

  • The Second Affiliated Hospital of Nanjing Medical University

    Nanjing, Jiangsu, 210011, China

  • Tokuyama clinic_Diabetic internal medicine

    Chiba, 261-0004, Japan

  • Tokyo-Eki Center-building Clinic_Internal Medicine

    Tokyo, 103-0027, Japan

  • Udyaan Health Care

    Lucknow, Uttar Pradesh, 226002, India

  • Univ Gen Hospital Larisa

    Larissa, 41110, Greece

  • Uniwersyteckie Centrum Kliniczne Regionalne Centrum Diabetologii

    Gdansk, 80-214, Poland

  • Velocity Clinical Res-Dallas

    Dallas, Texas, 75230, United States

  • Velocity Clinical Research- Cedar Park

    Austin, Texas, 78759, United States

  • Velocity Nova Sp. z o.o.

    Lublin, 20-362, Poland

  • Velocity Nova Sp. z o.o.

    Staszów, Świętokrzyskie Voivodeship, 28-200, Poland

  • Wade Family Medicine

    Bountiful, Utah, 84010, United States

  • İstanbul Üniversitesi İstanbul Tıp Fakültesi Hastanesi- Endokrinoloji

    Istanbul, 34390, Turkey (Türkiye)

  • Şişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi- Seyrantepe Yerleşkesi- Endokrinoloji

    Istanbul, 34371, Turkey (Türkiye)

Conditions

Explore the condition pages connected to this study.