Type 2 diabetes mellitus

Researchers are testing an experimental oral drug called MBX-102 in adults with type 2 diabetes whose blood sugar remains too high on metformin alone. The trial compares two doses of MBX-102 with a placebo and with Actos, an approved diabetes drug. About 242 participants take the…

This phase 2 trial tests whether LY3549492, an oral tablet, helps adults who are overweight or obese and have type 2 diabetes lose weight. Participants receive either LY3549492 or a placebo for about 11 months. Researchers measure changes in body weight and the percentage of peop…

This study compares continuing oral diabetes medications (like metformin) versus switching to insulin in hospitalized adults with type 2 diabetes. About 255 participants will be randomly assigned to either stay on their usual pills or receive insulin injections. The goal is to se…

This study tests whether an AI-enhanced digital tool called iMatter2 can help people with type 2 diabetes better manage their condition. About 353 participants will use the tool to report their symptoms and receive feedback, while researchers track changes in blood sugar levels o…

This study tests whether a supervised treadmill walking program can improve memory, attention, and other thinking skills in adults with type 2 diabetes. Participants will follow a personalized exercise plan, and researchers will measure changes in cognitive function and blood mar…

This study looked at whether people with type 2 diabetes should continue taking their usual metformin medication while hospitalized. The goal was to see if it helped control blood sugar, caused stomach issues, or affected how long patients stayed. Only 22 people took part before …

This study tested whether using a Freestyle Libre 2 continuous glucose monitor for 28 days, along with standard therapeutic education, helps people recently diagnosed with type 2 diabetes improve their blood sugar control. The trial enrolled 27 adults diagnosed within the past ye…

This study aimed to see if following the exact dosing instructions for oral semaglutide helps control blood sugar in people with type 2 diabetes who are already on metformin. Only one person enrolled before the study was stopped early. The main focus was on changes in blood sugar…

This early-stage trial tested a new drug called AP026, a fusion protein that targets two pathways (GLP-1 and FGF21) to potentially treat type 2 diabetes. The study planned to enroll 74 healthy adults but was terminated early after only 14 participants. The main goal was to check …

This small pilot study tested whether a low-carb diet (50-100 grams of carbs per day) combined with the diabetes drug dapagliflozin could improve blood sugar control in people with chronic kidney disease and prediabetes or type 2 diabetes. Four participants were split into two gr…

This study looked at whether a plant-based diet and lifestyle changes could help people with type 2 diabetes, prediabetes, or obesity improve their health. Researchers aimed for diabetes remission (normal blood sugar without medication for at least 3 months) or significant weight…

This study tested the drug empagliflozin (a diabetes medicine) in 20 people who had a kidney transplant, some with type 2 diabetes and some without. The goal was to see if the drug could help protect their heart and kidney function. The trial was stopped early, so the findings ar…

This study looked at whether taking probiotics alongside regular treatment could help lower blood sugar and improve lung function in people with both type 2 diabetes and chronic obstructive pulmonary disease (COPD). The trial planned to enroll 30 adults aged 50-85, but it was ter…

This study tested a new drug called CK-0045 in 90 adults with type 2 diabetes and overweight or obesity. Participants received weekly injections of CK-0045 or a placebo for 16 weeks to see if it improved blood sugar after meals and reduced body weight. The trial was terminated ea…

This study looked at whether liraglutide, a diabetes drug, can reduce liver fat and improve cholesterol in people with type 2 diabetes. It involved 127 patients who took liraglutide for 6 months, with liver fat measured by MRI. However, the trial was terminated early, so the full…

This study aimed to see if using a professional continuous glucose monitor (CGM) for 6 months, instead of 3 months, helps people with poorly controlled type 2 diabetes (who don't use insulin) spend more time with healthy blood sugar levels. Only 12 participants were enrolled befo…

This study tested a digital system called 'Live well with type 2 diabetes' to help people manage their condition. It compared the digital program to usual care for 138 adults recently diagnosed with type 2 diabetes. The main goal was to see if it improved blood sugar levels. Howe…

This study tested whether pemafibrate, a drug that lowers triglycerides, could reduce heart attacks, strokes, and heart-related deaths in over 10,000 people with type 2 diabetes and high triglycerides. Participants took either pemafibrate or a placebo twice daily. The trial was t…

This study compared two long-acting insulins, Toujeo and Tresiba, in people with type 2 diabetes who also have kidney problems and had never used insulin before. The goal was to see which one controls blood sugar better and causes fewer low blood sugar events. The trial was stopp…

This study tests whether an artificial intelligence program called NeoRetina can accurately detect diabetic retinopathy and diabetic macular edema from simple eye photographs. Researchers will compare the AI's analysis to standard exams by eye doctors. The goal is to see if this …

Researchers are testing whether a plant-based diet can improve heart health in police officers who are overweight or have type 2 diabetes. The trial enrolls 20 officers from the Washington, D.C. police department and randomly assigns them to either follow a vegan diet with weekly…

This study tested whether eating yoghurt daily for 24 weeks could improve blood sugar control in adults with prediabetes (high risk for type 2 diabetes). Only 8 people enrolled, and the study was stopped early, so no firm conclusions can be drawn. The goal was to see if a simple …

This study tested whether a five-week culturally tailored diabetes education program could help Hispanic men aged 18-64 with type 2 diabetes improve their self-management behaviors like healthy eating, physical activity, and medication use. The program was designed specifically f…

This study tested whether hospitalized adults with type 2 diabetes or prediabetes could safely do 30 minutes of resistance training each day. The goal was to see if this exercise routine is feasible and if it helps control blood sugar and prevent muscle loss during a hospital sta…

This study asks whether a single session of hyperbaric oxygen therapy (HBOT) can lower blood sugar or change glucagon levels in people with type 1 or type 2 diabetes. Participants will undergo one HBOT session and one control session (sitting in a room at normal pressure), while …

This study aims to understand how much insulin the body actually needs to keep blood sugar normal. Ten adults with obesity and high insulin levels will take a drug called diazoxide, which stops the pancreas from making insulin. Researchers will then measure their fasting blood su…

This study looks at how high blood sugar combined with a medication called moxifloxacin (an antibiotic known to affect heart rhythm) impacts the heart's electrical activity in people with insulin-resistant type 2 diabetes. Researchers will measure changes in heart tracings (ECGs)…

This study looked at whether people with type 2 diabetes who have a chronic cough also have damage to small nerves in their skin. Researchers compared diabetic patients with and without chronic cough using nerve tests and skin biopsies. The study was terminated early with only 7 …

This study aimed to find blood and tissue markers that could predict whether obese patients with type 2 diabetes would go into remission after bariatric surgery. Researchers planned to measure 9 specific molecules in blood samples and also collect fat and muscle tissue during sur…

This Stanford study looked at how changing when and what you eat affects blood sugar, body temperature, and sleep in people with prediabetes, type 2 diabetes, and healthy adults. Participants followed different meal-timing schedules, like eating within a 10-hour window starting e…

This study aimed to see how dapagliflozin, a diabetes drug, affects blood vessel health in people with type 2 diabetes. Researchers planned to measure blood pressure and other markers of vascular function. However, the trial was terminated early and only enrolled 4 participants, …

This study looked at whether people with type 1 or type 2 diabetes who have a 'Type A' (impatient, proactive) or 'Type B' (calm, slow) personality show different genetic markers linked to inflammation and stress. Researchers planned to collect blood samples and have participants …

This study looked at how the diabetes medication Liraglutide (Victoza) affects taste, food cravings, and eating habits in people with type 2 diabetes who are overweight. Researchers compared three groups: patients starting Liraglutide, diabetic patients not on the drug, and healt…

This study looked at whether eating most calories before 2 PM could help control blood sugar in people with type 2 diabetes. It planned to enroll 10 participants but was terminated after only 2 joined. The goal was to compare early eating with a typical eating pattern over six da…

This study aimed to see if a new urine test can accurately tell whether people with type 2 diabetes are taking their medications as prescribed. Researchers planned to compare the urine test results with standard methods like questionnaires and pharmacy records in 90 participants.…

This study looked at whether people with both rheumatoid arthritis and type 2 diabetes have a harder time controlling their diabetes than those with osteoarthritis and diabetes. Researchers planned to follow 176 adults to see how quickly they needed new diabetes treatments. Howev…