Tiny nerves may explain chronic cough in diabetes
NCT ID NCT03787511
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether people with type 2 diabetes who have a chronic cough also have damage to small nerves in their skin. Researchers compared diabetic patients with and without chronic cough using nerve tests and skin biopsies. The study was terminated early with only 7 participants, so results are very limited.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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7 people
The number who actually took part.
- Started
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Jun 2022
- Finished
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Dec 2022
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: In diabetic patients with chronic cough: * Chronic cough defined by cough for more than 8 weeks. * Normal chest X-ray * history of type 2 diabetes * Age of diabetes onset\> 40 years * Affiliated or beneficiary person of social security * Free, informed and written consent In diabetic patients without chronic cough * History of type 2 diabetes * Age of discovery of diabetes\> 40 years * Affiliated or beneficiary person of social security * Free, informed and written consent Exclusion Criteria: * Presence of physical signs of peripheral neuropathy * Active smoking or smoking cessation within the last 12 months * Pregnant or lactating woman * History of non-type 2 diabetes (type I, secondary diabetes, monogenic ...) * Cancer within the last 5 years (except cutaneous squamous cell carcinoma) * History of anti-cancer chemotherapy * Suspicion of autoimmune pathology * Active neurological pathology * Electromyography in favor of large fiber neuropathy * Chronic pathology that may interfere with the neurophysiological assessment * Patient who were given anticoagulation drug therapy, anti-cholinergic drugs, beta-blocker and impossibility to withdraw the treatment before neurophysiological tests In diabetic patients without chronic cough, another non-inclusion criteria is acute or chronic cough
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hôpital Larrey
Toulouse, 31059, France
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