Infectious disease

This study compares a high-dose flu vaccine to the standard dose in 312 children aged 3-17 who have received a kidney, heart, or liver transplant within the past two years. The goal is to see if the high-dose vaccine triggers a stronger immune response and is just as safe. Partic…

This study tests a new vaccine called GNG-DE to see how well it protects against meningococcal infections (a cause of meningitis). About 240 people aged 3 to 55 will receive either the new vaccine or a reference vaccine. Researchers will measure immune responses and check for sid…

This study tests whether a single dose of N-acetylcysteine (NAC), an antioxidant, can help adults with severe infections and liver dysfunction recover faster. 360 participants will receive either NAC or a placebo infusion within 24 hours of hospital admission. The main goal is to…

This study tests whether IgPro20 (HIZENTRA), a concentrated antibody solution given under the skin, can prevent infections in people with multiple myeloma who have low antibody levels due to bispecific antibody therapy. About 100 participants will either receive IgPro20 plus stan…

This study compares oral (pill) antibiotics to intravenous (IV) antibiotics for treating infected broken bones that haven't healed properly. About 250 adults with this condition will be randomly assigned to receive either oral or IV antibiotics for up to 6 weeks after surgery. Th…

This study tests whether adding immune cells from a family donor to standard antiviral drugs can help children and young adults clear stubborn adenovirus or cytomegalovirus infections after a stem cell transplant. About 69 participants will be randomly assigned to receive either …

This Phase 2 trial tests an experimental drug called AHB-137 in 84 adults with chronic hepatitis B who are already on antiviral therapy. The goal is to see if AHB-137 can clear the hepatitis B surface antigen and keep the virus under control, potentially leading to a functional c…

This study tests an experimental drug called recombinant human plasma gelsolin (rhu-pGSN) added to standard care for people with moderate-to-severe acute respiratory distress syndrome (ARDS) caused by pneumonia or other infections. About 600 hospitalized adults will receive eithe…

This Phase 3 trial tests whether giving immune globulin (IGI) regularly can prevent serious infections in adults with multiple myeloma who are receiving a bispecific antibody therapy. About 183 participants will be randomly assigned to get IGI right away for 12 months or only aft…

This study tests a special device called PIVO Pro that lets doctors draw blood for infection tests through an IV line already in the arm, avoiding extra needle sticks. The goal is to see if this method reduces contamination of the blood sample compared to the usual way. About 1,1…

This early-stage trial tests a new approach for chronic granulomatous disease (CGD), a genetic condition that leaves people vulnerable to severe infections. Researchers take a participant's own white blood cells, use mRNA to correct the genetic defect, and infuse the cells back. …

This trial tests whether nursing home residents who become acutely ill can be safely assessed and treated at home by municipal acute care teams, with remote consultation from a senior hospital physician, instead of being sent to the hospital. Participating nursing homes are rando…

This trial tests whether having clinical dietitians take the lead on nutrition care—rather than waiting for referrals—can help adult medical inpatients at risk of malnutrition. Researchers will compare a dietitian-driven model with usual care on three hospital wards, measuring le…

This trial tests whether changing from acid-blocking drugs to a stomach-lining protector called teprenone after a stem cell transplant can reduce the risk of acute graft-versus-host disease (aGVHD), a serious complication where donor immune cells attack the recipient's body. Abou…

This phase 2 trial tests an experimental drug called AHB-137 in 70 adults with chronic hepatitis B who are already on antiviral pills. The drug is given as a shot under the skin. The goal is to see if it can lower the virus to undetectable levels and allow some people to stop the…

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This study tests whether a medicine called Panzyga can prevent major infections in people with autoimmune or rheumatic conditions who have low antibody levels after receiving B-cell depletion therapy. About 360 adults will receive either Panzyga or a placebo, and researchers will…

This study tests a digital tool that gives doctors real-time, guideline-based advice on prescribing antibiotics. About 48 general practices in Belgium will use the tool during patient visits. The goal is to see if it reduces unnecessary antibiotic use and helps fight antibiotic r…

This study is testing a new knee replacement system called Persona Revision for people who need a second knee replacement surgery. The goal is to see if it improves knee function, reduces pain, and is safe. About 380 adults will be followed for two years after surgery.

This study compares a single dose of IV antibiotics followed by two days of oral antibiotics against the standard three days of IV antibiotics for children with complicated urinary tract infections (UTIs). The goal is to see if the shorter IV course is just as effective at resolv…

This trial investigates whether combining rapid molecular microbiology tests with predefined clinical criteria helps doctors optimize antibiotic use in hospitalized adults receiving strong, broad-spectrum antibiotics. The study compares a protocolized antimicrobial stewardship st…

This study tests whether giving antibody replacement therapy can reduce serious infections in people who have received CAR-T cell therapy for blood cancers. CAR-T therapy often lowers the body's natural antibodies, raising infection risk. The trial will compare the antibody treat…

This study tests whether transferring gut microbes from a mother to her baby after a cesarean section can restore the infant's gut microbiome to resemble that of a vaginally born baby. Researchers will give some infants a fecal transplant (containing bacteria or viruses) and comp…

This study tests whether monitoring levels of a harmless virus called TTV can help doctors personalize immune-suppressing drugs for kidney transplant patients. The goal is to prevent long-term complications like infections, cancer, and organ rejection. About 600 adults who receiv…

This study tests whether adding a pre-surgery scrub with isopropyl alcohol and chlorhexidine soap to the standard cleaning routine can lower the number of germs on the skin and reduce infections after elective foot and ankle surgery. About 100 adults having planned foot or ankle …

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This study tests whether using a patient's genetic profile to dose the antifungal drug voriconazole can help more patients reach the right drug levels faster. It will enroll 104 children and adults with blood cancer who have a fungal infection. Participants are randomly assigned …

This study is testing whether adults with sudden illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. Researchers will compare costs, patient experience, and health outcomes for 3,000 participants who receive hospital-level car…

This study tests whether copper supplements can improve liver function and safety in people with cirrhosis who have low copper levels. Researchers will give 30 participants either copper or a placebo and measure changes in blood copper levels and other health markers. The goal is…

This study tests a wireless, bioelectric bandage called PowerHeal™ on infected wounds. Researchers want to see if it clears infection and helps wounds close better than standard care. About 150 adults with infected traumatic wounds will take part. The bandage is changed regularly…

This study tests whether giving L-Citrulline, a natural supplement, for 28 days can help hospitalized children aged 1 month to 5 years who have fever and are at high risk of serious problems. About 888 children in Mozambique and Ethiopia will receive either the supplement or a pl…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method adjusts the dose based on the patient's kidney function, using only standard doses. The main goal is to see if this approach is easy for doctors to use and …

This study looks at whether removing certain food additives (like carrageenan and polysorbates) from the diet can improve symptoms and gut health in people with moderately active ulcerative colitis. About 70 participants will be randomly assigned to either a normal healthy diet o…

This study compares a new approach to managing infections in nursing home residents with dementia against usual care. The goal is to see if the new method reduces antibiotic use and avoids stressful procedures like hospital transfers. About 750 residents aged 60 and older with de…

This study looks at whether closely watching for infections without giving preventive antibiotics works as well as giving a daily antibiotic (ceftriaxone) in adults getting stem cell transplants. The goal is to see if skipping preventive antibiotics is safe, especially in hospita…

This study tests whether giving zinc supplements along with standard antibiotics can reduce deaths and improve recovery in young infants (0-59 days old) hospitalized with severe infections like sepsis or pneumonia. About 3,250 babies in Tanzania will receive either zinc or a plac…

This study compares immunoglobulin (given through a vein or under the skin) with antibiotics to see which better prevents severe infections in people with blood cancers like myeloma, lymphoma, or leukemia who have low antibody levels. About 900 adults will take part. The goal is …

This study compares two infection-prevention strategies in 900 people with blood cancers like myeloma and leukemia. One group gets an antibiotic (co-trimoxazole) daily, while another receives immunoglobulin infusions every few weeks. The goal is to see which approach better preve…

This study looks at whether giving lung transplant recipients a high-dose flu vaccine for two years in a row provides better protection against the flu than the standard-dose vaccine. About 60 people who already took part in a previous flu vaccine study will be randomly assigned …

This study tests whether giving a single 2-gram dose of azithromycin before starting labor induction can lower the risk of infections in both the mother and newborn. Researchers plan to enroll 400 pregnant women in their third trimester who are scheduled for labor induction. Half…

This study looks at two methods to help doctors prescribe fewer antibiotics for children with ear infections when they aren't needed. One method uses changes to electronic health records and feedback reports for doctors. The other adds a shared decision-making tool that involves …

This study collects blood samples from 20,000 adults with conditions like infections, heart disease, or kidney issues. Researchers will use these samples to develop and fine-tune new diagnostic tests that can deliver results quickly at the point of care. The goal is to make disea…

This study tests whether a rapid triage test (suPAR) can help doctors make better decisions about admitting or discharging children with fever. Over 5,000 children aged 2 months to 5 years in sub-Saharan Africa will be randomly assigned to standard care or standard care plus the …

This study tests a new diagnostic method called metagenomic sequencing to find hidden infections in people with eye inflammation (uveitis). Standard tests often miss the cause. Researchers will analyze fluid from the eye to detect bacteria, viruses, fungi, or parasites. The goal …

This study will test a new diagnostic device called the Nanopath assay, which aims to quickly detect bacteria or yeast causing vaginitis. Up to 1000 women with symptoms like itching or discharge will provide vaginal swab samples, either collected by a clinician or themselves. The…

This study aims to create and test a clinical prediction score called FUNGAL-P to help doctors identify fungal pneumonia early in adults who come to the hospital with pneumonia. Researchers will analyze medical records from past patients and then test the score on new patients to…

This study tests a new, non-invasive tool called the POP-Score to predict infection in newborns within the first 6 hours of life. The score combines light-based measurements of muscle oxygen with routine vital signs like heart rate and blood pressure. Researchers will enroll 93 n…

This study is testing whether a blood test called Karius Spectrum can help doctors find infections faster in adults with weakened immune systems (e.g., organ transplant recipients, cancer patients). The test looks for DNA from bacteria, fungi, viruses, and parasites in the blood.…

This study aims to see if a simple stool test can accurately detect Helicobacter pylori infection in children, avoiding the need for an invasive endoscopy under anesthesia. Researchers will compare the stool test results with standard biopsy results in 188 children aged 16 or you…

This study is testing whether an augmented reality (AR) system can help doctors guide needles during MRI scans. The AR system overlays digital information onto the real world, potentially making procedures like biopsies or injections more precise. Researchers will enroll 25 peopl…

This phase 3 trial is testing whether adding Gamunex-C (an immune globulin) to standard care can prevent serious infections in people with chronic lymphocytic leukemia, multiple myeloma, or non-Hodgkin lymphoma. About 49 participants will receive Gamunex-C through an IV every 4 w…

This study tests whether using quilting stitches (which attach skin to muscle) with just one drain under the arm works as well as using two drains after mastectomy. The goal is to prevent seroma (fluid buildup), infection, and pain. Sixty women having a modified radical mastectom…

This study tests whether a daily oral synbiotic (a mix of probiotics and prebiotics) can help women with a history of preterm birth carry their baby longer. About 400 pregnant women will take either the supplement or a placebo from early pregnancy. The goal is to see if the suppl…

This trial tests a pillow with a spine-shaped opening in the middle, designed to keep pressure off the surgical wound after back surgery. Standard pillows can rub against the incision, increasing the risk of infection and pain. The study will enroll 10 adults who have had lumbar …

This study tests whether giving antibiotics through a small, portable pump over 24 hours is safe and cost-effective for children with serious bacterial infections. About 150 kids who are stable enough for home care will receive the pump instead of multiple daily hospital injectio…

This study follows 500 adults in France who have either a genetic defect or autoantibodies that weaken their type I interferon immune response. Researchers will collect blood samples and health data over 1 to 4 years to track infections, autoimmune diseases, and cancers. The goal…

Researchers are building a long-term health study of 150,000 children born in Victoria, Australia, and their parents. The study follows participants from birth over their lifetime, collecting data on health, development, and environment through surveys, biosamples, and linked rec…

This study is tracking 20,000 people who have had or will have shoulder replacement surgery to see how well the implants work over at least 10 years. Researchers will measure pain, daily function, and strength using standard shoulder scores. The goal is to better understand the l…

This study aims to learn more about how HIV infects cells and affects the immune system by collecting blood samples from up to 2,419 adults, both with and without HIV. Researchers will analyze these samples to compare genetic and protein differences. The goal is to better underst…

Researchers are studying the bacteria that live in burn wounds and how they relate to patient outcomes. The trial compares standard laboratory cultures with next-generation DNA sequencing to see if the newer method gives a clearer picture of the wound microbiome. Up to 400 adults…

This study enrolls up to 400 people with known or suspected infections or inflammatory diseases that are not covered by other research protocols. The goal is to evaluate patients using standard medical practices, generate new ideas for future studies, and train doctors. No experi…

This study aims to improve how doctors evaluate and manage people who have been exposed to bioterrorism agents (like anthrax) or emerging infectious diseases (like SARS or new flu strains). Up to 200 participants, including patients and healthcare workers, will be monitored and t…

This study aims to learn more about Hyper IgE syndrome, a rare immune disorder that causes skin and lung infections. Researchers will follow 600 patients and their relatives over time, examining their health and genetics. The goal is to better understand the disease and improve c…

This observational study will enroll 1,500 adults hospitalized with acute infections across the globe. Researchers will collect medical data and biological samples to better understand how these infections progress, what factors affect recovery, and how to design better clinical …

This study looks at how doctors can improve antibiotic prescriptions for urinary tract infections (UTIs) after patients leave the emergency department. Researchers will check if adjusting antibiotics based on lab test results reduces the use of strong drugs like fluoroquinolones.…

This study looks at whether adults with cystic fibrosis can collect sputum samples at home and mail them in for infection testing, compared to standard clinic collection. With 150 participants, researchers will compare how well home samples detect bacteria like Pseudomonas aerugi…

This early study tests whether transferring nasal bacteria from a parent to a child can restore the child's nasal microbiome after they have been treated with antibiotics for staph bacteria. The study involves 175 children who have had staph in their nose and recently finished an…

This study will enroll 40,000 children under 18 with suspected infections across Asia to develop and validate an early recognition tool for sepsis. Researchers will test the Phoenix Sepsis Score and create a new toolkit (SORT) to help doctors identify sepsis earlier. The goal is …

This study looks at how the immune system changes with age and how that affects the risk of infections in people 60 and older. Researchers will collect blood, urine, stool, and other samples from elderly patients with infections and healthy older adults. By analyzing immune cells…

This study measures how common heart disease, diabetes, obesity, and infections like dengue and COVID-19 are among adults in La Reunion. Researchers will also look at possible risk factors, including gut bacteria, genetics, and social conditions. Participants provide blood, DNA, …

This study investigates why only some people develop severe infections from common germs. Researchers will analyze blood and skin samples from 2,000 participants with rare, serious infections to find genetic differences that may weaken immune defenses. The goal is to identify spe…

This study looks at how the types of bacteria in the mouth change in people with severe gum disease as they go from having some teeth left to having no teeth, and then after getting dental implants. Researchers will collect microbial samples and analyze DNA to see if different im…

This study will follow 2000 adults in France who are starting treatment for tuberculosis. Researchers will collect health data and samples like blood, urine, and breath over two years to see how well treatments work. The goal is to learn more about TB care and build a biobank for…

This study is testing a new rapid diagnostic device called In-Dx to quickly identify infections and antibiotic resistance in emergency patients with suspected sepsis. Researchers will compare the device's results to standard lab cultures using stored samples from 2,500 patients. …

This study is testing a risk prediction model for MDRGNB, a type of drug-resistant infection, in 1,000 ICU patients across multiple hospitals. Researchers will check how well the model predicts who gets infected, using data collected within 48 hours of ICU admission. The goal is …

This observational study follows 350 adults with blood cancers like lymphoma or multiple myeloma who are being treated with bispecific antibodies. Researchers will track how often infections occur, how severe they are, and what factors raise infection risk. The goal is to better …

This study prepares medical sites in Kenya, Malawi, Mozambique, and Uganda for future trials of a vaccine against Group B Streptococcus (GBS), a leading cause of serious infections in newborns. Researchers will track pregnancy and infant health data and monitor GBS cases in babie…

This study aims to collect blood and saliva samples from 2000 adults who come to the emergency room with a suspected respiratory infection. Researchers will use these samples to better understand how the body responds to infections and to find new ways to diagnose and treat them.…

This study checks whether lab tests that measure drug levels in body fluids are accurate and reliable. Researchers will collect blood, urine, and other samples from 100 adults who are taking certain medicines (like antibiotics, antivirals, birth control, or erectile dysfunction d…

This project works to improve how doctors diagnose and treat infections in people with heart devices like pacemakers. It brings together teams of specialists to follow best-practice guidelines. The goal is to identify infections faster and start the right treatment sooner. About …

This study looks at whether showering 48 hours after breast reconstruction surgery, while drain tubes are still in place, raises the chance of infection. It will follow 100 women for 90 days to check for infections and how showering affects their quality of life. The goal is to h…

This study tests whether patients with serious infections who are at risk for sepsis can be safely monitored at home using wearable devices and a smartphone app. About 120 adults will take part, and the goal is to see if this approach can reduce hospital visits while still catchi…

This study will track 1,200 adults in semi-rural Tanzania to find out how common chronic kidney disease (CKD) is and what factors increase the risk. Participants will have blood and urine tests at the start, after 90 days, and again after one year. The goal is to create better wa…

This study looks at whether bacteria in your mouth can influence the buildup of fatty plaques in the neck arteries that supply blood to the brain. Researchers will collect samples from 200 adults having surgery to remove these plaques and compare the bacteria found in the mouth, …

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study looks at whether a new way of organizing hospital care, called an Acute Medical Unit, can help older adults with sudden illnesses like infections or COPD get better faster and spend fewer days in the hospital. Researchers will compare 220 patients who receive this new …

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study looks at how common certain infections are among 250 asylum seekers living in reception centers in Italy. Participants must be adults who arrived in Italy between 2 and 36 months ago. The goal is to better understand infection rates to improve health screening and care…

This study will follow 3,000 children hospitalized with severe bacterial infections to understand what makes them so dangerous. Researchers will collect data on the bacteria, the children's health, and the care they receive. The goal is to find risk factors and early warning sign…

This study looks at how the antibiotic ceftazidime avibactam behaves in 30 children with severe infections who are in intensive care, some on life support. Researchers will measure drug levels in the blood to understand the right dose. The goal is to improve treatment for life-th…

This study aims to uncover genetic mutations or variations linked to uveitis, an inflammatory eye disease. Researchers will collect blood samples from 1,500 patients with uveitis (including infectious types) and analyze their DNA. The goal is to better understand what causes the …

This study explores whether experiencing awe—through a simple online game featuring nature images—can increase people's willingness to engage in prosocial behaviors like getting vaccinated, wearing masks, and social distancing to prevent infectious diseases. Researchers will recr…

This study looks at how the drug bulevirtide changes gut bacteria and bile acids in people with hepatitis delta (a serious liver infection). Researchers will follow 20 patients for 48 weeks, collecting stool and blood samples to see how these changes relate to liver health. The g…

This study looks at whether donor breast milk can help restore healthy gut bacteria in full-term babies born by C-section who need extra feeding. About 90 mothers and their infants will take part, with some babies getting donor milk and others getting formula. The goal is to see …

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing needs. About 60 children in intensive …

This study will collect data from 2,000 children admitted to pediatric intensive care units (PICUs) with severe infections across major Chinese cities. Over 10 years, researchers will track which germs cause these infections, how they are treated, and patient outcomes. The goal i…

This study is creating a large collection of leftover blood, urine, and other samples from 800 hospitalized patients. The samples will be stored with medical data to help researchers develop and evaluate rapid diagnostic tests for emerging infectious diseases and biological threa…

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam, or vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury than the other, using more sensitive markers …

This Phase 1 study is testing whether high doses of the antiviral drug favipiravir are safe and tolerable in healthy volunteers. About 39 participants will receive either favipiravir or a placebo for 14 days, with doses increasing in three groups. Researchers will also measure dr…

This study is developing a personalized immune score to predict severe infections in people with weakened immune systems, such as transplant recipients. Researchers will measure different immune cells and virus-specific responses in 150 adult and pediatric patients before or one …

This study looks at a rare but often deadly infection caused by Bacillus cereus bacteria in premature newborns. Researchers will analyze the DNA of 40 bacterial samples from infected babies in French hospitals to see which genetic features make some strains more dangerous. The go…

This study is checking for antibiotic-resistant bacteria in the gut of 200 people who take PrEP (HIV prevention pills). Researchers will collect rectal swabs during routine STI testing and analyze the bacteria for resistance. The goal is to understand how common resistance is in …

This study aims to understand the natural bacteria living on the surface of the eye in both healthy people and those with certain eye conditions. Researchers will collect eye swabs from 500 adults in middle Tennessee to build a database of what a normal eye microbiome looks like.…

This study aims to reduce deaths from maternal sepsis, a leading cause of death in new mothers in the U.S. Researchers will create and test a safety bundle in four hospitals, involving over 33,000 birthing people. The goal is to see if the bundle helps diagnose and treat sepsis f…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study tests whether using changes in procalcitonin levels over time (kinetics) is better than a single measurement for deciding when to start antibiotics in critically ill patients with suspected infection. About 250 adults in the ICU will be randomly assigned to one of two …

This study is looking at whether a protein called vasorin (Vasn) in the blood can help doctors quickly tell the difference between septic shock (caused by infection) and other types of shock (like after heart surgery). Currently, the best test for this is not always accurate. The…

This study looks at how two over-the-counter mouthwashes (Listerine and Lumineux Oral Essentials) affect bacteria and three common viruses in the mouth and gut. Two hundred healthy adults aged 18-25 will rinse twice daily with one of the mouthwashes or water for about six months.…

This study looks at data from the HeartMate 3 heart pump to see if it can help predict problems like bleeding, infection, or frailty in people with advanced heart failure. Researchers will track 150 adults getting the pump and compare pump alarms and readings to their health over…

This study tests whether an educational program can help doctors in intensive care units (ICUs) use fewer antibiotics. The program includes training sessions and feedback based on the latest guidelines. Researchers will compare antibiotic use in ICUs before and after the program,…

This early-stage study tests the safety and how the body handles a new antibiotic called BWC0977. It involves 48 healthy adults aged 18 to 55 who will receive either the drug or a placebo by IV. The goal is to find safe doses for future studies targeting drug-resistant bacterial …

This study is testing whether wearable devices (like smartwatches) can help catch infections early in children receiving cancer treatment. About 150 kids aged 5-18 will wear a device for 4 weeks to track heart rate, activity, and other health signs. The goal is to build a compute…

This pilot study is testing whether a smart wristband can accurately measure drug levels in sweat compared to standard blood tests. Researchers will collect sweat, saliva, and blood samples from 100 patients with chronic or infectious diseases who are taking medications like cycl…

This study from Indiana University looks at how the COVID-19 pandemic may have changed people's physical activity, sleep, diet, blood pressure, and mental stress. Researchers will track 100 adults aged 18-75 using wearable devices, fitness tests, blood samples, and blood pressure…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…

This early-stage trial in 16 healthy adults in China measures how much of the intravenous antibiotic Meropenem-Pralubactam gets into lung fluids and cells. Researchers aim to find the drug's concentration in plasma, epithelial lining fluid, and alveolar macrophages after four dos…

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …