Gene-Guided dosing may tame dangerous fungal infections in blood cancer

NCT ID NCT06510699

Recruiting now Disease control Sponsor: The University of Queensland Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether using a patient's genetic profile to dose the antifungal drug voriconazole can help more patients reach the right drug levels faster. It will enroll 104 children and adults with blood cancer who have a fungal infection. Participants are randomly assigned to either standard dosing or dosing guided by a genetic test and computer software. The goal is to see if personalized dosing improves treatment success and is practical for hospitals.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: voriconazole
What this could lead to: If successful, this could make antifungal treatment safer and more effective for people with blood cancer, reducing side effects and improving outcomes.
What could go wrong: This is a small Phase 2 trial, so results may not apply to everyone. Genetic testing may not always lead to better dosing, and the approach may be too complex for routine use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for BLOOD CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

fungal infectious disease hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm Infections infectious disease neoplasm systemic mycosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLOOD CANCER FUNGAL INFECTION HAEMATOLOGICAL MALIGNANCY INFECTIOUS DISEASE

Contacts and locations

Locations

Children's Hospital Queensland
RECRUITING

South Brisbane, Queensland, 4029, Australia
Fred Hutchinson Cancer Centre
RECRUITING

Seattle, Washington, 908109-1024, United States
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3053, Australia
Royal Adelaide Hospital
RECRUITING

Adelaide, South Australia, 5000, Australia
Royal Brisbane & Women's Hospital
RECRUITING

Brisbane, Queensland, 4029, Australia
Sydney Children's Hospital Network
RECRUITING

Sydney, New South Wales, 21452031, Australia
Westmead Hospital
RECRUITING

Sydney, New South Wales, 2145, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.