Developmental disorder of mental health

This study investigates whether combining the medication lovastatin with intensive reading tutoring can improve reading abilities in children and young adults (ages 8-20) with Neurofibromatosis Type 1 (NF1) who have reading disabilities. Participants first receive either lovastat…

This study tests a behavioral program called Individualized Developmental Care (NIDCAP) for newborns with complex congenital heart disease. The program aims to reduce stress from the hospital environment by supporting parent involvement, creating a soothing setting, and adjusting…

This study tests a gene therapy called NGN-401 in 33 girls with Rett syndrome, a rare genetic disorder that affects development and movement. The therapy delivers a working copy of the MECP2 gene to try to improve skills and daily function. Researchers will measure success by whe…

This phase 2 trial tests whether lamivudine, an antiviral drug, can improve symptoms in people with Rett syndrome, a rare genetic disorder that affects movement, communication, and behavior. Ten participants will take the drug by mouth for a set period, and researchers will measu…

This study tests whether a mobile app can help parents of children aged 5-8 with disruptive behavior. 324 families will use either a standalone app, a coach-assisted app, or a control app. The goal is to see if digital tools can improve parenting skills and child behavior at a la…

This study planned to test the drug bumetanide in children aged 5 to 17 with autism of known cause. The goal was to see if it could improve autism symptoms. However, the trial was withdrawn before enrolling any participants, so no new information was gathered.

This study tests a program called REAL Fathers in Uganda, where respected community men mentor young fathers (ages 16-25) on positive parenting, conflict resolution, and family planning. Over 4,700 participants are involved. The goal is to see if this approach reduces intimate pa…

This early-phase trial tests a single injection of AAV-MECP2 gene therapy into the spinal fluid of 8 girls aged 4-10 with Rett syndrome, a severe neurodevelopmental disorder. The goal is to see if the treatment is safe and can reduce disease severity. The study is not yet recruit…

This study compares a new blended therapy (online sessions plus in-person visits) to standard in-person therapy for teens with conduct disorder or antisocial behavior. Researchers want to see if the blended approach works just as well at reducing aggression, delinquency, and out-…

This study was designed to see if hyperbaric oxygen therapy or computerized cognitive training could help adults with Fetal Alcohol Spectrum Disorder (FASD) think and function better. It planned to enroll 0 participants and was withdrawn before starting, so no results are availab…

This study tests whether a structured parent training program can reduce autism symptoms in children up to age 5 and high-risk infants under 2. 250 children and their caregivers will be randomly assigned to receive either the training plus routine care, or routine care alone. Aft…

This study tests a telehealth program that teaches parents of children with autism and overweight or obesity how to help their child manage weight through nutrition, activity, and behavior skills. About 140 families will take part, with one group receiving the parent-based progra…

This study tests whether intensive home-based psychiatric treatment can help children and teens with mental health disorders as an alternative to being in the hospital. Over 3 months, participants receive 3 to 7 home visits per week from a team of doctors, therapists, and other s…

This study tests whether a mix of treatments—including the patient's own stem cells, a strict keto diet, and a fecal transplant—can improve social skills, communication, and gut health in 50 teens and adults with autism. Participants must be stable on their current medications. T…

This study tests whether leucovorin calcium, a vitamin-like supplement, can improve language and other symptoms in young children with autism spectrum disorder. Researchers will enroll 80 children aged 2.5 to 5 years with language delays. The trial lasts about 26 weeks and compar…

This study compares two ways to help people with both substance use and mental health disorders: a full team-based program called MISSION that provides counseling, peer support, and community outreach for 6 months, versus just linking them with a peer specialist. Researchers hope…

This study aims to reduce disparities in ADHD care by adapting an evidence-based school program with mobile health technology. Researchers will test the digital tool with 350 participants, including students, parents, teachers, and school mental health providers in low-income and…

This study tests a drug called CM-AT in children with autism who have low levels of a digestive enzyme. The goal is to see if the drug is safe and helps with behaviors like irritability and social withdrawal over a longer period. About 405 children aged 3 to 8 who completed a pre…

This study tests a new way of delivering mental health and addiction services to youth aged 14-17. Instead of standard hospital outpatient care, an integrated team offers rapid access to various services like therapy, peer support, and primary care in a youth-friendly setting. Re…

This study is testing the safety of an experimental drug called ML-004 in 120 adolescents and adults with autism spectrum disorder who have already completed a previous study. Participants will take ML-004 once daily, and researchers will monitor for side effects. The goal is to …

This study looks at whether having a trained peer (someone with similar experiences) as a case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either us…

This study tests whether helping families with money and parenting skills can improve behavior in children ages 10-14 with oppositional defiant or conduct disorder. About 900 children and their caregivers in Uganda will be split into three groups: one gets financial help, one get…

This study tests a mobile health program called i-PregMom, which includes a smartphone app and digital food diary, to help pregnant women manage their blood sugar and weight gain. Researchers will enroll 160 first-time mothers and track their progress from early pregnancy (10-14 …

This study tests a new gene therapy called TSHA-102 for girls aged 5 to 8 with Rett syndrome, a severe genetic disorder that affects brain development. The therapy is given as a single injection into the spinal fluid. The main goal is to check safety and side effects, while also …

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study is testing a smartphone app called QbMobile that measures attention, impulsivity, activity, and movement patterns. Researchers want to see if it can provide objective data to help diagnose ADHD in people aged 6 to 60. The study includes 700 participants with and withou…

This study tests a telemedicine tool called the TAP, designed to assess autism symptoms in toddlers aged 18-42 months. Researchers will compare diagnoses made via video call with traditional in-person evaluations to see how accurate the tool is. The goal is to make autism diagnos…

This study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…

This study is testing a new AI-based system called AIMAS that aims to assess motor skills in children aged 6 to 12. The goal is to see if the AI can reliably identify kids with developmental coordination disorder (DCD) compared to standard clinical methods. Researchers will enrol…

This study is testing whether artificial intelligence can analyze a person's speech to help diagnose mental health conditions like depression, anxiety, autism, and schizophrenia. Researchers will record 500 people speaking and compare the AI's predictions to standard clinical dia…

This study tests a 12-session program called Forging Hopeful Futures, designed to reduce violence among teens ages 13-19. The program uses group discussions and activities to help youth understand how racism, gender inequality, and economic injustice can lead to violence, and tea…

This study tests whether listening to special audio fairy tales before sleep can improve speech, motor skills, and independence in a child with autism and central auditory processing disorder. The child stays at home with their mother, avoiding clinic stress. Early results from t…

This study explores whether joining a weekly reading group can improve reading comprehension and communication confidence in adults with aphasia, a language disorder often caused by stroke. Participants read a book at home and then discuss it in a 90-minute group session each wee…

This study explores whether adding a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) to standard speech therapy can improve word-finding in people with aphasia after a stroke. The trial involves 50 adults who are at least six months …

This study tests whether DHA, a key omega-3 fatty acid found in fish oil, can improve symptoms of autism in children and adolescents aged 5 to 17. Participants receive either DHA or a placebo daily for 12 weeks. Researchers also look at genes and urine markers related to DHA to u…

This study explores whether high-intensity interval training (HIIT) is a practical and acceptable treatment for adults with ADHD. Researchers will recruit 30 adults diagnosed with ADHD to participate in a 14-week exercise program combining strength and endurance training. The goa…

This study tests an internet-based cognitive behavioral therapy (CBT) program designed to help autistic adolescents aged 11-17 manage anxiety. The program, called LUNA-Adolescent, is parent-led and delivered online, making it easier for families who cannot access in-person therap…

This trial explores whether spending time on a farm with animals and nature can help socially withdrawn young adults (ages 18–30) with autism spectrum disorder. Participants take part in supervised group activities on a farm twice a week for 12 weeks. Researchers will interview p…

This study tests whether a parent-led therapy called Pathways can improve social skills in 80 toddlers (16-30 months old) who show early signs of autism. One group of parents learns a technique to encourage mutual eye contact during play, while the other group uses the same thera…

This study tests whether wearing a virtual reality (VR) headset during dental treatment can reduce fear and stress in children with mild intellectual disabilities or autism spectrum disorder. Two hundred children aged 6 to 12 will either receive standard dental care or use a VR h…

This study tests a new virtual reality program designed to help adults with autism improve their social skills and daily functioning. 140 participants will either receive the VR training plus usual care, or usual care alone, for 3 months. Researchers will measure changes in socia…

This study tests whether training early intervention providers in Reciprocal Imitation Training can help children with autism improve imitation and communication skills. The program involves 440 children and their caregivers, with providers learning simple strategies during play.…

This study explores whether a photography-based program can help children aged 8-12 with ADHD better recognize and express emotions, and improve attention and impulsivity. Sixty children will take photos and learn photography skills as a tool to boost emotional well-being. The go…

This study compares two parent training programs for 3-5 year olds with sleep problems and early signs of ADHD. One program focuses on behavior, the other adds sleep strategies. Researchers want to see if the sleep-focused approach is more helpful and practical for families in pe…

This study tests a single online session that teaches a simple coping skill to youth ages 9-17 who are on a waitlist for therapy. The goal is to see if this quick digital tool can help ease symptoms of anxiety, depression, and stress while they wait. About 226 youth and their par…

This study tests whether personalized sequences of behavioral interventions can help minimally verbal preschoolers with autism improve their language skills. Researchers will compare two teaching approaches—JASPER (play-based) and DTT (structured)—to see which works best for each…

This study tests a speech therapy method called Rapid Syllable Transition (ReST) in children aged 5 to 8 with childhood apraxia of speech, a condition that makes it hard to say sounds correctly. The goal is to see if the therapy is practical and helps improve speech clarity and m…

This study tests a therapy called RETELL that helps people with severe mental illness explore and reshape their life stories. The goal is to improve personal recovery, quality of life, and identity. Twenty adults with conditions like schizophrenia, bipolar disorder, or PTSD will …

This study tests whether a community-based music mindfulness program can reduce anxiety and depression in children aged 8-12 with ADHD or anxiety. Participants attend bi-weekly sessions for 8 weeks, wear fitness trackers, and complete surveys. The goal is to see if this approach …

This study tests a new program called PEAR that helps parents and teachers work together to manage ADHD and disruptive behavior in preschool children aged 2-5. The program adds extra support to a proven behavior tool called the Daily Report Card. Researchers want to see if PEAR i…

This study tests a remote speech therapy program for 32 Korean-speaking people with Parkinson's disease and their families. The therapy includes 16 sessions over four weeks, plus daily home practice, to improve speech clarity. The goal is to see if this culturally adapted approac…

This study tests whether an autism-friendly mobile app can help children and teens (ages 8-17) with autism improve their toothbrushing skills and habits. Participants use either the special app or a basic control app for 3 months while researchers track brushing quality and habit…

This study tests whether a probiotic supplement called Neuralli® MP can help adults aged 18 to 50 who have autistic traits. Participants take two capsules daily and set their own personal goals to track progress. The trial is small and open-label, meaning everyone knows they are …

This pilot study tests whether a non-invasive device that gently stimulates the vagus nerve through the ear can improve letter learning in 100 adolescents with dyslexia. Participants will learn new letter-sound relationships during six 30-minute sessions while receiving either ac…

This study tests a 12-session group program called Family Connections Transdiagnostic for relatives of people with emotional dysregulation disorders (like eating disorders or personality disorders). The program teaches skills in mindfulness, emotional regulation, and problem mana…

This study tests whether 80 sessions of a gentle brain stimulation technique called tDCS, given over 12 months, can improve attention, social skills, and language in 180 children aged 6 to 11 who have autism along with rare diseases, genetic problems, or PANDAS. The treatment is …

This study tests whether combining transcranial magnetic stimulation (TMS) with virtual reality exercises and physical therapy can improve symptoms like balance, fatigue, and thinking in people with multiple sclerosis. Thirty participants will receive both real and sham TMS in a …

This study looks at whether changing the sound of your own voice (like adding echo or whisper) can help adults who stutter speak more smoothly. About 100 people will use a special app for one month. The goal is to see if this simple technique improves fluency over time.

This study tests a communication tool called Best Case/Worst Case-ICU for older adults (50+) with serious injuries in the ICU. The tool helps doctors, patients, and families discuss possible outcomes and treatment options using simple graphics. Researchers will measure if it impr…

This study tests whether a nurse-led sailing program can improve resilience, self-esteem, and social skills in school-aged children with autism. About 184 children aged 7 to 12 will either take part in a 6-day sailing program or do simple craft activities. Researchers will compar…

This study looks at whether N-acetylcysteine (NAC), a well-tolerated nutritional supplement, can reduce restricted and repetitive behaviors in children with autism spectrum disorder. About 144 children who previously took part in related NAC trials will receive the supplement and…

This study compares two fun approaches—creative movement (like dance and yoga) and play-based activities (like obstacle courses and building blocks)—to see which better improves motor skills, balance, and quality of life in children aged 5-8 with developmental delay. Twenty-eight…

This small pilot study at Yale University is testing a modified form of cognitive-behavioral therapy (CBT) for children with autism and intellectual disability who struggle with irritability, tantrums, and aggression. Up to 6 children aged with an IQ between 55 and 85 will receiv…

This study tests whether teaching parents of children with autism special behavior support techniques can reduce challenging behaviors and lower parenting stress. About 80 families in South Punjab, Pakistan, will take part in an 8-10 week program. The goal is to see if this appro…

This study tests a new medication (CTx-1301) for children aged 6 to 12 with ADHD. The goal is to see if it helps control symptoms like inattention and hyperactivity over a full school day. Children will take the drug or a placebo and be observed in a lab classroom for 14 hours. T…

This study tests whether a non-invasive device that gently stimulates the vagus nerve through the ear can improve speech recovery in people with aphasia after stroke or brain injury. Twelve adults with apraxia of speech will receive either active or sham stimulation during 16 wee…

This small study tests whether group drumming sessions can improve emotional well-being for parents of autistic children. Ten parents will take part in drumming groups and report changes in anxiety, depression, and feelings of belonging. The goal is to see if making music togethe…

This study planned to test whether a brain-computer interface (BCI) could help children with drug-resistant epilepsy improve their attention. Participants would have used brain electrodes already implanted for epilepsy surgery to train a decoder that gives real-time feedback when…

This study tests a new type of brain training for children with ADHD. It uses a device that measures brain activity and gives feedback, sometimes with virtual reality goggles. The goal is to see if this training can improve attention and reduce hyperactivity. About 110 children a…

This study tests whether folinic acid (leucovorin), a drug already used to reduce side effects from chemotherapy, can improve language skills in children with autism spectrum disorder. Researchers will give the drug or a placebo to 56 children aged 5 to 17 for 12 to 24 weeks and …

This study tests an online self-help program called Together After Cancer for Latina breast cancer survivors and their intimate partners. The program includes brief coach calls and aims to improve the survivor's quality of life and the couple's relationship satisfaction. About 48…

This study tests a program called Autism Parent Navigators, which offers six in-home sessions to support parents of young children (ages 2-6) recently diagnosed with autism. The goal is to help parents adjust, find services, and improve family well-being. About 360 parents are ta…

This study aimed to see if a telehealth skills group could help middle and high school students with ADHD improve their organization, motivation, and grades. Both the treatment and control groups were delivered via Zoom. However, the study was withdrawn before enrolling any parti…

This study tests whether a specially designed group yoga program is practical and helpful for adults with ADHD symptoms. Twenty participants will be randomly assigned to either yoga or general movement classes. Researchers will track how many people join, stay, and complete the p…

This study tests a 6-week mobile app program for 60 teens aged 13–16 with ADHD. The app includes interactive exercises, animations, and weekly calls with a therapist to help with coping skills, healthy habits, and emotions. Teens and their parents fill out questionnaires before, …

This study tests a 12-week online program for mothers of infants (12-36 months old) with SMA Type 1. The program aims to teach mothers how to support their baby's development and improve their own knowledge. Thirteen mothers will take part, with 10 receiving the program and 3 rec…

This study tests whether the Apollo System, a device, can reduce ADHD symptoms in children aged 8 to 17. About 100 kids with diagnosed or suspected ADHD will use the device or a placebo version. Researchers will measure changes in attention and hyperactivity using parent surveys …

This study tests if a therapy called FIRST, which uses five key principles to help youth manage negative emotions, works better than standard therapy. About 212 youth aged 7 to 15 with anxiety, depression, trauma, or behavior problems will take part. The goal is to see if FIRST i…

This study tests whether a 16-session program called HOPS can help 6th to 8th graders with ADHD improve their organization, time management, and planning skills. Researchers are working with 240 students and their teachers in real school settings to see if the program works outsi…

This study tests a program called MSE-PEACE, where parents and children with developmental disabilities (like autism or ADHD) attend 10 sensory sessions together. The goal is to see if it improves children's engagement and emotional control, and helps parents feel more confident …

This study tests an 8-week program called SCERTS for children aged 3 to 6 with mild or moderate autism. The program focuses on improving social communication and emotional regulation while supporting parents. Researchers will measure changes in the child's social skills and the f…

This study tests a digital health tool (CLS-D) that adapts an existing school-based behavioral program for students with ADHD. The goal is to make the program easier for schools with limited resources to use, especially those serving low-income families. About 216 students in 2nd…

This study compares a home-based, tailored sleep therapy (CBT-I) to a web-based version for 80 caregivers who have insomnia while caring for a child with autism. The goal is to see which approach is more acceptable and feasible for improving sleep and reducing caregiver burden. P…

This pilot study tests a specific type of drama therapy for people who have both a mental health condition (like depression or bipolar disorder) and a substance use disorder. Ten participants will attend weekly group drama therapy sessions for 12 weeks, then put on a performance.…

This study tests a 16-week parent-assisted social skills program for 60 preschoolers with autism. Children learn through puppet shows, role-playing, and structured play, while parents get coaching. The goal is to improve social skills like making friends and playing with peers.

This study tests whether a program of balance, coordination, and perception exercises can improve thinking, movement, and quality of life in 30 children with ADHD, ages 8 to 12. The training includes activities like balancing, shape perception, and eye-hand coordination. Research…

This study tests a virtual reality program where children with autism watch avatars of themselves doing social behaviors like making eye contact and then practice those behaviors. 75 children aged 6-11 will be split into three groups: one gets the VR training, one gets standard t…

This small pilot study at Boston Children's Hospital will test whether a handheld device that guides deep breathing can help children with ADHD pay attention and control impulses. Ten children aged 7 to 11 will use the tool and then complete computer tasks while their brain activ…

This pilot study tests whether benzodiazepines (midazolam and clonazepam) and, if needed, electroconvulsive therapy (ECT) can safely reduce catatonic symptoms in 30 adolescents aged 10–19 with profound autism. Participants first receive a midazolam challenge; those who respond th…

This study tests whether children with autism will do daily 5-10 minute exercises if they see themselves, other kids, or kids in rabbit suits in a mobile app. Twenty children and their parents will use the app for 8 weeks. Researchers will measure how long kids stick with the exe…

This study tests a group therapy program called Regulating Together for children with autism who struggle with intense emotions. The program teaches children and their caregivers skills to manage emotional reactions using techniques like cognitive behavioral therapy and mindfulne…

This study tests a program called I2-ART, where trained family navigators support caregivers of minority children with ADHD. The goal is to help families follow through with recommended treatments like medication or behavior therapy. The study involves about 108 participants and …

This study tests whether ChatGPT can act as a job coach for adults with autism spectrum disorder (ASD). Thirty motivated adults aged 18-45 will use ChatGPT to build resumes, practice interviews, and discuss workplace social skills over one week. Researchers will measure changes i…

This study tests whether watching immersive 360° videos of everyday actions can improve word-finding in people with anomic aphasia after a stroke. Forty participants will either watch first-person 360° videos or standard third-person videos over 12 sessions. The goal is to see if…

This study tests whether a mild electrical current applied to the brain (tDCS) during speech therapy can improve language recovery in people with aphasia after a stroke. Two hundred adults with language problems from left-brain damage will receive either real or fake stimulation …

This study tests a 6-8 week caregiver-child therapy called THRIVE, delivered by school counselors via video or in school, to improve emotional and behavioral health in children aged 3-7 who are near the clinical threshold for mental health problems. THRIVE is compared to an onlin…

This study tests an experimental drug called gemlapodect to see if it can safely reduce tics in people with Tourette syndrome. About 164 adults and teens with moderate to severe tics will take the drug or a placebo for 12 weeks. The main goal is to measure changes in tic severity…

This study tests whether an internet-based job interview training program (Virtual Interview Training) helps autistic young adults improve their interview skills and find jobs. About 200 participants will either use the training or continue with their usual services. Researchers …

This pilot study aimed to test a parent-only training program for children aged 8-12 with both ADHD and overweight or obesity. Parents would learn weight management skills and strategies to help their child's focus and planning. However, the study was withdrawn before any partici…

This study tests whether taking postbiotics (beneficial bacteria byproducts) can improve ADHD symptoms like mood and sleep in children aged 6-13. Eighty participants will take two capsules daily for 8 weeks, with a 4-week follow-up. Researchers will track symptom changes using pa…

This study compares virtual reality-supported speech therapy to traditional speech therapy in 100 children aged 3 to 6 with developmental language disorder. Each child receives the same amount of therapy, but one group uses a VR system with touchscreen exercises while the other u…

This study tests whether virtual reality games can improve executive functions—like memory, focus, and planning—in 50 youth aged 8 to 18 with autism and ADHD. Participants will either play VR cognitive games or receive standard care. Researchers will compare thinking skills befor…

This study looks at whether unlicensed professionals can successfully provide cognitive behavioral therapy (CBT) to patients in a general hospital. It includes 250 adults with conditions like anxiety, depression, OCD, and PTSD. The goal is to see if this approach improves psychol…

This study tests whether personalized computer games can help people with Rett syndrome use their arms more purposefully and reduce repetitive hand movements. Fourteen participants will play games that reward them for separating their hands and reaching for targets. The training …

This study tests whether a non-invasive device called tRNS can safely reduce ADHD symptoms in children aged 7 to 12 who are not on medication. Over 10 sessions in two weeks, kids receive either real or sham stimulation while playing a computer game. Researchers track symptom chan…

This study tests whether a type of brain stimulation called rTMS can reduce depression in people with autism. Twenty-four participants aged 13 to 26 will receive either real or sham (fake) stimulation to see if it helps. The goal is to find a new way to treat depression that hasn…

This study compares two suicide prevention programs designed specifically for autistic youth aged 12-24. One program is a safety planning intervention (SPI-A), and the other adds follow-up contacts (SPI-A+). Researchers will track changes in suicidal thoughts and behaviors over a…

This small study looks at whether morning flashed light therapy, combined with online sleep counseling, is acceptable and tolerable for teens aged 14-17 with ADHD and delayed sleep. Six participants will try the light therapy daily for six weeks and attend weekly video sessions. …

This study tests whether a parent training program called Project IMPACT can improve social communication and reduce autism symptoms in children aged 1.5 to 6.5 years. Eighty children will be randomly assigned to either the IMPACT group (parents do at least 10 hours of therapy pe…

This study tests whether giving both caregivers and teachers a resource package for managing hyperactive, inattentive, or impulsive behaviors helps children more than giving it only to teachers. About 100 children in grades K-5 will take part, and researchers will measure how fea…

This study tests a group therapy called Awareness, Courage, and Love (ACL) for older adults with psychiatric disorders who feel lonely. The therapy focuses on mindfulness, sharing feelings, and building connections. Researchers want to see if the program is practical and helpful …

This study tests a program called FACE-Rare, designed to support family caregivers of children with rare, life-limiting diseases. The program includes three sessions to help families prepare for future medical decisions and improve their quality of life. Researchers will compare …

This study tests whether adding a motor-sound intervention (PROMPT) to a play-based therapy (JASPER) helps minimally verbal children with autism speak more words and combine them into phrases. Fifty-six children aged 4-7 who use fewer than 20 words will receive either JASPER alon…

This study aimed to see if combining biofeedback, breathing exercises, nutrition counseling, and exercise could help children and teens aged 7-18 with ADHD. Participants would have learned to control body functions like heart rate and practiced relaxation techniques, while also g…

This study tests a parent training program called the New Forest Parenting Programme for children aged 3-12 who have ADHD or trouble with attention and activity. Researchers want to see if it is practical and acceptable for families in Danish community clinics. The study includes…

This study tests whether a probiotic called Saccharomyces boulardii can improve digestive health, immune function, nutrition, and behavior in children aged 5 to 12 with autism and a history of gut problems. Sixty-six children in Ecuador will take the probiotic for 4 months and th…

This study tests a 14-day digital writing program designed to help parents of autistic individuals manage stress and improve mental health. Participants use a WeChat mini-program to write about their feelings and practice self-kindness for about 5 minutes each day. The trial incl…

This study tests a gamified app called MITA designed to improve language and thinking skills in children with autism aged 2 to 5. Sixty children will be randomly assigned to either use the app alongside their usual therapy or continue with standard care alone. The goal is to see …

This pilot study tests whether a home-based computer training program can improve executive function (like shifting attention and controlling impulses) in autistic children aged 8 to 17. Fifteen participants will play two social-themed games for 30 minutes a day, five days a week…

This study tests a computer-based training program designed to improve executive function (thinking, self-control, and memory) in 40 autistic children aged 5-7 in South Korea. Children will play games on a tablet and do activities with a coach over several sessions. Researchers w…

This study tests a 22-week small-group program called Let's Know!2 for first graders with low language skills. The program uses fun lessons to build vocabulary and comprehension. Researchers will compare children who get the program to those who don't, tracking their progress thr…

This study tests a behavioral sleep and circadian intervention for 50 school-aged children (6–12 years) with autism who have sleep problems. Parents receive 5 Zoom sessions over 12 weeks to learn strategies to improve their child's sleep. The goal is to see if the program is feas…

This pilot study tests a telehealth-delivered training program for caregivers of infants (12-18 months old) who show early signs of ADHD, such as trouble with self-control or emotion regulation. The program teaches caregivers strategies to support their child's development throug…

This study looks at whether a set of thinking and memory tests can detect changes caused by a stimulant medication in children aged 6 to 17 who have both intellectual disability and ADHD. About 68 participants will receive either the medication or a placebo, then switch after a b…

This study tests whether neurofeedback—a non-invasive brain training technique—can reduce symptoms of attention deficit hyperactivity disorder (ADHD) in teenagers. Researchers in Tanta, Egypt, are enrolling 40 participants aged 12 to 18. The approach uses real-time brain activity…

This study tests whether a mild electrical current applied to the scalp (tDCS) can boost attention and working memory in adults with ADHD. Researchers will vary the strength and duration of the stimulation to find the best dose. 104 participants will complete attention tasks whil…

This study tests whether a special type of family therapy, called Narrative Family Therapy, can improve how families with an autistic child communicate and function. Sixty-three families will either receive eight therapy sessions or play family games. Researchers will also use br…

This study tests a family-centered program called Transitioning Together / Juntos en la Transición, designed to help autistic youth (ages 14-21) and their parents navigate the move to adulthood. The program includes one individual family session and four group sessions covering t…

This study tests two types of speech therapy for people with primary progressive aphasia, a brain disorder that slowly destroys language skills. Sixty participants will work on word retrieval or script practice with a clinician and at home. Researchers will measure changes in com…

This phase 2 trial tests whether sulforaphane, a compound found in broccoli, can improve core symptoms of autism. 48 males aged 13-30 with autism will receive either sulforaphane or a placebo for several weeks. Researchers will measure changes in behavior and social responsivenes…

This study looks at whether telehealth tools can help families concerned about autism in their infants. Researchers are testing an online assessment tool and a set of video modules that teach parents strategies to support their child's communication. 80 families will be randomly …

This study looks at whether adding three extra stress management sessions for parents can improve outcomes for families of young children with disruptive behavior disorders. About 120 families will either get the standard school readiness parenting program or that program plus th…

This study tests a speech-language telerehabilitation program for people with primary progressive aphasia (PPA), a dementia that slowly destroys language abilities. The program includes online therapy sessions and care partner training. Researchers will enroll 21 participants to …

This study was designed to test whether ADZENYS XR-ODT, a once-daily amphetamine tablet that dissolves in the mouth, could help manage ADHD symptoms in children aged 4 to less than 6 years. The trial was planned as a randomized, double-blind, placebo-controlled study, but it was …

This study tests a drug called pitolisant in 62 boys and teens aged 6 to 17 with autism. The goal is to see if it improves social skills and behavior. Participants are randomly assigned to receive the drug or a placebo, and neither they nor the researchers know who gets which. Th…

This study tests whether cannabidiol (CBD) can reduce severe behavior problems like aggression, self-harm, and repetitive actions in children with autism. About 42 boys aged 7-14 with severe autism and daily behavioral issues will receive both CBD and a placebo at different times…

This study tests a 6-week virtual group program that teaches parents strategies to encourage their toddler's vocalizations and shared smiling. The program is for children aged 12-42 months who have early signs or a diagnosis of autism or related social communication challenges. R…

This study tests whether adding in-home decluttering sessions to group cognitive-behavioral therapy can reduce hoarding severity in adults with hoarding disorder. About 90 participants in Sweden will receive 10 weekly home visits focused on guided decluttering, alongside standard…

This study tests whether a non-invasive brain stimulation technique called cTBS can improve how children with autism (ages 6-12) combine what they see and hear. Forty children will receive either real or sham stimulation over 10 sessions. Researchers will use brain scans, genetic…

This study tests whether a non-invasive brain stimulation technique called iTBS can improve attention and self-control in children aged 6 to 12 with ADHD. Over two weeks, 40 children will receive either real or sham stimulation, and researchers will measure changes in attention u…

This pilot study explores whether laughter yoga can reduce depression and anxiety in children with autism spectrum disorder (ages 8–12) and lower parenting stress for their parents. 66 families will either take part in laughter yoga sessions or be placed on a waiting list. The st…

This study tests a training program that teaches children with physical disabilities how to use their manual wheelchairs better. The goal is to help them move around on their own instead of relying on others, which can improve their confidence and social life. Four children aged …

This study tests a program called START that helps families of children with ADHD learn about the condition, reduce stigma, and overcome obstacles to getting care. About 106 children aged 6-12 with a new or recent ADHD diagnosis will take part. Some families get the START program…

This study tests a brain training method that combines EEG and fNIRS to help autistic children aged 8 to 12 improve attention, emotion control, and social skills. Thirty children will receive neurofeedback sessions and complete thinking and behavior assessments. The goal is to se…

This study tests whether a non-invasive brain stimulation technique called iTBS can improve ADHD symptoms in teenagers. For 10 days, participants receive magnetic pulses to a brain area linked to attention and memory. Researchers will measure changes in brain activity, working me…

This study planned to test whether sulforaphane, a compound found in broccoli, could improve social skills and behavior in people with autism spectrum disorder (ASD). Researchers aimed to enroll 50 people with ASD aged 12–34 and 30 healthy volunteers, giving the ASD group sulfora…

This study tests a robotic feeding device called Obi for people who cannot use their arms to eat on their own. About 50 participants, including patients, caregivers, and healthcare providers, will use the device at home or in care settings for one week. Afterward, they will fill …

This study investigates how the brain processes speech sounds to understand language. Researchers will record brain activity from people with epilepsy or brain tumors who already have electrodes implanted for medical reasons. Participants listen to short speech sounds while their…

This study was designed to see if cognitive behavioral therapy for insomnia (CBT-I) could help teenagers with ADHD who also have trouble sleeping. It planned to enroll adolescents aged 11-18 with both ADHD and insomnia. However, the trial was withdrawn before any participants wer…

This study aims to uncover the genetic and environmental factors behind autism spectrum disorders (ASD), including autism, Asperger's syndrome, and PDD. Researchers will analyze gene expression in 240 participants aged 18 months and older who have an ASD diagnosis. The goal is to…

This study uses MRI scans to look at the brains of children and adults with conditions like ADHD, autism, schizophrenia, and endocrine disorders, as well as healthy volunteers. Researchers aim to compare brain anatomy and function across different groups and ages. The goal is to …

This study tests a 10-week program called 'Grow to Recovery' for people with mental illness. The program is co-led by a peer (someone who also has a mental illness) and a professional. Researchers want to see if it helps participants feel more hopeful and capable. 138 people are …

This study tests a program that helps parents and teens work together to improve safe driving. It includes 588 teens aged 16-17 who have already received a traffic ticket. The program uses a smartphone app and in-car device to track risky driving and give feedback, aiming to redu…

This study uses brain scans and behavioral data from 267 adults (80 with autism, 79 with schizophrenia, and 108 healthy controls) to explore shared brain activity patterns related to social thinking. No new treatments are given; researchers analyze existing data to understand how…

This study aims to help people from underserved communities talk about their wishes for end-of-life care and complete advance directives. Researchers will use trusted community networks to host events where two conversation tools are tested. About 1500 adults will participate to …

This study is not a treatment trial. It aims to translate and test a new assessment tool (FARAS-IT) for adults with autism who are involved in the Italian criminal justice system. Researchers will enroll 100 adults with autism, including those in forensic psychiatric care, those …

This study follows nearly 600 people with Smith-Magenis syndrome (SMS), a rare genetic condition, to track how their health, behavior, and development change over time. Researchers will perform detailed medical exams, genetic tests, and surveys to better understand the syndrome's…

This study trains police officers and first responders to better communicate with people who have aphasia, a condition that affects speech and understanding. 75 participants from the Madison Police Department will take part for up to 6 months. The goal is to see if training impro…

This study tests a toolkit called PEACE, designed to help early intervention providers coach parents of young children with autism. Researchers will enroll 200 providers and 400 parent-child dyads to see if the toolkit improves how providers support families. The goal is to make …

This study aimed to see if monthly video calls could help track swallowing issues in people who had intensive rehab after throat cancer treatment. It planned to enroll adults with chronic swallowing problems and check if they could attend at least 3 out of 5 remote sessions. Howe…

This study compares 6 months of group music activities versus circus activities in 200 infants (8-12 months old) with or without a family history of dyslexia. Researchers will measure language skills, brain responses to sounds, and social-emotional factors. The goal is to see if …

This study compares two methods of training surgeons to have better conversations with patients about surgery risks and goals. About 60 surgeons and 660 patients will take part. One group of surgeons gets training from an education specialist, the other from a computer program. T…

This study tests whether a digital tool called QbMobile can accurately measure changes in ADHD symptoms after starting treatment. Researchers will enroll 175 people aged 6 to 60 who are newly diagnosed or not yet on medication. Participants use QbMobile to generate a symptom scor…

This study tests whether an early assessment of activity limitations by occupational therapists can help people with mental disorders return to work. 150 participants in specialized psychiatric care will either receive the assessment or usual care. The goal is to see if this lead…

This study tests a therapy where parents of children with autism (ages 1.5 to 3) get video feedback to help them better understand and respond to their child's signals. The goal is to improve joint attention, a key skill for social communication. Twenty-seven families will be ran…

This study looks at why children with autism spectrum disorder (ASD) have trouble imitating others. Researchers will have 201 children aged 8 to 12 perform imitation tasks while recording brain activity with EEG. The goal is to pinpoint where the breakdown happens, which could im…

This study tests a program called Preschool and Me (PreM) that helps families of children with developmental delays or disabilities connect with school-based services. The program uses a care plan and a navigator to guide families through the process. Researchers hope this will i…

This study investigates how the brain determines what's important to look at, balancing things that stand out (like bright colors) with things we know are relevant. Researchers will have 240 healthy adults perform visual tasks while measuring their response times and eye movement…

This study was designed to test whether scheduled video calls with a nurse could help family members who make medical decisions for hospitalized older adults with Alzheimer's or similar cognitive issues. The goal was to improve communication and reduce anxiety and depression. How…

This study looks at whether melatonin, a common sleep aid, can improve sleep spindles—special brain waves that help with sleep and attention—in 30 children with autism aged 12-18. Researchers want to understand why sleep and sensory issues happen in autism and test if melatonin c…

This study follows children born moderately or late preterm (32-36 weeks) to age 9, measuring their thinking, movement, language, behavior, and growth. Researchers compare these kids to full-term peers to understand long-term effects. The goal is to learn how early development pr…

This study looks at whether a special health check-up for older adults (called a geriatric assessment) can help them and their caregivers talk more effectively with their doctors about age-related concerns. About 479 older cancer patients and their caregivers are taking part. The…

This study looks at whether an 8-week program of daily brain training exercises, combined with a gentle electrical current applied to the scalp (tDCS), can improve thinking, reduce falls, and help seniors with mental health conditions stay independent. About 270 older adults livi…

This study tests whether a 12-week program that combines brain training, social activities, and exercise is practical and liked by seniors with mental health conditions living in community housing. About 18 participants will try the program in small groups, guided by a support wo…

This study tests whether coaching or communication classes for primary care clinicians can improve patient satisfaction scores and reduce clinician burnout. About 45 Mayo Clinic providers will take part, filling out questionnaires before, right after, and two months after the tra…

This study tests whether a structured educational program can improve primary school teachers' knowledge and classroom skills for managing students with ADHD. 175 teachers who have at least one student with a confirmed ADHD diagnosis will take part. The program covers ADHD basics…

This study follows about 12 children and young adults (ages 4 to 21) with autism who are already using intranasal insulin as part of their regular care. Researchers want to see if this treatment is safe and if it helps with social skills, communication, and behavior over 6 months…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study is developing and testing a smartphone app called R-Assist for people recently released from jail who have both substance use and mental health disorders. The app tracks symptoms, connects users to resources like housing and recovery groups, and measures how easy it is…

This pilot study explores a new language intervention called Milieu Teaching-AV for infant siblings of autistic children, who are at higher risk for autism or language delays. The intervention teaches caregivers to encourage babies to look at the mouth during play, aiming to impr…

This pilot study will test whether an online assessment battery is practical for children with autism who are receiving complementary and integrative healthcare. Twenty children aged 3-12 will complete online questionnaires and check-ins with their practitioners. The main goal is…

This study looks at tobacco, cannabis, and other drug use among homeless and at-risk youth in downtown Ottawa. Researchers will follow 520 participants aged 16 and older who are homeless or insecurely housed and have a history of cannabis use and mental illness. The goal is to un…

This study watches a single gynecology resident as they learn to perform a hysterectomy through the vagina using a special camera, leaving no belly scars. The goal is to see how quickly the resident improves, measuring surgery time and any complications. Nineteen women with benig…

This study looks at how the gut microbiome (the bacteria in our intestines) is linked to stress in children with autism or those who have experienced trauma. Researchers will give 75 children, ages 4 to 7, a probiotic powder for 4 weeks and measure changes in their gut bacteria a…

This small study will give 5 teens with autism a single dose of escitalopram (Lexapro) or a placebo, then scan their brains to see how the drug affects networks linked to rigid thinking and repetitive behaviors. The goal is to understand whether this medication might help with in…

This study looks at whether a group therapy program called Unstuck & On Target can improve flexibility and learning in 64 teens with autism aged 14-18. Researchers will use brain scans (MRI) to see if the therapy changes how the brain processes new information. The goal is to und…

This study planned to test vagus nerve stimulation (VNS) in children and adults with autism and developmental disabilities to see if it could improve behavior, thinking, and body rhythms. Participants would have chosen 1 to 3 months of daily VNS and completed monthly check-ins. T…

This study looks at whether genes and thinking skills like memory can predict how well someone with aphasia (trouble speaking after a stroke) responds to word-retrieval therapy. Researchers will work with 120 people who had a stroke at least six months ago. The goal is to move to…

This study tests whether a special technology tool can help deaf or hard-of-hearing children ages 3-10 improve their language skills. About 114 children will be randomly assigned to use the tool or continue their usual therapy. Researchers will measure changes in vocabulary, sent…

This study looks at whether a special syringe called EpiFaith® helps anesthesia residents learn how to place labor epidurals more quickly. 34 residents with little experience will each perform 20 epidural placements using either the standard syringe or the EpiFaith® syringe. Rese…

This study looks at a care approach called a time-limited trial (TLT) for ICU patients who need a breathing machine. Doctors, patients, and families agree to try treatments for a set time, then check if the patient is recovering. The goal is to see if this approach can reduce ICU…

This study looks at how eye movements, specifically eye vergence (how eyes work together for depth perception), relate to attention in people with ADHD and autism. Researchers will use computer-based eye-tracking tasks with 200 children and adults to see if these eye patterns can…

This study planned to use high-frequency brain signals to locate important brain areas and understand conditions like epilepsy, migraine, and ADHD. It aimed to create a large database of brain activity in people aged 1 day to 69 years. However, the study was withdrawn before any …

This study tests whether a non-invasive brain stimulation technique called repetitive Transcranial Magnetic Stimulation (rTMS) can change how adults with autism process social information. Researchers will measure brain responses with EEG and eye-tracking before and after stimula…

This study looks at how genes might be linked to behavior in 200 children aged 7-16 with disruptive behavior disorders like Conduct Disorder or Oppositional Defiant Disorder. Some of these children also have callous-unemotional traits, such as lack of guilt or shallow emotions. R…

Researchers at Arkansas Children's Hospital are studying how mitochondria work in children with autism spectrum disorder. They aim to identify distinct patterns of mitochondrial dysfunction that may relate to developmental delays. The study involves up to 5 visits with blood draw…

This study tests a new behavioral therapy designed to help veterans with traumatic brain injury (TBI) improve their storytelling and everyday communication. The therapy focuses on both story content and organization. The trial includes 34 veterans and aims to see if the treatment…

This study aims to understand why many people with Tourette syndrome are overly sensitive to everyday sensations like touch or noise. Researchers will monitor brain activity, heart rate, and sweat responses in 50 adults with Tourette syndrome while they experience different sound…

This study tests a method called SAIA-MH to help clinics in Mozambique better diagnose, treat, and follow up with people who have mental health conditions. Researchers will compare clinics using this approach to those that don't, involving about 155 patients. The goal is to see i…

This study looks at how the brain's temporal lobe helps process sound. Researchers will measure brain activity using EEG in 10 people who have had surgery to remove a lesion in a key hearing area. The goal is to better understand how the brain generates electrical responses to sp…

This study uses brain scans and magnetic stimulation to compare brain activity in 160 adults with autism, depression, both, or neither. Researchers want to understand how brain inflammation and the balance of excitation and inhibition relate to social and emotional symptoms. No t…

This study looks at whether taking common painkillers like paracetamol or ibuprofen during pregnancy can affect a child's brain development, behavior, and language skills. Researchers will follow 685 children aged 2 to 4 years whose mothers were part of an earlier study on painki…

This study looks at whether a parent coaching and family navigation program (Project AFECT) can help families right after a child is diagnosed with autism. About 200 parents of children aged 1 to 5, who are Hispanic/Latino, Black/African-American, or have Medi-Cal insurance, will…

This study is collecting genetic information and observable traits from 1500 people with autism and their families. The goal is to better understand how genes relate to autism. Participants must be at least 18 months old and have an autism diagnosis or a related genetic finding.

This study tests a new interactive multimedia program designed to teach ICU nurses about chemotherapy drug administration. Fifty nurses at a medical center in southern Taiwan will use the system for about 30 minutes and complete tests before and after to see if their knowledge an…

This study looks at whether a special training program called TEAMS helps therapists and teachers use proven autism therapies more effectively. Researchers will work with about 1206 people, including program leaders, providers, and parents of children with autism. The goal is to …

This study follows 192 teens aged 12 to 20 who are already receiving either Cognitive Behavioral Therapy (CBT) or Brief Strategic Therapy (BST) for anxiety, depression, or OCD. Researchers will track their progress using questionnaires and interviews over 9 months. The goal is to…

This study is testing a new online sex education program called 'Our Love, Our Style' for autistic young adults in South Korea. The program covers relationships, consent, and sexual health over 10 weekly sessions. Researchers want to see if it improves knowledge and relationship …

This study aims to learn more about diseases that affect the brain, such as Parkinson's disease and different types of dementia. Researchers will follow 500 adults with symptoms of these conditions over time, using brain scans and genetic tests to see how the diseases progress. T…

This study looks at whether a special fraction teaching program helps 4th-grade students, including those with math learning difficulties, improve their fraction skills. About 2,210 students will take part, with some teachers using the program and others teaching normally. The go…

This small pilot study aims to see if digital biomarkers—like heart rate and movement tracked by a watch—can help measure changes in autism symptoms during treatment with sulforaphane, a compound found in vegetables. Ten males aged 13-30 with autism who previously took part in a …

This study looks at how the cerebellum, a part of the brain, helps us learn and adjust our speech. Researchers will use brain scans, magnetic stimulation, and speaking tasks in people with cerebellar ataxia (a movement disorder) and healthy volunteers. The goal is to better under…

This research studies a program that places social workers in 25 children's doctor offices across Indiana. The goal is to help doctors spot and treat mental health issues like depression and anxiety sooner. About 575 patients and staff will take part to see if this approach impro…

This study tests a computer-based word retrieval practice for people with aphasia, a language disorder often caused by stroke. Twenty adults who have trouble finding words will practice naming pictures with feedback. The goal is to see if this practice can improve word retrieval …

This study looks at a special training program called Fundamentals of Communication in Surgery (FCS) for surgeons and surgery trainees. The goal is to see if the training helps surgeons communicate better with patients and each other. About 600 people will take part, and research…

This study tests whether artificial intelligence can improve how emergency call operators recognize strokes. Researchers will analyze 1,000 emergency calls to see if AI can detect signs of stroke more accurately than current methods. The goal is to help stroke patients get to the…

This study records brain activity from people with epilepsy or brain tumors who already have electrodes implanted for medical reasons. Participants listen to short speech sounds in English, Spanish, or Mandarin while their brain signals are measured. The goal is to understand how…

This pilot trial tests a culturally adapted parent training program for Navajo families of children with autism or developmental disabilities. About 29 parents will be randomly assigned to join the program right away or after a wait. The program is led by trained Navajo Family Ad…

This study looks at whether a power wheelchair that can lift a child from sitting to standing is practical for kids with conditions like cerebral palsy, spinal cord injuries, or genetic diseases. Only 4 children aged 5-17 are taking part. The goal is to see if the chair helps the…

This study looks at spinal posture, balance, and ankle muscle tightness in children with autism compared to typically developing children. Researchers will measure these physical traits using tools like the Spinal Mouse and balance tests. The goal is to understand if children wit…

This study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…

This study tests a computer program called GraphoLearn, designed to improve reading skills in children aged 6 to 10 with reading disabilities. Researchers will compare reading gains in children who use GraphoLearn versus those who use a math program. The goal is to see if the app…