Developmental disorder of mental health

This trial tests whether a smartphone app can enhance parent management training (PMT) for children aged 8 to 13 with disruptive behavior disorders, such as conduct disorder or ADHD. Parents receive 12 weekly PMT sessions, and half also use a digital tool with videos, a resource …

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This trial is testing whether an experimental medication called centanafadine, taken once daily as extended-release capsules, can help adults with attention-deficit/hyperactivity disorder (ADHD) who also experience emotional dysregulation—difficulty managing emotions like irritab…

This phase 2 trial explores whether fecal microbiota transplantation (FMT) is safe, tolerable, and practical for adolescents aged 13–17 with ADHD. Participants receive oral FMT capsules after bowel prep, alongside antibiotics, to see if changing gut bacteria can influence ADHD sy…

This trial tests a blended caregiver-led intervention for autistic toddlers under 3, combining social-communication strategies with social-emotional support. Caregivers are coached over 12 weekly sessions to embed these techniques into daily routines and play. The study aims to s…

This pilot trial tests whether a digital inhaler cap, which gives real-time guidance on inhaler technique, can help adolescents with intellectual and developmental disabilities (IDD) manage their asthma at home. The study will compare active use of the smart inhaler to passive us…

This trial tests whether an online training for preschool teachers, called WE PLAY, can increase physical activity among young children with autism. About 150 teacher-child pairs will be randomly assigned to either the WE PLAY training or a control training. The study measures ch…

This pilot study tests whether an antioxidant cocktail called Rett-T can improve motor function in children and adolescents with Rett syndrome, a rare genetic disorder that affects movement and coordination. Participants, aged 2 to 21 and at least partially able to walk, will rec…

General anesthesia in early childhood may raise the risk of ADHD-like behaviors and learning problems later on. This trial tests whether a non-invasive device delivering synchronized 40-Hz light and sound can help restore brain function after surgery. Researchers will monitor bra…

This trial tests a 12-week home-based program called SPRINT for infants aged 7-15 months who were born preterm or have a family history of conditions like ADHD, autism, or developmental delay. Parents use an app to guide daily play activities aimed at improving parenting skills a…

This study tests whether Foquest, a once-daily extended-release methylphenidate capsule, is safe and effective for treating ADHD in adults aged 65 and older. Participants take the medication for about 10 weeks, starting at 25 mg and adjusting up to 100 mg based on response. The m…

This study tests whether a telehealth-delivered applied behavior analysis (ABA) program can improve care for autistic adolescents and young adults hospitalized due to severe challenging behaviors like aggression or self-injury. Participants are randomly assigned to receive either…

This study tests a fully wireless brain-computer interface (BCI) that aims to decode attempted speech in real time for people with locked-in syndrome (LIS), often caused by ALS or stroke. The implant records brain signals from areas controlling the mouth and throat, then translat…

This study tests a computer-based practice method to help people with aphasia—a language disorder often caused by stroke—retrieve words more easily. Participants practice naming pictures with or without cues and receive feedback, repeating items until they meet a learning goal. T…

This trial tests whether the MIND diet, a brain-healthy eating plan rich in vegetables, berries, nuts, and fish, can reduce ADHD symptoms in children aged 6 to 12 who are not taking medication. Over 12 weeks, half the children follow the MIND diet while the other half receive sta…

This phase 3 trial tests whether viloxazine extended-release capsules, taken once daily, can safely reduce ADHD symptoms in Korean children and adolescents aged 6 to 17. Participants receive either the drug or a placebo for 8 weeks, with doses adjusted based on response. The stud…

This study tests two approaches—lifestyle medicine consultations and cognitive behavioral therapy (CBT)—to reduce cardiovascular risk in autistic individuals aged 9 to 26 who have a high body mass index. Participants are randomly assigned to receive lifestyle coaching, CBT sessio…

This early study tests a small, wireless brain implant designed to help people with severe speech problems communicate by thought. Four adults with conditions like locked-in syndrome or ALS will get the implant and learn to control it. The main goal is to see if the device is saf…

This study tests a brain implant called deep brain stimulation (DBS) to help six adults with severe aggression that hasn't improved with medication or other therapies. Participants have either autism or schizophrenia and live in locked psychiatric units. The implant targets a bra…

This study compares a semi-intensive therapy program (8 hours per week at a center plus online parent training) to the standard intensive program (15 hours per week) for young children with autism. The goal is to see if the remote approach works just as well for improving develop…

This study tests whether everolimus, a drug already approved for other conditions, can safely improve social abilities in people with PTEN Hamartoma Tumor Syndrome (PHTS). About 60 adults and children with PHTS and social difficulties will take either everolimus or a placebo for …

This phase 2 trial tests a low-dose immune drug called interleukin-2 (ILT-101) in 22 children aged 6 to 8 with moderate to severe autism whose mothers had an autoimmune condition during pregnancy. The goal is to see if the drug can increase helpful immune cells (Tregs) and improv…

This study tests a special type of talk therapy (cognitive-behavioral therapy, or CBT) designed for adults with ADHD who are in prison. Researchers will compare it to a standard prison program and a waitlist. They want to see if the therapy reduces ADHD symptoms, depression, anxi…

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This early-phase trial will test a new treatment called VGN-Ex05e, made from human embryonic stem cells, for children and teens with autism who have severe, treatment-resistant self-injury or aggression. The treatment is injected directly into a brain area linked to behavior. Onl…

This pilot study tests whether fecal microbiota transplantation (FMT) capsules can improve gut symptoms like constipation and diarrhea in children with autism, and possibly help their behavior. Twenty children aged 6-12 will be randomly assigned to receive either FMT capsules or …

This study looks at whether a special oral nutritional supplement, combined with dietary counseling, can improve growth in children who are not growing as expected. About 216 children will be randomly assigned to receive either the supplement plus counseling or counseling alone. …

This early-stage trial will test the safety of a single intravenous dose of stem cells derived from human bone marrow in 42 people aged 6 and older with autism spectrum disorder. Participants will receive one of three different doses. The study will monitor for side effects and a…

This study compares two treatments for teens aged 12-19 with oppositional defiant or conduct disorders. One group gets mentalization-based therapy (MBT), which helps teens understand their own and others' thoughts and feelings. The other group gets standard psychiatric care plus …

This study tests whether an AI-powered electric toothbrush and visual teaching materials can improve oral hygiene in children with autism. Fifty kids aged 5-13 will either use a manual toothbrush with picture guides or the smart toothbrush with an app. Researchers will check plaq…

This study tests whether an eye-tracking device can help detect autism in toddlers born prematurely (before 37 weeks). Children aged 14-48 months referred for autism evaluation will use the device, and researchers will see if the eye-tracking data points to autism. The goal is to…

This study tests a new system called AHEF designed to help doctors diagnose attention-deficit/hyperactivity disorder (ADHD) in children aged 6 to 12. The trial includes children with possible ADHD symptoms as well as healthy children, and measures how accurate and safe the system…

This study is testing a new cognitive assessment called the ExéSem battery, designed to help doctors tell the difference between language problems caused by memory loss versus those caused by thinking difficulties. Researchers will enroll 140 people, including those with Alzheime…

This study explores whether eye-tracking technology can help screen for autism in children aged 4 to 10. Researchers will compare how children with and without autism look at faces and other social cues. The goal is to develop a simpler diagnostic tool that doesn't require strong…

This study will test a machine-assisted system that uses five simple behavioral tasks—like responding to their name or pointing—to screen toddlers for autism. Researchers will enroll 1,000 children aged 1.5 to 2.5 years, including those with autism, developmental delays, language…

This study tests a language intervention called Milieu Teaching-AV for infants aged 6-12 months who have an older sibling with autism, putting them at higher risk for autism or language delays. The intervention encourages babies to look at caregivers' faces and mouths during play…

This study compares three types of therapy for children aged 8 to 16.5 with severe irritability. Participants will receive either exposure-based cognitive behavioral therapy, parent management training, or supportive psychoeducation over 12 sessions. The goal is to see which appr…

This study will test whether a wearable device called Apollo Neuro is practical and acceptable for autistic children aged 6 to 14 who hurt themselves. The device delivers low-intensity vibrations through the skin. For about a month, 18 children will wear it at least 3 hours a day…

This trial tests whether cognitive behavioural therapy for insomnia (CBT-I), with or without bright light therapy, can improve sleep and other outcomes in adolescents with ADHD who also have insomnia and a late sleep schedule. Participants aged 10-24 will receive CBT-I plus eithe…

This study tests whether a 12-week program of dance, yoga, and mindful movement can improve the lives of adults aged 18 to 35 with autism spectrum disorder (ASD). Researchers want to see if the program can enhance social skills, communication, quality of life, and overall well-be…

This trial is testing whether a specially adapted form of cognitive behavioral therapy, called CBT-DAY, can reduce depressive symptoms in autistic youth aged 11 to 17. Participants will be randomly assigned to receive either CBT-DAY or standard care, and researchers will compare …

This study tests whether LEGO®-Based Play Therapy can help children with autism spectrum disorder improve their social and play skills. Children aged 6 to 12 will participate in weekly group sessions for 12 weeks, working together to build LEGO models while taking on roles like E…

This trial tests whether adding hippotherapy—therapeutic horseback riding—to a standard special education program can improve physical function, bladder and bowel symptoms, and social communication in children with autism spectrum disorder. Thirty children will receive either the…

This study asks whether the timing of an autism diagnosis affects how well children respond to occupational therapy. Researchers will compare sensory processing and executive function improvements in children diagnosed early versus late. The therapy focuses on daily living skills…

This study tests whether a new medication, KarXT + KarX-EC, can reduce irritability in children and teens (ages 5 to 17) with autism. About 176 participants will receive either the drug or a placebo. The main goal is to see if the drug improves irritability scores after 8 weeks.

This trial tests whether a telehealth program called Babble Boot Camp can improve early communication in babies born very preterm (before 32 weeks). Parents in the treatment group join weekly 15-minute coaching sessions with a speech pathologist for six months, learning activitie…

This study tests an investigational drug called Omega-DEK plus L-carnitine in 34 children aged 3 to 6 with childhood apraxia of speech (CAS). The study lasts 20 weeks and first gives everyone the treatment, then randomly assigns some to a placebo to see if the treatment helps mai…

This randomized trial tests whether adding animal-assisted therapy (AAT) — structured sessions with a trained dog and/or rabbits — to standard rehabilitation can improve motor abilities, independence, and quality of life in older adults with dementia who are hospitalized in a med…

This study adapts a psychosocial support program called Caregiver Speaks for parents of children with Rett syndrome. Delivered through a private Facebook group over six weeks, the program aims to reduce caregiver stress and improve well-being. Researchers will test whether the ap…

This trial tests whether a smartphone app called LISTEN can help people with brain tumors who have trouble speaking (aphasia) communicate more easily. The app uses artificial intelligence to adapt to each user's needs and can be used with voice input and output. Researchers will …

This trial tests whether a structured, task-focused occupational therapy program delivered at school can improve handwriting, fine motor skills, and visual-motor integration in second- and third-graders who struggle with these skills. Children will be randomly assigned to either …

This trial tests whether a two-week tongue-strengthening exercise, done with a non-invasive device, can improve speech fluency in people with tongue-tie or slurred speech. The exercise relies on muscle resistance training, not medication or electronics. Researchers will measure c…

This study tests a new, non-drug treatment for veterans with ADHD who still struggle with impulsivity despite medication. The treatment, called intermittent theta-burst stimulation (iTBS), uses magnetic pulses to gently stimulate brain areas linked to self-control. Thirty-five ve…

This study investigates whether a synbiotic supplement—a mix of probiotics and prebiotics—can improve emotion regulation and reduce gastrointestinal problems in adults with ADHD. Participants take either the synbiotic or a placebo capsule daily for 12 weeks. The main focus is on …

This phase 1 trial tests whether low-energy focused ultrasound can safely and temporarily reduce tics in people with Tourette syndrome. Twenty participants aged 16 and older receive ultrasound to deep brain regions or the motor cortex, or a sham treatment, across four sessions. T…

This study compares two well-known early autism interventions, ESDM and PRT, to see which one helps young children with autism improve their communication skills more. Researchers will enroll 140 children aged 2 to 5 and randomly assign them to one of the two therapies for 24 wee…

This study tests an AI-based simulation that lets parents of autistic children (ages 3–12) practice calm, supportive responses to challenging situations. The goal is to improve parent-child communication and emotional regulation. Around 140 parents will be randomly assigned to us…

This study tests whether adding electroacupuncture at specific acupoints (Xuanzhong and Tongli) to standard speech therapy improves language recovery in people with post-stroke aphasia. Participants receive daily electroacupuncture sessions for four weeks, plus speech therapy. Th…

This Phase 3 study tests whether a combination of two drugs, KarXT and KarX-EC, can safely reduce irritability in children and adolescents aged 5 to 17 with autism spectrum disorder. About 176 participants will receive either the drug combo or a placebo for 8 weeks. The main goal…

This study tests whether brief, 1-2 minute videos featuring personal stories from other parents can reduce stigma and improve help-seeking among parents of children aged 6-18 with depression, ADHD, or substance use problems. Researchers will recruit 1,600 parents online and rando…

This trial tests whether a gentle, non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can reduce inattention in adults with ADHD. Forty adults with ADHD will receive either real or fake tDCS for five days in a row. Researchers will meas…

This study looks at whether posture and tongue position affect how children pronounce Hebrew sounds. Researchers will test if adding muscle-strengthening exercises to regular speech therapy helps kids learn correct pronunciation faster. About 80 children with and without speech i…

This study tests whether virtual reality (VR) exercises can improve attention, memory, and thinking skills in children with autism aged 4 to 6. Thirty children will be split into two groups: one using VR training and the other using traditional paper-and-pencil activities. The go…

This study tests whether ganaxolone, a drug already approved for certain seizures, can reduce irritability in autistic children aged 5 to 17. About 66 participants will receive either the drug or a placebo for 12 weeks. The main goal is to see if it improves emotional regulation …

This study will test whether adding music therapy to standard physical therapy helps children with spastic cerebral palsy improve their concentration and walking. Forty children aged 5 to 7 will either receive physical therapy alone or physical therapy combined with rhythmic musi…

This study will test a behavioral program to improve sleep and daily rhythms in autistic teenagers aged 13-17 who have sleep problems. The goal is to see if the program is practical and helps teens sleep better, which may also improve their mood and thinking. The study involves 1…

This study tests whether a 10-week therapeutic climbing program can improve motor skills and confidence in 16 children with Developmental Coordination Disorder (DCD). The program uses a problem-solving approach called CO-OP and is led by occupational therapists. The goal is to se…

This study tests whether an AI-based app called HiDongDong can improve speech in children aged 2 to 14 who have trouble pronouncing words. Forty-eight children will either use the app at home for 20 minutes a day, five days a week, or receive standard speech therapy. The goal is …

This early-stage study tests whether a non-invasive ultrasound device aimed at a deep brain region can safely improve social skills in people with autism. Twenty participants aged 13 to 25 will receive the treatment and be monitored with brain scans and behavior tests. The goal i…

This study will test if acupuncture can reduce tics (uncontrolled movements or sounds) in children aged 5 to 18. Researchers will also use special brain scans to see how acupuncture might affect the brain. The goal is to find a safe, non-drug treatment for tic disorders.

This study tests whether daily iron supplements can improve restless sleep and ADHD symptoms in 70 children with ADHD who have low iron levels. Participants will take either iron or a placebo for 3 months, and their sleep and attention will be measured using motion-sensing leg ba…

This study tests whether intensive music therapy can improve thinking skills like memory, attention, and decision-making in people recovering from a stroke. It will include 36 adults in Malaysia who had a stroke within the last 3 months and have mild to moderate cognitive problem…

This study tests whether photobiomodulation (a type of light therapy) can improve core autism symptoms like social interaction, communication, and behavior in 30 children aged 2 to 6. Participants will receive standard therapies plus light therapy. Researchers will measure change…

This study tests a daily oral medication called SCI-110, made from cannabinoids, to see if it can safely reduce tics in adults with Tourette syndrome. About 164 adults aged 18 to 65 with moderate to severe tics will receive either the drug or a placebo, then switch after 12 weeks…

This study tests a program that offers mental health screening, therapy, and follow-up to pregnant women who are in the hospital for medical complications. About 50 participants will receive brief counseling and symptom tracking during their stay and for three months after. The g…

This study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…

This study explores whether a non-invasive brain stimulation technique called tDCS can be practically used during routine speech therapy for people who have had a stroke and now have aphasia (trouble speaking or understanding language). Researchers will enroll 30 stroke survivors…

This study tests a program called MENU that gives caregivers of young children (ages 2-5) practical tools while they wait for an autism evaluation. The program is tailored to each family's needs and includes strategies to improve caregiver mental health, child communication, and …

This study tests whether a home-based music program can improve attention and thinking speed in people who have had a stroke. About 36 Malaysian stroke survivors with mild to moderate cognitive issues will take part. They will use music exercises at home, with help from a caregiv…

This trial tests whether an intensive, personalized speech therapy program (ICAP) helps people with post-stroke aphasia communicate better and feel better. 334 adults who had a stroke at least 3 months ago will be randomly assigned to either ICAP (100 hours over 4 weeks) or stand…

This study will test a new occupational therapy program in schools for children aged 6 to 14 with Autism Spectrum Disorder or Intellectual Disability. The program focuses on improving sensory processing and daily living skills through weekly 50-minute sessions over 10 to 12 weeks…

This study compares two treatments to help 150 children aged 8-11 with developmental language disorder learn passive sentence structures. One treatment uses repetition and listening, while the other teaches grammar rules directly. Children will be tested before, right after, and …

This study tests whether a mild electrical current applied to the scalp (tDCS) can improve naming ability in people who have trouble speaking after a recent stroke. Twenty-eight adults with aphasia will receive either real or sham stimulation over five days. The goal is to see if…

This study tests a short, guided self-help program designed to help parents of autistic children aged 6-17 feel less stressed and more compassionate toward themselves. About 6-8 parents will use a workbook and audio tracks, plus get weekly support calls over 13 weeks. The goal is…

This study tests a behavioral program called TranS-C to help autistic adults with sleep and circadian problems. The program teaches regular sleep routines, daytime habits, and helpful sleep beliefs. Researchers will enroll 24 autistic adults to see if the treatment improves overa…

This study looks at whether a therapy called Acceptance and Commitment Therapy (ACT) can help fathers of children with special needs feel more flexible in their thinking and improve their mental health. About 50 fathers will take part, with half getting ACT and the other half rec…

This study aims to see if online speech therapy works as well as face-to-face sessions for children aged 5 to 11 with repaired cleft palate. Sixty-four children will receive 30-minute speech therapy twice a week for 10 weeks, either online or in person. Researchers will measure i…

This early study tests whether inhaling a gas called xenon for 10 minutes a day over 10 days can improve social functioning in children with autism. 72 children aged 4-18 will receive either xenon or a placebo. Researchers will check social skills right after treatment and again …

This study tests whether toe spread-out exercises, with or without walking on different surfaces, can improve foot arch support and jumping ability in children with autism who have flatfoot. Thirty-four children aged 7 to 12 will do the exercises three times a week for eight week…

This study tests whether buspirone, a medication used for anxiety, is safe and effective for autistic youth aged 7 to 17 who also have anxiety disorders. Researchers will measure changes in anxiety symptoms over 16 weeks. The goal is to see if this drug can ease anxiety in this s…

This study tests whether a virtual reality system (VRRS) can improve executive functions like memory, planning, and attention in 50 children aged 8-12 with ADHD. Kids will do 12 sessions of VR-based cognitive exercises over 6 weeks. Researchers will also check if these skills hel…

This study will test whether adapted karate training can improve self-regulation, daily function, and social participation in children aged 6-12 with ADHD. Fifty-five participants will either receive karate training first or wait, then switch. The training involves two 60-minute …

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can help people over 70 recover swallowing after a stroke. Twenty participants will receive either active or sham stimulation alongside standard speech therapy for three weeks. Researchers wi…

This study tests if a diet rich in fiber and fermented foods can reduce core ADHD symptoms in adults aged 18-50. Two hundred participants will be randomly assigned to either this special diet or standard healthy eating advice for 12 weeks. Researchers will track changes in sympto…

This study tests a program that combines a daily digital game for children aged 5-8 with autism and weekly online coaching for their parents. The goal is to improve executive functions like self-control, memory, and flexibility. Researchers will measure changes using computer tas…

This study will compare two behavioral programs for children aged 9-12 with ADHD: the OutSMARTers group program and individual counseling. About 100 children will be randomly assigned to one of the programs or a short waitlist. Researchers will measure changes in behavior, emotio…

This study tests whether a special type of speech training using five musical tones can help people with aphasia (trouble speaking) after a stroke. Researchers will enroll 120 adults who had a stroke and have non-fluent aphasia. Participants will receive either five-tone therapy …

This study tests whether playing a virtual reality game called Electrical Maze can improve sustained attention in neurodivergent children aged 9 to 18, including those with autism, ADHD, or learning differences. Over 6 weeks, 40 participants will play the VR game twice a week for…

This study tests a new visual safety plan designed for autistic teenagers who have had suicidal thoughts or self-harm. About 90 teens aged 13-18 will be randomly assigned to either get the visual plan plus usual care, or just usual care. The goal is to see if the plan is easy to …

This study compares voice therapy delivered in-person versus via telehealth for adults aged 55 and older with age-related voice problems. Thirty participants will receive four sessions of PhoRTE® voice exercises either face-to-face or through video calls. Researchers will measure…

This study tests a special light therapy (850 nm) on 66 adults who had a stroke within the past year and now have trouble speaking or understanding language (aphasia). The goal is to see if shining this light on the head can improve brain activity and language skills. Participant…

This study compares two medications, methylphenidate and guanfacine, to see which works better for treating ADHD in children ages 3 to 5. About 370 children with moderate to severe ADHD will take one of the drugs, and doctors will rate how much their symptoms improve. The goal is…

This study tests a mobile app called 'Heart Voice: Starry Journey' designed to help parents and caregivers of children with autism feel more flexible and less anxious or depressed. About 52 caregivers will use the app for 6 weeks, doing interactive stories and exercises based on …

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce symptoms of ADHD and autism in children and teens aged 6-19. Participants will receive either real or sham (fake) stimulation over three weeks. The goal is to see if it is safe and if it im…

This study tests a structured lifestyle program for mothers who are the primary caregivers of children with autism. The program includes eight sessions over four weeks, focusing on stress management, healthy routines, and balancing daily activities. Researchers want to see if thi…

This study tests a rhythmic auditory training program designed to help children with Autism Spectrum Disorder (ASD) improve their language skills. 24 children aged 3 to 6 with a formal ASD diagnosis and language delay will practice reproducing the syllable rhythms of speech. Rese…

This study tests whether intensive music-based rhythm training can improve attention, thinking, and reading in children aged 8 to 10 with complex neurodevelopmental disorders (like ADHD plus dyslexia). Six children will take part in a structured program, and researchers will meas…

This Phase 2 pilot study will test whether a single high dose of psilocybin (the active ingredient in magic mushrooms) combined with speech therapy can improve fluency and reduce struggle in 25 adults who stutter. Researchers will measure changes in stuttering severity and brain …

This study will test whether a device called NeuroCytotron, which sends low-energy magnetic pulses to specific brain areas, can safely improve social communication and reduce repetitive behaviors in children with autism. 256 children aged 3 to 12 will be randomly assigned to rece…

This study tests two ways to deliver a group training program for caregivers of children with autism in low-resource areas. The program aims to reduce caregiver stress and improve the child's communication and behavior. About 320 caregivers of children aged 2 to 8 will take part.…

This study tests a cannabis plant extract called NTI164, which has very low THC (the compound that causes a high), in 40 females aged 4-25 with Rett syndrome, a rare genetic condition causing severe physical and mental challenges. Participants will receive either NTI164 or a plac…

This study tests whether a full-spectrum cannabis plant extract called NTI164 can help reduce core autism symptoms (like social challenges and repetitive behaviors) in children and young adults aged 6 to 25. About 98 participants will receive either NTI164 or a placebo for 16 wee…

This pilot study will test whether a program called Facing Your Fears can help reduce anxiety in 24 children aged 12-18 who have both autism spectrum disorder and intellectual disability. The program uses cognitive behavioral therapy techniques like gradual exposure to feared sit…

This study looks at whether an 8-week exercise program (balance, strength, and stretching) can improve physical fitness in children aged 7-14 with specific learning disabilities. 18 children will be split into an exercise group and a control group. The goal is to see if regular e…

This study will test a new, non-invasive treatment called transcranial photobiomodulation (tPBM) for children with ADHD. The treatment uses light to stimulate the brain. Researchers will enroll 54 children aged 6 to 18 to see if tPBM can improve ADHD symptoms, sleep, and brain ac…

This study tests whether the PEERS® program, a social skills training from the US, can help Italian teens aged 10-14 with autism make and keep friends. Thirty-six teens will either take the program or continue their usual care. Researchers will measure changes in social knowledge…

This study tests a shortened version of Parent-Child Interaction Therapy (PCIT) that uses videos and 360-degree virtual reality films to help parents manage disruptive behavior in children aged 2-7. Fifteen families will receive up to 10 therapy sessions. Researchers will measure…

This study looks at whether children with ADHD and their parents will actually use a digital app called LUSHA for three months. The app is designed as a game to motivate behavior change and improve parent-child interaction. Researchers will track how often families use the app an…

This study tests whether listening to music for 30 minutes a day for 8 weeks can improve attention, language, and quality of life in people with aphasia after a stroke. Researchers will compare music listening to audiobook listening and a control group. The trial involves 45 adul…

This early-phase trial tests whether giving adults with autism a 6-week course of vancomycin followed by a fecal transplant from a close relative can improve social and language problems. Ten participants will be tracked for changes in autism symptoms, quality of life, and gut he…

This study tests a behavioral program called KF-STRIDE that helps autistic adults recognize their strengths and talk about them appropriately in job interviews. Thirty participants will practice in mock interviews and be rated by experts. The goal is to see if the program is prac…

This study looks at whether structured breathing exercises can help 12th graders reduce exam anxiety, improve attention, and boost academic performance. Sixty students preparing for university entrance exams will practice specific breathing techniques over several sessions. Resea…

This study looks at brain activity in teenagers aged 10 to 17 with ADHD, OCD, or no diagnosis. Researchers will use EEG, MRI, and MEG to measure brain signals while participants do computer tasks. The goal is to understand how the brain controls thinking and behavior, which may h…

This study looks at stroke survivors who have mild aphasia—a condition causing language difficulties. Researchers want to see if these individuals also struggle with 'executive control' of language, which helps us manage and switch between words and ideas. By testing 30 participa…

This study looks back at the medical records of 60 adults with head and neck cancer who received radiation therapy, with or without chemotherapy, and used a topical mouth rinse made from olive oil, betaine, and xylitol. The goal is to see how often severe mouth sores (oral mucosi…

This study investigates whether a familiarization session before a treadmill time-to-exhaustion test can reduce learning effects and improve measurement consistency. Healthy, physically active adults will complete a practice trial followed by an experimental trial. Researchers wi…

This study looks at whether using simulation (practicing with mannequins or actors) helps first-year nursing students become better communicators compared to traditional teaching methods like role-play and group discussion. Fifty students will be randomly assigned to either simul…

This study tests a program to help people with certain genetic mutations share their results with at-risk relatives and make informed decisions about genetic testing and care. About 2100 adults in the U.S. who speak English or Spanish will take part. The program provides free gen…

This trial tests an AI-powered teaching platform called iLN, which uses a large language model to help medical students learn about lupus nephritis. Fifty fourth-year medical students are randomly assigned to either use iLN or attend a traditional PowerPoint lecture. The study me…

This study explores whether a flipped learning approach—where students review digital materials before class and use class time for active problem-solving—improves clinical decision-making and academic performance in third-year physiotherapy students. Participants take part in ed…

This observational study looks at whether snack consumption and eating behavior are linked to the severity of ADHD in children aged 6 to 12. Researchers will survey children with ADHD and a control group about their eating habits and snack choices. The goal is to understand if ce…

This study will test a mobile app called ¡Iniciando! designed to help Latino young adults with autism and their families navigate the move to adulthood. The app includes virtual group sessions and coaching over 12 weeks. The goal is to see if the app is easy to use, acceptable, a…

This study investigates whether one year of boxing training can improve attention in adolescent athletes aged 13-15. Researchers will use the Attention Network Test to measure changes in alerting, orienting, and executive control. The goal is to understand how boxing affects brai…

This study explores whether a full English course built on the DeepSeek artificial intelligence platform can improve orthopedic nurses' professional English skills. Twenty nurses will take an 11-week blended online and offline course covering topics like trauma nursing, joint rep…

This study compares how well teens with autism spectrum disorder (ASD) drive compared to neurotypical teens. Researchers will use a driving simulator and a real road test to measure errors, visual attention, and anxiety. The goal is to understand differences in driving performanc…

This study looks at how common heart problems are in children with ADHD. Researchers will compare 50 children with ADHD who take medication to 50 healthy children. They will use ECG and echocardiograms to check for heart issues.

This study tests whether a simple, non-invasive brain test (EEG) can predict which of two common ADHD medications—methylphenidate or amphetamines—works best for a child. About 220 children aged 7-11 with ADHD will try both medicines in a random order over 7 weeks. The goal is to …

This study looks at how the tiny organisms in the gut (the microbiome) are connected to brain development and daily skills in children with autism. Researchers will collect stool samples and measure movement, thinking, and behavior in 600 children aged 3 to 12. The goal is to bet…

Researchers at the University of Haifa are studying the ankles and Achilles tendons of 80 adults with autism to see if structural differences relate to sensory responsiveness and toe walking. Participants will undergo ultrasound and strength tests. This observational study aims t…

This study looks at whether drinking caffeinated coffee helps professional chess players think faster and make better moves during tournament games. Twelve top-level players (rated 2300-2600 Elo) will play chess after drinking either regular coffee or decaf, without knowing which…

This observational study looks at 200 children aged 4-12 with autism to see if trunk control (balance and stability) explains why some have lower exercise capacity. Participants do a trunk control test and a 6-minute walk during a single clinic visit. No treatment is given—the go…

This study looks at whether a guided self-help workbook can help autistic adults feel better. Ten participants will use the workbook with a trained supporter over 4-6 sessions. They will fill out wellbeing questionnaires and share their thoughts in interviews. The goal is to see …

This study will check how often people with ADHD also have fibromyalgia, and vice versa. Researchers will collect blood and urine samples from 100 adults to look for shared biological markers. The goal is to better understand why these two conditions often occur together.

This study aims to collect blood samples from 450 people, including individuals with autism spectrum disorder (ASD), their relatives, and healthy controls. Researchers will isolate cells from the blood to study genetic factors and biological processes linked to autism. The goal i…

This pilot study will test whether autism can be diagnosed in toddlers (16-36 months) using a telehealth protocol, instead of an in-person visit. Researchers will enroll 100 children from Georgia's early intervention program who are at moderate or high risk for autism. The goal i…

This study looks at how the brain works in 200 children with hard-to-treat epilepsy who are already scheduled for brain monitoring. Researchers will measure brain activity during tasks like learning and decision-making. The goal is to better understand thinking and memory, which …

This study will develop and test an online training program for nurses who give powerful cancer drugs like chemotherapy. About 238 nurses from two cancer centers in Oman will take part. Half will get the e-learning course, and half will continue with usual training. Researchers w…

This study aims to create a therapy program using Acceptance and Commitment Therapy (ACT) for fathers of children with special needs in Hong Kong. Researchers will interview 20 fathers and social workers to understand their challenges and what kind of support would help. The goal…

This study interviews people with learning differences and surveys medical students to understand what future doctors need to learn to provide better care. The goal is to use these insights to create volunteer-led teaching sessions. The study is small, with 15 participants, and a…

This study looks at using simple, low-cost communication tools like picture boards and gestures for children with autism who have trouble speaking. It involves 500 children and their caregivers in rural Virginia and western Kenya. The goal is to find better ways to match each chi…

This study looks at how emotional regulation varies across the menstrual cycle in autistic women. Researchers will compare them to women with borderline personality disorder, premenstrual dysphoric disorder, and those without any diagnosed condition. The goal is to better underst…

This study is looking for early clues—like brain activity, genetics, and environment—that might predict autism, ADHD, and related mental health issues in children and young adults. Researchers will follow 800 participants from infancy through young adulthood across 10 internation…

This study gives 40 adults—half with autism, half without—a single dose of MDMA (the active ingredient in ecstasy) or a placebo to see how it changes oxytocin levels in the blood. Oxytocin is often called the 'love hormone' and helps with social bonding. The goal is not to treat …

This study tests a new computer-based training program designed to help autistic children ages 8-11 improve their thinking and problem-solving skills. The goal is to see if this training can reduce repetitive behaviors and improve daily functioning. 95 children will be randomly a…

This study looks at how quickly children aged 3 to 6 with pervasive developmental disorders (like autism) react and move, compared to typically developing kids. Researchers will test 30 children using simple reaction time tasks and motor skill assessments. The goal is to understa…

This study tests a new training program called CIPP-A for pediatric providers who care for autistic youth at risk of suicide. About 70 providers will be randomly assigned to learn either the new program or a standard safety planning approach. Researchers will measure how often pr…

This study looks at how the brains of children with Williams syndrome and autism differ, focusing on social and thinking skills. Researchers will compare 75 children aged 3-12 from three groups: those with Williams syndrome, those with autism, and typically developing kids. No tr…

This study examines how person-centered care affects the health and well-being of older adults and staff in academic nursing homes in Sweden. Researchers will survey 600 participants, including residents and staff, over time. The goal is to understand how to make elderly care mor…

This study aims to understand the biological causes of autism by growing tiny 3D brain models called organoids from cells of people with autism. Researchers will compare these organoids to those from siblings without autism to see how genetic differences affect brain cell develop…

This study looks at how often people develop speech or swallowing problems after a jaw-advancement surgery for obstructive sleep apnea. Researchers will measure nasality, speech, and swallowing in 28 adults before and after surgery at five different times. The goal is to better u…

This study will follow 120 Mandarin-speaking children with autism and typically developing children to understand how speech develops over time. Researchers will use parent reports and play sessions to track language skills. The goal is to create models that help predict speech p…

This study looks at how people with mild intellectual disability process emotions compared to those with autism and typically developing individuals. It also tests a special therapy program to help them regulate emotions. 40 people with intellectual disability will take part in t…

This study looks at whether training primary care clinicians to diagnose autism in children aged 18 to 36 months can shorten the time from a positive screening to a final diagnosis. About 300 children will take part across multiple clinics. Researchers will compare diagnosis time…

This observational study will monitor brain activity (EEG) in 330 people during anesthesia or sedation to see how it relates to drug levels and patient factors. It includes children with and without autism, adults over 70, and adults having sedation for endoscopy. The goal is to …

This study will look at sleep in 34 children with Tourette syndrome, comparing them to children without the condition. Researchers will use a special tic index, a watch-like movement tracker, and overnight sleep recordings to see how tics affect sleep quality. The goal is to bett…

This pilot study will test whether eye-tracking and balance tests can help identify early signs of ADHD in children aged 3 to 5. Researchers will compare 30 children with ADHD symptoms to 30 healthy children of the same age. The goal is to develop a platform for earlier detection…

This study will look at balance, posture, and fine motor skills in 38 children aged 6–18 who have specific learning disabilities. Researchers will use simple tests like standing on a balance beam and picking up small objects. The goal is to better understand the motor challenges …

This study looks at 48 teenagers with autism who were checked for psychotic symptoms 10 years ago. Researchers want to see how their mental health and daily functioning are now. They will compare those who had early signs of psychosis with those who did not, using interviews and …

This study watches real conversations between healthcare staff and people with dementia after hip fracture surgery. The goal is to find which words and phrases work best to encourage patients to stand or walk early. Researchers will record up to 50 care sessions on hospital wards…

This study looks at whether children with ADHD have different levels of inflammation and nutrition markers compared to children without ADHD. Researchers will follow 80 children aged 7 to 17 for one year to see if these markers affect how well they respond to common ADHD medicati…

This study looks at how children with autism spectrum disorder (ASD) process visual information over very short time intervals. Researchers will use eye-tracking tasks to measure how quickly children with ASD can integrate separate images into one and how fast they can shift atte…

This study looks at whether adding decoding and encoding practice to the ALLSTAR literacy program helps children with complex communication needs learn to read better. Sixty children aged 5-12 who use augmentative and alternative communication (AAC) will be split into two groups:…

This study looks at how adolescents with autism handle stress, anxiety, and depression compared to teens without autism. Researchers will use questionnaires and interviews to understand coping strategies. The goal is to find better ways to support mental health in teens with auti…

This study tests an online program for 40 caregivers of children aged 7–12 with autism in South Korea. The program helps parents think through and prepare for telling their child about the diagnosis. Researchers will check if the program is helpful and easy to use, and if it impr…

This study will compare how well an AI program (Blings) measures speech clarity in 40 adults with speech disorders from stroke or other neurological conditions. Two speech therapists will also rate the same speech samples. The goal is to see if the AI can reliably replace or assi…

This study will check how much psychiatric clients know about occupational therapy (OT) and whether their expectations are realistic. It will also evaluate how well OT interns explain health information and conduct interviews. Researchers will develop new tools to measure these s…

This study aims to create a system to assess and improve motor skills in children aged 4 to 12 with neurodevelopmental disorders like ADHD. Researchers will test different exercise programs to see which ones best help these children move better and think more clearly. The goal is…

This study will test whether using a metaverse environment with virtual patients helps nursing students improve their communication skills, stay engaged in learning, and reduce daydreaming. One hundred fourth-year nursing students will be randomly assigned to either metaverse tra…

This study looks at whether chemicals and other substances in a mother's body during pregnancy can help predict if her child will develop autism. Researchers will use stored urine and cord blood samples from 600 first-time mothers. The goal is to build a model that could estimate…

This study tests a culturally adapted home program for Arab toddlers in Israel. 240 families with children aged 18-36 months will receive either eight weekly sessions teaching parents how to boost language and problem-solving through play and routines, or eight sessions on genera…

This observational study will look at 185 children with epilepsy to find out how many also have ADHD symptoms. Researchers will track changes in ADHD symptoms and quality of life over 12 weeks. The goal is to identify risk factors and understand how ADHD affects epilepsy outcomes…

This observational study will examine the results of genetic testing (karyotyping) in 75 children aged 1 month to 12 years who have both birth defects and developmental delays. Researchers will collect medical histories, perform physical exams, and analyze genetic test results to…

This study tests two different approaches for bringing autistic people and Applied Behavior Analysis (ABA) providers together to discuss research priorities. One approach uses a restorative justice framework to ensure autistic voices are heard and respected. The goal is to find b…

This study looks at 27 children with autism to see if how they process sensory information is related to tightness in their ankle muscles, which can cause toe-walking. Researchers will measure ankle flexibility and have parents fill out a detailed questionnaire about their child'…

This study tests a training program where pediatricians practice talking about contraception with computer-generated avatars of a teen and her mother. The goal is to see if this boosts doctors' confidence and skills in shared decision-making. The study will enroll 166 medical res…