Brain training for autism: can therapy rewire learning in teens?

NCT ID NCT05131659

Ongoing Knowledge-focused Sponsor: Children's National Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a group therapy program called Unstuck & On Target can improve flexibility and learning in 64 teens with autism aged 14-18. Researchers will use brain scans (MRI) to see if the therapy changes how the brain processes new information. The goal is to understand how learning and flexibility are connected, and whether therapy can boost these skills.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Executive function group therapy (Unstuck & On Target)
What this could lead to: If successful, this could show that behavioral therapy can change how the brain learns and adapts in teens with autism, pointing toward more effective interventions.
What could go wrong: This is an early-stage study with only 64 participants, so results may not apply to everyone. The therapy may not produce lasting changes in brain activity or behavior.

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Conditions

The condition(s) this trial relates to.

Adolescent Behavior autism spectrum disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADOLESCENT BEHAVIOR AUTISM SPECTRUM DISORDER EXECUTIVE DYSFUNCTION

Contacts and locations

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Locations

Children's National Hospital

Washington D.C., District of Columbia, 20010, United States
Georgetown University

Washington D.C., District of Columbia, 20057, United States

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