Anemia

This study tests whether a single intravenous (IV) dose of iron works better than daily oral iron pills to treat moderate anemia in new mothers. About 4,800 women who have moderate anemia 6 to 48 hours after delivery will receive either a one-time IV iron infusion plus folic acid…

This study tested a drug called bitopertin in 15 adults with Diamond-Blackfan anemia (DBA), a rare inherited condition that causes severe anemia. Participants took the pill daily for 8 months, with doses possibly increasing over time. The goal was to see if the drug could raise h…

This study tests whether a single intravenous dose of ferumoxytol raises hemoglobin more effectively than daily oral ferrous sulfate in pregnant women with iron deficiency anemia. Participants are between 24 and 34 weeks pregnant with a single baby. The trial measures hemoglobin …

This phase 2 trial investigates ANX005, an investigational drug given intravenously, for people with warm autoimmune hemolytic anemia (wAIHA). The study aims to assess the safety and tolerability of repeated doses, and to measure changes in blood markers like hemoglobin and bilir…

This trial investigates whether anemic patients scheduled for hip or knee replacement surgery benefit from taking an iron supplement (Sideremil Vita) for 30 days before the operation, compared to taking it for only 15 days. The goal is to see if the longer treatment reduces the n…

This study tested whether low doses of the hormone drug danazol can slow the shortening of telomeres—the protective caps on DNA—in people with telomere diseases. These conditions can cause bone marrow failure, lung scarring, and liver damage. Eighteen participants took danazol fo…

This study tested whether giving children with transfusion-dependent thalassemia a combination of hydroxyurea and thalidomide works better than either drug alone. Ninety children aged 3-18 were split into three groups: one getting both drugs, one getting only hydroxyurea, and one…

This study tested the drug RAD001 (everolimus) in 29 patients with relapsed or hard-to-treat blood cancers like leukemia, lymphoma, and myelofibrosis. The goal was to find the safest highest dose and see if it helps control the disease. It was a small early-phase trial at a singl…

This study tested whether an iron injection works better than iron pills for treating anemia in 200 new mothers within 10 days of giving birth. Participants had mild to moderate anemia and were randomly assigned to receive either a single injection of ferric carboxymaltose or ora…

This study tested whether giving oral iron every other day works as well as daily dosing for treating iron deficiency anemia in children up to 5 years old. Sixty children participated, and researchers measured changes in hemoglobin and ferritin levels. The goal was to find a simp…

This study tested whether adding a structured treadmill walking program to standard iron therapy improves exercise tolerance and quality of life in young women with mild-to-moderate iron deficiency anemia. Sixty women aged 18-28 were split into two groups: one received iron suppl…

This study tested whether measuring oxygen levels in the blood (ScvO2) can help doctors decide when to give blood transfusions to anemic patients after heart surgery. 100 patients were randomly assigned to receive transfusions based on standard guidelines or only if their ScvO2 w…

This completed Phase 3 trial tested ravulizumab in 18 adults in China with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder that destroys red blood cells. The study measured changes in LDH, a marker of red blood cell breakdown, to see if the drug could control the…

This study tested the long-term safety of a drug called pegcetacoplan in people with PNH, a rare blood disease that destroys red blood cells. All 137 participants had already completed a prior pegcetacoplan study and continued treatment. The main goal was to track side effects ov…

This study tested a new drug called pelabresib in people with certain blood cancers, including myelofibrosis and leukemia. In the first part, the drug was given alone to find the safest dose. In the second part, it was given with or without another drug (ruxolitinib) to see if it…

This study tested whether giving iron supplements daily or weekly works better to prevent anemia in healthy Thai infants aged 6 to 12 months. A total of 287 babies were randomly assigned to receive iron daily or weekly for 3 months, then all switched to weekly for another 3 month…

This early-phase study tested a new drug called TQ05105 in 79 adults with certain blood cancers (myeloproliferative neoplasms). The main goals were to find the safest dose and understand side effects. The drug works by blocking a protein (JAK2) that can cause abnormal blood cell …

This study tested a new drug called TQ05105 in 107 people with moderate to high-risk myelofibrosis, a rare bone marrow disorder that often causes an enlarged spleen. The goal was to see if TQ05105 could shrink the spleen better than the standard drug hydroxyurea. Participants too…

This study tested eculizumab in 25 adults with PNH in China who had not previously taken complement inhibitors. Participants received infusions over 62 weeks. The main goal was to see if the drug reduced LDH levels, a marker of disease activity. Results showed a decrease in LDH, …

This study looked at 1331 women aged 18-45 who had low iron stores but normal hemoglobin (no anemia). They were split into three groups: one got daily oral iron pills for 3 months, another got three IV iron infusions over 3 months, and a third got no treatment. The goal was to se…

This early-phase study tested a new drug called TGR-1202 combined with the standard drug ruxolitinib in 60 people with myelofibrosis or polycythemia vera. The goal was to see if the combination is safe and tolerable. Participants either had not responded well to ruxolitinib alone…

This early-stage study tested a new gene-edited stem cell transplant in 2 children with severe β-thalassemia, a serious blood disorder requiring lifelong transfusions. The treatment aims to help the body produce healthy red blood cells and reduce or stop the need for transfusions…

This phase 2 trial tested a combination of rabbit antithymocyte globulin (Thymoglobuline) and ciclosporin in 35 people with acquired aplastic anemia, a condition where the bone marrow stops making enough blood cells. The goal was to see if this rabbit-based immune-suppressing tre…

This early study tested an experimental drug called OMS906 (zaltenibart) in 15 adults with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disease where red blood cells break apart. The main goal was to check safety and how the body handles the drug. Researchers also look…

This study followed 120 adults with paroxysmal nocturnal hemoglobinuria (PNH) who switched from the older drug eculizumab to the newer ravulizumab. Researchers measured changes in a blood marker called LDH to see if the new drug controlled red blood cell breakdown just as well or…

This study tested whether the drug eculizumab (Soliris) can help children with a severe kidney condition called STEC-HUS recover faster. The trial gave 100 children either eculizumab or a placebo over several weeks. The main goal was to see if the drug reduces the number of days …

This study tested a drug called luspatercept in 30 adults from China and Japan who have a bone marrow disorder (MDS) and need regular red blood cell transfusions. The goal was to see if the drug could help them go without transfusions for at least 8 weeks. The drug works by helpi…

This phase 2 trial tested whether combining thalidomide and hydroxyurea can reduce the need for blood transfusions in people with transfusion-dependent beta thalassemia. The study enrolled 100 patients over age 2 in Pakistan, where thalassemia is common and life expectancy is low…

This study tested a drug called mitapivat (AG-348) in 52 adults with pyruvate kinase deficiency, a rare genetic condition that causes red blood cells to break down too quickly, leading to anemia. The goal was to see if different doses of the drug are safe and help control the dis…

This pilot study tested a stem cell transplant from closely matched unrelated donors for 8 patients with severe sickle cell disease or thalassemia major. The donated stem cells were specially processed to remove certain immune cells to reduce the risk of rejection and graft-versu…

This study tested whether a mineral-enriched powder taken daily for six months could raise blood iron levels in women aged 18-35 with iron deficiency. Participants mixed the powder or a placebo into water and provided blood samples monthly. The goal was to see if the powder reduc…

This completed Phase 4 trial tested two drugs—hydroxyurea and metformin—in 96 people with transfusion-dependent beta-thalassemia. Participants took one of the two drugs for a year. Researchers measured changes in fetal hemoglobin levels and how often blood transfusions were neede…

This study tested whether adding eltrombopag to standard immunosuppressive therapy improves early recovery in patients with severe aplastic anemia, a rare condition where the bone marrow stops making enough blood cells. 202 participants received either standard treatment (horse a…

This study tested the drug eltrombopag in 34 people with moderate aplastic anemia, a condition where the bone marrow doesn't make enough blood cells. Eltrombopag is a pill that mimics a natural protein to stimulate blood cell production. Researchers measured whether it safely imp…

This study tested a new drug called DISC-0974 in 55 adults with chronic kidney disease (not on dialysis) who also have anemia. The goal was to check the drug's safety and how the body processes it. Participants received either the drug or a placebo by injection. The results will …

This study tested whether a peanut-based nutritional supplement could improve health in adults aged 60 and older living in peri-urban Ghana. Over 12 weeks, 81 participants either took the supplement daily or served as a control group. Researchers measured weight, blood pressure, …

This completed study looked at 128 adults with chronic kidney disease (not on dialysis) who also had iron-deficiency anemia. Researchers compared two intravenous iron treatments—ferric carboxymaltose and iron sucrose—to see which raises hemoglobin and iron levels better and with …

This study looked at whether giving the antibiotic vancomycin helps cancer patients who have diarrhea and a positive screening test for C. difficile but a negative toxin test. Only 9 patients were enrolled, far fewer than planned. Researchers measured changes in C. difficile leve…

This study tested a two-step stem cell transplant for people with blood cancers like leukemia and lymphoma. First, patients received low-dose chemotherapy and radiation to prepare their bodies. Then, they got donor stem cells followed by drugs to prevent the donor cells from atta…

This study compared two drugs—roxadustat and darbepoetin alfa—for treating anemia in 35 adults on hemodialysis. The goal was to see if roxadustat improves iron levels and reduces the need for IV iron. Researchers measured changes in iron profile, hemoglobin, and kidney function o…

This study tested a combination of two drugs, fedratinib and nivolumab, in 30 adults with myelofibrosis whose disease no longer responded well to standard JAK-inhibitor treatment. The goal was to see if the combination could shrink the spleen, improve symptoms, or reduce the need…

This study tested an experimental drug called MT-6548 in 42 people in Japan who have anemia due to chronic kidney disease and are on peritoneal dialysis. The goal was to see if the drug can safely raise and maintain healthy red blood cell levels. Participants either switched from…

This study tested a personalized geriatric optimization plan (GO!) in 30 adults aged 60 and older who were getting a donor stem cell transplant for blood cancers or bone marrow failure. The plan included tailored advice on diet, sleep, activity, and medications to improve physica…

This study tested a new drug called MT-6548 against a standard treatment (darbepoetin alfa) for anemia in people on dialysis for chronic kidney disease. About 323 participants in Japan received either the new drug or the standard one to see if it worked as well at keeping hemoglo…

This phase 3 trial tested an oral drug called MT-6548 (vadadustat) against a standard injected drug (darbepoetin alfa) for anemia in people with chronic kidney disease who are not on dialysis. The study enrolled 304 participants in Japan to see if the oral drug is at least as goo…

This phase 3 trial tested an oral drug called vadadustat (MT-6548) in 24 Japanese adults on hemodialysis who had anemia due to chronic kidney disease. The goal was to see if the drug could raise and maintain healthy hemoglobin levels safely. Participants took the tablet daily, an…

This early-stage study tested whether adding a drug called BMS-986004 to standard immune-suppressing medicine could help prevent acute graft-versus-host disease (GVHD) in 45 adults with blood cancers or disorders receiving a stem cell transplant. GVHD occurs when donor immune cel…

This phase II trial tested whether adding the drug itacitinib to standard medications (tacrolimus and sirolimus) can better prevent graft-versus-host disease (GVHD) in 59 patients with blood cancers receiving donor stem cell transplants. GVHD occurs when donor immune cells attack…

This study tested a stem cell transplant from a half-matched family donor for people with severe aplastic anemia, a condition where the bone marrow stops making enough blood cells. The goal was to see if this approach could improve survival one year after the transplant. The tria…

This phase 2 trial looked at whether giving a JAK inhibitor (ruxolitinib) before a donor stem cell transplant helps people with myelofibrosis. The study enrolled 61 patients with primary or secondary myelofibrosis. The goal was to see if this approach improves survival and reduce…

This study tested a combination of two drugs, ruxolitinib and azacytidine, in 121 people with myelofibrosis or related blood cancers. The goal was to see if the combo could shrink tumors or improve blood counts. While the treatment aims to control the disease, it is not a cure, a…

This study tested whether a hydrochloric acid lock can help treat central line infections in 212 cancer and blood disease patients. The acid solution was placed in the line for 10 minutes, repeated three times, alongside standard antibiotics. The goal was to see if it reduces tre…

This study tested an experimental drug called M281 (nipocalimab) in 25 pregnant women at high risk for early-onset severe hemolytic disease of the fetus and newborn (HDFN), a condition where the mother's immune system attacks the baby's red blood cells. The goal was to see if the…

This study tested whether adding the experimental drug navitoclax to the standard drug ruxolitinib works better than ruxolitinib alone for people with myelofibrosis, a type of bone marrow cancer. The main goal was to see if the combination could shrink an enlarged spleen by at le…

This phase 2 trial tested a combination of treosulfan, fludarabine, and rabbit antithymocyte globulin before a bone marrow transplant in 40 people with bone marrow failure diseases like Diamond-Blackfan anemia and Shwachman-Diamond syndrome. The goal was to see if this conditioni…

This study gave 223 children aged 12-18 months in India either iron- and zinc-biofortified pearl millet or regular pearl millet for 9 months. Researchers measured changes in iron levels, growth, and immune responses. The goal was to see if this enriched grain could help prevent c…

This study looked at ways to reduce the need for blood transfusions in patients having planned heart surgery with a heart-lung machine. The researchers tested two approaches: improving how doctors decide to give transfusions and treating low iron and anemia before and after surge…

This pilot study tested a combined bone marrow and kidney transplant from a partially matched family donor in 10 people with both a blood disorder and chronic kidney disease. The goal was to treat both conditions at once and possibly reduce the need for lifelong anti-rejection dr…

This early-phase study tested a new cell therapy called YTS109 in 7 people with a severe type of autoimmune anemia that did not get better after at least 3 other treatments. The therapy uses specially engineered immune cells to target and destroy the faulty cells causing the dise…

This study reviewed medical records of 13 Korean children with severe aplastic anemia, a condition where the bone marrow stops making enough blood cells. Researchers wanted to see if adding eltrombopag to standard immunosuppressive therapy was safe and effective. Over 6 months, t…

This early-phase study tested a new gene-edited stem cell treatment (CS-101) in 5 people with beta-thalassemia, a severe blood disorder requiring regular blood transfusions. The goal was to see if the treatment is safe and can help patients produce healthy red blood cells, potent…

This study tested a new tablet called HSK39297 in 36 adults with paroxysmal nocturnal hemoglobinuria (PNH) who still had anemia despite stable treatment with anti-C5 antibodies. The goal was to see if the pill could raise hemoglobin levels and reduce the need for blood transfusio…

This study tested a new 9-day treatment plan for people with severe aplastic anemia, a rare condition where the bone marrow stops making enough blood cells. The treatment combines three drugs (rabbit antithymocyte globulin, cyclosporine, and levamisole) to suppress the immune sys…

This trial compared two approaches for twin-to-twin transfusion syndrome (TTTS) stage 1: immediate laser surgery versus careful observation. 179 pregnant women with TTTS stage 1 and favorable conditions took part. The goal was to see which strategy leads to better survival and br…

This phase 2 trial tested a combination of two drugs, bortezomib and dexamethasone, in 18 adults with acquired pure red cell aplasia whose disease did not improve or came back after first treatment. The goal was to see if the combination could safely control the condition. The st…

This study tested a new treatment called ET-01 in 3 people with transfusion-dependent beta-thalassemia, a blood disorder that requires regular blood transfusions. The treatment uses the patient's own stem cells, which are modified and then transplanted back. The goal was to see i…

This early-stage study tested a single dose of a gene therapy called CS-101 in 9 people with beta-thalassemia major, a severe blood disorder requiring lifelong transfusions. The main goals were to check safety and see if the treatment helps the body make more healthy hemoglobin. …

This completed Phase 1 trial tested whether a single IV dose of ferric carboxymaltose works better than daily oral polysaccharide iron complex capsules for treating iron deficiency anemia in pregnant women. 112 women in their second trimester with low hemoglobin levels took part.…

This study tested whether red blood cells from umbilical cord blood are safe and work as well as standard adult donor blood for transfusions in extremely preterm infants (born before 28 weeks). 41 babies received small transfusions, and researchers monitored their vital signs, ox…

This study tested whether giving weekly iron and folic acid supplements along with nutrition education and a small cash payment to mothers could reduce anemia in adolescent girls in flood-affected areas of Pakistan. Over 2,100 girls aged 15-19 took part. The goal was to see if th…

This study tested a once-weekly injection called dulaglutide (a GLP-1 drug) against daily insulin in 80 children aged 10-18 with transfusion-dependent thalassemia and diabetes. The goal was to see if the weekly shot could control blood sugar just as well or better than insulin ov…

This study looked at how well the drug Roxadustat works for anemia in people with diabetic kidney disease stages 3-4. 124 participants took the drug for 24 weeks, and researchers measured changes in hemoglobin and iron levels. The goal was to see if the drug can safely raise red …

This study tested a drug called navitoclax, either alone or added to the standard drug ruxolitinib, in 191 people with myelofibrosis. The main goal was to see if the treatment could shrink the spleen by at least 35% after 24 weeks. The trial also looked at whether it could reduce…

This study tested three types of iron supplements in 187 adults who had low iron before major surgery and developed anemia after it. The goal was to see which treatment—two different IV iron formulas or oral iron pills—worked best to quickly raise hemoglobin levels. The results h…

This study tested whether dapagliflozin, a drug typically used for diabetes, can slow kidney decline, improve anemia, and support heart health in 100 adults with chronic kidney disease who do not have diabetes. Participants took either the drug or a placebo daily for 12 months al…

This study tested an oral medication called iptacopan in 52 adults with Paroxysmal Nocturnal Hemoglobinuria (PNH) who were already stable on standard infusion treatments. Participants switched from their usual therapy to iptacopan pills taken twice daily. The main goal was to see…

This study tested whether adding eltrombopag (a platelet booster) to standard immune-suppressing drugs (r-ATG and cyclosporine A) helps patients with severe aplastic anemia, a rare condition where the bone marrow stops making enough blood cells. Thirty-six East-Asian adults and c…

This phase 3 trial tested a new drug called HRS-5965 in 39 adults with paroxysmal nocturnal hemoglobinuria (PNH) who remained anemic even after standard anti-C5 antibody treatment. The study aimed to see if the drug could raise hemoglobin levels without needing blood transfusions…

This study tested whether giving iron through a vein (IV) works better than iron pills for improving heart pumping function in people who recently had a heart attack and also have low iron. About 300 adults took part, receiving either IV iron or oral iron. The main goal was to se…

This study tested whether adding erythropoietin (EPO) to the standard drug hydroxyurea can safely raise hemoglobin levels in adults with sickle cell disease. Seventeen participants with chronic anemia took both drugs for 12 weeks. The main goal was to see if at least a 1.0 g/dL i…

This study tested whether taking oral iron every second day at double the standard dose helps people with iron deficiency absorb more iron and raise their hemoglobin faster than taking it daily. 29 adults with low iron but not severe anemia participated for 12 weeks. Researchers …

This study tested whether a low dose of the drug cyclophosphamide, given after a stem cell transplant, can prevent graft-versus-host disease (GVHD) — a common and serious complication where donor cells attack the patient's body. The trial involved 35 adults with various blood dis…

This study tested whether giving an intravenous iron infusion to anemic patients before elective heart surgery helps them recover faster. Nearly 1,000 adults with anemia received either IV iron or a placebo 1 to 10 weeks before their surgery. The main goal was to see if the iron …

This study tested the drug dasatinib in 68 adults with several types of blood and bone marrow disorders, including certain leukemias, myelofibrosis, and mastocytosis. The goal was to see if dasatinib could help control the disease and to check its safety. Participants took dasati…

This study tested a drug called eltrombopag in 20 Chinese adults with severe aplastic anemia, a condition where the bone marrow stops making enough blood cells. Participants had not responded to previous treatments. The drug was given daily for up to a year to see if it could imp…

This study tested a program that combines small loans and group support to help people with HIV in Kenya. The goal was to improve HIV medication adherence, mental health, and family relationships. 843 people took part, and the program aimed to reduce depression, anxiety, and PTSD…

This study tested a new pill called HSK39297 against a standard infusion drug (eculizumab) in 73 adults with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder that destroys red blood cells. Participants had not received prior complement inhibitor treatment. The mai…

This Phase 2 study tested an experimental drug called etavopivat in 53 people with thalassemia or sickle cell disease. The goal was to see if the pill could safely reduce the number of red blood cell transfusions needed and raise hemoglobin levels. Participants took 400 mg of eta…

This study tested a single treatment using CRISPR gene editing to modify a person's own blood stem cells, aiming to help people with severe beta-thalassemia stop needing regular blood transfusions. 59 participants received the therapy and were monitored for safety and how long th…

This phase II trial tested two drugs—sirolimus and azacitidine—in 57 people with high-risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) that had come back or didn't respond to standard treatment. The goal was to see if the combination could shrink or control the…

This study looked at the long-term safety and effectiveness of the drug mitapivat in 90 adults with pyruvate kinase deficiency, a rare genetic blood disorder that causes red blood cells to break down too quickly. Participants had already completed earlier studies of mitapivat and…

This study looked at 50 patients who needed a stem cell transplant from a partially matched donor but had antibodies that could attack the donor cells. Before transplant, they received a blood purification treatment called protein A immunoadsorption to remove those antibodies, so…

This study looked at whether giving more red blood cell transfusions (liberal strategy) to extremely low birth weight babies (under 1000 grams) helps them survive without brain damage compared to a more restrictive approach. Over 1800 infants from NICUs were followed until 22-26 …

This study tested a new iron supplement called ferric maltol (given as an oral suspension) against the standard ferrous sulfate liquid in children aged 2 to 17 with iron-deficiency anaemia, and also tested ferric maltol alone in infants aged 1 month to 2 years. The goal was to se…

This study tested a drug called daprodustat in children aged 3 months to under 18 years who have anemia due to chronic kidney disease. The goal was to see how the drug moves through the body and if it is safe. Only 4 children took part, and they received the drug for up to 52 wee…

This study tested a two-step stem cell transplant for people with high-risk blood cancers like leukemia and lymphoma. First, patients got low-dose chemotherapy and radiation to prepare the body. Then, they received donor stem cells and immune cells to help destroy remaining cance…

This study tested a drug called pegcetacoplan in 24 adults with cold agglutinin disease, a rare condition where the immune system destroys red blood cells. Participants received either the drug or a placebo twice a week for 24 weeks. The goal was to see if the drug could raise he…

This completed trial tested a single 15-minute infusion of ferumoxytol, a type of intravenous iron, in 60 people with iron deficiency anemia who couldn't take oral iron. The goal was to see if this quick dose safely raises hemoglobin levels. Researchers checked for side effects r…

This small study tested whether L-glutamine, a common supplement, can reduce high blood pressure in the lungs of adults with non-transfusion-dependent thalassemia. Eight participants took either glutamine plus standard care or standard care alone for 60 days. The main goal was to…

This early-phase trial tested a new drug called flonoltinib maleate in 31 people with myeloproliferative neoplasms (MPNs), a group of bone marrow cancers. The main goals were to check safety, find the right dose, and see how the body processes the drug. Researchers hope this drug…

This study tested a new drug called OMS906 in 12 adults with paroxysmal nocturnal hemoglobinuria (PNH) who were not getting enough benefit from the standard treatment ravulizumab. The goal was to see if OMS906 is safe and can improve hemoglobin levels. Participants received OMS90…

This study tested whether taking vitamin D every day could reduce lung complications in children and teens with sickle cell disease. Lung problems like infections, asthma attacks, and acute chest syndrome are major causes of illness and death in this condition. Researchers gave d…

This study reviews a modified transplant conditioning regimen for severe aplastic anemia in 72 patients across two hospitals. The approach uses a combination of fludarabine, melphalan, and cyclophosphamide to prepare the body for a stem cell transplant. Researchers looked at how …

This early-stage trial tested a single dose of the drug BIVV020 in 12 adults with cold agglutinin disease, a rare condition where the immune system mistakenly attacks red blood cells. The main goal was to see if the drug is safe and tolerable. Researchers also looked at how it af…

This study looked at whether raising hemoglobin levels with a drug called epoetin (Neorecormon) could improve quality of life and slow kidney function decline in people who had a kidney transplant and now have chronic graft dysfunction. About 128 adults who had a transplant 1 to …

This study looks at the long-term safety of bomedemstat, an oral drug, in 81 people with myeloproliferative neoplasms (MPNs) like essential thrombocythemia and primary myelofibrosis. Participants had already taken bomedemstat in a prior study. Researchers tracked side effects, sp…

This study looked at whether giving children with iron-deficiency anemia oral iron for 6 to 12 weeks before elective surgery can raise their hemoglobin levels. Researchers enrolled 755 children in South Africa to test this simple, low-cost approach. The goal is to see if treating…

This phase 2 trial tested whether adding luspatercept to standard cyclosporine treatment helps people with non-severe aplastic anemia. The study enrolled 58 newly diagnosed adults who had low blood counts but did not yet need transfusions. The goal was to see if the combination c…

This pilot study looked at whether taking an iron supplement called sucrosomial iron for three months can raise hemoglobin levels in blood donors who have iron deficiency. Fifty donors with low iron took the supplement daily. Researchers measured changes in hemoglobin, ferritin, …

This study gave sutimlimab to 7 adults in Japan with cold agglutinin disease (CAD) who had already completed earlier trials and still needed treatment. The goal was to monitor safety and side effects over time until the drug became commercially available. It is a small, open-labe…

This small study tested whether a daily iron-rich yeast drink with SOD can improve anemia and skin condition in women aged 18-35. Eleven women with mild anemia drank the supplement for four weeks. Researchers measured blood iron levels and skin-related markers before and after to…

This trial tested a program where community health workers used a tablet app to screen pregnant women in rural India for anemia, high blood pressure, and diabetes. Over 3,400 women took part. The goal was to see if this screening and referral system could lower anemia rates and i…

This study looked at how well MIRCERA works for anemia in people with chronic kidney disease stages 3-4 who are not yet on dialysis. Researchers tracked 144 patients over 12 months to see if their hemoglobin levels stayed in a healthy range. The goal was to gather real-world data…

This study tested a monthly injection of Mircera in 75 adults with chronic kidney disease who were not yet on dialysis and had anemia. The goal was to see if the drug could safely raise and maintain hemoglobin levels. Results showed improvement in hemoglobin during the evaluation…

This study tested a special way to treat donated red blood cells to kill germs, called the INTERCEPT Blood System. It involved 581 people having complex heart surgery who needed blood transfusions. The goal was to see if this treated blood is as safe and works as well as regular …

This Phase 3 study tested a new oral medication, HRS-5965, against the standard infusion eculizumab in 76 adults with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder. The main goal was to see if HRS-5965 could raise hemoglobin levels to normal without needing blo…

This study tested whether a once-monthly injection of Mircera works as well as the standard epoetin alfa treatment for managing anemia in people on dialysis. About 233 adults with chronic kidney disease-related anemia participated. The goal was to see if Mircera could keep hemogl…

This study compared two intravenous iron treatments—ferric carboxymaltose and iron sucrose—in 40 pregnant women with anemia. The goal was to see which one raised hemoglobin levels more. Both are already used in practice, but local data was lacking. The trial is now complete, and …

This phase 1 trial tested a gene therapy called RP-L301 in 4 people with pyruvate kinase deficiency, a rare inherited blood disorder that causes severe anemia and often requires frequent blood transfusions. The treatment uses the patient's own blood stem cells, which are modified…

This phase 2 study tested the drug itacitinib in 4 people with myelofibrosis (a bone marrow disorder) who had already tried other treatments like ruxolitinib or fedratinib. The main goals were to check safety and find the right dose, and to see if it could shrink an enlarged sple…

This study tested a new MRI technique called QSM to measure iron levels in the liver more accurately than current methods. Researchers compared MRI results from 55 patients before liver transplant with chemical analysis of their removed livers. The goal is to improve diagnosis an…

This completed study tested whether artificial intelligence can estimate iron deficiency and anemia risk in African children without a blood draw. Researchers collected blood samples, images, and videos from 126 children under 6 years old to train AI algorithms. The goal is to de…

This study tested whether a non-invasive device that uses light (pulse co-oximetry) can accurately measure hemoglobin levels in children undergoing brain or spine surgery, compared to the standard method of drawing blood from an artery. The goal was to see if this painless, conti…

This study looked at 100 children with beta-thalassemia major and iron overload to see if simple blood tests (ferritin and hepcidin) can detect liver scarring (fibrosis) as accurately as other non-invasive methods. Researchers measured these blood markers and compared them to ult…

This study tested whether quercetin, a natural substance found in some foods, could help prevent a type of mouth cancer in people with Fanconi anemia, a rare genetic condition that raises cancer risk. 48 participants took quercetin to see if it reduced certain cell changes linked…

This study tested whether taking a daily supplement of lactoferrin (a protein found in milk) can help prevent iron deficiency anemia in pregnant women with obesity. 23 women at risk for anemia took part from mid-pregnancy through labor. The main goal was to see if the approach wa…

This study tested whether adding daily multivitamins and an extra dose of deworming medication to standard prenatal care could prevent severe anemia in pregnant women in Zanzibar, Tanzania. Over 2,500 pregnant women took part, comparing the enhanced package to the usual WHO-recom…

This study tested whether giving intravenous iron to pregnant women who have low iron stores but not yet anemia can prevent them from becoming anemic and help their babies grow normally. 600 women took part. The goal is to see if a single IV dose works better than usual care.

This study looked at whether touch-massage can reduce anxiety in people with blood disorders (like leukemia or lymphoma) who are hospitalized in a sterile, isolated room. Sixty-two patients received three massage sessions, and researchers measured their anxiety levels before and …

This study looked at whether a single intravenous iron dose could improve exercise capacity in people with severe aortic stenosis and iron deficiency who were scheduled for a valve replacement. About 100 participants received either iron or a placebo. The main goal was to see if …

This study tested a monthly online peer support group for young adults (ages 18-39) who had received a stem cell transplant. The group met for one hour over six months, led by a nurse and social worker. The goal was to see if the program was practical and helpful for reducing anx…

This study tested whether montelukast (Singulair), a common asthma drug, can reduce the number and severity of infusion reactions in people receiving monoclonal antibody treatments for blood disorders. Forty adults were given montelukast along with standard premedication before t…

This study looked at whether giving iron supplements to children with ADHD, restless legs syndrome, and low iron levels could improve their symptoms. Twelve kids aged 10-15 took iron for 3 months. Researchers measured changes in brain iron, blood iron, and symptoms using sleep mo…

This completed study looked at red and white blood cells in people with a rare blood disorder called PNH who also have bone marrow failure. Over 5,500 participants aged 10 and older with aplastic anemia or related conditions provided blood samples. The goal was simply to learn mo…

This study follows children in France diagnosed with severe autoimmune cytopenia—conditions where the immune system attacks blood cells. Researchers will track their health over time to see who achieves remission and what factors influence their recovery. The goal is to better un…

This study examined the link between obesity and iron deficiency anemia in 165 nonpregnant Indonesian women aged 19-29. Participants took daily iron-folic acid supplements for 90 days. Researchers compared iron levels between overweight/obese and normal-weight women to see if wei…

This study looked for a virus called HHV6 in the skin and blood of 37 adults with blood cancers who developed a rash during hospital stays. The goal was to see if the virus is linked to the rash, which could help doctors diagnose and treat the rash more effectively. The study is …

This pilot study investigates how common low energy availability, iron deficiency, and low vitamin D levels are among Black collegiate athletes. Participants who are found to have low iron or vitamin D will receive daily supplements for 12 weeks. The goal is to better understand …

This study looked at how well iron-deficient women absorb iron from two plant-based sources—iron chlorophyllin and soy hemoglobin—compared to standard ferrous sulfate and animal-based heme iron. Forty-five women with low iron stores but not anemic took each type of iron in water …

This completed study looked at 324 extremely low birth weight preterm infants (≤1250 grams) to see how anemia and red blood cell transfusions affect oxygen levels in their digestive tract. Researchers used a non-invasive device to measure tissue oxygen and collected blood, urine,…

This completed study looked at blood vessel cells from 30 people with primary myelofibrosis, a rare bone marrow disorder. Researchers wanted to see if these cells act like stem cells that could be the origin of the disease. By growing the cells in the lab, they aimed to understan…

This study looked at how long donor red blood cells survive in children with sickle cell disease who get regular blood transfusions. Researchers labeled a small part of the transfused blood with a harmless marker and tracked it over time. The goal was to better understand why som…

This study looked at how often people with certain blood cancers or related conditions have an acquired deficiency of an enzyme called pyruvate kinase, which can cause anemia. Researchers took a single blood sample from 18 participants to measure enzyme activity and check for rel…

This study examined 236 adults in a surgical intensive care unit who needed a breathing machine for more than 4 days. Researchers wanted to see if the length of time a patient had anemia (low red blood cells) was linked to how long they stayed on the ventilator. The goal was to b…

This completed study looked at how well healthy pre-menopausal women with low iron stores absorb iron from two different supplements: Spatone (a natural iron-rich water) and ferrous sulphate (a standard iron pill). Fourteen women took three different doses (5, 10, and 15 mg) of e…

This study looked at whether it is safe to lower the number of platelets needed before placing a central line (a special IV) in patients with blood disorders. Normally, patients get a platelet transfusion if their count is below 50, but this study tested a lower trigger of 10. Th…

This study looked at how weight loss from a calorie-restricted diet affects iron levels in people with obesity and iron deficiency. Researchers measured a protein called hepcidin, which controls iron in the body, along with iron levels before and after a 60-day diet. The goal was…

This completed study surveyed 97 Hungarian anesthesiologists and intensive care doctors about how they decide when to give blood transfusions to critically ill patients. The focus was on whether they use certain physiological signs (like lactate levels or oxygen saturation) recom…

This study looked at why many older adults (over 70) have anemia even when doctors can't find a reason. Researchers measured how long red blood cells live in younger and older adults by marking them with a vitamin called Biotin. The goal was to understand if faster red blood cell…

This study followed 179 children aged 4 to 16 who were born from twin pregnancies complicated by twin-to-twin transfusion syndrome (TTTS). Researchers checked their heart function, blood pressure, kidney health, and blood sugar control to see if the condition during pregnancy cau…

This study looked at whether a special kidney scan (scintigraphy) can find early kidney damage in children and young adults with sickle cell disease better than standard tests. 18 patients were checked during their annual visit. The goal is to catch kidney problems sooner so trea…

This study looked at how well two different capsule forms of TP-3654 are absorbed by the body and whether taking them with food changes absorption. It involved 24 healthy adults and was completed. The results will help design future studies for people with myelofibrosis, a bone m…

This study explored whether low hemoglobin (anemia) is linked to an enlarged heart (cardiomegaly) in children up to 18 years old. Researchers used chest X-rays and echocardiograms to check for heart enlargement in 56 anemic children. The goal was to better understand how anemia a…

This study looked at whether iron supplements improve how well vaccines work in pregnant women with anemia (low iron). Researchers compared their immune responses to tetanus, diphtheria, and COVID-19 vaccines against women without anemia. The goal was to see if correcting iron de…

This study tested a new, simpler method to measure iron buildup inside red blood cells of people with beta thalassemia major. The goal was to find a cheaper and easier way to monitor iron overload compared to current tests. Researchers analyzed blood samples from 100 patients to …

This study looked at how well pregnant women with iron deficiency anemia tolerate and stick with oral iron therapy. Researchers tracked side effects and checked if iron levels improved using blood tests. The goal was to better understand how to treat this common condition during …

This completed study looked at 830 two-year-olds in France to see if drinking toddler milk formula helps prevent iron deficiency, a common problem that can affect brain development. Researchers checked iron levels in blood and asked parents about diet and background. The goal is …

This study looked at whether adding folic acid and vitamin B12 to locally made cereals can improve the nutrition, thinking skills, and mood of teenage girls in rural Ethiopia. About 472 girls aged 13-19 took part. The goal was to see if small-scale food fortification can help pre…

This study tested whether weekly community-led group discussions could improve trust and openness to COVID-19 testing and vaccination. Fifty-seven adults from nine housing agencies took part in online meetings and completed surveys over six months. The goal was to see if peer-led…

This study tested whether weekly community-led group discussions about health topics could change how people feel about COVID-19 testing and vaccines. 49 adults from housing authority agencies took part in Zoom meetings and completed surveys over 18 weeks. The goal was to see if …

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This study looked at 201 very premature babies born before 31 weeks to see how often they received blood transfusions that went beyond French guidelines. Researchers found that many transfusions were given even when not recommended, possibly due to the babies' fragile health. The…

This study looked at how certain immune cells, called T cells, behave in people with autoimmune hemolytic anemia, a condition where the body attacks its own red blood cells. Researchers compared blood samples from 27 patients and healthy volunteers to understand the disease bette…

This study gathered information from 250 children aged 6 months to 6 years to develop artificial intelligence that can estimate iron levels from images and videos. The goal is to create a non-invasive way to screen for iron deficiency, replacing blood tests. Parents and doctors a…

This completed study tested whether artificial intelligence and MRI scans could help automate the planning of total marrow irradiation, a type of radiation therapy given before a bone marrow transplant for blood cancers. Researchers aimed to reduce the 10-day planning time and be…

This study collected health information from over 6,000 people with Paroxysmal Nocturnal Hemoglobinuria (PNH), a rare blood disorder. The goal was to track the safety of two medications, Soliris and Ultomiris, and to understand how PNH changes over time. Participants were followe…

This study reviewed medical records of 355 people in Turkey with myelofibrosis (a type of bone marrow cancer) who were treated with the drug ruxolitinib for at least 3 months. Researchers collected information on patient demographics, disease characteristics, and how the drug was…

This study looked at 70 people—some with primary myelofibrosis and some healthy—to understand how certain immune cells called MDSCs fuel inflammation in this rare bone marrow disease. Researchers also checked how these cells change with treatment and whether they help form new bl…

This study looked at 1,753 patients needing a stem cell transplant for blood cancers or other serious blood disorders. Researchers compared two strategies: first searching for a matched unrelated donor, then trying an alternative donor if needed, versus going straight to an alter…

This study looked at over 13,000 adults who had heart surgery to understand how blood transfusions given during the operation might explain why patients with anemia before surgery are more likely to have complications afterward. The goal is to help doctors make better decisions a…

This study looked at whether giving oral iron supplements to iron-deficient women in Kenya before or at the same time as vaccination improves their immune response. 180 women received iron either before or with three vaccines (COVID-19, meningitis, and typhoid), or a placebo. The…

This study looked at why people with sickle cell disease often get hard-to-heal leg ulcers. Researchers measured blood flow, nerve function, and blood markers in 70 patients with and without ulcers. The goal was to better understand what causes these wounds, not to test a new tre…

This study looked at over 1,200 people in Denmark who had a stem cell transplant for blood diseases, some as far back as 1970. Researchers used detailed surveys to measure late effects and quality of life. The goal is to find out what medical and personal factors help survivors f…

This completed study followed 724 people in China with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder. Researchers aimed to better understand how the disease progresses and how patients respond to different treatments, including the newly available drug eculizum…

This study looked at how different stages of muscle warm-up affect knee joint awareness, jumping power, agility, and balance in 25 professional youth soccer players under 18. Players were tested during rest, after warm-up, and when fatigued. The goal was to understand how warm-up…

This early-stage study tested a new drug, LP-005, in 68 healthy adults aged 18 to 50. The main goal was to check if the drug is safe and how the body handles it. This information will help design future studies for people with a rare blood disorder called PNH.

This phase 1 trial in 40 healthy adults tests how TQ05105, a drug for myelofibrosis, interacts with other medications that affect liver enzymes. Participants take TQ05105 alone and then with either itraconazole or rifampicin to see how these drugs change TQ05105 levels in the bod…

This study looked at how many women with fibromyalgia at a pain clinic might have iron deficiency. 81 women completed a questionnaire about symptoms like heavy periods and past iron issues. The goal was to see if iron deficiency is common and if treating it could help their pain.

This study measured blood vessel function in 49 adults with sickle cell disease to see how it relates to disease severity. Researchers used laser and pulse wave tests to check small and large blood vessels. The goal was to better understand the disease, not to test a new treatmen…

This study looked at whether intravenous iron treatments (ferric carboxymaltose or ferric derisomaltose) can cause a rare side effect called methemoglobinemia, where blood can't carry oxygen properly. Researchers measured methemoglobin levels in 50 anemic patients before and afte…

This study looked at 10 people with rare genetic conditions that cause very low cholesterol and trouble absorbing vitamins. Researchers measured a protective pigment in the eye called macular pigment, which may be low in these patients and could explain why some still develop vis…

This completed study examined lung CT scans from 148 adults with blood diseases to identify common patterns of lung involvement. Researchers tracked how often certain radiological features appeared and counted complications. The goal was to better understand the range of lung iss…

This completed registry study followed 80 children and young adults with severe immune cytopenias, including immune thrombocytopenia, autoimmune hemolytic anemia, and Evans syndrome. Researchers observed participants over up to 4 years to improve diagnosis and track the disease c…

This study looked at whether adding nutrition and hygiene support to an existing farming program can reduce malnutrition in pregnant women and their children. About 1,200 pregnant women in Kenya took part, with half getting the extra nutrition help. The goal was to see if childre…

This completed study looked at how often a rare blood condition called methemoglobinemia occurs after treatment with the IV iron drug ferric carboxymaltose. Researchers measured methemoglobin levels in nearly 1,000 adults receiving the drug for iron-deficiency anemia and compared…

This completed study looked at how often hemoglobin disorders (like thalassemia and sickle cell disease) occur in people visiting a hospital in Chattogram, Bangladesh. Researchers tested blood samples from 760 volunteers using advanced methods to find different hemoglobin types. …

This study looked at whether eating beef every day for 30 days could improve thinking and visual skills in healthy young women. 80 women aged 18-40 took part, with one group eating beef and the other eating a plant-based protein. Researchers measured their performance on a 3D tra…

This completed study looked at 209 patients with bacterial endocarditis, a serious heart valve infection, to understand how common anemia is and what causes it. Researchers measured blood markers for inflammation and anemia from diagnosis up to 6 months after hospital discharge. …

This study tested how different warm-up protocols affect flexibility, explosive power, and balance in 15 adolescent male football goalkeepers. Participants performed aerobic running, static stretching, dynamic stretching, or movement preparation before tests. The goal is to ident…

This study followed 17 pregnant women and their babies who were at high risk for early onset severe hemolytic disease of the fetus and newborn (EOS-HDFN). The goal was to see how the condition is currently managed and what outcomes occur. No new drugs were tested; instead, resear…

This pilot study tested whether a combination of two drugs (G-CSF and plerixafor) could safely collect enough stem cells from the blood of children with Fanconi anemia for future gene therapy. Only 4 patients took part, and the main goal was to see if the cell collection process …

This study followed 58 babies with sickle cell disease from 3 months to 2 years old to find early clues that might predict a life-threatening spleen complication called acute splenic sequestration. Researchers took blood samples and used special scans to measure spleen size and f…

This study looked at whether iron deficiency anemia makes COVID-19 vaccines less effective in young women. Researchers gave intravenous iron to 121 participants and measured their immune responses. The goal was to see if correcting iron deficiency could boost vaccine protection.