Could a month of iron before knee or hip surgery cut transfusion risk?

NCT ID NCT05806437

Completed Disease control Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio Source: ClinicalTrials.gov ↗

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This trial investigates whether anemic patients scheduled for hip or knee replacement surgery benefit from taking an iron supplement (Sideremil Vita) for 30 days before the operation, compared to taking it for only 15 days. The goal is to see if the longer treatment reduces the number of patients who need a blood transfusion. The study includes adults over 40 with low iron or hemoglobin levels who are candidates for prosthetic surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Sideremil Vita (iron supplement)
What this could lead to: If it works, this could show that a longer course of iron before surgery helps anemic patients avoid blood transfusions.
What could go wrong: This is a small, early-stage study with 142 participants. The supplement may not reduce transfusions, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

iron deficiency anemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANEMIA, IRON DEFICIENCY

Contacts and locations

Locations

IRCCS Istituto Ortopedico Galeazzi-Istituto Clinico San Siro

Milan, Italy

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