IV iron drug may cause rare blood disorder, new study investigates

NCT ID NCT06958822

Completed Knowledge-focused Sponsor: Ordu University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at how often a rare blood condition called methemoglobinemia occurs after treatment with the IV iron drug ferric carboxymaltose. Researchers measured methemoglobin levels in nearly 1,000 adults receiving the drug for iron-deficiency anemia and compared them to healthy controls. The goal was to better understand the risk of this potentially serious side effect.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ferric carboxymaltose (IV iron)
What this could lead to: If this study finds a clear link, it could help doctors monitor for methemoglobinemia and make IV iron therapy safer.
What could go wrong: This is an observational study, not a controlled trial, so it can't prove cause and effect. The condition is rare and usually mild, so the findings may not change practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

iron deficiency anemia methemoglobinemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANEMIA, IRON DEFICIENCY FERRIC CARBOXYMALTOSE METHEMOGLOBINEMIA PARENTERAL IRON THERAPY

Contacts and locations

Locations

Akdeniz University Hospital

Konyaalti, Antalya, 07070, Turkey (Türkiye)
Antalya City Hospital

Antalya, Kepez, 07080, Turkey (Türkiye)
Balıkesir University Health Practice and Research Hospital

Merkez, Balıkesir, 10145, Turkey (Türkiye)
Bursa City Hospital

Nilufer, Bursa, 16110, Turkey (Türkiye)
Bursa Kestel State Hospital

Bursa, Kestel, 16450, Turkey (Türkiye)
Bursa Yuksek Ihtisas Training and Research

Bursa, Yıldırım, 16310, Turkey (Türkiye)
Izmir Bakircay University Cigli Training and Research Hospital

Çiğli, İzmir, 35610, Turkey (Türkiye)
Karabuk University Training and Research Hospital

Karabük, Karabük Province, 78100, Turkey (Türkiye)
Kayseri City Hospital

Kocasinan, Kayseri, 38080, Turkey (Türkiye)
Mardin Artuklu University Training and Research Hospital

Merkez, Mardin, 47100, Turkey (Türkiye)
Mardin Kızıltepe State Hospital

Mardin, Kızıltepe, 47400, Turkey (Türkiye)
Marmara University Training and Research Hospital

Pendik, Istanbul, 34890, Turkey (Türkiye)
Mehmet Yılmaz Aydınlar Acıbadem University

Ataşehir, Istanbul, 34758, Turkey (Türkiye)
Ordu University Training and Research Hospital

Altinordu, Ordu, 52200, Turkey (Türkiye)
Recep Tayyip Erdoğan University Faculty of Medicine Training and Research Hospital

Rize, Rize Province, 53100, Turkey (Türkiye)
Sakarya University Training and Research Hospital

Adapazarı, Sakarya, 54100, Turkey (Türkiye)
Siirt University Faculty of Medicine Training and Research Hospital

Siirt, Siirt, 56100, Turkey (Türkiye)
Umraniye Training and Research Hospital

Ümraniye, Istanbul, 34764, Turkey (Türkiye)
University of Health Sciences Adana City Health Application and Research Center

Adana, Adana, 01100, Turkey (Türkiye)
University of Health Sciences Diyarbakır Gazi Yaşargil Training and Research Hospital

Kayapınar, Diyarbakır, 21070, Turkey (Türkiye)
Van Yüzüncü Yıl University Training and Research Hospital

Merkez, Van, 65000, Turkey (Türkiye)
Çankırı State Hospital

Çankırı, Çankırı, 18100, Turkey (Türkiye)
Çorlu Vatan Hospital

Tekirdağ, Çorlu, 59850, Turkey (Türkiye)

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