Hormone drug may slow Aging-Related diseases in rare condition
NCT ID NCT03312400
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether low doses of the hormone drug danazol can slow the shortening of telomeres—the protective caps on DNA—in people with telomere diseases. These conditions can cause bone marrow failure, lung scarring, and liver damage. Eighteen participants took danazol for one year, and researchers measured changes in telomere length, lung function, and liver health. The goal was to see if the drug is safe and can reduce the rate of telomere loss.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Danazol (a synthetic hormone)
What this could lead to
If successful, this could provide a treatment option to slow disease progression in people with telomere-related conditions.
What could go wrong
This is a small, early-phase trial with only 18 participants, so results may not apply broadly. Danazol can cause hormonal side effects, and the long-term benefits are uncertain.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States