Could a Low-Dose hormone drug slow down aging at the cellular level?

NCT ID NCT03312400

First seen Jan 11, 2026 · Last updated May 06, 2026 · Updated 15 times

Summary

This study tests whether a low dose of the hormone drug danazol can safely slow the rate at which telomeres shorten in people with telomere diseases. Telomeres are protective caps on our DNA that get shorter as we age; people with certain gene changes have very short telomeres, which can lead to bone marrow, lung, or liver disease. About 40 participants aged 3 and older will take danazol twice daily for a year and be monitored for side effects and changes in their condition.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.