New combo aims to shrink enlarged spleens in bone marrow cancer
NCT ID NCT04472598
First seen Apr 12, 2026 · Last updated May 15, 2026 · Updated 2 times
Summary
This study tests whether adding the experimental drug navitoclax to the standard drug ruxolitinib works better than ruxolitinib alone for people with myelofibrosis, a type of bone marrow cancer. About 252 adults with myelofibrosis took part. The main goal was to see if the combo could shrink an enlarged spleen by at least 35% after 24 weeks. The study also tracked symptom changes and side effects.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for MYELOFIBROSIS (MF) are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
AOU Policlinico G. Rodolico - San Marco /ID# 219085
Catania, 95123, Italy
-
AP-HP - Hopital Necker /ID# 231318
Paris, 75015, France
-
ASST Papa Giovanni XXIII /ID# 221907
Bergamo, 24127, Italy
-
ASST degli Spedali Civili di Brescia /ID# 241273
Brescia, 25123, Italy
-
AZ Sint-Jan Brugge /ID# 218805
Bruges, 8000, Belgium
-
AZ-Delta /ID# 221466
Roeselare, West-Vlaanderen, 8800, Belgium
-
Acibadem City Clinic Tokuda University Hospital EAD /ID# 231036
Sofia, 1407, Bulgaria
-
Albert Schweitzer Ziekenhuis /ID# 224015
Dordrecht, South Holland, 3318 AT, Netherlands
-
Alberts Cellular Therapy /ID# 232073
Pretoria, Gauteng, 0044, South Africa
-
Almazov National Medical Research Centre /ID# 221033
Saint Petersburg, 197341, Russia
-
Aotearoa Clinical Trials /ID# 230770
Papatoetoe, Auckland, 2025, New Zealand
-
Asan Medical Center /ID# 219054
Seoul, Seoul Teugbyeolsi, 05505, South Korea
-
Augusta University Georgia Cancer Center /ID# 221551
Augusta, Georgia, 30912-0003, United States
-
Azienda Ospedaliero Universitaria Careggi /ID# 219086
Florence, Firenze, 50134, Italy
-
BAG Freiberg-Richter, Jacobasch, Illmer, Wolf /ID# 221347
Dresden, Saxony, 01307, Germany
-
Bagcilar Medipol Mega Universite Hastanesi /ID# 230757
Istanbul, 34214, Turkey (Türkiye)
-
Beth Israel Deaconess Medical Center /ID# 224261
Boston, Massachusetts, 02215-5400, United States
-
Border Medical Oncology Research Unit Albury Wodonga Regiona /ID# 231311
East Albury, New South Wales, 2640, Australia
-
CH Roubaix - Hopital Victor Provo /ID# 219116
Roubaix, Hauts-de-France, 59100, France
-
CHU NIMES - Hopital Caremeau /ID# 219114
Nîmes, Gard, 30029, France
-
CHU de Liège /ID# 218874
Liège, Liege, 4000, Belgium
-
CHU de Nantes, Hotel Dieu -HME /ID# 219113
Nantes, Pays de la Loire Region, 44000, France
-
CHUQ- Hôpital de l'Enfant-Jesus /ID# 221754
Québec, Quebec, G1J 1Z4, Canada
-
CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 230721
Madrid, 28027, Spain
-
Centre Hospitalier Métropole Savoie - Site Hôpital de Chambéry /ID# 224506
Chambéry, Savoie, 73007, France
-
Centre Hospitalier Universitaire de Bordeaux /ID# 222518
Pessac, Gironde, 33604, France
-
Chi Mei Hospital - Liouying /ID# 221145
Tainan, Tainan, 73657, Taiwan
-
China Medical University Hospital /ID# 218978
Taichung, 40447, Taiwan
-
Chu Angers /Id# 219115
Angers, 49933, France
-
Clin Hosp Ctr Bezanijska Kosa /ID# 230946
Belgrade, Beograd, 11080, Serbia
-
Clinic UZI 4D /ID# 221024
Pyatigorsk, Stavropol Kray, 357502, Russia
-
Clinica Universidad de Navarra - Pamplona /ID# 230720
Pamplona, Navarre, 31008, Spain
-
Clinical Hospital Dubrava /ID# 230795
Zagreb, City of Zagreb, 10000, Croatia
-
Columbus Regional Research Institute /ID# 227272
Columbus, Georgia, 31904-8915, United States
-
Communal non-profit enterprise Regional Center of Oncology /ID# 230832
Kharkiv, Kharkivs’ka Oblast’, 61070, Ukraine
-
Dana-Farber Cancer Institute /ID# 218010
Boston, Massachusetts, 02215, United States
-
Dokkyo Medical University Saitama Medical Center /ID# 222333
Koshigaya, Saitama, 343-0845, Japan
-
Duplicate_ASST Sette Laghi /ID# 219084
Varese, 21100, Italy
-
Duplicate_Chiba University Hospital /ID# 239345
Chiba, Chiba, 260-8677, Japan
-
Duplicate_Clinical Center Vojvodina /ID# 230853
Novi Sad, Vojvodina, 21000, Serbia
-
Duplicate_Emory University /ID# 221562
Atlanta, Georgia, 30322-1013, United States
-
Duplicate_Hokkaido University Hospital /ID# 242667
Sapporo, Hokkaido, 060-8648, Japan
-
Duplicate_Hospital Clínico Universitario de Santiago-CHUS /ID# 222264
Santiago de Compostela, A Coruna, 15706, Spain
-
Duplicate_Inje University Busan Paik Hospital /ID# 231667
Busan, Busan Gwang Yeogsi, 47392, South Korea
-
Duplicate_Kawasaki Medical School Hospital /ID# 221481
Kurashiki-shi, Okayama-ken, 701-0192, Japan
-
Duplicate_Klinicki bolnicki centar Split /ID# 230796
Split, Split-Dalmatia County, 21000, Croatia
-
Duplicate_Kyungpook National University Hospital /ID# 231666
Daegu, Daegu Gwang Yeogsi, 41944, South Korea
-
Duplicate_Medizinische Universitaet Graz /ID# 220910
Graz, Styria, 8010, Austria
-
Duplicate_Rush University Medical Center /ID# 221581
Chicago, Illinois, 60612, United States
-
Duplicate_Sahlgrenska University Hospital /ID# 218776
Gothenburg, Västra Götaland County, 413 45, Sweden
-
Duplicate_Seoul National University Bundang Hospital /ID# 219053
Seongnam, Gyeonggido, 13620, South Korea
-
Duplicate_Skane University Hospital Lund /ID# 220835
Lund, Skåne County, 221 41, Sweden
-
Duplicate_University General Hospital Attikon /ID# 230784
Athens, Attica, 12462, Greece
-
Duplicate_Wits Clinical Research Site /ID# 232071
Johannesburg, Gauteng, 2193, South Africa
-
Ege University Medical Faculty /ID# 230753
Izmir, 35040, Turkey (Türkiye)
-
Ehime University Hospital /ID# 221443
Toon-shi, Ehime, 791-0295, Japan
-
Feofaniya Clinical Hospital of State Management of Affairs /ID# 232370
Kyiv, 03143, Ukraine
-
Florida Cancer Specialist - South /ID# 221726
Fort Myers, Florida, 33901-8108, United States
-
Florida Cancer Specialists - East /ID# 221728
West Palm Beach, Florida, 33401, United States
-
Florida Cancer Specialists - North /ID# 221727
St. Petersburg, Florida, 33705-1449, United States
-
Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 219083
Rome, Roma, 00168, Italy
-
Fujita Health University Hospital /ID# 221537
Toyoake, Aichi-ken, 470-1192, Japan
-
Fukushima Medical University Hospital /ID# 222752
Fukushima, Fukushima, 960-1295, Japan
-
Gabrail Cancer Center Research /ID# 230488
Canton, Ohio, 44718, United States
-
Gachon University Gil Medical Center /ID# 222089
Incheon, Gyeonggido, 21565, South Korea
-
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 230786
Athens, 10676, Greece
-
General Hospital of Athens Laiko /ID# 230785
Athens, Attica, 11527, Greece
-
Gosford Hospital /ID# 221499
Gosford, New South Wales, 2250, Australia
-
Gunma University Hospital /ID# 221480
Maebashi, Gunma, 371-8511, Japan
-
Gunmaken Saiseikai Maebashi Hospital /ID# 242806
Maebashi, Gunma, 371-0821, Japan
-
Guys and St Thomas NHS Foundation Trust /ID# 219185
London, Greater London, SE1 9RT, United Kingdom
-
HCL - Hopital Lyon Sud /ID# 222913
Pierre-Bénite, Rhone, 69495, France
-
Hacettepe University Medical Faculty /ID# 230759
Ankara, 06230, Turkey (Türkiye)
-
Hackensack Univ Med Ctr /ID# 221654
Hackensack, New Jersey, 07601, United States
-
Hadassah Medical Center-Hebrew University /ID# 219110
Jerusalem, Jerusalem, 91120, Israel
-
Haemato-Onkologie /ID# 221061
Munich, Bavaria, 81241, Germany
-
Hanusch Krankenhaus /ID# 220909
Vienna, 1140, Austria
-
Highlands Oncology Group, PA /ID# 221824
Springdale, Arkansas, 72762, United States
-
Hitachi General Hospital /ID# 240048
Hitachi-shi, Ibaraki, 317-0077, Japan
-
Hopital Avicenne - APHP /ID# 221286
Bobigny, Île-de-France Region, 93000, France
-
Hospital Clinico Universitario de Valencia /ID# 220875
Valencia, 46010, Spain
-
Hospital Parc de Salut del Mar /ID# 220913
Barcelona, 08003, Spain
-
Hospital Universitario 12 de Octubre /ID# 229691
Madrid, 28041, Spain
-
Hospital Universitario Dr. Negrin /ID# 220897
Las Palmas de Gran Canaria, Las Palmas, 35019, Spain
-
Hospital Universitario Germans Trias i Pujol /ID# 229936
Badalona, Barcelona, 08916, Spain
-
Hospital Universitario Ramon y Cajal /ID# 220877
Madrid, 28034, Spain
-
Hospital Universitario Vall d'Hebron /ID# 229690
Barcelona, 08035, Spain
-
Hospital Universitario Virgen de la Victoria /ID# 220878
Málaga, 29010, Spain
-
Hôpital Saint-Louis /ID# 221288
Paris, 75010, France
-
ICANS - Institut de Cancérologie Strasbourg Europe /ID# 229978
Strasbourg, 67033, France
-
IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 220867
Bologna, Emilia-Romagna, 40138, Italy
-
Indiana Blood & Marrow Transpl /ID# 221586
Indianapolis, Indiana, 46237, United States
-
Inonu University Medical Faculty /ID# 230758
Malatya, 44280, Turkey (Türkiye)
-
Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital /ID# 239100
Nagoya, Aichi-ken, 453-8511, Japan
-
Juntendo University Hospital /ID# 221405
Bunkyo-ku, Tokyo, 113-8431, Japan
-
Juntendo University Shizuoka Hospital /ID# 221782
Izunokuni-shi, Shizuoka, 410-2295, Japan
-
Juravinski Cancer Centre /ID# 221752
Hamilton, Ontario, L8V 1C3, Canada
-
Kanazawa University Hospital /ID# 238424
Kanazawa, Ishikawa-ken, 920-8641, Japan
-
Kansai Medical University Hospital /ID# 221482
Hirakata-shi, Osaka, 573-1191, Japan
-
Kaohsiung Chang Gung Memorial Hospital /ID# 218984
Kaohsiung City, Kaohsiung, 833, Taiwan
-
Kindai University Hospital /ID# 221479
Osakasayama-shi, Osaka, 589-8511, Japan
-
Klinicka bolnica Merkur /ID# 231155
Zagreb, City of Zagreb, 10000, Croatia
-
Klinicki bolnicki centar Zagreb /ID# 230793
Zagreb, City of Zagreb, 10000, Croatia
-
Klinikum Wels-Grieskirchen GmbH /ID# 220901
Wels, Upper Austria, 4600, Austria
-
Klinikum rechts der Isar /ID# 221520
Munich, 81675, Germany
-
Kobe University Hospital /ID# 246236
Kobe, Hyōgo, 650-0017, Japan
-
Kurashiki Central Hospital /ID# 221692
Kurashiki-shi, Okayama-ken, 710-8602, Japan
-
Kyoto University Hospital /ID# 238423
Kyoto, Kyoto, 606-8507, Japan
-
Kyushu University Hospital /ID# 221783
Fukuoka, Fukuoka, 812-8582, Japan
-
Lakeridge Health - Oshawa /ID# 222080
Oshawa, Ontario, L1G 2B9, Canada
-
Leningrad Regional Clinical Hospital /ID# 221028
Saint Petersburg, 194291, Russia
-
Linkou Chang Gung Memorial Hospital /ID# 218983
Taoyuan City, 333, Taiwan
-
Liverpool Hospital /ID# 221803
Liverpool, New South Wales, 2170, Australia
-
Lynn Cancer Institute, Boca /ID# 230687
Boca Raton, Florida, 33486, United States
-
Massachusetts General Hospital /ID# 221559
Boston, Massachusetts, 02114, United States
-
Medical Center OK Clinic LLC, International Institute of Clinical Research /ID# 230834
Kyiv, 02091, Ukraine
-
Medical Corporation Seijinkai Ikeda Hospital /ID# 242172
Kanoya-shi, Kagoshima-ken, 893-0024, Japan
-
Medizinische Universitaet Wien /ID# 220906
Vienna, State of Vienna, 1090, Austria
-
Meir Medical Center /ID# 221374
Kfar Saba, Central District, 4428164, Israel
-
Mid Illinois Hematology & Oncology Associates, Ltd /ID# 224204
Normal, Illinois, 61761, United States
-
MidAmerica Division, Inc. /ID# 221743
Kansas City, Missouri, 64132, United States
-
Mie University Hospital /ID# 221664
Tsu, Mie-ken, 514-8507, Japan
-
Minnesota Oncology Hematology /ID# 227357
Edina, Minnesota, 55435, United States
-
Moores Cancer Center at UC San Diego /ID# 218012
La Jolla, California, 92093, United States
-
Moscow State budget healthcare /ID# 221025
Moscow, Moscow, 125284, Russia
-
National Cancer Center Hospital East /ID# 226093
Kashiwa-shi, Chiba, 277-8577, Japan
-
National Taiwan University Hospital /ID# 218976
Taipei City, Taipei, 100, Taiwan
-
Niagara Health System /ID# 230994
St. Catharines, Ontario, L2S 0A9, Canada
-
Nippon Medical School Hospital /ID# 221674
Bunkyo-ku, Tokyo, 113-8602, Japan
-
Northwell Health - Monter Cancer Center /ID# 222996
Lake Success, New York, 11042, United States
-
Ogaki Municipal Hospital /ID# 240173
Ogaki-shi, Gifu, 503-8502, Japan
-
OncoResearch Lerchenfeld GmbH /ID# 230867
Hamburg, 22081, Germany
-
Oncology Hematology Care, Inc. /ID# 222556
Cincinnati, Ohio, 45236-2725, United States
-
Ordensklinikum Linz GmbH Elisabethinen /ID# 220813
Linz, Upper Austria, 4010, Austria
-
Orebro Universitetssjukhuset /ID# 220829
Örebro, Örebro County, 701 85, Sweden
-
Oxford University Hospitals NHS Foundation Trust /ID# 219192
Oxford, Oxfordshire, OX3 9DU, United Kingdom
-
Peter MacCallum Cancer Ctr /ID# 229795
Melbourne, Victoria, 3000, Australia
-
Providence - St. Jude Medical Center /ID# 241646
Fullerton, California, 92835, United States
-
Pusan National University Hospital /ID# 222087
Busan, Busan Gwang Yeogsi, 49241, South Korea
-
Radboud Universitair Medisch Centrum /ID# 218948
Nijmegen, Gelderland, 6525 GA, Netherlands
-
Rambam Health Care Campus /ID# 219120
Haifa, H_efa, 3109601, Israel
-
Republican hospital named after V.A. Baranov /ID# 221412
Petrozavodsk, Murmansk Oblast, 185019, Russia
-
Rocky Mountain Cancer Centers - Littleton /ID# 222562
Littleton, Colorado, 80120, United States
-
Royal Perth Hospital /ID# 223203
Perth, Western Australia, 6000, Australia
-
Royal Victoria Hospital /ID# 222636
Barrie, Ontario, L4M 6M2, Canada
-
Russian Research Institute of Hematology and Transfusiology of the FMBA /ID# 221029
Saint Petersburg, 191024, Russia
-
SI Institute of Blood Pathology and Transfusion Medicine of NAMS of Ukraine /ID# 230833
Lviv, 79044, Ukraine
-
Samsung Medical Center /ID# 221068
Seoul, Seoul Teugbyeolsi, 06351, South Korea
-
Seoul National University Hospital /ID# 219055
Seoul, Seoul Teugbyeolsi, 03080, South Korea
-
Taipei Veterans General Hosp /ID# 221146
Taipei, 11217, Taiwan
-
Tel Aviv Sourasky Medical Center /ID# 219134
Tel Aviv, Tel Aviv, 6423906, Israel
-
Texas Oncology - Northeast Texas /ID# 241813
Tyler, Texas, 75702, United States
-
The Alfred Hospital /ID# 221501
Melbourne, Victoria, 3004, Australia
-
The Catholic University of Korea, Seoul St. Marys Hospital /ID# 219056
Seoul, Seoul Teugbyeolsi, 06591, South Korea
-
The Chaim Sheba Medical Center /ID# 219137
Ramat Gan, Tel Aviv, 5265601, Israel
-
The Christie Hospital /ID# 219191
Manchester, M20 4BX, United Kingdom
-
The Kinghorn Cancer Centre /ID# 221503
Darlinghurst, New South Wales, 2010, Australia
-
The Ohio State University /ID# 221584
Columbus, Ohio, 43210, United States
-
The University of Osaka Hospital /ID# 221478
Suita-shi, Osaka, 565-0871, Japan
-
Thompson Cancer Survival Ctr /ID# 231689
Knoxville, Tennessee, 37916, United States
-
Townsville University Hospital /ID# 229794
Douglas, Queensland, 4814, Australia
-
Trakya University Medical Facu /ID# 230754
Edirne, Istanbul, 22030, Turkey (Türkiye)
-
Tula Regional Clinical Hospital /ID# 221027
Tula, 300053, Russia
-
UMHAT Alexandrovska EAD /ID# 231056
Sofiya, Sofia, 1431, Bulgaria
-
UMHAT Dr Georgi Stranski EAD /ID# 231161
Pleven, 5800, Bulgaria
-
UMHAT Sveti Georgi /ID# 231053
Plovdiv, 4002, Bulgaria
-
UMHAT Sveti Ivan Rilski /ID# 231028
Sofia, 1431, Bulgaria
-
UPMC Hillman Cancer Ctr /ID# 218134
Pittsburgh, Pennsylvania, 15232, United States
-
UZ Gent /ID# 221125
Ghent, Oost-Vlaanderen, 9000, Belgium
-
United Lincolnshire Hospitals NHS Trust /ID# 231471
Lincoln, Lincolnshire, LN2 4AX, United Kingdom
-
Universitaetsklinikum Aachen /ID# 221519
Aachen, North Rhine-Westphalia, 52074, Germany
-
Universitaetsklinikum Essen /ID# 221522
Essen, 45147, Germany
-
Universitair Medisch Centrum Groningen /ID# 218947
Groningen, 9713 GZ, Netherlands
-
Universitair Medisch Centrum Utrecht /ID# 218949
Utrecht, 3584 CX, Netherlands
-
Universitair Ziekenhuis Leuven /ID# 218806
Leuven, Vlaams-Brabant, 3000, Belgium
-
Universitatsklinikum Mannheim /ID# 221523
Mannheim, Baden-Wurttemberg, 68167, Germany
-
University Clinical Center Kragujevac /ID# 230855
Kragujevac, Sumadijski Okrug, 34000, Serbia
-
University Clinical Center Serbia /ID# 230854
Belgrade, Beograd, 11000, Serbia
-
University Hospitals Birmingham NHS Foundation Trust /ID# 221333
Birmingham, B15 2TH, United Kingdom
-
University of Kansas Cancer Center /ID# 218144
Fairway, Kansas, 66205-2528, United States
-
University of Michigan /ID# 221658
Ann Arbor, Michigan, 48109-5000, United States
-
University of Miyazaki Hospital /ID# 221483
Miyazaki, Miyazaki, 889-1692, Japan
-
University of Texas MD Anderson Cancer Center /ID# 217994
Houston, Texas, 77030, United States
-
University of Utah /ID# 221009
Salt Lake City, Utah, 84112-5500, United States
-
University of Yamanashi Hospital /ID# 221701
Chuo-shi, Yamanashi, 409-3821, Japan
-
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 221127
Yvoir, Namur, 5530, Belgium
-
Utah Cancer Specialists Salt Lake Clinic /ID# 221961
Salt Lake City, Utah, 84106, United States
-
VA Puget Sound Health Care System /ID# 231691
Seattle, Washington, 98108-1597, United States
-
Virginia Cancer Specialists - Fairfax /ID# 242682
Fairfax, Virginia, 22031, United States
-
Vitaz /Id# 229861
Sint-Niklaas, Oost-Vlaanderen, 9100, Belgium
-
Weill Cornell Medical College /ID# 220933
New York, New York, 10065, United States
-
Wits Clinical Research /ID# 232072
Johannesburg, Gauteng, 1864, South Africa
-
Yitzhak Shamir Medical Center /ID# 222957
Ẕerifin, Central District, 70300, Israel
-
ZAS Cadix /ID# 221465
Antwerp, Antwerpen, 2030, Belgium
Conditions
Explore the condition pages connected to this study.