New combo aims to shrink enlarged spleens in bone marrow cancer

NCT ID NCT04472598

First seen Apr 12, 2026 · Last updated May 15, 2026 · Updated 2 times

Summary

This study tests whether adding the experimental drug navitoclax to the standard drug ruxolitinib works better than ruxolitinib alone for people with myelofibrosis, a type of bone marrow cancer. About 252 adults with myelofibrosis took part. The main goal was to see if the combo could shrink an enlarged spleen by at least 35% after 24 weeks. The study also tracked symptom changes and side effects.

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Contacts and locations

Locations

  • AOU Policlinico G. Rodolico - San Marco /ID# 219085

    Catania, 95123, Italy

  • AP-HP - Hopital Necker /ID# 231318

    Paris, 75015, France

  • ASST Papa Giovanni XXIII /ID# 221907

    Bergamo, 24127, Italy

  • ASST degli Spedali Civili di Brescia /ID# 241273

    Brescia, 25123, Italy

  • AZ Sint-Jan Brugge /ID# 218805

    Bruges, 8000, Belgium

  • AZ-Delta /ID# 221466

    Roeselare, West-Vlaanderen, 8800, Belgium

  • Acibadem City Clinic Tokuda University Hospital EAD /ID# 231036

    Sofia, 1407, Bulgaria

  • Albert Schweitzer Ziekenhuis /ID# 224015

    Dordrecht, South Holland, 3318 AT, Netherlands

  • Alberts Cellular Therapy /ID# 232073

    Pretoria, Gauteng, 0044, South Africa

  • Almazov National Medical Research Centre /ID# 221033

    Saint Petersburg, 197341, Russia

  • Aotearoa Clinical Trials /ID# 230770

    Papatoetoe, Auckland, 2025, New Zealand

  • Asan Medical Center /ID# 219054

    Seoul, Seoul Teugbyeolsi, 05505, South Korea

  • Augusta University Georgia Cancer Center /ID# 221551

    Augusta, Georgia, 30912-0003, United States

  • Azienda Ospedaliero Universitaria Careggi /ID# 219086

    Florence, Firenze, 50134, Italy

  • BAG Freiberg-Richter, Jacobasch, Illmer, Wolf /ID# 221347

    Dresden, Saxony, 01307, Germany

  • Bagcilar Medipol Mega Universite Hastanesi /ID# 230757

    Istanbul, 34214, Turkey (Türkiye)

  • Beth Israel Deaconess Medical Center /ID# 224261

    Boston, Massachusetts, 02215-5400, United States

  • Border Medical Oncology Research Unit Albury Wodonga Regiona /ID# 231311

    East Albury, New South Wales, 2640, Australia

  • CH Roubaix - Hopital Victor Provo /ID# 219116

    Roubaix, Hauts-de-France, 59100, France

  • CHU NIMES - Hopital Caremeau /ID# 219114

    Nîmes, Gard, 30029, France

  • CHU de Liège /ID# 218874

    Liège, Liege, 4000, Belgium

  • CHU de Nantes, Hotel Dieu -HME /ID# 219113

    Nantes, Pays de la Loire Region, 44000, France

  • CHUQ- Hôpital de l'Enfant-Jesus /ID# 221754

    Québec, Quebec, G1J 1Z4, Canada

  • CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 230721

    Madrid, 28027, Spain

  • Centre Hospitalier Métropole Savoie - Site Hôpital de Chambéry /ID# 224506

    Chambéry, Savoie, 73007, France

  • Centre Hospitalier Universitaire de Bordeaux /ID# 222518

    Pessac, Gironde, 33604, France

  • Chi Mei Hospital - Liouying /ID# 221145

    Tainan, Tainan, 73657, Taiwan

  • China Medical University Hospital /ID# 218978

    Taichung, 40447, Taiwan

  • Chu Angers /Id# 219115

    Angers, 49933, France

  • Clin Hosp Ctr Bezanijska Kosa /ID# 230946

    Belgrade, Beograd, 11080, Serbia

  • Clinic UZI 4D /ID# 221024

    Pyatigorsk, Stavropol Kray, 357502, Russia

  • Clinica Universidad de Navarra - Pamplona /ID# 230720

    Pamplona, Navarre, 31008, Spain

  • Clinical Hospital Dubrava /ID# 230795

    Zagreb, City of Zagreb, 10000, Croatia

  • Columbus Regional Research Institute /ID# 227272

    Columbus, Georgia, 31904-8915, United States

  • Communal non-profit enterprise Regional Center of Oncology /ID# 230832

    Kharkiv, Kharkivs’ka Oblast’, 61070, Ukraine

  • Dana-Farber Cancer Institute /ID# 218010

    Boston, Massachusetts, 02215, United States

  • Dokkyo Medical University Saitama Medical Center /ID# 222333

    Koshigaya, Saitama, 343-0845, Japan

  • Duplicate_ASST Sette Laghi /ID# 219084

    Varese, 21100, Italy

  • Duplicate_Chiba University Hospital /ID# 239345

    Chiba, Chiba, 260-8677, Japan

  • Duplicate_Clinical Center Vojvodina /ID# 230853

    Novi Sad, Vojvodina, 21000, Serbia

  • Duplicate_Emory University /ID# 221562

    Atlanta, Georgia, 30322-1013, United States

  • Duplicate_Hokkaido University Hospital /ID# 242667

    Sapporo, Hokkaido, 060-8648, Japan

  • Duplicate_Hospital Clínico Universitario de Santiago-CHUS /ID# 222264

    Santiago de Compostela, A Coruna, 15706, Spain

  • Duplicate_Inje University Busan Paik Hospital /ID# 231667

    Busan, Busan Gwang Yeogsi, 47392, South Korea

  • Duplicate_Kawasaki Medical School Hospital /ID# 221481

    Kurashiki-shi, Okayama-ken, 701-0192, Japan

  • Duplicate_Klinicki bolnicki centar Split /ID# 230796

    Split, Split-Dalmatia County, 21000, Croatia

  • Duplicate_Kyungpook National University Hospital /ID# 231666

    Daegu, Daegu Gwang Yeogsi, 41944, South Korea

  • Duplicate_Medizinische Universitaet Graz /ID# 220910

    Graz, Styria, 8010, Austria

  • Duplicate_Rush University Medical Center /ID# 221581

    Chicago, Illinois, 60612, United States

  • Duplicate_Sahlgrenska University Hospital /ID# 218776

    Gothenburg, Västra Götaland County, 413 45, Sweden

  • Duplicate_Seoul National University Bundang Hospital /ID# 219053

    Seongnam, Gyeonggido, 13620, South Korea

  • Duplicate_Skane University Hospital Lund /ID# 220835

    Lund, Skåne County, 221 41, Sweden

  • Duplicate_University General Hospital Attikon /ID# 230784

    Athens, Attica, 12462, Greece

  • Duplicate_Wits Clinical Research Site /ID# 232071

    Johannesburg, Gauteng, 2193, South Africa

  • Ege University Medical Faculty /ID# 230753

    Izmir, 35040, Turkey (Türkiye)

  • Ehime University Hospital /ID# 221443

    Toon-shi, Ehime, 791-0295, Japan

  • Feofaniya Clinical Hospital of State Management of Affairs /ID# 232370

    Kyiv, 03143, Ukraine

  • Florida Cancer Specialist - South /ID# 221726

    Fort Myers, Florida, 33901-8108, United States

  • Florida Cancer Specialists - East /ID# 221728

    West Palm Beach, Florida, 33401, United States

  • Florida Cancer Specialists - North /ID# 221727

    St. Petersburg, Florida, 33705-1449, United States

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 219083

    Rome, Roma, 00168, Italy

  • Fujita Health University Hospital /ID# 221537

    Toyoake, Aichi-ken, 470-1192, Japan

  • Fukushima Medical University Hospital /ID# 222752

    Fukushima, Fukushima, 960-1295, Japan

  • Gabrail Cancer Center Research /ID# 230488

    Canton, Ohio, 44718, United States

  • Gachon University Gil Medical Center /ID# 222089

    Incheon, Gyeonggido, 21565, South Korea

  • General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 230786

    Athens, 10676, Greece

  • General Hospital of Athens Laiko /ID# 230785

    Athens, Attica, 11527, Greece

  • Gosford Hospital /ID# 221499

    Gosford, New South Wales, 2250, Australia

  • Gunma University Hospital /ID# 221480

    Maebashi, Gunma, 371-8511, Japan

  • Gunmaken Saiseikai Maebashi Hospital /ID# 242806

    Maebashi, Gunma, 371-0821, Japan

  • Guys and St Thomas NHS Foundation Trust /ID# 219185

    London, Greater London, SE1 9RT, United Kingdom

  • HCL - Hopital Lyon Sud /ID# 222913

    Pierre-Bénite, Rhone, 69495, France

  • Hacettepe University Medical Faculty /ID# 230759

    Ankara, 06230, Turkey (Türkiye)

  • Hackensack Univ Med Ctr /ID# 221654

    Hackensack, New Jersey, 07601, United States

  • Hadassah Medical Center-Hebrew University /ID# 219110

    Jerusalem, Jerusalem, 91120, Israel

  • Haemato-Onkologie /ID# 221061

    Munich, Bavaria, 81241, Germany

  • Hanusch Krankenhaus /ID# 220909

    Vienna, 1140, Austria

  • Highlands Oncology Group, PA /ID# 221824

    Springdale, Arkansas, 72762, United States

  • Hitachi General Hospital /ID# 240048

    Hitachi-shi, Ibaraki, 317-0077, Japan

  • Hopital Avicenne - APHP /ID# 221286

    Bobigny, Île-de-France Region, 93000, France

  • Hospital Clinico Universitario de Valencia /ID# 220875

    Valencia, 46010, Spain

  • Hospital Parc de Salut del Mar /ID# 220913

    Barcelona, 08003, Spain

  • Hospital Universitario 12 de Octubre /ID# 229691

    Madrid, 28041, Spain

  • Hospital Universitario Dr. Negrin /ID# 220897

    Las Palmas de Gran Canaria, Las Palmas, 35019, Spain

  • Hospital Universitario Germans Trias i Pujol /ID# 229936

    Badalona, Barcelona, 08916, Spain

  • Hospital Universitario Ramon y Cajal /ID# 220877

    Madrid, 28034, Spain

  • Hospital Universitario Vall d'Hebron /ID# 229690

    Barcelona, 08035, Spain

  • Hospital Universitario Virgen de la Victoria /ID# 220878

    Málaga, 29010, Spain

  • Hôpital Saint-Louis /ID# 221288

    Paris, 75010, France

  • ICANS - Institut de Cancérologie Strasbourg Europe /ID# 229978

    Strasbourg, 67033, France

  • IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 220867

    Bologna, Emilia-Romagna, 40138, Italy

  • Indiana Blood & Marrow Transpl /ID# 221586

    Indianapolis, Indiana, 46237, United States

  • Inonu University Medical Faculty /ID# 230758

    Malatya, 44280, Turkey (Türkiye)

  • Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital /ID# 239100

    Nagoya, Aichi-ken, 453-8511, Japan

  • Juntendo University Hospital /ID# 221405

    Bunkyo-ku, Tokyo, 113-8431, Japan

  • Juntendo University Shizuoka Hospital /ID# 221782

    Izunokuni-shi, Shizuoka, 410-2295, Japan

  • Juravinski Cancer Centre /ID# 221752

    Hamilton, Ontario, L8V 1C3, Canada

  • Kanazawa University Hospital /ID# 238424

    Kanazawa, Ishikawa-ken, 920-8641, Japan

  • Kansai Medical University Hospital /ID# 221482

    Hirakata-shi, Osaka, 573-1191, Japan

  • Kaohsiung Chang Gung Memorial Hospital /ID# 218984

    Kaohsiung City, Kaohsiung, 833, Taiwan

  • Kindai University Hospital /ID# 221479

    Osakasayama-shi, Osaka, 589-8511, Japan

  • Klinicka bolnica Merkur /ID# 231155

    Zagreb, City of Zagreb, 10000, Croatia

  • Klinicki bolnicki centar Zagreb /ID# 230793

    Zagreb, City of Zagreb, 10000, Croatia

  • Klinikum Wels-Grieskirchen GmbH /ID# 220901

    Wels, Upper Austria, 4600, Austria

  • Klinikum rechts der Isar /ID# 221520

    Munich, 81675, Germany

  • Kobe University Hospital /ID# 246236

    Kobe, Hyōgo, 650-0017, Japan

  • Kurashiki Central Hospital /ID# 221692

    Kurashiki-shi, Okayama-ken, 710-8602, Japan

  • Kyoto University Hospital /ID# 238423

    Kyoto, Kyoto, 606-8507, Japan

  • Kyushu University Hospital /ID# 221783

    Fukuoka, Fukuoka, 812-8582, Japan

  • Lakeridge Health - Oshawa /ID# 222080

    Oshawa, Ontario, L1G 2B9, Canada

  • Leningrad Regional Clinical Hospital /ID# 221028

    Saint Petersburg, 194291, Russia

  • Linkou Chang Gung Memorial Hospital /ID# 218983

    Taoyuan City, 333, Taiwan

  • Liverpool Hospital /ID# 221803

    Liverpool, New South Wales, 2170, Australia

  • Lynn Cancer Institute, Boca /ID# 230687

    Boca Raton, Florida, 33486, United States

  • Massachusetts General Hospital /ID# 221559

    Boston, Massachusetts, 02114, United States

  • Medical Center OK Clinic LLC, International Institute of Clinical Research /ID# 230834

    Kyiv, 02091, Ukraine

  • Medical Corporation Seijinkai Ikeda Hospital /ID# 242172

    Kanoya-shi, Kagoshima-ken, 893-0024, Japan

  • Medizinische Universitaet Wien /ID# 220906

    Vienna, State of Vienna, 1090, Austria

  • Meir Medical Center /ID# 221374

    Kfar Saba, Central District, 4428164, Israel

  • Mid Illinois Hematology & Oncology Associates, Ltd /ID# 224204

    Normal, Illinois, 61761, United States

  • MidAmerica Division, Inc. /ID# 221743

    Kansas City, Missouri, 64132, United States

  • Mie University Hospital /ID# 221664

    Tsu, Mie-ken, 514-8507, Japan

  • Minnesota Oncology Hematology /ID# 227357

    Edina, Minnesota, 55435, United States

  • Moores Cancer Center at UC San Diego /ID# 218012

    La Jolla, California, 92093, United States

  • Moscow State budget healthcare /ID# 221025

    Moscow, Moscow, 125284, Russia

  • National Cancer Center Hospital East /ID# 226093

    Kashiwa-shi, Chiba, 277-8577, Japan

  • National Taiwan University Hospital /ID# 218976

    Taipei City, Taipei, 100, Taiwan

  • Niagara Health System /ID# 230994

    St. Catharines, Ontario, L2S 0A9, Canada

  • Nippon Medical School Hospital /ID# 221674

    Bunkyo-ku, Tokyo, 113-8602, Japan

  • Northwell Health - Monter Cancer Center /ID# 222996

    Lake Success, New York, 11042, United States

  • Ogaki Municipal Hospital /ID# 240173

    Ogaki-shi, Gifu, 503-8502, Japan

  • OncoResearch Lerchenfeld GmbH /ID# 230867

    Hamburg, 22081, Germany

  • Oncology Hematology Care, Inc. /ID# 222556

    Cincinnati, Ohio, 45236-2725, United States

  • Ordensklinikum Linz GmbH Elisabethinen /ID# 220813

    Linz, Upper Austria, 4010, Austria

  • Orebro Universitetssjukhuset /ID# 220829

    Örebro, Örebro County, 701 85, Sweden

  • Oxford University Hospitals NHS Foundation Trust /ID# 219192

    Oxford, Oxfordshire, OX3 9DU, United Kingdom

  • Peter MacCallum Cancer Ctr /ID# 229795

    Melbourne, Victoria, 3000, Australia

  • Providence - St. Jude Medical Center /ID# 241646

    Fullerton, California, 92835, United States

  • Pusan National University Hospital /ID# 222087

    Busan, Busan Gwang Yeogsi, 49241, South Korea

  • Radboud Universitair Medisch Centrum /ID# 218948

    Nijmegen, Gelderland, 6525 GA, Netherlands

  • Rambam Health Care Campus /ID# 219120

    Haifa, H_efa, 3109601, Israel

  • Republican hospital named after V.A. Baranov /ID# 221412

    Petrozavodsk, Murmansk Oblast, 185019, Russia

  • Rocky Mountain Cancer Centers - Littleton /ID# 222562

    Littleton, Colorado, 80120, United States

  • Royal Perth Hospital /ID# 223203

    Perth, Western Australia, 6000, Australia

  • Royal Victoria Hospital /ID# 222636

    Barrie, Ontario, L4M 6M2, Canada

  • Russian Research Institute of Hematology and Transfusiology of the FMBA /ID# 221029

    Saint Petersburg, 191024, Russia

  • SI Institute of Blood Pathology and Transfusion Medicine of NAMS of Ukraine /ID# 230833

    Lviv, 79044, Ukraine

  • Samsung Medical Center /ID# 221068

    Seoul, Seoul Teugbyeolsi, 06351, South Korea

  • Seoul National University Hospital /ID# 219055

    Seoul, Seoul Teugbyeolsi, 03080, South Korea

  • Taipei Veterans General Hosp /ID# 221146

    Taipei, 11217, Taiwan

  • Tel Aviv Sourasky Medical Center /ID# 219134

    Tel Aviv, Tel Aviv, 6423906, Israel

  • Texas Oncology - Northeast Texas /ID# 241813

    Tyler, Texas, 75702, United States

  • The Alfred Hospital /ID# 221501

    Melbourne, Victoria, 3004, Australia

  • The Catholic University of Korea, Seoul St. Marys Hospital /ID# 219056

    Seoul, Seoul Teugbyeolsi, 06591, South Korea

  • The Chaim Sheba Medical Center /ID# 219137

    Ramat Gan, Tel Aviv, 5265601, Israel

  • The Christie Hospital /ID# 219191

    Manchester, M20 4BX, United Kingdom

  • The Kinghorn Cancer Centre /ID# 221503

    Darlinghurst, New South Wales, 2010, Australia

  • The Ohio State University /ID# 221584

    Columbus, Ohio, 43210, United States

  • The University of Osaka Hospital /ID# 221478

    Suita-shi, Osaka, 565-0871, Japan

  • Thompson Cancer Survival Ctr /ID# 231689

    Knoxville, Tennessee, 37916, United States

  • Townsville University Hospital /ID# 229794

    Douglas, Queensland, 4814, Australia

  • Trakya University Medical Facu /ID# 230754

    Edirne, Istanbul, 22030, Turkey (Türkiye)

  • Tula Regional Clinical Hospital /ID# 221027

    Tula, 300053, Russia

  • UMHAT Alexandrovska EAD /ID# 231056

    Sofiya, Sofia, 1431, Bulgaria

  • UMHAT Dr Georgi Stranski EAD /ID# 231161

    Pleven, 5800, Bulgaria

  • UMHAT Sveti Georgi /ID# 231053

    Plovdiv, 4002, Bulgaria

  • UMHAT Sveti Ivan Rilski /ID# 231028

    Sofia, 1431, Bulgaria

  • UPMC Hillman Cancer Ctr /ID# 218134

    Pittsburgh, Pennsylvania, 15232, United States

  • UZ Gent /ID# 221125

    Ghent, Oost-Vlaanderen, 9000, Belgium

  • United Lincolnshire Hospitals NHS Trust /ID# 231471

    Lincoln, Lincolnshire, LN2 4AX, United Kingdom

  • Universitaetsklinikum Aachen /ID# 221519

    Aachen, North Rhine-Westphalia, 52074, Germany

  • Universitaetsklinikum Essen /ID# 221522

    Essen, 45147, Germany

  • Universitair Medisch Centrum Groningen /ID# 218947

    Groningen, 9713 GZ, Netherlands

  • Universitair Medisch Centrum Utrecht /ID# 218949

    Utrecht, 3584 CX, Netherlands

  • Universitair Ziekenhuis Leuven /ID# 218806

    Leuven, Vlaams-Brabant, 3000, Belgium

  • Universitatsklinikum Mannheim /ID# 221523

    Mannheim, Baden-Wurttemberg, 68167, Germany

  • University Clinical Center Kragujevac /ID# 230855

    Kragujevac, Sumadijski Okrug, 34000, Serbia

  • University Clinical Center Serbia /ID# 230854

    Belgrade, Beograd, 11000, Serbia

  • University Hospitals Birmingham NHS Foundation Trust /ID# 221333

    Birmingham, B15 2TH, United Kingdom

  • University of Kansas Cancer Center /ID# 218144

    Fairway, Kansas, 66205-2528, United States

  • University of Michigan /ID# 221658

    Ann Arbor, Michigan, 48109-5000, United States

  • University of Miyazaki Hospital /ID# 221483

    Miyazaki, Miyazaki, 889-1692, Japan

  • University of Texas MD Anderson Cancer Center /ID# 217994

    Houston, Texas, 77030, United States

  • University of Utah /ID# 221009

    Salt Lake City, Utah, 84112-5500, United States

  • University of Yamanashi Hospital /ID# 221701

    Chuo-shi, Yamanashi, 409-3821, Japan

  • Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 221127

    Yvoir, Namur, 5530, Belgium

  • Utah Cancer Specialists Salt Lake Clinic /ID# 221961

    Salt Lake City, Utah, 84106, United States

  • VA Puget Sound Health Care System /ID# 231691

    Seattle, Washington, 98108-1597, United States

  • Virginia Cancer Specialists - Fairfax /ID# 242682

    Fairfax, Virginia, 22031, United States

  • Vitaz /Id# 229861

    Sint-Niklaas, Oost-Vlaanderen, 9100, Belgium

  • Weill Cornell Medical College /ID# 220933

    New York, New York, 10065, United States

  • Wits Clinical Research /ID# 232072

    Johannesburg, Gauteng, 1864, South Africa

  • Yitzhak Shamir Medical Center /ID# 222957

    Ẕerifin, Central District, 70300, Israel

  • ZAS Cadix /ID# 221465

    Antwerp, Antwerpen, 2030, Belgium

Conditions

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