Microcytic anemia

This study compares IV iron to oral iron pills for treating moderate anemia after a C-section. The goal is to see if better iron levels can reduce the risk of postpartum depression. About 2,860 women will take part, and their mood will be checked 8 weeks after delivery.

This study tests whether a low-dose liposomal iron supplement works better and causes fewer stomach issues than the standard high-dose iron pills for people with iron deficiency anemia after sleeve gastrectomy. About 70 adults who had this weight-loss surgery at least 6 months ag…

This study tests a program that combines face-to-face counseling with a mobile app to help teenage girls with iron deficiency anemia. About 160 girls aged 14-17 with low iron levels will either get the program or standard care. The goal is to see if the program raises their hemog…

This phase 3 trial tests whether the drug nipocalimab can reduce the risk of severe anemia in unborn babies whose mothers have a condition called hemolytic disease of the fetus and newborn (HDFN). The study enrolls 120 pregnant women with a history of severe HDFN. Participants re…

This study tests whether giving a combination of iron, erythropoietin, and vitamin C before major heart surgery can lower the need for blood transfusions in adults with iron-deficiency anemia. About 400 participants will receive either the combined regimen or standard care. The g…

This study tests whether giving preterm babies (born before 32 weeks) a drug called darbepoetin plus a slow-release intravenous iron can reduce the need for blood transfusions, keep their iron levels healthy, and improve their brain development. About 120 infants will be enrolled…

This study looks at whether giving iron supplements to children with low iron before hip surgery can reduce their need for blood transfusions and improve recovery. The trial includes 180 children aged 0-18 who are scheduled for a specific type of hip surgery, many of whom have ce…

This study looks at different ways to give iron to people with kidney failure who are on peritoneal dialysis. Participants will get either high-dose or low-dose intravenous iron, or oral iron tablets. The main goal is to see if a larger trial is possible by checking how many peop…

This study tests whether a special type of iron supplement (Sucrosomial iron) helps children with celiac disease who also have low iron or anemia. The trial will compare children who take the supplement plus a gluten-free diet to those who only follow the diet. The goal is to see…

This study tests whether giving intravenous iron to older adults (70+) after heart surgery helps them recover from anemia and reduces disability. About 310 patients will receive either iron or a placebo. The main goal is to see if iron improves daily functioning 90 days after sur…

This study tests whether taking an iron pill every other day works as well as taking one daily for pregnant women with iron-deficiency anemia. About 120 pregnant women with low iron will be randomly assigned to one of two schedules. The goal is to see if both approaches can raise…

This study tests whether testicular tissue frozen before puberty can be transplanted back into adult men to restore sperm production. Five men who had fertility-threatening treatments as children will receive their own preserved tissue. The goal is to see if sperm can be found in…

This study tests a medicine called ferumoxytol, given as an IV infusion, to treat iron deficiency anemia in children aged 2 to 17. It is for kids who cannot take or do not respond to oral iron supplements. The main goal is to see if it safely raises hemoglobin levels after 5 week…

This study tests a drug called ferumoxytol, a type of intravenous iron, to treat iron deficiency anemia in children aged 2 to 17 with chronic kidney disease. The trial compares ferumoxytol to another iron drug, iron sucrose, to see which is safer and works better. About 129 child…

This study tests an intravenous iron medicine (ferric derisomaltose) in 200 children aged 0 to 18 who have iron deficiency anemia due to chronic kidney disease or who cannot take or do not respond to oral iron. The goal is to see if one or two doses can raise hemoglobin levels sa…

This study is checking whether unlicensed cord blood units are safe to use for stem cell transplants in children and adults with blood disorders. Researchers will closely watch for any infusion-related problems. The goal is to see if these units can be a safe option for patients …

This study looks at whether giving anemic patients a combination of iron, erythropoietin, and vitamin C for three days before heart surgery can improve their quality of life, sleep, and fatigue over the long term. Researchers will compare these patients to those receiving standar…

This study tests whether the drug lusutrombopag can help restore platelet levels faster in patients who have had a stem cell transplant for blood disorders. About 45 adults will receive the drug after transplant, and doctors will check platelet counts at 21 days. The goal is to i…

This study tests two oral iron supplements, Sucrosomial® Iron and Ferric Maltol, in 146 women with mild to moderate iron deficiency anemia. The goal is to see if Sucrosomial® Iron works as well as Ferric Maltol at raising hemoglobin levels after 12 weeks, while causing fewer stom…

This study tests whether giving iron through a vein (IV) after heart surgery helps people with iron-deficiency anemia recover better. About 60 adults having planned open-heart surgery will receive either IV iron or a placebo. The goal is to see if this treatment is practical and …

This study tests whether giving iron through a vein can help people with pulmonary hypertension (high blood pressure in the lungs) who also have low iron levels. Many patients with this condition have trouble absorbing iron from pills. The trial will compare intravenous iron to a…

This study tests whether taking an iron pill every other day works as well as taking one daily for adults with iron deficiency anemia. About 114 participants will be randomly assigned to one of two groups for 8 weeks. Researchers will check blood levels and side effects to see if…

This study tests whether giving iron through a vein (IV) early in the second trimester works better than iron pills for treating anemia in pregnancy. About 80 pregnant women with mild iron deficiency will be randomly assigned to one of the two treatments. The goal is to see which…

This study tests whether giving intravenous iron to teens with iron deficiency before spinal fusion surgery can lower their need for blood transfusions. About 120 participants aged 10-19 will receive either IV iron or a placebo. The goal is to see if correcting iron levels improv…

This study is for adults with blood disorders who are getting a stem cell transplant from a matched donor. Researchers want to see if giving a special potato starch along with a drug that lowers iron (deferasirox) can help prevent serious complications like graft-versus-host dise…

This study tests whether intravenous iron works better than oral iron pills for treating iron deficiency anemia in people who have had gastric bypass or sleeve gastrectomy surgery. About 104 participants will be randomly assigned to receive either a single IV dose of ferumoxytol …

This study tests whether a daily oral iron supplement (sucrosomial iron with vitamin C) can improve exercise ability and quality of life in people with chronic heart failure and iron deficiency. About 60 participants will receive either the iron supplement or a placebo for 24 wee…

This study in Burkina Faso and Pakistan will enroll 3,200 pregnant women to see if taking daily calcium and iron-containing multiple micronutrient supplements together is as effective as taking them at different times. The goal is to simplify supplement routines without harming t…

This study tests a robot-assisted capsule (a pill-sized camera) to examine the stomach and small bowel in people with iron deficiency anaemia whose cause hasn't been found by standard tests. The goal is to see if this less invasive method works as well as traditional upper endosc…

This study tests whether a probiotic called LP299V can help pregnant women at risk of iron deficiency absorb more iron from their diet. Researchers will give 250 women either the probiotic or a placebo from early pregnancy until labor. The goal is to see if the probiotic improves…

This study tests whether a group program for newly married women, their husbands, and mothers-in-law can reduce anemia and improve nutrition. About 2,100 people in 140 villages will take part. The program includes education on nutrition and gender norms, plus micronutrient supple…

This study looks at whether taking a daily iron supplement after sleeve gastrectomy surgery can prevent iron deficiency anemia. Researchers will compare two groups of adults who had the surgery: one group takes extra iron plus a multivitamin, the other takes only a multivitamin. …

This study tests whether a gentle electrical stimulation on acupoints or resistance exercises can help raise hemoglobin levels in women with iron deficiency anemia. Sixty women aged 20-30 with moderate anemia will be split into three groups: one receiving the electrical stimulati…

This study looks at whether taking lactoferrin (a protein found in milk) along with a small amount of iron can improve iron levels and exercise performance in active women who have low iron stores. About 30 women aged 18-45 who exercise at least 5 hours a week will take one of th…

This early-stage study tests a new drug called APG-5918 in healthy volunteers and people with anemia (low red blood cells). The main goal is to check safety and how the body handles the drug, while also seeing if it can raise hemoglobin levels. About 105 participants will take pa…

This study tests whether a single dose of intravenous iron (ferric derisomaltose) can improve exercise capacity in people with heart failure with preserved ejection fraction who also have iron deficiency. About 66 adults will receive either the iron infusion or a placebo, and the…

This study tests whether giving iron infusions after a minimally invasive heart valve replacement (TAVI) helps patients with aortic stenosis and iron deficiency feel better and walk farther. About 402 older adults will be randomly assigned to receive iron or standard care. Resear…

This study collects blood stem cells and immune cells from healthy volunteers and patients with primary immune deficiencies or blood disorders. The cells are used in the lab to develop new gene and cell therapies. Up to 850 adults aged 18-70 will participate. The goal is to advan…

This study investigates whether a pregnant woman's body fat influences how well she responds to daily iron supplements. Over 300 pregnant women will take either 25 mg or 50 mg of iron each day from week 12 until delivery. Researchers will track iron levels in blood and other heal…

This study collects blood, bone marrow, urine, and tissue samples from up to 6,000 people with solid tumors, blood cancers, or non-cancerous blood disorders, as well as from their healthy family members who are stem cell donors. The samples are stored and used in research to bett…

This study looks for better ways to detect lung inflammation and infections early in people who have received a stem cell transplant from a donor. About 40 participants aged 5 to 70 will get regular lung scans, breathing tests, blood draws, and a procedure where a tube collects f…

This study is a global registry that will follow 175 pregnant people whose babies are at risk for hemolytic disease of the fetus and newborn (HDFN), a condition where the mother's and baby's blood types clash, causing rapid red blood cell breakdown. Researchers will track how oft…

This study tests whether an AI system that analyzes routine blood test results can help doctors detect iron deficiency more often. About 2,196 adults visiting outpatient clinics will take part, but no extra blood draws or procedures are needed—the AI simply adds a risk alert to t…

This study uses MRI scans to track where iron travels in the body after an intravenous iron infusion. Researchers will monitor 12 iron-deficient adults over hours, days, and weeks to see how iron is absorbed by organs like the heart, liver, and spleen. The goal is to better under…

This study looks at new guidelines for diagnosing and managing breath-holding spells in children under 5 in southern Sweden. Researchers want to see if the guidelines safely reduce the need for extra tests like ECGs and blood work. They will also check if iron supplements help le…

This study looks at how much iron healthy US adults actually need. Current guidelines are based mostly on European data, so researchers want to update them for Americans. About 300 men and premenopausal women aged 18–50 will take a safe, stable iron isotope and give blood samples…

This study compares two forms of iron (ferrous fumarate and ferrous bisglycinate) in daily prenatal supplements for 172 pregnant women in Vancouver. Researchers will measure iron levels in blood and stool samples to see which form is better absorbed and causes fewer side effects.…

This study is a large registry that collects health information from up to 200,000 people with blood disorders such as hemophilia, thrombosis, and sickle cell disease. Participants are seen at Hemophilia Treatment Centers across the U.S. The goal is to gather real-world data to h…

This study looks at how different types and doses of oral iron supplements affect iron levels, exercise performance, and gut health in young female athletes with low iron stores. Participants will take one of three iron supplements every other day for 12 weeks and complete fitnes…

This study looks at how well young women with overweight or obesity absorb iron from their diet compared to women at a healthy weight. Researchers will track iron levels and losses over time in 70 South African women. The goal is to understand why obesity raises the risk of iron …

This study looks at how gut bacteria and the immune system interact in children and adults receiving stem cell transplants or CAR-T therapy. Researchers will collect stool and blood samples over time to find patterns linked to complications like infections or graft-versus-host di…

This study looks at whether doctors at Siriraj Hospital follow a new guideline for treating anemia in patients before major surgery. Anemia is common in surgical patients and can lead to more blood transfusions and worse outcomes. The researchers will track 93 anemic patients to …

This study looks at whether wrapping lactoferrin, a natural protein in milk, in a protective coating helps women with low iron absorb more iron from their food. Forty-five women with low iron stores but no anemia will eat labeled iron with different forms of lactoferrin. Research…

This study follows 102 women who had fertility preservation before cancer treatment to see what happens long-term. Researchers want to know if they get pregnant naturally, use stored eggs or tissue, or decide not to have children. The goal is to improve support and care for femal…

This study is collecting long-term safety and effectiveness data on treatments for various blood disorders, including hemophilia, sickle cell disease, and clotting disorders. It aims to enroll 3000 people of any age with these conditions. Researchers will monitor side effects, co…

This study is creating a collection of blood samples from 2,000 people with various blood disorders. The samples will be stored and used for future research approved by an ethics board. No treatments or drugs are being tested, and participants continue their normal care.

This study looks at families who carry a change in the DDX41 gene, which may raise the risk of blood cancers like leukemia. Researchers will collect health questionnaires and saliva samples from up to 910 people to track who develops blood problems and when. The goal is to better…

This study is observing 1000 adults having moderate- to high-risk surgery to see if the type and severity of anemia they have before surgery affects their risk of complications like heart injury, kidney injury, or stroke. Researchers will compare patients with iron-deficiency ane…

This study looks at using a needle placed into the bone marrow (intraosseous infusion) to give fluids and medicines quickly to critically ill patients with blood diseases. Researchers will enroll 52 adults aged 18-65 to see how often the first attempt works and how safe it is. Th…

This study is a registry that tracks patients with blood diseases who receive stem cell transplants at a hospital on the Qinghai-Tibet Plateau. Researchers will collect information on recovery, complications, and costs over time. The goal is to understand how high altitude affect…

This study looks at whether a quick ultrasound of the thigh muscle can detect muscle loss (sarcopenia) in people who have finished cancer treatment. Researchers will compare the ultrasound results with a standard whole-body scan (DEXA) in 55 adults aged 18-74 with certain cancers…