Laser surgery or watchful waiting? trial seeks best care for twin syndrome
NCT ID NCT01220011
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This trial compared two approaches for twin-to-twin transfusion syndrome (TTTS) stage 1: immediate laser surgery versus careful observation. 179 pregnant women with TTTS stage 1 and favorable conditions took part. The goal was to see which strategy leads to better survival and brain health for the babies at 6 months of age.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Fetoscopic laser surgery
- What this could lead to
- If laser surgery proves better, it could become the standard treatment for early-stage TTTS, improving survival and reducing brain damage in twins.
- What could go wrong
- This is a completed trial with 179 participants, so results are limited. Laser surgery carries risks like preterm labor or infection, and the benefit over observation may be small or none.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Children's Hospital Colorado and Colorado Fetal Care Center
Aurora, Colorado, 80045, United States
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Fetal Care Center of Cincinnati, Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229-3026, United States
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Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Fetal Therapy Program, Evergrenn Hospital Medical Center
Kirkland, Washington, 98034, United States
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Fetal Treatment Program of New England, Hasbro Children's Hospital, The Warren Alpert Medical School of Brown University.
Providence, Rhode Island, 02903, United States
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Hospital Ste-Justine
Montreal, Quebec, H3T 1R2, Canada
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Mount Sinai Hospital, University of Toronto
Toronto, Ontario, ON M5X 1X5, Canada
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Necker Enfants Malades
Paris, 75006, France
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The Ohio State University / OSU Fetal Therapy Program
Columbus, Ohio, 43221, United States
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The Texas Fetal Center, Children's Memorial Hermann Hospital, University of Texas Medical School
Houston, Texas, 77030, United States
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University of MD /Department of Obstetrics, Gynecology & Reproductive Sciences
Baltimore, Maryland, 21000, United States
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