New drug combo offers hope for myelofibrosis patients who failed standard therapy

NCT ID NCT05393674

Completed Disease control Sponsor: Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest Source: ClinicalTrials.gov ↗

First seen Jan 11, 2026 · Last updated Jun 05, 2026 · Updated 21 times

Summary

This study tested a combination of two drugs, fedratinib and nivolumab, in 30 adults with myelofibrosis whose disease no longer responded well to standard JAK-inhibitor treatment. The goal was to see if the combination could shrink the spleen, improve symptoms, or reduce the need for blood transfusions. The study is now complete, and results will help determine if this approach is safe and effective enough for further testing.

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Contacts and locations

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Locations

Johannes Wesling Klinikum

Minden, Germany
Medizinische Hochschule

Hanover, Germany
Uniklinik Ulm

Ulm, Germany
University Medicine Greifswald

Greifswald, Germany
Universitätsklinikum Freiburg

Freiburg im Breisgau, Germany
Universitätsklinikum Halle (Saale)

Halle, Germany
Universitätsklinikum Schleswig-Holstein

Lübeck, Germany

Conditions

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PRIMARY MYELOFIBROSIS SECONDARY MYELOFIBROSIS