Could iron pills make vaccines work better?

NCT ID NCT05919472

Completed Knowledge-focused Sponsor: Nicole Stoffel Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether giving oral iron supplements to iron-deficient women in Kenya before or at the same time as vaccination improves their immune response. 180 women received iron either before or with three vaccines (COVID-19, meningitis, and typhoid), or a placebo. The goal was to see if iron timing affects antibody levels. Results are not yet available, but the study aims to find a simple way to help vaccines work better in undernourished populations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: oral iron supplements (ferrous sulfate)
What this could lead to: If it works, this could point toward a simple way to improve vaccine effectiveness in iron-deficient populations.
What could go wrong: This is a small, completed study focused on immune markers, not disease prevention. Results may not apply broadly or lead to immediate changes in practice.

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Conditions

The condition(s) this trial relates to.

anemia Iron Deficiencies iron deficiency anemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IRON DEFICIENCY ANEMIA

Contacts and locations

Locations

Msambweni County Referral Hospital

Msambweni, 80404, Kenya

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