Kidney failure

This study looks at how well the HPV9 vaccine (Gardasil 9) works in people who have had a kidney transplant. Researchers will measure antibody levels in 30 transplant recipients over 24 months and compare them to published data from healthy individuals. The goal is to see if the …

This study looks at the long-term safety of a drug called iptacopan for adults with a kidney disease called primary IgA nephropathy. Participants have already completed earlier studies and will continue taking the drug to monitor side effects and see if it helps slow kidney damag…

This phase 2 trial tests whether dapagliflozin, a drug already used for diabetes and chronic kidney disease, can slow kidney damage in people with lupus nephritis. Lupus nephritis is a serious complication of lupus that causes kidney inflammation and can lead to chronic kidney di…

This study tests a drug called belantamab mafodotin in people with multiple myeloma that has come back or stopped responding to treatment, and who also have kidney problems—from mild impairment to end-stage disease requiring dialysis. The drug is an antibody-drug conjugate that t…

This trial tests whether dapagliflozin (Farxiga), a drug originally developed for diabetes, can protect kidney function in people who have received a heart transplant. Kidney failure is a common and serious complication after heart transplant. The study involves 430 participants …

This phase 3 study tests whether adding baxdrostat to the standard drug dapagliflozin can better slow chronic kidney disease (CKD) progression in adults with CKD and high blood pressure. About 2,500 participants will receive either the combination or dapagliflozin alone for 24 mo…

This early study tests whether the drug theophylline can prevent kidney injury in newborns who experienced oxygen deprivation at birth (HIE) and are receiving cooling therapy. Thirty infants will receive one or two doses of theophylline within 18 hours of birth. The main goal is …

This study tests whether a new drug called vicadrostat, combined with the existing drug empagliflozin, can help people with chronic kidney disease (CKD) that is getting worse. About 492 adults with CKD will be randomly assigned to start both drugs together or one after the other …

This study compares two types of dialysis in 64 adults with end-stage kidney disease. One group gets standard hemodialysis, the other gets hemodiafiltration, which uses both diffusion and convection to remove waste. The main goal is to see if hemodiafiltration leads to less weigh…

This phase 3 trial tests ravulizumab, a drug that blocks part of the immune system, against a placebo in 579 adults with IgA nephropathy—a kidney disease that can lead to kidney failure. The goal is to see if ravulizumab reduces protein in the urine and preserves kidney function …

This study tests the safety of a drug called ferric citrate in children aged 6 to 17 with chronic kidney disease who have high phosphorus levels. The drug is taken by mouth to help control phosphorus, which can cause bone and heart problems if too high. The study involves 45 chil…

This early-phase study tests the safety and best dose of a drug called veliparib when given with two chemotherapy drugs (carboplatin and paclitaxel) in people with advanced solid tumors that have spread or can't be removed. It includes patients who also have liver or kidney probl…

This phase II trial tests whether intensive blood pressure management (targeting systolic BP below 120 mmHg) is better than standard care (below 140 mmHg) for patients with advanced kidney or thyroid cancer starting anti-angiogenic TKI therapy. The study enrolls 61 participants a…

This phase 3 trial is testing whether the drug retatrutide can lower the chance of serious heart problems (like heart attacks and strokes) and slow kidney disease in 10,000 overweight adults who already have heart or kidney disease. Participants receive either retatrutide or a pl…

This study looks at how well the body handles a radioactive drug (lutetium vipivotide tetraxetan) in men with advanced prostate cancer that has spread and no longer responds to hormone therapy. Researchers want to see if different levels of kidney function change how the drug spr…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This early-stage trial tests whether the drug dexmedetomidine can reduce acute kidney injury in 78 adults undergoing ascending aortic surgery with a heart-lung machine. Half receive the drug, half get a placebo. The goal is to see if the drug's anti-inflammatory effects help prev…

This phase 3 trial tests whether the drug atrasentan can slow kidney function loss in people with IgA nephropathy, a disease that can lead to kidney failure. About 404 participants receive either atrasentan or a placebo, along with standard care. The main goal is to see if atrase…

This study tests whether a natural supplement called nicotinamide riboside can improve artery stiffness and lower blood pressure in people with moderate to severe chronic kidney disease. About 118 adults aged 35-80 will take either the supplement or a placebo for 3 months. The go…

This study tests whether a special form of calcium and magnesium (effervescent calcium-magnesium citrate) can slow down harmful calcium buildup in the heart and blood vessels of people with end-stage kidney disease on dialysis. About 269 adults will take either this supplement or…

This study tests a drug called vonsetamig in 43 people with chronic kidney disease who are on dialysis and have very high levels of anti-HLA antibodies, making it nearly impossible to find a matching kidney donor. The drug aims to safely lower these antibodies so that a kidney tr…

This study looks at whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have had a kidney transplant. Twenty-five participants who are at least three months post-transplant will follow a plant-based diet for 16 weeks after a two-…

This study tests whether the drug APX-115 can prevent kidney injury caused by contrast dye used in heart procedures. About 230 adults with kidney disease will receive either the drug or a placebo before and after their procedure. The goal is to see if the drug reduces kidney dama…

This Phase 3 trial tests whether dapagliflozin (Forxiga), a drug originally for diabetes, can reduce the risk of death, kidney failure, and heart failure hospitalization in 1750 people with severe chronic kidney disease. Unlike earlier studies, this trial includes patients on dia…

This study tests whether a short course of two drugs, dasatinib and quercetin, can clear senescent (aging) cells in people with chronic kidney disease. The goal is to see if this reduces frailty and improves stem cell function. Thirty participants aged 40-80 with moderate-to-seve…

This study is testing whether eating Brazil nuts can reduce inflammation and oxidative stress in people with chronic kidney disease. Fifty patients will take Brazil nut supplements for six months while researchers measure changes in blood and gut bacteria. It is a small, early-st…

This study looks at whether a combination of nurse health coaching, doctor training, and subsidies for a kidney-protecting drug can help slow the worsening of chronic kidney disease. About 724 adults with moderate-to-severe kidney disease in Singapore will be randomly assigned to…

This study looks at whether taking cinnamon supplements for three months can lower inflammation and improve gut health in people with chronic kidney disease. Thirty patients will take either cinnamon capsules or a placebo. Researchers will measure markers of inflammation and oxid…

This Phase 2 trial tests whether tirzepatide, a drug already used for diabetes and weight loss, can improve kidney health in 140 people with obesity and chronic kidney disease (with or without type 2 diabetes). Researchers will use MRI scans to measure changes in kidney fat and b…

This study tests an experimental drug called Auxora in 150 adults with acute kidney injury and breathing failure. Patients receive either Auxora or a placebo daily for five days. The goal is to see if Auxora helps patients survive, breathe without a machine, and avoid kidney dial…

This study tests whether a drug called Angiotensin II can raise blood pressure more effectively than standard medications in people with liver cirrhosis who have septic shock. Researchers will measure how well the heart and blood vessels work together over 24 hours. The trial inv…

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. About 1,900 adults with uncontrolled hypertension will receive the procedure and be followed for years. The goal is to see if this approach safely and …

This study looks at whether adding more magnesium to the fluid used during dialysis can help people with kidney failure live longer and have fewer heart-related hospital stays. Many dialysis patients have low magnesium, which can lead to muscle cramps and heart issues. The trial …

This study tests whether the drug finerenone can lower protein levels in the urine of people with chronic kidney disease who are not taking certain blood pressure medications. About 180 adults will receive either finerenone or a placebo for 6 months. The goal is to see if fineren…

This study tests whether ambrisentan, a drug approved for lung blood pressure, can help patients with hepatorenal syndrome—a serious kidney problem that can occur in advanced liver cirrhosis. About 54 hospitalized adults will receive either ambrisentan or the standard drug terlip…

This Phase 3 trial is testing whether a monthly injection of ziltivekimab can reduce the risk of heart attacks and strokes in 6,200 people who already have heart disease, chronic kidney disease, and signs of inflammation. Participants receive either the drug or a placebo for up t…

This study tests whether teaching kidney transplant recipients to eat a whole-food plant-based diet can improve their blood pressure, blood sugar, and weight, and reduce hospital visits and infections. About 49 adults who had a kidney transplant in the past 2–12 months and have h…

This study tests the safety and how the body processes migalastat in 14 adults with Fabry disease who have severe kidney impairment or are on dialysis. Participants take migalastat capsules, and researchers measure drug levels in blood and dialysate. The goal is to ensure proper …

This study explores whether eating alkalizing fruits and vegetables, delivered to your home, can help manage metabolic acidosis in people with chronic kidney disease. The usual treatment, sodium bicarbonate, often causes side effects and doesn't always work. The trial will see if…

This phase 3 study tests BION-1301 (Zigakibart) in 383 adults with IgA nephropathy, a kidney disease that can lead to kidney failure. Participants receive either the drug or a placebo as a shot every 2 weeks for 2 years. The main goal is to see if the drug helps preserve kidney f…

This study looks at whether drinking nitrate-rich beetroot juice every day for three months can improve blood vessel health, movement, and thinking in people with chronic kidney disease. About 92 participants with moderate kidney disease will receive either the active beetroot ju…

This study tests whether a drug called Angiotensin II can help control blood pressure during liver transplant surgery, reducing the need for other strong blood pressure medicines. It involves 50 adults with severe liver disease who are receiving a liver from a deceased donor. The…

This study compares two drugs, mannitol and nitroglycerin, given during robotic prostate or bladder surgery to prevent acute kidney injury. The surgery can reduce blood flow to the kidneys, and these drugs may help protect them. 90 adults with normal or mildly reduced kidney func…

This study is tracking over 1,000 Japanese patients with chronic kidney disease who are taking JARDIANCE® (empagliflozin) daily for a long period. Researchers are monitoring side effects and whether the drug helps slow kidney decline in real-world conditions. The goal is to see i…

This study looks at whether treating patients at home for conditions like infections, heart failure, diabetes, and COPD can lead to better health outcomes and satisfaction compared to traditional hospital stays. Nearly 10,000 adults will receive hospital-level care at home, inclu…

This study looks at whether canagliflozin, a drug used for diabetes, can safely reduce protein in the urine (a sign of kidney damage) in people with advanced chronic kidney disease (CKD), including those on dialysis. About 35 adults with CKD stage 4 or 5 will take the drug for up…

This study compares two methods for placing peritoneal dialysis catheters in adults with advanced chronic kidney disease. The Moncrief-Popovich technique buries the catheter under the skin before use, while the conventional method places it directly. Researchers will track how lo…

This study tests whether a daily dose of alpha lipoic acid, an antioxidant supplement, can lower the risk of heart problems in 50 children who are on regular hemodialysis. Participants will either take the supplement or a placebo pill for a period, and researchers will monitor fo…

This study tests a new pill, vadadustat, taken three times a week, against the usual injected medicine for anemia in people with kidney failure who are on dialysis. About 350 adults will take part to see if the pill can safely keep their red blood cell levels in a healthy range. …

This study tests whether taking potassium supplements can slow down kidney function loss in people with moderate-to-severe chronic kidney disease (CKD) and high blood pressure. About 532 adults with CKD stage 3b or 4 will receive potassium or a placebo. The goal is to see if pota…

This study tests a special device that uses radiofrequency energy to calm overactive kidney nerves, which can help lower blood pressure. It is for adults aged 18-65 with uncontrolled high blood pressure and chronic kidney disease who are already on at least two blood pressure med…

This study tests whether kidneys from donors with hepatitis C (HCV) can be safely transplanted into people who do not have HCV and are waiting for a kidney. Researchers will track 31 recipients for one year to see how well the kidney and patient survive. The goal is to increase t…

This study is testing the drug dapagliflozin in 731 Chinese adults with chronic kidney disease. The goal is to see if the drug can slow kidney decline and is safe. Participants take the drug by mouth, and researchers track kidney function and side effects over time.

This study looks at whether a natural substance called fisetin can help people with advanced chronic kidney disease. Researchers will measure changes in inflammation, stem cell health, and physical frailty after 14 days of treatment. The study involves 30 adults aged 40-80 with m…

This study tests whether a 16-week program of group diet coaching and hands-on cooking classes can help Black Americans at risk for chronic kidney disease stick to the low-sodium DASH diet. The program involves 48 participants who either get the coaching and classes right away or…

This study compares two types of peritoneal dialysis—standard and incremental—in 100 adults starting dialysis. The goal is to see if using less dialysis solution (incremental) helps preserve remaining kidney function and reduces cell damage compared to the standard approach. Part…

This study tests a once-weekly injection called retatrutide in 320 adults with type 2 diabetes and moderate to severe kidney disease who are not controlling their blood sugar well on insulin. Participants will receive either the drug or a placebo for about 14 months. The goal is …

This study compares vasopressin to the standard drug noradrenaline for managing blood pressure after heart surgery. The goal is to see if vasopressin reduces the number of patients who develop acute kidney failure or die. About 840 adults having scheduled heart surgery with a hea…

This study tests whether a bone marrow transplant, given after a kidney transplant, can help the body accept the new kidney without needing lifelong anti-rejection drugs. About 20 adults aged 18-65 who already have a well-functioning kidney transplant will receive an investigatio…

This early-stage study tests a conditioning regimen to make the recipient's immune system accept a donor kidney without needing lifelong anti-rejection medication. About 20 adults with kidney failure receiving their first transplant from a living donor will participate. The main …

This early study tests whether the drug belumosudil, given with donor stem cells, can help the body accept a new kidney without needing strong anti-rejection drugs for life. Sixteen adults with end-stage kidney disease will receive a living donor kidney and stem cell transplant, …

This study looks at how well a new robotic surgery system (Medtronic Hugo) works for urologic procedures like removing prostate, bladder, or kidney tumors. About 144 adults will have surgery with the robot, and doctors will check if the surgery is completed without switching to a…

This study tests a new drug called BT8009, alone or with another drug (pembrolizumab), in people with advanced solid tumors like bladder, breast, lung, or ovarian cancer. The drug targets a protein called Nectin-4 found on some cancer cells. The trial aims to find safe doses and …

This study tests a device called the Selective Cytopheretic Device (SCD) in ICU patients with acute kidney injury and hepatorenal syndrome, a serious complication of liver disease. The device filters white blood cells from the blood for 7 days to see if it improves kidney functio…

This study planned to test a daily pill called vadadustat for anemia in children with chronic kidney disease. It aimed to see if the pill could safely replace standard injections. However, the trial was withdrawn before enrolling any participants, so no results are available.

This study was designed to test a once-daily pill called vadadustat for treating anemia in children with chronic kidney disease. The goal was to see if the drug could safely raise red blood cell levels without the need for injections. However, the study was withdrawn before enrol…

This study was designed to test whether volenrelaxin could help adults with chronic kidney disease by reducing protein in the urine and preserving kidney function. It was a phase 2, placebo-controlled trial planned to last about 24 weeks. However, the study was withdrawn before e…

This study tests whether dapagliflozin, a drug used in adults for diabetes and kidney protection, can reduce protein leakage in the urine of children with chronic kidney disease. Ten children aged 4 to 18 with persistent proteinuria despite standard therapy will take the drug, an…

This phase 4 study tested whether a once-monthly injection of darbepoetin alfa works as well as the standard every-2-week schedule for maintaining healthy hemoglobin levels in people with advanced chronic kidney disease who are not on dialysis. Forty Korean adults completed the 1…

This study looks at whether SGLT-2 inhibitors, a type of diabetes medication, can prevent kidney damage from contrast dye used during heart procedures like angioplasty. Researchers will follow 3,600 adults with acute coronary syndrome who are undergoing invasive treatment. The go…

This study tests whether irbesartan, a blood pressure medication, can reduce the risk of major heart problems and kidney disease in people who had acute kidney injury while in the intensive care unit (ICU). About 500 adults aged 18-75 will take either irbesartan or a placebo for …

This study aimed to see if an ultrasound score called VEXUS could help detect acute kidney injury in adults after heart surgery. About 20% of patients develop this complication, which raises the risk of death. However, the study was withdrawn before enrolling any participants, so…

This study looks at whether a substance called UDP-glucose in urine can help doctors find kidney injury earlier in children after heart surgery. Current tests often miss early signs, delaying treatment. About 305 children under 8 years old having heart surgery will provide urine …

This study involves 800 adults in intensive care who provide urine samples to test a new lab test called ProNephro AKI (NGAL). The goal is to find the right cutoff value that best identifies patients at risk for moderate to severe acute kidney injury within 48-72 hours. The test …

This study tests whether portable ultrasound and blood glucose monitors can help doctors catch chronic conditions like diabetes, heart disease, and kidney disease earlier than usual. About 200 adults will use these devices or receive standard care for 6 months. The goal is to see…

This study tests whether a kidney ultrasound can help doctors detect acute kidney injury early in people who have had a hemorrhagic stroke. Researchers will measure blood flow in the kidneys of 45 adult patients and see if it predicts kidney problems. The goal is to catch kidney …

This study tests a new ultrasound technique called super-resolution ultrasound imaging (SRUI) to see tiny blood vessels in the kidneys. Researchers will give an FDA-approved contrast agent called Definity to healthy volunteers and people with chronic kidney disease (CKD) who need…

This study tests whether giving a drug called angiotensin 2 during liver transplant surgery can prevent acute kidney injury, a common and serious complication. About 30 adults with end-stage liver disease will be randomly assigned to receive either the drug plus standard care or …

This study tests whether a drug called deferoxamine can prevent acute kidney injury in adults undergoing heart surgery. The drug works by removing excess iron, which is thought to damage the kidneys during surgery. About 320 participants will receive either the drug or a placebo …

This study tests a non-invasive ear stimulation technique (taVNS) to prevent acute kidney injury in 152 adults having heart surgery with a heart-lung machine. Half receive real stimulation before and after surgery; the other half get a sham. The main goal is to see if fewer peopl…

This study tests whether a computer program that spots early signs of acute kidney injury can improve patient care. Hospitalized adults at risk are randomly assigned to get an early kidney specialist visit or standard care. The goal is to see if early specialist advice can preven…

This study tests whether a device called RenalGuard can prevent acute kidney injury in 300 adults undergoing heart surgery. The device monitors and manages urine output during and after surgery. Half the patients will get RenalGuard, the other half standard care. Researchers will…

This study tests a digital mindfulness app called Calm Health in 26 adults with chronic kidney disease. Participants use the app for 6 weeks while wearing a wrist sensor to track sleep, activity, and heart rate. The goal is to see if the app is easy to use and if it helps reduce …

This study tests whether adding mindfulness (guided meditation) to a group exercise program during dialysis can improve safety, adherence, and quality of life for people with chronic kidney disease. Thirty participants will be split into two groups: one doing exercise plus mindfu…

This study tests whether a 6-month program of aerobic and resistance exercises, done during dialysis sessions, can improve body composition, muscle oxygen levels, and physical function in 40 adults with chronic kidney disease. Participants are randomly assigned to either the exer…

This study tests if anakinra is better than prednisone for treating gout flares in people with advanced chronic kidney disease or who have had a kidney transplant. Gout causes sudden, severe joint pain. Standard treatments can be risky for these patients. The study measures pain …

This study tests a virtual reality platform designed for people on hemodialysis. The platform includes games to encourage exercise, plus nutritional advice and psychological support. Researchers hope it will improve patients' walking ability, quality of life, and overall well-bei…

This study tests whether a group exercise program shown on TVs during hemodialysis is safe and doable for people with chronic kidney failure. About 45 adults will follow along with exercise videos while receiving dialysis. The goal is to see if this approach can help fight muscle…

This study tests a new device called the Catheter Caps Case (C3) for dialysis patients. The goal is to see if it is more comfortable and easier to use than the usual gauze and tape. Ten adults with a dialysis catheter will try the device for 15 minutes, and researchers will measu…

This study compares continuous spinal anesthesia to general anesthesia for people receiving a kidney transplant. The goal is to see if the spinal method keeps blood pressure more stable and reduces pain. Sixty adults with end-stage kidney disease are taking part.

This study tests whether a 12-week exercise program done during dialysis can improve muscle oxygen levels and dialysis quality in kidney patients who also have muscle loss (sarcopenia). About 40 patients will either exercise on a bike and do resistance moves during their first tw…

This study investigates why people with advanced chronic kidney disease (not yet on dialysis) often feel deep fatigue. Researchers will measure muscle strength and fatigue using simple tests like hand grip and walking speed. The goal is to understand how kidney disease affects ne…

This observational study follows 150,000 people with chronic kidney disease and type 2 diabetes to see how finerenone (Kerendia) works in everyday medical care. Researchers will compare those taking finerenone to those not taking it, looking at rates of heart attacks and heart fa…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This observational study follows over 4,600 adults with chronic kidney disease and type 2 diabetes who are starting finerenone, a drug that helps slow kidney damage. Researchers will collect data from routine doctor visits over 12 months to understand why doctors prescribe it, ho…

This long-term study follows over 5,000 people with chronic kidney disease to learn how the condition affects the heart and blood vessels. Researchers are tracking kidney function, heart events like heart attacks and strokes, and various risk factors. The goal is to find better w…

This study looks at why people who have had an organ transplant are more likely to get cancer. Researchers will combine existing health records from over 85,000 transplant patients in England to track cancer cases and deaths. The goal is to better understand risks and improve car…

Hispanic/Latino and American Indian patients are less likely to get kidney transplants, even though they have higher rates of kidney failure. This study compares two methods to help them complete the transplant evaluation process: a fast-track evaluation done in one day or within…

This study follows thousands of critically ill adults in intensive care units across China to better understand acute kidney injury (AKI), a common and dangerous complication. Researchers will collect medical data, images, and biological samples to build a large database. The goa…

This study investigates whether a single infusion of L-arginine, an amino acid, can reduce abnormally high sympathetic nerve activity in people with chronic kidney disease (CKD). High nerve activity is linked to increased cardiovascular risk in CKD patients. Researchers will meas…

This study looks at whether using a simple bedside ultrasound exam on all hospitalized patients can shorten their hospital stay. Researchers will check the heart, kidneys, liver, and lungs for common problems. The goal is to see if this routine check helps doctors make faster dec…

This study observes 69 adults with chronic kidney disease who are on hemodialysis. Researchers want to find the best way to diagnose malnutrition using the GLIM criteria and other tools. The goal is to see which methods best predict declines in quality of life, muscle strength, a…

This study reviews medical records of 1200 Indian adults with chronic kidney disease and type 2 diabetes who started finerenone between August 2022 and April 2024. Researchers will analyze how doctors prescribed the drug, dose changes, and lab results like kidney function and pot…

This study tests two ways to help older adults with kidney failure make informed choices about their care. One approach offers education and decision aids; the other adds a supportive care program for those who choose non-dialysis options. Researchers will compare how many patien…

This study aims to find the genetic causes of kidney diseases like FSGS and nephrotic syndrome. Researchers will collect saliva and urine samples from up to 2,050 participants, including patients and their family members, as well as healthy volunteers. The goal is to understand w…

This study tests a questionnaire called NECPAL to see if it can spot patients with serious long-term illnesses like cancer, heart failure, or kidney disease who might benefit from palliative care. Researchers will check 200 adults in the hospital or day clinic to see how many are…

This study examines how different hospital treatments—sedation, temperature control, and blood pressure management—after a cardiac arrest impact kidney function. Researchers will follow 3500 adults who were resuscitated from a heart attack outside the hospital. The goal is to und…

The APOLLO study looks at how variations in the APOL1 gene, common in people of African ancestry, affect kidney transplant outcomes. Researchers are testing DNA from 5,000 kidney donors and recipients to see if certain gene variants lead to faster kidney failure or harm living do…

This early study is testing whether the diabetes and heart failure drug empagliflozin (Jardiance) is safe for people on dialysis for kidney failure. The drug is already approved for other uses but has not been studied in dialysis patients. Researchers will give 24 participants ei…

This study gives a single dose of bepirovirsen to 32 adults with hepatitis B, some with kidney disease and some healthy. Researchers measure how much drug gets into the blood and how long it stays. The goal is to see if kidney problems change drug levels, which could affect futur…

This study looks at whether low levels of pyrophosphate, a natural substance that prevents mineral buildup, can predict artery hardening in people with moderate chronic kidney disease. Researchers will measure pyrophosphate in blood samples from 242 patients and track artery chan…

This study planned to test whether giving doctors machine-learning alerts about patient risks after surgery could reduce serious complications like kidney injury or unplanned ICU stays. It was designed for high-risk patients, but the study was withdrawn before enrolling anyone, s…

This study is testing whether a detailed MRI scan can provide better information about chronic kidney disease (CKD) than standard tests. Researchers will scan 486 adults with CKD and track their health over time to see if the MRI can predict which patients will get worse. The goa…

This study was designed to see how a new experimental drug for chronic kidney disease, nurandociguat, affects the way the body processes two common medicines: rosuvastatin (a cholesterol drug) and dabigatran (a blood thinner). Healthy adults would have taken these drugs alone and…

This study was designed to track the long-term health of hospitalized patients in China who develop acute kidney injury (AKI). Researchers planned to monitor kidney function decline, new heart problems, and death rates over time. However, the study was withdrawn before any partic…

This study looks at whether SGLT2 inhibitors, a type of diabetes drug, can help prevent or manage anemia in people with chronic kidney disease. Researchers will analyze data from 15,000 patients in Japan to see how these drugs affect anemia rates, treatments, and costs. The goal …

This study is creating a registry of 5,000 adults with chronic kidney disease (CKD) to collect information on their health, treatments, and outcomes. Researchers aim to understand how the disease progresses, identify risk factors, and see how well current treatments match guideli…

This study looks at whether advanced monitoring devices can accurately measure blood thickness (hematocrit) and oxygen levels during continuous dialysis in critically ill patients with acute kidney injury or end-stage kidney failure. About 30 adults in the intensive care unit wil…

This study looks at how kidney dialysis affects brain blood flow in 37 adults with chronic kidney failure. Researchers use a special breathing device called RespirAct to measure the brain's response to carbon dioxide before and after dialysis sessions. The goal is to find ways to…

This study looks at over 10,000 adults in Ecuador to understand why some people with diabetes develop kidney disease. Researchers will collect health surveys, blood and urine samples, and kidney tissue to study social, environmental, and biological factors. The goal is to find ne…

This study looks at how common kidney injury is in newborns in intensive care and what factors increase the risk. Researchers will review medical records of about 4,000 babies from hospitals around the world. The goal is to better understand short- and long-term kidney health, bu…

This study tests a new tool that personalizes lab results for older adults (65+) with chronic kidney disease. Researchers want to see if the new reports help patients better understand their results and feel less anxious. About 255 participants will review different report design…

This study follows about 793 people with chronic kidney disease who previously took part in a program designed to help them talk to doctors and family about kidney transplants. Researchers want to see if the program's effects last over time, including whether patients start trans…

This study follows about 36 children weighing 2.5-10 kg who have acute kidney injury or fluid overload and are treated with the Carpediem continuous renal replacement therapy system. Researchers will track survival, kidney recovery, and hospital stay lengths to see how well the d…

This study explores the experiences of young adults aged 16 to 30 who receive haemodialysis in a hospital or clinic. Researchers want to understand what makes social interaction difficult and how to reduce loneliness. Through surveys, interviews, and workshops, they aim to create…

This study screened over 16,600 adults aged 45-70 with at least one risk factor (like high blood pressure or smoking) but no known heart disease. Researchers used ultrasound and simple blood and urine tests to find hidden signs of atherosclerosis, pre-diabetes, and kidney disease…

This observational study looks at medical records of 43,000 hospitalized patients to find out how often acute kidney injury (AKI) develops during a hospital stay. Researchers will also compare death rates and readmission rates between patients who develop AKI and those who do not…

This study planned to use a biomarker test called NGAL to predict which critically ill children and newborns would develop severe kidney injury. The goal was to help doctors make better decisions about fluids and dialysis. However, the study was withdrawn before enrolling any par…

This study planned to use a machine learning algorithm to estimate blood potassium levels from a single-lead ECG in hospitalized patients. It was designed as a retrospective analysis of existing data from a home hospital program. However, the study was withdrawn before enrolling …

This study collects information from about 1000 critically ill infants who need a special type of dialysis (blood cleaning) using a new machine called CARPEDIEM. The goal is to learn why doctors start this treatment, how to best use it, and what happens to the babies afterward. T…

This study looks at whether a biomarker test (NGAL) can help doctors better manage fluids and dialysis in children with acute kidney injury in the pediatric ICU. Researchers will follow 420 children at risk for kidney problems to see if the test helps make faster, safer treatment…

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study examines whether SGLT2 inhibitors, a type of diabetes drug, can improve red blood cell production and heart/kidney function in people with chronic heart failure. Researchers will compare blood tests, heart ultrasound measures, and clinical outcomes between 85 patients …

This pilot study tests whether keeping blood pressure higher than usual during and after major surgery can reduce serious complications like heart attack, kidney injury, and confusion. About 80 adults aged 45 and older who take blood pressure medication and are having long surger…

This study follows 1,600 people with chronic kidney disease for 10 years to see how different types of exercise affect harmful toxins in the blood, physical fitness, and overall health. Participants include those in early stages, on dialysis, or with a kidney transplant. The goal…

This study compares a proactive, prescription-based fluid management plan to usual care in 150 critically ill patients who need kidney replacement therapy (dialysis). The goal is to see if a standardized daily prescription can help achieve a neutral or negative fluid balance, pre…

This study aimed to compare costs and health outcomes for heart surgery patients who developed acute kidney injury versus those who did not. Researchers planned to review medical records from UK hospitals over a 10-year period. The study was withdrawn before enrolling any partici…

This study looks at whether vitamin D levels in the blood can help identify kidney injury in people who have had heart surgery. Researchers will compare vitamin D measurements with standard kidney function tests in 46 adults with different levels of kidney health. The goal is to …

This study tests a new digital platform that helps doctors and nurses share important patient information when a person is moved from one hospital to another. About 1,000 adults being transferred to a major hospital will take part. The goal is to see if better information sharing…

This observational study follows 2000 adults with type 2 diabetes and diabetic kidney disease from underserved communities. Researchers collect health data from medical records and questionnaires over 24 months to understand how the disease progresses and what treatments are used…

This study re-analyzes data from a previous trial of 343 heart surgery patients who received a blood purification device (oXiris) connected to the heart-lung machine. The original trial found a 12% reduction in acute kidney injury within 7 days. Now researchers will examine how t…

This study tracks 300,000 donated kidneys from 2010 to 2025 across many countries. Researchers want to see why some kidneys are discarded and how to use them better. The goal is to help more people get transplants and reduce organ waste.

This study uses advanced MRI techniques to measure changes in heart muscle tissue in 8,000 adults with heart failure, heart muscle disease, inflammation, coronary artery disease, or chronic kidney disease. The goal is to see if these measurements can help doctors better diagnose …

This study tests a program that gives kidney failure patients personalized support to help them find a living donor for a kidney transplant. The goal is to increase the number of living donor transplants in Alberta, Canada. About 66 patients will take part, and researchers will t…

This pilot study tests a support program called MuST AKT for people with kidney failure who need a transplant. The program helps patients talk to family and friends about living kidney donation. Researchers want to see if this support leads to more potential donors starting the e…

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common dise…

This study looks at 100 people who spent at least a week in the ICU and had kidney injury. Researchers will measure kidney function, muscle loss, and bone health to understand long-term effects. The goal is to improve follow-up care for ICU survivors.

This study tests a special education program for veterans with advanced chronic kidney disease. The goal is to help them understand their condition and choose the best type of dialysis, especially home dialysis. About 656 veterans will take part to see if this program improves th…

This study looks at how well muscle strength tests work for people with chronic kidney disease. It also tests if a supervised online exercise program is helpful and safe. 50 adults with kidney disease (on dialysis or with a transplant) will take part.

This study was designed to see if doctors could predict kidney damage in children after heart surgery by using an ultrasound probe in the esophagus and a light-based oxygen sensor on the skin. The goal was to catch kidney problems early. However, the study was withdrawn before an…

This study aimed to see if simple electronic reminders could help doctors reduce risky medication combinations in older patients. It planned to enroll primary care clinicians and use behavioral nudges in the electronic health record. However, the trial was withdrawn before any pa…

This pilot study tests a program that screens older dialysis patients for common age-related problems like falls, memory trouble, and medication issues. A geriatrics team then gives personalized recommendations to the dialysis clinic. The goal is to see if this approach is practi…

This study was designed to observe people with chronic kidney disease (CKD) and end-stage kidney disease (ESKD) to understand how the disease naturally progresses and how well current treatments work. It planned to enroll adults diagnosed with CKD or ESKD and follow their health …

This study tests whether an educational program and a mobile health app can help adults with kidney failure find a living donor for a transplant. About 775 participants who haven't yet identified a donor will take part. The goal is to see if these tools increase the number of liv…

This study looks at better ways to check fluid levels in adults with acute kidney injury (AKI). AKI is a sudden drop in kidney function that can be made worse by too little or too much fluid. Researchers will compare different assessment methods, including physical exams and bioi…

This study tests a computer system that uses patient data to predict complications after surgery. Doctors and the computer will each give risk scores for 200 patients, and researchers will compare which is more accurate. The goal is to see if technology can help improve surgical …

This study compares two types of dialysis filters in 30 kidney patients to see which one causes less damage to white blood cells and reduces inflammation. One filter is made of a special material called PMMA that may remove more harmful substances. The goal is to understand how d…

This study aims to identify clinical, lifestyle, and genetic factors that affect blood sugar control and kidney complications in adults with type 2 diabetes in Mexico. Researchers will collect medical history, physical test results, and blood samples from 1,000 participants. The …

This study follows 1,800 adults with reduced kidney function (not on dialysis) to see how nutrition and lifestyle affect their health. Researchers will track changes in kidney function, heart health, bone health, and thinking skills over time. The goal is to find better ways to m…

This study looks at whether a telehealth program called ECHO can help healthcare teams in New Mexico better care for patients with diabetes and other chronic conditions. The program connects primary care providers with specialists through video sessions for training and case disc…

This pilot study tests a new educational tool to help people with chronic kidney disease (CKD) make informed decisions about pregnancy and contraception. About 70 participants will receive a decision aid before a routine nephrology appointment and then complete a survey to measur…

This study follows 600 people with and without chronic kidney disease (CKD) for up to four years to compare how often memory loss, confusion, and daily activity problems occur. Researchers will also look for risk factors that make thinking and memory worse in CKD patients. Partic…

This study looks at how two drugs, Sacubitril/Valsartan (Entresto) and MANP, affect people with a type of heart failure called HFpEF, which also involves chronic kidney disease or shortness of breath during exercise. Researchers will measure changes in body chemicals and kidney f…

This observational study follows 350 adults with pulmonary hypertension to see if certain biomarkers in urine and blood are linked to worsening kidney function. Participants undergo standard tests but receive no experimental treatment. The goal is to better understand how kidney …

This observational study will follow over 10,000 adult patients in intensive care units to understand how often acute kidney injury occurs, how severe it gets, and what happens to patients afterward. Researchers will track kidney function, need for dialysis, and survival up to on…

This study is a review of many smaller trials that looked at what happens when people replace animal protein (like meat, dairy, eggs) with plant protein (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weight,…

This study was designed to see how changing the amount of fluid, the time it stays in the belly, and the sugar level in the dialysis fluid affects how much fluid is removed during automated peritoneal dialysis. It was meant for adults with chronic kidney disease on dialysis for a…

This study tests whether an AI model can predict if a clot-removal procedure will work for people with severe deep vein thrombosis (DVT) in the leg. Thirty adults will receive a catheter-based treatment that breaks up and removes clots, and the AI will analyze MRI scans to see if…

This study looks at 120 adults on regular hemodialysis to see if a simple blood test called the neutrophil-to-lymphocyte ratio (NLR) can help detect peripheral artery disease (PAD). PAD is a common but often overlooked complication in kidney patients. The goal is to find a cheap,…

This study looks at how muscle loss (sarcopenia) affects people with chronic kidney disease (CKD) compared to healthy individuals. Researchers will measure body composition and muscle function in 80 participants. The goal is to better understand when and how muscle loss happens i…

This study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…

This study follows over 3,000 Black people with HIV in the UK to understand how genes and lifestyle affect their risk for kidney disease, heart disease, diabetes, and obesity. Researchers collect health data and blood/urine samples to find genetic markers that predict these condi…

This trial compares two ways to screen First Nations adults in Manitoba for chronic kidney disease. One group gets a letter and lab form in the mail; the other group's primary care network is also contacted. The goal is to see which method leads to more people getting screened, s…

This study follows 300 adults with chronic kidney disease who are already taking SGLT2 inhibitors. Researchers want to see if the amount of sugar in their urine is linked to changes in protein levels, a key marker of kidney damage. The goal is to find a simple way to tell if the …

This study planned to test two new methods for spotting acute kidney injury early in adults after heart surgery. Researchers wanted to see if these methods could predict kidney damage better than current tools. However, the study was withdrawn before enrolling any participants, s…