New drug aims to slow kidney disease in IgA nephropathy patients

NCT ID NCT06291376

Ongoing Disease control Sponsor: Alexion Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests ravulizumab, a drug that blocks part of the immune system, against a placebo in 579 adults with IgA nephropathy—a kidney disease that can lead to kidney failure. The goal is to see if ravulizumab reduces protein in the urine and preserves kidney function over about two years. Participants must have a confirmed diagnosis and signs of active disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ravulizumab
What this could lead to: If it works, this could provide a new treatment option to slow kidney damage and delay the need for dialysis or transplant in people with IgA nephropathy.
What could go wrong: This is a large phase 3 trial, but ravulizumab is not a cure—patients may still need ongoing care. It also carries risks like increased susceptibility to certain infections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic renal failure syndrome IgA glomerulonephritis IgA nephropathy, susceptibility to, 1 proteinuria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IGAN IMMUNOGLOBULIN A NEPHROPATHY

Contacts and locations

Locations

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Alabaster, Alabama, 35007, United States
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Phoenix, Arizona, 85054, United States
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Los Angeles, California, 90022, United States
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Los Angeles, California, 90027, United States
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Los Angeles, California, 90095, United States
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Orange, California, 92868, United States
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San Bernardino, California, 92408, United States
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San Diego, California, 92120, United States
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San Francisco, California, 94143, United States
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Stanford, California, 94305, United States
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Torrance, California, 90502, United States
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Valencia, California, 91355, United States
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Bay Pines, Florida, 33744, United States
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Miami, Florida, 33136, United States
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Orlando, Florida, 32806, United States
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Acworth, Georgia, 30101, United States
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Atlanta, Georgia, 30322, United States
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Lawrenceville, Georgia, 30046, United States
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New Orleans, Louisiana, 70121, United States
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Boston, Massachusetts, 02111, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02115, United States
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Worcester, Massachusetts, 01655, United States
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Minneapolis, Minnesota, 55435, United States
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Minneapolis, Minnesota, 55455, United States
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Kansas City, Missouri, 64111, United States
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North Las Vegas, Nevada, 89086, United States
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Albany, New York, 12208, United States
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New York, New York, 10016, United States
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The Bronx, New York, 10468, United States
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Columbus, Ohio, 43210, United States
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Knoxville, Tennessee, 37920, United States
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Arlington, Texas, 76002, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77054, United States
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San Antonio, Texas, 78229, United States
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Shenandoah, Texas, 77384, United States
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Charlottesville, Virginia, 22908, United States
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Milwaukee, Wisconsin, 53226, United States
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Ciudad de Buenos Aires, C1015ABO, Argentina
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Ciudad de Buenos Aires, C1425AGC, Argentina
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Córdoba, X5016KET, Argentina
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La Plata, B1902COS, Argentina
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Rosario, 2000, Argentina
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Canberra, 2605, Australia
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Clayton, 3168, Australia
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Concord, 2139, Australia
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Herston, 4029, Australia
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Liverpool, 2170, Australia
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Perth, 6000, Australia
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Southport, 4222, Australia
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St Albans, 3021, Australia
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Graz, 8036, Austria
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Innsbruck, 6020, Austria
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Linz, 4020, Austria
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Brussels, 1090, Belgium
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Edegem, 2650, Belgium
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Leuven, 3000, Belgium
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Belo Horizonte, 30110-934, Brazil
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Belo Horizonte, 30150-221, Brazil
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Botucatu, 18618-687, Brazil
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Curitiba, 80440-020, Brazil
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Fortaleza, 60430-270, Brazil
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Recife, 50670-901, Brazil
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Ribeirão Preto, 14051-140, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 04038-002, Brazil
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São Paulo, 05403-000, Brazil
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Winnipeg, Manitoba, R2V 3M3, Canada
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Brampton, Ontario, L6T 5T6, Canada
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London, Ontario, N6A 5W9, Canada
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Toronto, Ontario, M5G 2C4, Canada
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Araucania, 4781151, Chile
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Providencia, 7500000, Chile
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Santiago, 7500922, Chile
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Santiago, 8330034, Chile
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Valdivia, 5090146, Chile
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Baotou, 14010, China
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Beijing, 100029, China
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Beijing, 100034, China
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Beijing, 100044, China
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Changsha, 410013, China
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Changzhou, 272100, China
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Chengdu, 610000, China
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Chengdu, 610072, China
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Chongqing, 400010, China
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Guangzhou, 510100, China
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Hangzhou, 310003, China
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Jinan, 250021, China
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Jinhua, 321000, China
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Lanzhou, 730000, China
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Luoyang, 471000, China
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Nanchang, 330006, China
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Nanchang, 330008, China
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Nanjing, 210009, China
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Nanjing, 210011, China
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Nanjing, 210029, China
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Ningbo, 315010, China
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Qingdao, 110016, China
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Shanghai, 200025, China
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Shanghai, 200040, China
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Shanghai, 200065, China
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Shenzhen, 518036, China
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Shenzhen, 518053, China
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Ürümqi, 831118, China
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Wuhan, 430060, China
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Wuxi, 214023, China
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Xi'an, 710061, China
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Yantai, 264000, China
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Yibin, 610500, China
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Yinchuan, 750004, China
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Zhengzhou, 450052, China
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Nový Jičín, 741 01, Czechia
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Prague, 128 00, Czechia
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Prague, 140 00, Czechia
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Amiens, 80054, France
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Bayonne, 64100, France
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Brest, 29200, France
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Chambéry, 73011, France
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Le Kremlin-Bicêtre, 94270, France
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Marseille, 13385, France
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Nantes, 44093, France
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Paris, 75010, France
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Paris, 75015, France
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Saint-Priest-en-Jarez, 42270, France
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Strasbourg, 67091, France
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Toulouse, 31059, France
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Aachen, 52074, Germany
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Berlin, 10117, Germany
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Erlangen, 91054, Germany
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Essen, 45122, Germany
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Greifswald, 17475, Germany
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Hanover, 30625, Germany
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Mainz, 55131, Germany
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München, 81377, Germany
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München, 81657, Germany
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Villingen-Schwenningen, 78052, Germany
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Athens, 11527, Greece
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Athens, 12462, Greece
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Heraklion, 71500, Greece
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Thessaloniki, 57010, Greece
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Hong Kong, 999077, Hong Kong
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Hong Kong, Hong Kong
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Haifa, 3109601, Israel
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Jerusalem, 91120, Israel
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Nazareth, 16100, Israel
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Petah Tikva, 49372, Israel
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Tel Aviv, 6423906, Israel
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Agrigento, 92100, Italy
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Bologna, 40138, Italy
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Brescia, 25123, Italy
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Cagliari, 09121, Italy
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Florence, 50134, Italy
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Milan, 20122, Italy
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Milan, 20132, Italy
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Padova, 35128, Italy
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Parma, 43126, Italy
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Torino, 10154, Italy
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Torrette, 60126, Italy
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Verona, 37126, Italy
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Bunkyō City, 113-8431, Japan
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Chiba, 260-8677, Japan
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Chiba, 260-8712, Japan
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Fukuoka, 815-8555, Japan
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Kamakura, 247-8533, Japan
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Kasugai-shi, 486-8510, Japan
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Kitakyushu-shi, 802-8555, Japan
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Kobe, 650-0047, Japan
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Matsumoto-shi, 390-8621, Japan
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Matsuyama, 790-8524, Japan
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Nagoya, 466-8650, Japan
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Osaka, 534-0021, Japan
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Osaka, 545-8586, Japan
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Sapporo, 060-8604, Japan
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Urayasu-shi, 279-0021, Japan
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Ipoh, 30990, Malaysia
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Johor Bahru, 80100, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Seremban, 70300, Malaysia
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Amsterdam, 1105 AZ, Netherlands
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Rotterdam, 3045 PM, Netherlands
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Bialystok, 15-276, Poland
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Bialystok, 15-540, Poland
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Krakow, 31-513, Poland
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Lodz, 92-213, Poland
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Lublin, 20-090, Poland
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Olsztyn, 10-561, Poland
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Poznan, 60-355, Poland
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Szczecin, 70-111, Poland
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Warsaw, 02-006, Poland
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Warsaw, 02-507, Poland
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Dammam, 31444, Saudi Arabia
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Jeddah, 21499, Saudi Arabia
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Riyadh, 11211, Saudi Arabia
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Riyadh, 12231, Saudi Arabia
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Banská Bystrica, 974 01, Slovakia
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Martin, 03659, Slovakia
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Anyang-si, 14068, South Korea
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Busan, 49241, South Korea
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Deagu, 41944, South Korea
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Gwangju, 61469, South Korea
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Gyeonggi-do, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05278, South Korea
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Suwon, 16499, South Korea
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A Coruña, 15006, Spain
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Alcalá de Henares, 28805, Spain
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Lleida, 25198, Spain
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Madrid, 28031, Spain
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Madrid, 28040, Spain
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Málaga, 29010, Spain
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Murcia, 30120, Spain
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Oviedo, 33011, Spain
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Seville, 41013, Spain
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Tarragona, 09-43005, Spain
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Zaragoza, 50009, Spain
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Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 81362, Taiwan
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Kaohsiung City, 833401, Taiwan
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New Taipei City, 220, Taiwan
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New Taipei City, 23561, Taiwan
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Taichung, 40705, Taiwan
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Taichung, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 10002, Taiwan
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Taoyuan, 333, Taiwan
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Bangkok, 10330, Thailand
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Bangkok, 10400, Thailand
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Bangkok, 10700, Thailand
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Chiang Mai, 50200, Thailand
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Khon Kaen, 40002, Thailand
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Ankara, 06560, Turkey (Türkiye)
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Bursa, 16059, Turkey (Türkiye)
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Istanbul, 34098, Turkey (Türkiye)
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Istanbul, 34452, Turkey (Türkiye)
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Kayseri, 38039, Turkey (Türkiye)
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Kocaeli, 41380, Turkey (Türkiye)
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Konya, 42080, Turkey (Türkiye)
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Cambridge, CB2 0QQ, United Kingdom
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Doncaster, DN2 5LT, United Kingdom
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Leicester, Le5 4PW, United Kingdom
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London, E1 1BB, United Kingdom
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Manchester, M13 9WL, United Kingdom
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Reading, RG1 5AN, United Kingdom
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Stevenage, SG1 4AB, United Kingdom

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